FR2157727A1 - !,#dimethyl-8-aminopurines - with analgesicantitussive and other theophylline-like activities - Google Patents

!,#dimethyl-8-aminopurines - with analgesicantitussive and other theophylline-like activities

Info

Publication number
FR2157727A1
FR2157727A1 FR7138943A FR7138943A FR2157727A1 FR 2157727 A1 FR2157727 A1 FR 2157727A1 FR 7138943 A FR7138943 A FR 7138943A FR 7138943 A FR7138943 A FR 7138943A FR 2157727 A1 FR2157727 A1 FR 2157727A1
Authority
FR
France
Prior art keywords
alkoxyalkyl
hydroxyalkyl
alkyl
optionally
substd
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7138943A
Other languages
French (fr)
Other versions
FR2157727B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Brun Lab SA Le
Original Assignee
Brun Lab SA Le
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brun Lab SA Le filed Critical Brun Lab SA Le
Priority to FR7138943A priority Critical patent/FR2157727A1/en
Publication of FR2157727A1 publication Critical patent/FR2157727A1/en
Application granted granted Critical
Publication of FR2157727B1 publication Critical patent/FR2157727B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/22—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6

Abstract

Cpds. of formula: where R is H; halogen; aminomethyl, alkylthio; CN; OR3 where R3 is alkyl hydroxyalkyl, alkoxyalkyl or R is where R4, R5 (same or different) = H, alkyl, hydroxyalkyl, acyloxyalkyl, alkoxyalkyl, trifluoromethylphenyl, dialkylaminoalkyl; or R4 + R5 and the attached N-atom form a heterocyclic 5- or 6-membered ing optionally contng. another heteroatom and optionaly substd. by one or more alkyl, OH hydroxyalkyl, alkoxyalkyl; R1, R2 (same or different) are alkyl; hydroxyalkyl; haloalkyl; alkoxyalkyl, acyloxyalkyl furfuryl, benzyl optionally substd. on the nucleus by one or more halogen, alkoxy; 3,4-methylenedioxybenzyl; or R1 and R2 and the attached N-atom form a 5- or 6-membered heterocyclic ring optionally contng. another heteroatom and optionally substd. by one or more alkyl, OH, hydroxyalkyl, alkoxyalkyl. The cpds. have thiophylline-like activity, esp. analgesic and antitussive activity for use in human and veterinary medicine.
FR7138943A 1971-10-29 1971-10-29 !,#dimethyl-8-aminopurines - with analgesicantitussive and other theophylline-like activities Granted FR2157727A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7138943A FR2157727A1 (en) 1971-10-29 1971-10-29 !,#dimethyl-8-aminopurines - with analgesicantitussive and other theophylline-like activities

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7138943A FR2157727A1 (en) 1971-10-29 1971-10-29 !,#dimethyl-8-aminopurines - with analgesicantitussive and other theophylline-like activities

Publications (2)

Publication Number Publication Date
FR2157727A1 true FR2157727A1 (en) 1973-06-08
FR2157727B1 FR2157727B1 (en) 1975-02-07

Family

ID=9085079

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7138943A Granted FR2157727A1 (en) 1971-10-29 1971-10-29 !,#dimethyl-8-aminopurines - with analgesicantitussive and other theophylline-like activities

Country Status (1)

Country Link
FR (1) FR2157727A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0258191A1 (en) * 1986-08-28 1988-03-02 Sandoz Ag Xanthine derivatives
WO1988005775A1 (en) * 1987-01-30 1988-08-11 Sandoz-Erfindungen Verwaltungsgesellschaft M.B.H. Novel xanthine derivatives

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1281229A (en) * 1959-11-09 1962-01-12 Thomae Gmbh Dr K Improvements to the processes for preparing amino-substituted purine derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1281229A (en) * 1959-11-09 1962-01-12 Thomae Gmbh Dr K Improvements to the processes for preparing amino-substituted purine derivatives

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0258191A1 (en) * 1986-08-28 1988-03-02 Sandoz Ag Xanthine derivatives
WO1988005775A1 (en) * 1987-01-30 1988-08-11 Sandoz-Erfindungen Verwaltungsgesellschaft M.B.H. Novel xanthine derivatives

Also Published As

Publication number Publication date
FR2157727B1 (en) 1975-02-07

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