JP2005510536A5 - - Google Patents
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- JP2005510536A5 JP2005510536A5 JP2003546838A JP2003546838A JP2005510536A5 JP 2005510536 A5 JP2005510536 A5 JP 2005510536A5 JP 2003546838 A JP2003546838 A JP 2003546838A JP 2003546838 A JP2003546838 A JP 2003546838A JP 2005510536 A5 JP2005510536 A5 JP 2005510536A5
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- JP
- Japan
- Prior art keywords
- compound
- vitamin
- composition
- administered
- amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 229930003316 Vitamin D Natural products 0.000 claims 42
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims 42
- 235000019166 vitamin D Nutrition 0.000 claims 42
- 239000011710 vitamin D Substances 0.000 claims 42
- 229940046008 vitamin d Drugs 0.000 claims 42
- -1 vitamin D compound Chemical class 0.000 claims 34
- 239000000203 mixture Substances 0.000 claims 30
- 125000003342 alkenyl group Chemical group 0.000 claims 18
- 239000002246 antineoplastic agent Substances 0.000 claims 17
- 239000003795 chemical substances by application Substances 0.000 claims 16
- 229940034982 antineoplastic agent Drugs 0.000 claims 15
- 210000004027 cell Anatomy 0.000 claims 15
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 15
- 125000000217 alkyl group Chemical group 0.000 claims 12
- 229910052791 calcium Inorganic materials 0.000 claims 12
- 239000011575 calcium Substances 0.000 claims 12
- 229940079593 drug Drugs 0.000 claims 9
- 239000003814 drug Substances 0.000 claims 9
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 8
- 238000000034 method Methods 0.000 claims 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 7
- 230000002401 inhibitory effect Effects 0.000 claims 7
- 210000005170 neoplastic cell Anatomy 0.000 claims 7
- 150000003710 vitamin D derivatives Chemical class 0.000 claims 7
- 125000002252 acyl group Chemical group 0.000 claims 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims 6
- 125000004991 fluoroalkenyl group Chemical group 0.000 claims 6
- 125000003709 fluoroalkyl group Chemical group 0.000 claims 6
- 230000003211 malignant effect Effects 0.000 claims 6
- 102000009310 vitamin D receptors Human genes 0.000 claims 6
- 108050000156 vitamin D receptors Proteins 0.000 claims 6
- 210000000988 bone and bone Anatomy 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 230000003463 hyperproliferative effect Effects 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 150000001721 carbon Chemical group 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 239000011203 carbon fibre reinforced carbon Substances 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 208000037147 Hypercalcaemia Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 230000001028 anti-proliverative effect Effects 0.000 claims 2
- 229940041181 antineoplastic drug Drugs 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 2
- 230000000148 hypercalcaemia Effects 0.000 claims 2
- 208000030915 hypercalcemia disease Diseases 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 2
- NEETXMRNUNEBRH-GOTXBORWSA-N (1r,3s,5z)-5-[(2e)-2-[(1r,3as,7ar)-1-[(2r,5s)-5,6-dimethylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1h-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CC[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C NEETXMRNUNEBRH-GOTXBORWSA-N 0.000 claims 1
- GMRQFYUYWCNGIN-ZVUFCXRFSA-N 1,25-dihydroxy vitamin D3 Chemical compound C1([C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=CC=C1C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-ZVUFCXRFSA-N 0.000 claims 1
- ZGLHBRQAEXKACO-XJRQOBMKSA-N 1alpha,25-dihydroxyvitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](\C=C\[C@H](C)C(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C ZGLHBRQAEXKACO-XJRQOBMKSA-N 0.000 claims 1
- HVAVRRBYXYEBNC-RKULPTJNSA-N 24-hydroxyvitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/C(C)(O)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C HVAVRRBYXYEBNC-RKULPTJNSA-N 0.000 claims 1
- 229940122361 Bisphosphonate Drugs 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 102000016736 Cyclin Human genes 0.000 claims 1
- 108050006400 Cyclin Proteins 0.000 claims 1
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
- 208000028018 Lymphocytic leukaemia Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 201000000582 Retinoblastoma Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 208000021712 Soft tissue sarcoma Diseases 0.000 claims 1
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 1
- 206010057644 Testis cancer Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 229940100198 alkylating agent Drugs 0.000 claims 1
- 239000002168 alkylating agent Substances 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 230000000340 anti-metabolite Effects 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 229940100197 antimetabolite Drugs 0.000 claims 1
- 239000002256 antimetabolite Substances 0.000 claims 1
- 150000004663 bisphosphonates Chemical group 0.000 claims 1
- 206010006007 bone sarcoma Diseases 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 210000003679 cervix uteri Anatomy 0.000 claims 1
- 238000011260 co-administration Methods 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- HKXBNHCUPKIYDM-CGMHZMFXSA-N doxercalciferol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C HKXBNHCUPKIYDM-CGMHZMFXSA-N 0.000 claims 1
- 210000004696 endometrium Anatomy 0.000 claims 1
- 210000003128 head Anatomy 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 208000003747 lymphoid leukemia Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 231100000782 microtubule inhibitor Toxicity 0.000 claims 1
- 208000025113 myeloid leukemia Diseases 0.000 claims 1
- 210000003739 neck Anatomy 0.000 claims 1
- 229960003552 other antineoplastic agent in atc Drugs 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 229910052697 platinum Inorganic materials 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 210000004872 soft tissue Anatomy 0.000 claims 1
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 1
- 230000002381 testicular Effects 0.000 claims 1
- 201000003120 testicular cancer Diseases 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 210000003932 urinary bladder Anatomy 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/995,911 US20020128240A1 (en) | 1996-12-30 | 2001-11-28 | Treatment of hyperproliferative diseases using active vitamin D analogues |
| PCT/US2002/038263 WO2003045333A2 (en) | 2001-11-28 | 2002-11-26 | Treatment of hyperproliferative diseases using active vitamin d analogues |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005510536A JP2005510536A (ja) | 2005-04-21 |
| JP2005510536A5 true JP2005510536A5 (enExample) | 2006-10-26 |
Family
ID=25542333
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003546838A Pending JP2005510536A (ja) | 2001-11-28 | 2002-11-26 | 活性ビタミンｄ類縁物質を使用した過剰増殖性疾病の治療 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20020128240A1 (enExample) |
| EP (1) | EP1448150A4 (enExample) |
| JP (1) | JP2005510536A (enExample) |
| KR (1) | KR20040061000A (enExample) |
| CN (1) | CN1596115A (enExample) |
| AU (1) | AU2002346596A1 (enExample) |
| CA (1) | CA2466867A1 (enExample) |
| IL (1) | IL161195A0 (enExample) |
| MX (1) | MXPA04003465A (enExample) |
| WO (1) | WO2003045333A2 (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040009958A1 (en) * | 1991-01-08 | 2004-01-15 | Bone Care International, Inc. | Methods for preparation and use of 1alpha,24(S)-dihydroxyvitamin D2 |
| US20040043971A1 (en) * | 1995-04-03 | 2004-03-04 | Bone Care International, Inc. | Method of treating and preventing hyperparathyroidism with active vitamin D analogs |
| US20020183288A1 (en) * | 1995-04-03 | 2002-12-05 | Bone Care International, Inc. | Method for treating and preventing hyperparathyroidism |
| PT1392313E (pt) * | 2001-05-16 | 2007-07-17 | Novartis Ag | Combinação que compreende n - ( 5- [ 4- ( metil-piperazinomrtil ) - benxoilamido ] - 2 -metilfenil ) - 4 -( 3 - piridil ) - 2 - pirimidina-amina e um agente quimioterapêutico |
| US20030191093A1 (en) * | 2001-12-03 | 2003-10-09 | Novacea, Inc. | Pharmaceutical compositions comprising active vitamin D compounds |
| US20040058895A1 (en) * | 2002-09-18 | 2004-03-25 | Bone Care International, Inc. | Multi-use vessels for vitamin D formulations |
| US7148211B2 (en) * | 2002-09-18 | 2006-12-12 | Genzyme Corporation | Formulation for lipophilic agents |
| US20050101576A1 (en) * | 2003-11-06 | 2005-05-12 | Novacea, Inc. | Methods of using vitamin D compounds in the treatment of myelodysplastic syndromes |
| WO2004047673A2 (en) * | 2002-11-21 | 2004-06-10 | Novacea, Inc. | Treatment of liver disease with active vitamin d compounds |
| US7361691B2 (en) * | 2002-12-02 | 2008-04-22 | Arqule, Inc. | Method of treating cancers using β-lapachone or analogs or derivatives thereof |
| US20050026877A1 (en) * | 2002-12-03 | 2005-02-03 | Novacea, Inc. | Pharmaceutical compositions comprising active vitamin D compounds |
| CA2528359A1 (en) * | 2003-06-11 | 2004-12-23 | Novacea, Inc. | Treatment of cancer with active vitamin d compounds in combination with radiotherapeutic agents and treatments |
| ZA200510025B (en) * | 2003-06-11 | 2007-03-28 | Novacea Inc | Pharmaceutical compositions comprising active vitamin D compounds |
| JP2007501864A (ja) * | 2003-06-11 | 2007-02-01 | ノバセア インコーポレイティッド | 活性ビタミンｄ化合物単独または他の治療薬との併用による、免疫介在疾患の治療法 |
| PT103177A (pt) * | 2003-09-24 | 2005-03-31 | Bioxell Spa | 1-alfa-fluoro-25-hidroxi-16,23e-dieno-26,27-bis-homo-20-epi-colecalciferol, seus sais ou esteres e sua utilizacao no fabrico de medicamentos |
| EP1663250A4 (en) * | 2003-09-24 | 2006-12-20 | Bioxell Spa | TREATMENT OF MALFUNCTION OF BLADDER |
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| US20070275934A1 (en) * | 2004-05-10 | 2007-11-29 | Curd John G | Treatment of pancreatic cancer with active vitamin d compounds in combination with other treatments |
| PL1765391T3 (pl) * | 2004-06-07 | 2013-08-30 | Qu Biologics Inc | Kompozycje bakteryjne do leczenia nowotworów |
| US9107864B2 (en) | 2004-06-07 | 2015-08-18 | Qu Biologics Inc. | Tissue targeted antigenic activation of the immune response to treat cancers |
| JP2008519808A (ja) * | 2004-11-12 | 2008-06-12 | ビオエクセル エスピーエー | 膀胱癌治療のためのビタミンｄ誘導体及び抗増殖薬の併用 |
| SI1993559T1 (sl) | 2006-02-03 | 2017-01-31 | Opko Renal, Llc | Zdravljenje nezadostnosti in pomanjkanja vitamina D s 25-hidroksivitaminon D2 in 25-hidroksivitaminom D3 |
| US20100009949A1 (en) * | 2006-03-24 | 2010-01-14 | Bioxell S.P.A. | Novel method |
| DK3357496T3 (da) | 2006-06-21 | 2020-05-11 | Opko Ireland Global Holdings Ltd | Terapi ved brug af vitamin d-repletteringsmiddel og vitamin d-hormonsubstitutionsmiddel |
| US20080051375A1 (en) * | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods for treating cancer comprising the administration of a vitamin d compound and an additional therapeutic agent, and compositions containing the same |
| US20080051380A1 (en) * | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods and compositions for treating cancer |
| EP1972341A1 (en) * | 2007-03-23 | 2008-09-24 | Novartis AG | Pharmaceutical compositions comprising a bisphosphonate and vitamin D |
| ES3047207T3 (en) | 2007-04-25 | 2025-12-03 | Opko Renal Llc | Method of safely and effectively treating and preventing secondary hyperparathyroidism in chronic kidney disease |
| PT2148684E (pt) | 2007-04-25 | 2013-04-19 | Cytochroma Inc | Método de tratamento para a insuficiência e deficiência de vitamina d |
| PT2148661E (pt) | 2007-04-25 | 2013-03-06 | Proventiv Therapeutics Llc | Composições orais de libertação controlada compreendendo um composto de vitamina d e veículo ceroso |
| US8377913B2 (en) * | 2007-11-20 | 2013-02-19 | Abbvie Inc. | Vitamin D receptor activators and methods of making |
| CN106853250A (zh) | 2008-04-02 | 2017-06-16 | 赛特克罗公司 | 用于维生素d缺乏症和相关障碍的方法、组合物、用途和试剂盒 |
| US9155592B2 (en) | 2009-06-16 | 2015-10-13 | Intuitive Surgical Operations, Inc. | Virtual measurement tool for minimally invasive surgery |
| US11672809B2 (en) | 2010-03-29 | 2023-06-13 | Eirgen Pharma Ltd. | Methods and compositions for reducing parathyroid levels |
| ES2645509T3 (es) | 2010-07-26 | 2017-12-05 | Qu Biologics Inc | Composiciones antiinflamatorias inmunogénicas |
| CN102648917A (zh) * | 2012-04-25 | 2012-08-29 | 杨烨 | 维生素d3在制备治疗多发性骨髓瘤药物中的应用 |
| KR101847947B1 (ko) | 2013-03-15 | 2018-05-28 | 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 | 안정화되고 변형된 비타민 ｄ 방출 제형 |
| CA3254723A1 (en) | 2014-05-02 | 2025-04-15 | Qu Biologics Inc | ANTIMICROBIAL IMMUNOMODULATION |
| US10220047B2 (en) | 2014-08-07 | 2019-03-05 | Opko Ireland Global Holdings, Ltd. | Adjunctive therapy with 25-hydroxyvitamin D and articles therefor |
| WO2017182237A1 (en) | 2016-03-28 | 2017-10-26 | Opko Ireland Global Holdings, Limited | Methods of vitamin d treatment |
| CN106008301B (zh) * | 2016-05-24 | 2017-12-26 | 中国医药集团总公司四川抗菌素工业研究所 | 26‑甲基‑25‑羟基维生素d3化合物及其制备方法和应用 |
| WO2018023017A1 (en) | 2016-07-29 | 2018-02-01 | Janssen Pharmaceutica Nv | Methods of treating prostate cancer |
| CN106496330B (zh) * | 2016-11-07 | 2018-07-03 | 陕西理工学院 | 一种VDR-His融合蛋白及其DNA序列、表达方法和应用 |
| CN111789957B (zh) * | 2020-07-23 | 2022-04-22 | 苏州大学 | 敲低lncBCAS1-4_1细胞株与活性维生素D联用在制备抗肿瘤药物中的应用 |
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-
2001
- 2001-11-28 US US09/995,911 patent/US20020128240A1/en not_active Abandoned
-
2002
- 2002-11-26 AU AU2002346596A patent/AU2002346596A1/en not_active Abandoned
- 2002-11-26 CA CA002466867A patent/CA2466867A1/en not_active Abandoned
- 2002-11-26 EP EP02784667A patent/EP1448150A4/en not_active Withdrawn
- 2002-11-26 JP JP2003546838A patent/JP2005510536A/ja active Pending
- 2002-11-26 MX MXPA04003465A patent/MXPA04003465A/es not_active Application Discontinuation
- 2002-11-26 CN CNA028237498A patent/CN1596115A/zh active Pending
- 2002-11-26 IL IL16119502A patent/IL161195A0/xx unknown
- 2002-11-26 KR KR10-2004-7008156A patent/KR20040061000A/ko not_active Withdrawn
- 2002-11-26 WO PCT/US2002/038263 patent/WO2003045333A2/en not_active Ceased
-
2006
- 2006-05-11 US US11/382,887 patent/US20070043005A1/en not_active Abandoned
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