JP2005509038A - 多環式グアニン誘導体ホスホジエステラーゼｖ阻害剤 - Google Patents

多環式グアニン誘導体ホスホジエステラーゼｖ阻害剤 Download PDF

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Publication number
JP2005509038A
JP2005509038A JP2003544052A JP2003544052A JP2005509038A JP 2005509038 A JP2005509038 A JP 2005509038A JP 2003544052 A JP2003544052 A JP 2003544052A JP 2003544052 A JP2003544052 A JP 2003544052A JP 2005509038 A JP2005509038 A JP 2005509038A
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moieties
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Japanese (ja)
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JP2005509038A5 (enExample
Inventor
セオドロス アスベロム，
ジョン ダブリュー． クラダー，
ユエチン フ，
ディミトリ エー． ピッサーニトスキ，
スタムフォード，　アンドリュー　ダブリュー．
ルオ シュー，
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Merck Sharp and Dohme LLC
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Schering Corp
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Publication of JP2005509038A publication Critical patent/JP2005509038A/ja
Publication of JP2005509038A5 publication Critical patent/JP2005509038A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Reproductive Health (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2003544052A 2001-11-09 2002-11-07 多環式グアニン誘導体ホスホジエステラーゼｖ阻害剤 Pending JP2005509038A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34449801P 2001-11-09 2001-11-09
PCT/US2002/035721 WO2003042216A1 (en) 2001-11-09 2002-11-07 Polycyclic guanine derivative phosphodiesterase v inhibitors

Related Child Applications (1)

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JP2005306453A Division JP2006077023A (ja) 2001-11-09 2005-10-20 多環式グアニン誘導体ホスホジエステラーゼｖ阻害剤

Publications (2)

Publication Number Publication Date
JP2005509038A true JP2005509038A (ja) 2005-04-07
JP2005509038A5 JP2005509038A5 (enExample) 2006-01-05

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JP2003544052A Pending JP2005509038A (ja) 2001-11-09 2002-11-07 多環式グアニン誘導体ホスホジエステラーゼｖ阻害剤
JP2005306453A Pending JP2006077023A (ja) 2001-11-09 2005-10-20 多環式グアニン誘導体ホスホジエステラーゼｖ阻害剤

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Country Status (7)

Country Link
US (2) US6943171B2 (enExample)
EP (1) EP1442042A1 (enExample)
JP (2) JP2005509038A (enExample)
CN (1) CN1585771A (enExample)
CA (1) CA2465893A1 (enExample)
MX (1) MXPA04004370A (enExample)
WO (1) WO2003042216A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
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JP2012510993A (ja) * 2008-12-06 2012-05-17 イントラ−セルラー・セラピーズ・インコーポレイテッド 有機化合物
JP2014516086A (ja) * 2011-06-10 2014-07-07 イントラ−セルラー・セラピーズ・インコーポレイテッド 有機化合物

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IL160307A0 (en) 2001-08-31 2004-07-25 Univ Rockefeller Phosphodiesterase activity and regulation of phosphodiesterase 1-b-mediated signaling in brain
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KR20120012831A (ko) 2007-12-06 2012-02-10 인트라-셀룰라 써래피스, 인코퍼레이티드. 유기 화합물
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JP6810613B2 (ja) 2014-06-20 2021-01-06 イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． 有機化合物
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Cited By (2)

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Publication number Priority date Publication date Assignee Title
JP2012510993A (ja) * 2008-12-06 2012-05-17 イントラ−セルラー・セラピーズ・インコーポレイテッド 有機化合物
JP2014516086A (ja) * 2011-06-10 2014-07-07 イントラ−セルラー・セラピーズ・インコーポレイテッド 有機化合物

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Publication number Publication date
EP1442042A1 (en) 2004-08-04
WO2003042216A1 (en) 2003-05-22
MXPA04004370A (es) 2004-08-11
CA2465893A1 (en) 2003-05-22
US20030176413A1 (en) 2003-09-18
US20050171129A1 (en) 2005-08-04
US6943171B2 (en) 2005-09-13
JP2006077023A (ja) 2006-03-23
CN1585771A (zh) 2005-02-23

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