JP2005508953A5 - - Google Patents

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Publication number
JP2005508953A5
JP2005508953A5 JP2003534421A JP2003534421A JP2005508953A5 JP 2005508953 A5 JP2005508953 A5 JP 2005508953A5 JP 2003534421 A JP2003534421 A JP 2003534421A JP 2003534421 A JP2003534421 A JP 2003534421A JP 2005508953 A5 JP2005508953 A5 JP 2005508953A5
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JP
Japan
Prior art keywords
hydrogen
compound
alkyl
compound according
ring
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JP2003534421A
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English (en)
Japanese (ja)
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JP2005508953A (ja
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Priority claimed from PCT/US2002/032354 external-priority patent/WO2003031438A1/en
Publication of JP2005508953A publication Critical patent/JP2005508953A/ja
Publication of JP2005508953A5 publication Critical patent/JP2005508953A5/ja
Withdrawn legal-status Critical Current

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JP2003534421A 2001-10-10 2002-10-10 キナーゼ阻害剤としての３−［４−（置換ヘテロサイクリル）−ピロール−２−イルメチリデン］−２−インドリノン誘導体 Withdrawn JP2005508953A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32822601P 2001-10-10 2001-10-10
PCT/US2002/032354 WO2003031438A1 (en) 2001-10-10 2002-10-10 3-[4-(substituted heterocyclyl)-pyrrol-2-ylmethylidene]-2-indolinone derivatives as kinase inhibitors

Publications (2)

Publication Number Publication Date
JP2005508953A JP2005508953A (ja) 2005-04-07
JP2005508953A5 true JP2005508953A5 (OSRAM) 2006-01-05

Family

ID=23280071

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003534421A Withdrawn JP2005508953A (ja) 2001-10-10 2002-10-10 キナーゼ阻害剤としての３−［４−（置換ヘテロサイクリル）−ピロール−２−イルメチリデン］−２−インドリノン誘導体

Country Status (7)

Country Link
US (1) US6642232B2 (OSRAM)
EP (1) EP1434774A1 (OSRAM)
JP (1) JP2005508953A (OSRAM)
BR (1) BR0213185A (OSRAM)
CA (1) CA2462950A1 (OSRAM)
MX (1) MXPA04003385A (OSRAM)
WO (1) WO2003031438A1 (OSRAM)

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TW200640443A (en) * 2005-02-23 2006-12-01 Alcon Inc Methods for treating ocular angiogenesis, retinal edema, retinal ischemia, and diabetic retinopathy using selective RTK inhibitors
US8394742B2 (en) * 2005-04-15 2013-03-12 The Translation Genomics Research Institute Methods, compounds and compositions with genotype selective anticancer activity
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US20100256392A1 (en) * 2007-11-21 2010-10-07 Teva Pharmaceutical Industries Ltd. Polymorphs of sunitinib base and processes for preparation thereof
JP2011516488A (ja) * 2008-03-31 2011-05-26 テバ ファーマシューティカル インダストリーズ リミティド スニチニブ及びその塩の調製方法
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CN102066339B (zh) * 2008-04-16 2014-09-24 波托拉医药品公司 作为syk或jak蛋白激酶抑制剂的2，6-二氨基-嘧啶-5-基甲酰胺类化合物
US8138339B2 (en) 2008-04-16 2012-03-20 Portola Pharmaceuticals, Inc. Inhibitors of protein kinases
WO2010011834A2 (en) * 2008-07-24 2010-01-28 Teva Pharmaceutical Industries Ltd. Sunitinib and salts thereof and their polymorphs
GB0920014D0 (en) * 2009-11-13 2009-12-30 Medical Res Council Cell sampling device
SG193527A1 (en) * 2011-04-08 2013-10-30 Beta Pharma Inc New indolinone protein kinase inhibitors
EP2782579B1 (en) 2011-11-23 2019-01-02 Portola Pharmaceuticals, Inc. Pyrazine kinase inhibitors
CN104829596B (zh) 2014-02-10 2017-02-01 石家庄以岭药业股份有限公司 吡咯取代吲哚酮类衍生物、其制备方法、包含该衍生物的组合物、及其用途
WO2018059556A1 (zh) * 2016-09-29 2018-04-05 贝达药业股份有限公司 激酶抑制剂化合物的多晶型、含其的药物组合物及其制备方法和应用

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