JP2005506275A - 新規線維芽細胞増殖因子 - Google Patents

新規線維芽細胞増殖因子 Download PDF

Info

Publication number
JP2005506275A
JP2005506275A JP2002548141A JP2002548141A JP2005506275A JP 2005506275 A JP2005506275 A JP 2005506275A JP 2002548141 A JP2002548141 A JP 2002548141A JP 2002548141 A JP2002548141 A JP 2002548141A JP 2005506275 A JP2005506275 A JP 2005506275A
Authority
JP
Japan
Prior art keywords
fgf
polypeptide
nucleotide sequence
cells
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2002548141A
Other languages
English (en)
Japanese (ja)
Other versions
JP2005506275A5 (cg-RX-API-DMAC7.html
Inventor
ダブリュ. ブリングマン,ピーター
フォールズ,ダリル
ミトロビック,ブラニスラバ
スリニバサン,スブハ
オヌファー,ジェイムズ
Original Assignee
シエーリング アクチエンゲゼルシャフト
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by シエーリング アクチエンゲゼルシャフト filed Critical シエーリング アクチエンゲゼルシャフト
Publication of JP2005506275A publication Critical patent/JP2005506275A/ja
Publication of JP2005506275A5 publication Critical patent/JP2005506275A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/1825Fibroblast growth factor [FGF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/38Drugs for disorders of the endocrine system of the suprarenal hormones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/50Fibroblast growth factor [FGF]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Transplantation (AREA)
  • Psychology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2002548141A 2000-12-08 2001-12-10 新規線維芽細胞増殖因子 Pending JP2005506275A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25183700P 2000-12-08 2000-12-08
US10/005,646 US20020151496A1 (en) 2000-12-08 2001-12-07 Novel fibroblast growth factors
PCT/US2001/047350 WO2002046424A2 (en) 2000-12-08 2001-12-10 Fibroblast growth factors

Publications (2)

Publication Number Publication Date
JP2005506275A true JP2005506275A (ja) 2005-03-03
JP2005506275A5 JP2005506275A5 (cg-RX-API-DMAC7.html) 2005-06-09

Family

ID=26674594

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002548141A Pending JP2005506275A (ja) 2000-12-08 2001-12-10 新規線維芽細胞増殖因子

Country Status (21)

Country Link
US (2) US20020151496A1 (cg-RX-API-DMAC7.html)
EP (1) EP1389237A2 (cg-RX-API-DMAC7.html)
JP (1) JP2005506275A (cg-RX-API-DMAC7.html)
KR (1) KR20040052442A (cg-RX-API-DMAC7.html)
CN (1) CN1518597A (cg-RX-API-DMAC7.html)
AU (1) AU2603402A (cg-RX-API-DMAC7.html)
BG (1) BG107888A (cg-RX-API-DMAC7.html)
BR (1) BR0116507A (cg-RX-API-DMAC7.html)
CA (1) CA2431374A1 (cg-RX-API-DMAC7.html)
CZ (1) CZ20031570A3 (cg-RX-API-DMAC7.html)
EE (1) EE200300269A (cg-RX-API-DMAC7.html)
HU (1) HUP0400657A1 (cg-RX-API-DMAC7.html)
IL (1) IL156259A0 (cg-RX-API-DMAC7.html)
MX (1) MXPA03005142A (cg-RX-API-DMAC7.html)
NO (1) NO20032573L (cg-RX-API-DMAC7.html)
PL (1) PL366158A1 (cg-RX-API-DMAC7.html)
RU (1) RU2329058C2 (cg-RX-API-DMAC7.html)
SI (1) SI21372A (cg-RX-API-DMAC7.html)
SK (1) SK7012003A3 (cg-RX-API-DMAC7.html)
WO (1) WO2002046424A2 (cg-RX-API-DMAC7.html)
ZA (1) ZA200305236B (cg-RX-API-DMAC7.html)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7253266B2 (en) 1999-07-27 2007-08-07 Curagen Corporation Polypeptides of FGF-CX
US6982250B2 (en) 2000-11-06 2006-01-03 Curagen Corporation Methods of prevention and treatment of inflammatory bowel disease
US7189693B2 (en) 2000-11-06 2007-03-13 Curagen Corporation Treatment of inflammatory bowel disease using fibroblast growth factor CX polypeptides
WO2003059270A2 (en) * 2002-01-15 2003-07-24 Eli Lilly And Company Method for reducing morbidity and mortality in critically ill patients
EP1608411B1 (en) * 2003-04-01 2010-09-29 United States Government as represented by the Department of Veteran's Affaires Stem-cell, precursor cell, or target cell-based treatment of multi-organ failure.
WO2004105787A1 (en) * 2003-05-28 2004-12-09 The University Of Kyoto Methods of using combinations of egf-2 and egf-20 to treat central nervous system disorders
LT2726511T (lt) 2011-07-01 2019-11-11 Ngm Biopharmaceuticals Inc Kompozicijos, panaudojimai ir būdai, skirti metabolinių sutrikimų ir ligų gydymui
US9290557B2 (en) 2012-11-28 2016-03-22 Ngm Biopharmaceuticals, Inc. Compositions comprising variants and fusions of FGF19 polypeptides
AU2013352363B2 (en) 2012-11-28 2018-04-12 Ngm Biopharmaceuticals, Inc. Compositions and methods for treatment of metabolic disorders and diseases
AU2013370404B2 (en) 2012-12-27 2017-11-02 Ngm Biopharmaceuticals, Inc. Methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases
US9273107B2 (en) 2012-12-27 2016-03-01 Ngm Biopharmaceuticals, Inc. Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases
MX377380B (es) 2013-10-28 2025-03-10 Ngm Biopharmaceuticals Inc Modelos de cáncer y métodos asociados.
SI3097122T1 (sl) 2014-01-24 2020-07-31 Ngm Biopharmaceuticals, Inc. Protitelesa, ki se vežejo v domeni beta klotho 2, in metode za njihovo uporabo
WO2015183890A2 (en) 2014-05-28 2015-12-03 Ngm Biopharmaceuticals, Inc. Methods and compositions for the treatment of metabolic disorders and diseases
EP3155005A4 (en) 2014-06-16 2018-07-11 NGM Biopharmaceuticals, Inc. Methods and uses for modulating bile acid homeostasis and treatment of bile acid disorders and diseases
UA123763C2 (uk) 2014-10-23 2021-06-02 Енджіем Байофармасьютикалз, Інк. Фармацевтична композиція для контролю або лікування захворювання або порушення, пов’язаного з fgf19
US10434144B2 (en) 2014-11-07 2019-10-08 Ngm Biopharmaceuticals, Inc. Methods for treatment of bile acid-related disorders and prediction of clinical sensitivity to treatment of bile acid-related disorders
WO2017019957A2 (en) 2015-07-29 2017-02-02 Ngm Biopharmaceuticals, Inc. Binding proteins and methods of use thereof
CA3003616C (en) 2015-11-09 2020-07-28 Ngm Biopharmaceuticals, Inc. Methods for treatment of bile acid-related disorders
CA3034399A1 (en) 2016-08-26 2018-03-01 Ngm Biopharmaceuticals, Inc. Methods of treating fibroblast growth factor 19-mediated cancers and tumors
CN107050428B (zh) * 2017-03-23 2020-05-05 温州医科大学 Fgf20药物及其对脑创伤的治疗应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5A (en) * 1836-08-10 Thomas Blanchard Machine for mortising solid wooden shells of ships' tackle-blocks
WO2000060085A1 (en) * 1999-04-02 2000-10-12 Millennium Pharmaceuticals, Inc. Fibroblast growth factor-20
JP2003512841A (ja) * 1999-10-22 2003-04-08 カイロン コーポレイション ヒトおよびラットfgf−20遺伝子および遺伝子発現産物
JP2003516731A (ja) * 1999-11-18 2003-05-20 カイロン コーポレイション ヒトfgf−21遺伝子および遺伝子発現産物
AU2001262934A1 (en) * 2000-06-01 2001-12-11 Eli Lilly And Company Human fgf-20 nucleic acids and polypeptides
WO2002002625A2 (en) * 2000-07-03 2002-01-10 Curagen Corporation Novel fibroblast growth factors and nucleic acids encoding same

Also Published As

Publication number Publication date
CA2431374A1 (en) 2002-06-13
HUP0400657A1 (en) 2006-04-28
US20080057076A1 (en) 2008-03-06
ZA200305236B (en) 2005-06-29
SI21372A (sl) 2004-06-30
EP1389237A2 (en) 2004-02-18
RU2003119657A (ru) 2005-02-27
AU2002226034A2 (en) 2002-06-18
IL156259A0 (en) 2004-01-04
BR0116507A (pt) 2004-01-06
NO20032573D0 (no) 2003-06-06
RU2329058C2 (ru) 2008-07-20
CN1518597A (zh) 2004-08-04
CZ20031570A3 (cs) 2004-01-14
KR20040052442A (ko) 2004-06-23
BG107888A (bg) 2004-08-31
AU2603402A (en) 2002-06-18
US20020151496A1 (en) 2002-10-17
NO20032573L (no) 2003-07-22
WO2002046424A3 (en) 2003-11-27
EE200300269A (et) 2003-10-15
PL366158A1 (en) 2005-01-24
MXPA03005142A (es) 2004-10-15
SK7012003A3 (en) 2004-04-06
WO2002046424A2 (en) 2002-06-13

Similar Documents

Publication Publication Date Title
US20080057076A1 (en) Novel fibroblast growth factors
EP0836380B1 (en) Fgf9 as a specific ligand for fgfr3
Caday et al. Fibroblast growth factor (FGF) levels in the developing rat brain
US8986690B2 (en) Modulation of activity of neurotrophins
JP3275024B2 (ja) 血管内皮増殖因子−b
JP2007209349A (ja) 新規な神経栄養因子
JPH09510103A (ja) 線維芽細胞成長因子−10
HK1203217A1 (en) Single domain tdf-related compounds and analogs thereof
Kimura et al. Schwannoma-derived growth factor promotes the neuronal differentiation and survival of PC12 cells.
WO1998022499A2 (en) Arretin, a neurite outgrowth modulator, antibodies thereto and uses thereof
WO1998022499A9 (en) Arretin, a neurite outgrowth modulator, antibodies thereto and uses thereof
US20030211990A1 (en) Neural regeneration peptides and methods for their use in treatment of brain damage
AU2002226034B2 (en) Fibroblast growth factors
WO2001032197A2 (en) Methods of using lp8, a pdgf-related protein, to treat musculoskeletal disorders
AU2002226034A1 (en) Fibroblast growth factors
JP2004504042A (ja) グリコシル化vegf−b及び可溶性vegf−bの量を増加させるための方法
AU2007203341A1 (en) Fibroblast growth factors
HK1068648A (en) Novel fibroblast growth factors
MURAMATSU Search for New Cell-Surface Recognition Molecules Important in Mammalian Embryogenesis
MXPA98003767A (en) Receivers of the neurotrophic factor derived from cell line gl
AU2016213791A1 (en) Single domain TDF-related compounds and analogs thereof

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20041206

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20080115

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20080414

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20080421

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20080916