JP2005511535A5 - - Google Patents
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- Publication number
- JP2005511535A5 JP2005511535A5 JP2003536238A JP2003536238A JP2005511535A5 JP 2005511535 A5 JP2005511535 A5 JP 2005511535A5 JP 2003536238 A JP2003536238 A JP 2003536238A JP 2003536238 A JP2003536238 A JP 2003536238A JP 2005511535 A5 JP2005511535 A5 JP 2005511535A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- compound according
- independently
- administering
- integer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 27
- 238000000034 method Methods 0.000 claims 10
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 241000725303 Human immunodeficiency virus Species 0.000 claims 4
- 241000124008 Mammalia Species 0.000 claims 4
- 208000036142 Viral infection Diseases 0.000 claims 4
- 238000002512 chemotherapy Methods 0.000 claims 4
- 238000001959 radiotherapy Methods 0.000 claims 4
- 230000009385 viral infection Effects 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 201000004384 Alopecia Diseases 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 2
- 150000001204 N-oxides Chemical class 0.000 claims 2
- 239000000654 additive Substances 0.000 claims 2
- 230000000996 additive effect Effects 0.000 claims 2
- 231100000360 alopecia Toxicity 0.000 claims 2
- 230000010261 cell growth Effects 0.000 claims 2
- 125000005265 dialkylamine group Chemical group 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 230000003463 hyperproliferative effect Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 239000002184 metal Substances 0.000 claims 2
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 229910052698 phosphorus Inorganic materials 0.000 claims 2
- 239000000651 prodrug Substances 0.000 claims 2
- 229940002612 prodrug Drugs 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 229910000039 hydrogen halide Inorganic materials 0.000 claims 1
- 239000012433 hydrogen halide Substances 0.000 claims 1
- 229910052740 iodine Inorganic materials 0.000 claims 1
- -1 isomers Chemical class 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32943701P | 2001-10-15 | 2001-10-15 | |
| US33696201P | 2001-12-03 | 2001-12-03 | |
| PCT/US2002/033052 WO2003033499A2 (en) | 2001-10-15 | 2002-10-15 | Inhibitors of cyclin-dependent kinases, compositions and uses related thereto |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005511535A JP2005511535A (ja) | 2005-04-28 |
| JP2005511535A5 true JP2005511535A5 (enExample) | 2005-12-22 |
Family
ID=26986788
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003536238A Pending JP2005511535A (ja) | 2001-10-15 | 2002-10-15 | サイクリン依存性キナーゼの阻害剤、組成物及びその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20050090471A1 (enExample) |
| EP (2) | EP1832589A1 (enExample) |
| JP (1) | JP2005511535A (enExample) |
| CA (1) | CA2463571A1 (enExample) |
| PL (1) | PL369742A1 (enExample) |
| WO (1) | WO2003033499A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6559152B2 (en) * | 1998-10-13 | 2003-05-06 | Dupont Pharmaceuticals Company | 6-substituted pyrazolo[3,4-d]pyrimidin-4-ones useful as cyclin dependent kinase inhibitors |
| US7605175B2 (en) | 2001-03-02 | 2009-10-20 | Gpc Biotech Ag | Inhibitors of cyclin-dependent kinases, compositions and uses related thereto |
| JP4343534B2 (ja) * | 2001-03-02 | 2009-10-14 | ゲーペーツェー バイオテック アクチェンゲゼルシャフト | ３ハイブリッド・アッセイ・システム |
| US7456169B2 (en) | 2003-02-27 | 2008-11-25 | Abbott Laboratories Inc. | Heterocyclic kinase inhibitors |
| US7320986B2 (en) | 2003-03-07 | 2008-01-22 | Abbott Labortories | Fused tri and tetra-cyclic pyrazole kinase inhibitors |
| JP5064795B2 (ja) | 2003-04-07 | 2012-10-31 | アジェニックス ユーエスエー インク． | サイクリン依存性キナーゼの阻害剤、組成物及びそれに関連する使用 |
| BRPI0418095A (pt) * | 2003-12-23 | 2007-04-17 | Gpc Biotech Inc | inibidores de quinases dependentes de ciclina, composições e usos relacionados aos mesmos |
| ES2551293T3 (es) | 2004-03-24 | 2015-11-17 | Abbvie Inc. | Inhibidores de quinasas de pirazol tricíclicos |
| EP2298292A3 (en) | 2004-06-18 | 2011-08-10 | Agennix USA Inc. | Kinase inhibitors for treating cancers |
| EP1797096B1 (en) | 2004-09-06 | 2011-07-27 | Bayer Schering Pharma Aktiengesellschaft | Pyrazolopyrimidines as inhibitors of protein kinase b (akt) |
| US20070231906A1 (en) * | 2005-10-25 | 2007-10-04 | Invitrogen Corporation | Three Frame cDNA Expression Libraries for Functional Screening of Proteins |
| EP2019101A1 (en) | 2007-07-26 | 2009-01-28 | GPC Biotech AG | Pyrazol[3,4-d]pyrimidin-4-one useful as Kinase Inhibitor |
| JP7166252B2 (ja) | 2016-11-30 | 2022-11-07 | メディツィーニシェ・ウニヴェルジテート・インスブルック | サイクリン依存性キナーゼ阻害剤としての３－アミノ－１，５－ジヒドロピラゾロ［３，４－ｄ］ピリミジン－４－オン |
| US20220195059A1 (en) | 2019-04-30 | 2022-06-23 | Instituto de Medicina Molecular João Lobo Antunes | Rank Pathway Inhibitors in Combination with CDK Inhibitors |
| CN111238890B (zh) * | 2020-01-16 | 2024-03-19 | 南昌准好生物科技有限公司 | 基于离心法的液基制片技术用于液基真菌的检测方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3211732A (en) * | 1965-10-12 | Pyrazolob:x-d]pyrlil/hdines | ||
| US2989538A (en) * | 1960-02-10 | 1961-06-20 | Smith Kline French Lab | Process for preparing pyrazoloindenone hydrazones |
| CH398626A (de) * | 1960-05-11 | 1966-03-15 | Ciba Geigy | Verfahren zur Herstellung neuer Pyrazolopyrimidine |
| US5564705A (en) * | 1993-05-31 | 1996-10-15 | K.K. Endo Seisakusho | Golf club head with peripheral balance weights |
| US5593997A (en) * | 1995-05-23 | 1997-01-14 | Pfizer Inc. | 4-aminopyrazolo(3-,4-D)pyrimidine and 4-aminopyrazolo-(3,4-D)pyridine tyrosine kinase inhibitors |
| US6407103B2 (en) * | 1998-04-21 | 2002-06-18 | Bristol-Myers Squibb Pharma Company | Indeno [1,2-c] pyrazol-4-ones and their uses |
| EP1071668B1 (en) * | 1998-04-21 | 2009-06-03 | Bristol-Myers Squibb Pharma Company | 5-aminoindeno[1,2-c]pyrazol-4-ones as anti-cancer and anti-proliferative agents |
| US6531477B1 (en) * | 1998-10-13 | 2003-03-11 | Dupont Pharmaceuticals Company | 6-substituted pyrazolo [3,4-d] pyrimidin-4-ones useful as cyclin dependent kinase inhibitors |
| US6291504B1 (en) * | 1999-10-20 | 2001-09-18 | Dupont Pharmaceuticals Company | Acylsemicarbazides and their uses |
| US6753329B2 (en) * | 2001-12-03 | 2004-06-22 | Gpc Biotech Inc. | Inhibitors of cyclin-dependent kinases, compositions and uses related thereto |
-
2002
- 2002-10-15 PL PL02369742A patent/PL369742A1/xx not_active Application Discontinuation
- 2002-10-15 EP EP07008359A patent/EP1832589A1/en not_active Withdrawn
- 2002-10-15 CA CA002463571A patent/CA2463571A1/en not_active Abandoned
- 2002-10-15 US US10/492,116 patent/US20050090471A1/en not_active Abandoned
- 2002-10-15 JP JP2003536238A patent/JP2005511535A/ja active Pending
- 2002-10-15 EP EP02797047A patent/EP1446405A2/en not_active Ceased
- 2002-10-15 WO PCT/US2002/033052 patent/WO2003033499A2/en not_active Ceased
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