JP2005508896A5 - - Google Patents
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- Publication number
- JP2005508896A5 JP2005508896A5 JP2003524561A JP2003524561A JP2005508896A5 JP 2005508896 A5 JP2005508896 A5 JP 2005508896A5 JP 2003524561 A JP2003524561 A JP 2003524561A JP 2003524561 A JP2003524561 A JP 2003524561A JP 2005508896 A5 JP2005508896 A5 JP 2005508896A5
- Authority
- JP
- Japan
- Prior art keywords
- sti571
- pharmaceutical composition
- composition according
- homoharringtonine
- combination
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229960002411 imatinib Drugs 0.000 claims description 22
- KTUFNOKKBVMGRW-UHFFFAOYSA-N imatinib Chemical compound C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 KTUFNOKKBVMGRW-UHFFFAOYSA-N 0.000 claims description 22
- 239000008194 pharmaceutical composition Substances 0.000 claims 19
- HYFHYPWGAURHIV-UHFFFAOYSA-N homoharringtonine Natural products C1=C2CCN3CCCC43C=C(OC)C(OC(=O)C(O)(CCCC(C)(C)O)CC(=O)OC)C4C2=CC2=C1OCO2 HYFHYPWGAURHIV-UHFFFAOYSA-N 0.000 claims 16
- HYFHYPWGAURHIV-JFIAXGOJSA-N omacetaxine mepesuccinate Chemical compound C1=C2CCN3CCC[C@]43C=C(OC)[C@@H](OC(=O)[C@@](O)(CCCC(C)(C)O)CC(=O)OC)[C@H]4C2=CC2=C1OCO2 HYFHYPWGAURHIV-JFIAXGOJSA-N 0.000 claims 16
- 229960002230 omacetaxine mepesuccinate Drugs 0.000 claims 16
- 239000000063 antileukemic agent Substances 0.000 claims 8
- UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 claims 7
- 239000002777 nucleoside Substances 0.000 claims 7
- 229960000684 cytarabine Drugs 0.000 claims 5
- 150000003833 nucleoside derivatives Chemical class 0.000 claims 5
- 102000006992 Interferon-alpha Human genes 0.000 claims 4
- 108010047761 Interferon-alpha Proteins 0.000 claims 4
- 210000000066 myeloid cell Anatomy 0.000 claims 4
- 239000003528 protein farnesyltransferase inhibitor Substances 0.000 claims 4
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 3
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 3
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 3
- 230000002559 cytogenic effect Effects 0.000 claims 3
- 230000002489 hematologic effect Effects 0.000 claims 3
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 2
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 2
- 229940124226 Farnesyltransferase inhibitor Drugs 0.000 claims 2
- 208000014767 Myeloproliferative disease Diseases 0.000 claims 2
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 2
- 125000003835 nucleoside group Chemical group 0.000 claims 2
- 230000035755 proliferation Effects 0.000 claims 2
- XAUDJQYHKZQPEU-KVQBGUIXSA-N 5-aza-2'-deoxycytidine Chemical compound O=C1N=C(N)N=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 XAUDJQYHKZQPEU-KVQBGUIXSA-N 0.000 claims 1
- 206010033661 Pancytopenia Diseases 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 208000024389 cytopenia Diseases 0.000 claims 1
- 229960003603 decitabine Drugs 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 231100000226 haematotoxicity Toxicity 0.000 claims 1
- 230000003463 hyperproliferative effect Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 229940079322 interferon Drugs 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 230000004083 survival effect Effects 0.000 claims 1
- 230000002195 synergetic effect Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- RXRGZNYSEHTMHC-BQBZGAKWSA-N troxacitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1O[C@@H](CO)OC1 RXRGZNYSEHTMHC-BQBZGAKWSA-N 0.000 claims 1
- 229950010147 troxacitabine Drugs 0.000 claims 1
- WEVYNIUIFUYDGI-UHFFFAOYSA-N 3-[6-[4-(trifluoromethoxy)anilino]-4-pyrimidinyl]benzamide Chemical compound NC(=O)C1=CC=CC(C=2N=CN=C(NC=3C=CC(OC(F)(F)F)=CC=3)C=2)=C1 WEVYNIUIFUYDGI-UHFFFAOYSA-N 0.000 description 1
- 102000001253 Protein Kinase Human genes 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 229940043355 kinase inhibitor Drugs 0.000 description 1
- XGXNTJHZPBRBHJ-UHFFFAOYSA-N n-phenylpyrimidin-2-amine Chemical compound N=1C=CC=NC=1NC1=CC=CC=C1 XGXNTJHZPBRBHJ-UHFFFAOYSA-N 0.000 description 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 description 1
- 108060006633 protein kinase Proteins 0.000 description 1
- 239000005483 tyrosine kinase inhibitor Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31696701P | 2001-09-05 | 2001-09-05 | |
| US60/316,967 | 2001-09-05 | ||
| PCT/IB2002/003992 WO2003020252A2 (en) | 2001-09-05 | 2002-09-05 | Treatment of chronic myelogenous leukemia, resistant or intolerant to sti571, involving homoharringtonine alone or combined with other agents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009021692A Division JP2009102408A (ja) | 2001-09-05 | 2009-02-02 | ホモハリングトニンを単独で、または他の薬剤と組み合わせて用いる、ｓｔｉ５７１に耐性または不耐性の慢性骨髄性白血病の治療 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005508896A JP2005508896A (ja) | 2005-04-07 |
| JP2005508896A5 true JP2005508896A5 (https=) | 2009-04-02 |
| JP4794816B2 JP4794816B2 (ja) | 2011-10-19 |
Family
ID=23231501
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003524561A Expired - Fee Related JP4794816B2 (ja) | 2001-09-05 | 2002-09-05 | ホモハリングトニンを単独で、または他の薬剤と組み合わせて用いる、ｓｔｉ５７１に耐性または不耐性の慢性骨髄性白血病の治療 |
| JP2009021692A Pending JP2009102408A (ja) | 2001-09-05 | 2009-02-02 | ホモハリングトニンを単独で、または他の薬剤と組み合わせて用いる、ｓｔｉ５７１に耐性または不耐性の慢性骨髄性白血病の治療 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009021692A Pending JP2009102408A (ja) | 2001-09-05 | 2009-02-02 | ホモハリングトニンを単独で、または他の薬剤と組み合わせて用いる、ｓｔｉ５７１に耐性または不耐性の慢性骨髄性白血病の治療 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6987103B2 (https=) |
| EP (2) | EP1443933B1 (https=) |
| JP (2) | JP4794816B2 (https=) |
| AT (2) | ATE548041T1 (https=) |
| AU (1) | AU2002337410A1 (https=) |
| CA (1) | CA2459822C (https=) |
| CY (2) | CY1109799T1 (https=) |
| DE (1) | DE60234708D1 (https=) |
| DK (2) | DK2177223T3 (https=) |
| ES (2) | ES2383771T3 (https=) |
| PT (2) | PT2177223E (https=) |
| WO (1) | WO2003020252A2 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6613753B2 (en) * | 2001-02-21 | 2003-09-02 | Supergen, Inc. | Restore cancer-suppressing functions to neoplastic cells through DNA hypomethylation |
| US6905669B2 (en) | 2001-04-24 | 2005-06-14 | Supergen, Inc. | Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase |
| US6998391B2 (en) * | 2002-02-07 | 2006-02-14 | Supergen.Inc. | Method for treating diseases associated with abnormal kinase activity |
| US20040192652A1 (en) * | 2002-12-06 | 2004-09-30 | Giles Francis J. | Pharmaceutical combinations and methods for the treatment of leukemia |
| US20050037992A1 (en) * | 2003-07-22 | 2005-02-17 | John Lyons | Composition and method for treating neurological disorders |
| US20050059682A1 (en) * | 2003-09-12 | 2005-03-17 | Supergen, Inc., A Delaware Corporation | Compositions and methods for treatment of cancer |
| US7250416B2 (en) | 2005-03-11 | 2007-07-31 | Supergen, Inc. | Azacytosine analogs and derivatives |
| US7700567B2 (en) | 2005-09-29 | 2010-04-20 | Supergen, Inc. | Oligonucleotide analogues incorporating 5-aza-cytosine therein |
| US20070117776A1 (en) * | 2005-11-04 | 2007-05-24 | John Lyons | Low Dose Therapy Of DNA Methylation Inhibitors |
| ES2400375T3 (es) * | 2006-04-07 | 2013-04-09 | Novartis Ag | Combinación que comprende A) un compuesto de pirimidilaminobenzamida y B)un inhibidor de cinasa THR315LLE |
| EP2049096A4 (en) * | 2006-08-02 | 2012-05-09 | Univ South Florida | METHOD FOR TREATING CHRONIC MYELOGENIC LEUKEMIA CELLS |
| AU2008240044B2 (en) * | 2007-04-13 | 2013-09-12 | Teva Pharamceuticals International Gmbh | Oral cephalotaxine dosage forms |
| EP2229160A1 (en) * | 2007-12-07 | 2010-09-22 | ChemGenex Pharmaceuticals, Inc. | Leukemic stem cell ablation |
| JP5617175B2 (ja) | 2008-04-17 | 2014-11-05 | 富士電機株式会社 | ワイドバンドギャップ半導体装置とその製造方法 |
| AU2012275190B2 (en) * | 2011-06-29 | 2016-05-19 | The Penn State Research Foundation | Compositions, methods and kits for treating leukemia |
| EP2750768B1 (en) | 2011-08-30 | 2018-10-03 | Astex Pharmaceuticals, Inc. | Decitabine derivative formulations |
| AU2016287585B2 (en) | 2015-07-02 | 2020-12-17 | Otsuka Pharmaceutical Co., Ltd. | Lyophilized pharmaceutical compositions |
| KR20200035438A (ko) | 2017-08-03 | 2020-04-03 | 오쓰까 세이야꾸 가부시키가이샤 | 약물 화합물 및 이의 정제 방법 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030148955A1 (en) * | 1999-04-19 | 2003-08-07 | Pluenneke John D. | Soluble tumor necrosis factor receptor treatment of medical disorders |
-
2002
- 2002-09-05 AU AU2002337410A patent/AU2002337410A1/en not_active Abandoned
- 2002-09-05 CA CA2459822A patent/CA2459822C/en not_active Expired - Fee Related
- 2002-09-05 WO PCT/IB2002/003992 patent/WO2003020252A2/en not_active Ceased
- 2002-09-05 PT PT09172828T patent/PT2177223E/pt unknown
- 2002-09-05 EP EP02772653A patent/EP1443933B1/en not_active Expired - Lifetime
- 2002-09-05 DK DK09172828.7T patent/DK2177223T3/da active
- 2002-09-05 JP JP2003524561A patent/JP4794816B2/ja not_active Expired - Fee Related
- 2002-09-05 AT AT09172828T patent/ATE548041T1/de active
- 2002-09-05 ES ES09172828T patent/ES2383771T3/es not_active Expired - Lifetime
- 2002-09-05 EP EP20090172828 patent/EP2177223B9/en not_active Expired - Lifetime
- 2002-09-05 AT AT02772653T patent/ATE451106T1/de active
- 2002-09-05 ES ES02772653T patent/ES2334774T3/es not_active Expired - Lifetime
- 2002-09-05 DE DE60234708T patent/DE60234708D1/de not_active Expired - Lifetime
- 2002-09-05 DK DK02772653.8T patent/DK1443933T3/da active
- 2002-09-05 PT PT02772653T patent/PT1443933E/pt unknown
-
2003
- 2003-03-27 US US10/397,267 patent/US6987103B2/en active Active
-
2009
- 2009-02-02 JP JP2009021692A patent/JP2009102408A/ja active Pending
-
2010
- 2010-02-10 CY CY20101100126T patent/CY1109799T1/el unknown
-
2012
- 2012-06-06 CY CY20121100501T patent/CY1112817T1/el unknown
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