EP2049096A4 - Method of treating chronic myelogenous leukemia cells - Google Patents
Method of treating chronic myelogenous leukemia cellsInfo
- Publication number
- EP2049096A4 EP2049096A4 EP07813692A EP07813692A EP2049096A4 EP 2049096 A4 EP2049096 A4 EP 2049096A4 EP 07813692 A EP07813692 A EP 07813692A EP 07813692 A EP07813692 A EP 07813692A EP 2049096 A4 EP2049096 A4 EP 2049096A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- myelogenous leukemia
- chronic myelogenous
- leukemia cells
- treating chronic
- treating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US82118406P | 2006-08-02 | 2006-08-02 | |
PCT/US2007/075061 WO2008017024A2 (en) | 2006-08-02 | 2007-08-02 | Method of treating chronic myelogenous leukemia cells |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2049096A2 EP2049096A2 (en) | 2009-04-22 |
EP2049096A4 true EP2049096A4 (en) | 2012-05-09 |
Family
ID=38997865
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP07813692A Withdrawn EP2049096A4 (en) | 2006-08-02 | 2007-08-02 | Method of treating chronic myelogenous leukemia cells |
Country Status (3)
Country | Link |
---|---|
US (1) | US7799788B2 (en) |
EP (1) | EP2049096A4 (en) |
WO (1) | WO2008017024A2 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7861014B2 (en) * | 2007-08-31 | 2010-12-28 | International Business Machines Corporation | System for supporting partial cache line read operations to a memory module to reduce read data traffic on a memory channel |
WO2009108755A2 (en) * | 2008-02-27 | 2009-09-03 | Wyeth | Pharmaceutical combinations for the treatment of cancer |
EP3143166A4 (en) * | 2014-05-16 | 2018-04-18 | University of Massachusetts | Treating chronic myelogenous leukemia (cml) |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2177223B9 (en) * | 2001-09-05 | 2012-10-31 | Ivax International Gmbh | Homoharringtonine alone or combined with other agents for use in treating chronic myelogenous leukemia resistant or intolerant to protein kinase inhibitors other than STI 571 |
US20030147813A1 (en) * | 2002-02-07 | 2003-08-07 | John Lyons | Method for treating chronic myelogenous leukemia |
-
2007
- 2007-08-02 WO PCT/US2007/075061 patent/WO2008017024A2/en active Application Filing
- 2007-08-02 EP EP07813692A patent/EP2049096A4/en not_active Withdrawn
-
2009
- 2009-02-02 US US12/364,009 patent/US7799788B2/en not_active Expired - Fee Related
Non-Patent Citations (11)
Title |
---|
BLOOD, vol. 106, no. 11, Part 1, November 2005 (2005-11-01), 47TH ANNUAL MEETING OF THE AMERICAN-SOCIETY-OF-HEMATOLOGY; ATLANTA, GA, USA; DECEMBER 10 -13, 2005, pages 204A, ISSN: 0006-4971 * |
BRADEEN HEATHER A ET AL: "COMPARISON OF IMATINIB, MESYLATE, DASATINIB (BMS-354825), AND NILOTINIB (AMN107) IN AN N-ETHYL-N-NITROSOUREA (ENU)-BASED MUTAGENESIS SCREEN: HIGH EFFICACY OF DRUG COMBINATIONS", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 108, no. 7, 1 October 2006 (2006-10-01), pages 2332 - 2338, XP009082064, ISSN: 0006-4971, DOI: 10.1182/BLOOD-2006-02-004580 * |
DAI YUN ET AL: "Blockade of histone deacetylase inhibitor-induced RelA/p65 acetylation and NF-kappaB activation potentiates apoptosis in leukemia cells through a process mediated by oxidative damage, XIAP downregulation, and c-Jun N-terminal kinase 1 activation.", MOLECULAR AND CELLULAR BIOLOGY JUL 2005 LNKD- PUBMED:15964800, vol. 25, no. 13, July 2005 (2005-07-01), pages 5429 - 5444, XP002672184, ISSN: 0270-7306 * |
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; November 2005 (2005-11-01), SKAGGS BRIAN J ET AL: "Altered oncogenic fitness of imatinib- and dasatinib-resistant BCR-ABL mutants is due to differential intrinsic kinase activity and signaling pathway selection defined by phosphoproteome profiling.", XP002672183, Database accession no. PREV200600183062 * |
FISKUS W ET AL: "Combined effects of novel tyrosine kinase inhibitor AMN107 and histone deacetylase inhibitor LBH589 against Bcr-Abl-expressing human leukemia cells", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 108, no. 2, 15 July 2006 (2006-07-15), pages 645 - 652, XP008131474, ISSN: 0006-4971, [retrieved on 20060314], DOI: 10.1182/BLOOD-2005-11-4639 * |
FISKUS W ET AL: "Cotreatment with vorinostat (suberoylanilide hydroxamic acid) enhances activity of dasatinib (BMS-354825) against imatinib mesylate-sensitive or imatinib mesylate-resistant chronic myelogenous leukemia cells", CLINICAL CANCER RESEARCH 20061001 US LNKD- DOI:10.1158/1078-0432.CCR-06-0980, vol. 12, no. 19, 1 October 2006 (2006-10-01), pages 5869 - 5878, XP002672182, ISSN: 1078-0432 * |
KELLY W K ET AL: "HISTONE DEACETYLASE INHIBITORS: FROM TARGET TO CLINICAL TRIALS", EXPERT OPINION ON INVESTIGATIONAL DRUGS, ASHLEY PUBLICATIONS LTD., LONDON, GB, vol. 11, no. 12, 1 December 2002 (2002-12-01), pages 1695 - 1713, XP001202636, ISSN: 1354-3784, DOI: 10.1517/13543784.11.12.1695 * |
MANLEY ET AL: "Advances in the structural biology, design and clinical development of Bcr-Abl kinase inhibitors for the treatment of chronic myeloid leukaemia", BIOCHIMICA ET BIOPHYSICA ACTA (BBA) - PROTEINS & PROTEOMICS, ELSEVIER, NETHERLANDS, vol. 1754, no. 1-2, 30 December 2005 (2005-12-30), pages 3 - 13, XP005214189, ISSN: 1570-9639, DOI: 10.1016/J.BBAPAP.2005.07.040 * |
NIMMANAPALLI R ET AL: "Cotreatment with the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) enhances imatinib-induced apoptosis of Bcr-Abl-positive human acute leukemia cells", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 101, no. 8, 15 April 2003 (2003-04-15), pages 3236 - 3239, XP002263976, ISSN: 0006-4971, DOI: 10.1182/BLOOD-2002-08-2675 * |
THOMAS O'HARE ET AL: "In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 65, no. 11, 1 June 2005 (2005-06-01), pages 4500 - 4505, XP002626481, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-05-0259 * |
TOKARSKI JOHN S ET AL: "The structure of dasatinib (BMS-354825) bound to activated ABL kinase domain elucidates its inhibitory activity against imatinib-resistant ABL mutants", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 66, no. 11, 1 June 2006 (2006-06-01), pages 5790 - 5797, XP002431105, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-05-4187 * |
Also Published As
Publication number | Publication date |
---|---|
EP2049096A2 (en) | 2009-04-22 |
US20090215792A1 (en) | 2009-08-27 |
WO2008017024A2 (en) | 2008-02-07 |
US7799788B2 (en) | 2010-09-21 |
WO2008017024A3 (en) | 2008-04-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20090216 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR |
|
AX | Request for extension of the european patent |
Extension state: AL BA HR MK RS |
|
DAX | Request for extension of the european patent (deleted) | ||
RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61K 31/4745 20060101ALI20120326BHEP Ipc: G01N 33/50 20060101ALI20120326BHEP Ipc: A61P 35/02 20060101ALI20120326BHEP Ipc: A61K 45/06 20060101ALI20120326BHEP Ipc: A61K 31/506 20060101ALI20120326BHEP Ipc: A61K 31/19 20060101AFI20120326BHEP |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20120410 |
|
17Q | First examination report despatched |
Effective date: 20141021 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20150303 |