JP2005508940A5 - - Google Patents
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- Publication number
- JP2005508940A5 JP2005508940A5 JP2003533918A JP2003533918A JP2005508940A5 JP 2005508940 A5 JP2005508940 A5 JP 2005508940A5 JP 2003533918 A JP2003533918 A JP 2003533918A JP 2003533918 A JP2003533918 A JP 2003533918A JP 2005508940 A5 JP2005508940 A5 JP 2005508940A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- alkyl
- hydroxy
- unsubstituted
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 *C(C[C@@](*)C(BI)=*)CN(*)C(*)C(I)=* Chemical compound *C(C[C@@](*)C(BI)=*)CN(*)C(*)C(I)=* 0.000 description 6
- XDOIVOKWAWFBRI-UHFFFAOYSA-N CC[ClH]C(OC)=O Chemical compound CC[ClH]C(OC)=O XDOIVOKWAWFBRI-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32724301P | 2001-10-05 | 2001-10-05 | |
| PCT/US2002/032010 WO2003030886A2 (en) | 2001-10-05 | 2002-10-04 | Allylamides useful in the treatment of alzheimer's disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005508940A JP2005508940A (ja) | 2005-04-07 |
| JP2005508940A5 true JP2005508940A5 (enExample) | 2006-01-05 |
Family
ID=23275725
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003533918A Pending JP2005508940A (ja) | 2001-10-05 | 2002-10-04 | アルツハイマー病の治療に有用なアリルアミド |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20050027007A1 (enExample) |
| EP (1) | EP1434580A2 (enExample) |
| JP (1) | JP2005508940A (enExample) |
| AU (1) | AU2002335794A1 (enExample) |
| BR (1) | BR0213138A (enExample) |
| CA (1) | CA2462875A1 (enExample) |
| MX (1) | MXPA04003244A (enExample) |
| WO (1) | WO2003030886A2 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7521481B2 (en) | 2003-02-27 | 2009-04-21 | Mclaurin Joanne | Methods of preventing, treating and diagnosing disorders of protein aggregation |
| CN100475786C (zh) * | 2005-02-18 | 2009-04-08 | 中国科学院上海药物研究所 | 一类4-羟基戊酰胺类化合物及其制备方法和用途 |
| US7838676B2 (en) | 2005-11-21 | 2010-11-23 | Amgen Inc. | Beta-secretase modulators and methods of use |
| US7872009B2 (en) | 2005-11-21 | 2011-01-18 | Amgen Inc. | Beta-Secretase modulators and methods of use |
| US7745484B2 (en) | 2005-11-21 | 2010-06-29 | Amgen Inc. | Beta-secretase modulators and methods of use |
| AU2006316620B2 (en) | 2005-11-21 | 2011-03-03 | Amgen Inc. | Beta-secretase modulators and methods of use |
| CA2676715A1 (en) | 2007-02-12 | 2008-08-21 | Merck & Co., Inc. | Piperazine derivatives for treatment of ad and related conditions |
| WO2008147544A1 (en) | 2007-05-25 | 2008-12-04 | Amgen Inc. | Substituted hydroxyethyl amine compounds as beta-secretase modulators and methods of use |
| CL2008001500A1 (es) | 2007-05-25 | 2008-12-26 | Amgen Inc | Compuestos derivados de hidroxietil amina sustituidas, moduladores de betasecretasa; proceso de preparacion de dichos c ompuestos; composicion farmaceutica que los comprende; y su uso para tratar un trastorno neurologico, tal como alzheimer, sindrome de down, demencia degenerativa, entre otros. |
| US7803809B2 (en) | 2008-11-12 | 2010-09-28 | Amgen Inc. | Substituted pyrano [2,3-b] pyridinamine compounds as beta-secretase modulators and methods of use |
| WO2009128057A2 (en) | 2008-04-18 | 2009-10-22 | UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN et al | Psycho-pharmaceuticals |
| WO2010030954A1 (en) | 2008-09-11 | 2010-03-18 | Amgen Inc. | Spiro-tetracyclic ring compounds as betasecretase modulators and methods of use |
| US9296698B2 (en) | 2009-11-23 | 2016-03-29 | Amgen Inc. | Amino heteroaryl compounds as beta-secretase modulators and methods of use |
| US8822485B2 (en) | 2009-11-23 | 2014-09-02 | Amgen Inc. | Amino heteroaryl compounds as beta-secretase modulators and methods of use |
| US8735384B2 (en) | 2010-01-19 | 2014-05-27 | Amgen Inc. | Amino heteroaryl compounds as beta-secretase modulators and methods of use |
| ES2450568T3 (es) | 2010-03-15 | 2014-03-25 | Amgen Inc. | Compuestos espiero de amino-dihidrooxazina y amino-dihidrotiazina como moduladores de beta-secretasa y su uso médico |
| CA2791281A1 (en) | 2010-03-15 | 2011-09-22 | Amgen Inc. | Spiro-tetracyclic ring compounds as beta-secretase modulators |
| US9346827B2 (en) | 2011-02-07 | 2016-05-24 | Amgen Inc. | 5-amino-oxazepine and 5-amino-thiazepane compounds as beta secretase antagonists and methods of use |
| WO2013044092A1 (en) | 2011-09-21 | 2013-03-28 | Amgen Inc. | Amino-oxazines and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use |
| US9725469B2 (en) | 2012-11-15 | 2017-08-08 | Amgen, Inc. | Amino-oxazine and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use |
| CN111087386B (zh) * | 2020-01-02 | 2020-12-18 | 牡丹江医学院 | 一种用于治疗阿尔茨海默病的化合物及其合成方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG52731A1 (en) * | 1991-11-08 | 1998-09-28 | Merck & Co Inc | Hiv protease inhibitors useful for the treatment of aids |
| NZ500868A (en) * | 1997-05-17 | 2001-08-31 | Glaxo Group Ltd | Antiviral combinations comprising 1592U89 and HIV protease inhibitors |
| US20020147197A1 (en) * | 1999-10-08 | 2002-10-10 | Newman Michael J. | Methods and compositions for enhancing pharmaceutical treatments |
| JP2003528071A (ja) * | 2000-03-23 | 2003-09-24 | エラン ファーマスーティカルズ インコーポレイテッド | アルツハイマー病治療用組成物および方法 |
| AU2001259817A1 (en) * | 2000-05-04 | 2001-11-12 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, The National Institutes Of Health | Methods of and compounds for inhibiting calpains |
-
2002
- 2002-10-04 MX MXPA04003244A patent/MXPA04003244A/es not_active Application Discontinuation
- 2002-10-04 US US10/491,841 patent/US20050027007A1/en not_active Abandoned
- 2002-10-04 WO PCT/US2002/032010 patent/WO2003030886A2/en not_active Ceased
- 2002-10-04 EP EP02770558A patent/EP1434580A2/en not_active Withdrawn
- 2002-10-04 BR BR0213138-2A patent/BR0213138A/pt not_active IP Right Cessation
- 2002-10-04 AU AU2002335794A patent/AU2002335794A1/en not_active Abandoned
- 2002-10-04 JP JP2003533918A patent/JP2005508940A/ja active Pending
- 2002-10-04 CA CA002462875A patent/CA2462875A1/en not_active Abandoned
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