FR2116302A1 - 8-aminotheophyllines - with coronary - vasodilator bronchodilator diuretic, spasmolytic, antiinflammatory and analgesic activity - Google Patents

8-aminotheophyllines - with coronary - vasodilator bronchodilator diuretic, spasmolytic, antiinflammatory and analgesic activity

Info

Publication number
FR2116302A1
FR2116302A1 FR7043891A FR7043891A FR2116302A1 FR 2116302 A1 FR2116302 A1 FR 2116302A1 FR 7043891 A FR7043891 A FR 7043891A FR 7043891 A FR7043891 A FR 7043891A FR 2116302 A1 FR2116302 A1 FR 2116302A1
Authority
FR
France
Prior art keywords
alkyl
aminotheophyllines
spasmolytic
bronchodilator
vasodilator
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7043891A
Other languages
French (fr)
Other versions
FR2116302B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Brun Lab SA Le
Original Assignee
Brun Lab SA Le
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brun Lab SA Le filed Critical Brun Lab SA Le
Priority to FR7043891A priority Critical patent/FR2116302A1/en
Publication of FR2116302A1 publication Critical patent/FR2116302A1/en
Application granted granted Critical
Publication of FR2116302B1 publication Critical patent/FR2116302B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cpds of formula: their metallic and acid-addn salts (where R=alkyl, hydroxyalkyl, haloalkyl, benzyl, opt. ring substd >=1 alkoxy, gp. phenethyl substd by >=1 alkoxy gp. or the gp R1 is 1-6C alkyl, phenyl, phenethyl benzyl substd in the nucleus by >=1 alkoxy, OH, NO2, NH2 or halogen 3,4-methylenedioxybenzyl, the gp: 2-furfuryl; the gp. -Alk-(4-alkylpiperidinyl); or R and R1 with the attached N-atom form a 4-R4-piperazinyl, 4-R4-piperidyl or 3-hydroxyalkylpyrrolidinyl gp; R2=1-6C alkyl, R3=H 1-6C alkyl or 8-theophyllinyl; R4=Et hydroxyalkyl, phenyl benzyl, Alk=alkylene; provided that R is not hydroxyalkyl when R1 is alkyl or phenethyl and R1 is not alkyl when R is benzl). Cpds are used in human or veterinary medicine.
FR7043891A 1970-12-07 1970-12-07 8-aminotheophyllines - with coronary - vasodilator bronchodilator diuretic, spasmolytic, antiinflammatory and analgesic activity Granted FR2116302A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7043891A FR2116302A1 (en) 1970-12-07 1970-12-07 8-aminotheophyllines - with coronary - vasodilator bronchodilator diuretic, spasmolytic, antiinflammatory and analgesic activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7043891A FR2116302A1 (en) 1970-12-07 1970-12-07 8-aminotheophyllines - with coronary - vasodilator bronchodilator diuretic, spasmolytic, antiinflammatory and analgesic activity

Publications (2)

Publication Number Publication Date
FR2116302A1 true FR2116302A1 (en) 1972-07-13
FR2116302B1 FR2116302B1 (en) 1974-06-21

Family

ID=9065324

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7043891A Granted FR2116302A1 (en) 1970-12-07 1970-12-07 8-aminotheophyllines - with coronary - vasodilator bronchodilator diuretic, spasmolytic, antiinflammatory and analgesic activity

Country Status (1)

Country Link
FR (1) FR2116302A1 (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4599338A (en) * 1984-01-17 1986-07-08 Adir, S.A.R.L. Antimigraine 8-[3-(4-aminocarbonyl piperazino and piperidino) propyl[xanthines
WO2002024698A1 (en) * 2000-09-19 2002-03-28 Schering Corporation Xanthine phosphodiesterase v inhibitors
US6943171B2 (en) 2001-11-09 2005-09-13 Schering Corporation Polycyclic guanine derivative phosphodiesterase V inhibitors
US6969719B2 (en) 2001-08-28 2005-11-29 Schering Corporation Polycyclic guanine phosphodiesterase V inhibitors
WO2014081821A2 (en) * 2012-11-20 2014-05-30 Discoverybiomed, Inc. Small Molecule Bicyclic and Tricyclic CFTR Correctors
US9221840B2 (en) 2011-05-17 2015-12-29 Discoverybiomed Inc. Treating protein folding disorders with small molecule CFTR correctors
US9676779B2 (en) 2012-11-20 2017-06-13 Discoverybiomed, Inc. Small molecule CFTR correctors

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4599338A (en) * 1984-01-17 1986-07-08 Adir, S.A.R.L. Antimigraine 8-[3-(4-aminocarbonyl piperazino and piperidino) propyl[xanthines
WO2002024698A1 (en) * 2000-09-19 2002-03-28 Schering Corporation Xanthine phosphodiesterase v inhibitors
US6821978B2 (en) 2000-09-19 2004-11-23 Schering Corporation Xanthine phosphodiesterase V inhibitors
US7268141B2 (en) 2000-09-19 2007-09-11 Schering Corporation Xanthine phosphodiesterase V inhibitors
US7531544B2 (en) 2000-09-19 2009-05-12 Schering Corporation Xanthine phosphodiesterase V inhibitors
US6969719B2 (en) 2001-08-28 2005-11-29 Schering Corporation Polycyclic guanine phosphodiesterase V inhibitors
US6943171B2 (en) 2001-11-09 2005-09-13 Schering Corporation Polycyclic guanine derivative phosphodiesterase V inhibitors
US9221840B2 (en) 2011-05-17 2015-12-29 Discoverybiomed Inc. Treating protein folding disorders with small molecule CFTR correctors
WO2014081821A2 (en) * 2012-11-20 2014-05-30 Discoverybiomed, Inc. Small Molecule Bicyclic and Tricyclic CFTR Correctors
WO2014081821A3 (en) * 2012-11-20 2014-08-28 Discoverybiomed, Inc. Small Molecule Bicyclic and Tricyclic CFTR Correctors
US9546176B2 (en) 2012-11-20 2017-01-17 Discoverybiomed, Inc. Small molecule bicyclic and tricyclic CFTR correctors
US9676779B2 (en) 2012-11-20 2017-06-13 Discoverybiomed, Inc. Small molecule CFTR correctors

Also Published As

Publication number Publication date
FR2116302B1 (en) 1974-06-21

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