JP2005505602A - 予め規定された放出プロファイルを有するリポソーム調剤の製造方法 - Google Patents

予め規定された放出プロファイルを有するリポソーム調剤の製造方法 Download PDF

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Publication number
JP2005505602A
JP2005505602A JP2003535751A JP2003535751A JP2005505602A JP 2005505602 A JP2005505602 A JP 2005505602A JP 2003535751 A JP2003535751 A JP 2003535751A JP 2003535751 A JP2003535751 A JP 2003535751A JP 2005505602 A JP2005505602 A JP 2005505602A
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Prior art keywords
liposome
active agent
ammonium
release profile
liposomes
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Japanese (ja)
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JP2005505602A5 (https=
Inventor
バレンホルツ，イエチエズケル
ワツサーマン，ベロニカ
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YISSUM RESEARCH DEVELOPMENT COMPANY PF THE HEBREW UNIVERSITY OP JERUSALEM
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YISSUM RESEARCH DEVELOPMENT COMPANY PF THE HEBREW UNIVERSITY OP JERUSALEM
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Publication of JP2005505602A5 publication Critical patent/JP2005505602A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dispersion Chemistry (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2003535751A 2001-09-06 2002-09-09 予め規定された放出プロファイルを有するリポソーム調剤の製造方法 Pending JP2005505602A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31718701P 2001-09-06 2001-09-06
PCT/IL2002/000745 WO2003032947A2 (en) 2001-09-06 2002-09-09 A method for preparing liposome formulations with a predefined release profile

Publications (2)

Publication Number Publication Date
JP2005505602A true JP2005505602A (ja) 2005-02-24
JP2005505602A5 JP2005505602A5 (https=) 2006-01-05

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Family Applications (1)

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JP2003535751A Pending JP2005505602A (ja) 2001-09-06 2002-09-09 予め規定された放出プロファイルを有するリポソーム調剤の製造方法

Country Status (7)

Country Link
US (2) US20060165766A1 (https=)
EP (1) EP1429726A2 (https=)
JP (1) JP2005505602A (https=)
AU (1) AU2002334358B2 (https=)
CA (1) CA2460209A1 (https=)
IL (1) IL160350A0 (https=)
WO (1) WO2003032947A2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016504352A (ja) * 2012-12-28 2016-02-12 チョン クン ダン ファーマシューティカル コーポレーション アニオン性薬理学的活性物質の徐放性脂質初期製剤およびこれを含む薬剤学的組成物
JP2020505451A (ja) * 2017-01-18 2020-02-20 テマセク・ライフ・サイエンシーズ・ラボラトリー・リミテッドＴｅｍａｓｅｋ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌａｂｏｒａｔｏｒｙ Ｌｉｍｉｔｅｄ 超安定リポソームによる有糸分裂細胞の標的化の増加

Families Citing this family (19)

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Publication number Priority date Publication date Assignee Title
AU2004233873B2 (en) 2003-04-25 2010-11-18 The Penn State Research Foundation Method and system for systemic delivery of growth arresting, lipid-derived bioactive compounds
US20050129753A1 (en) * 2003-11-14 2005-06-16 Gabizon Alberto A. Method for drug loading in liposomes
WO2006027787A1 (en) * 2004-09-09 2006-03-16 Yissum Research Development Company Of The Hebrew University Of Jerusalem Liposomal compositions of glucocorticoid and glucocorticoid derivatives
JP2008512444A (ja) * 2004-09-09 2008-04-24 イッスム・リサーチ・ディベロップメント・カンパニー・オブ・ザ・ヘブルー・ユニバーシティ・オブ・エルサレム 神経変性状態の治療のための、両親媒性弱塩基様テンパミンを含むリポソーム製剤
EP1802277B1 (de) 2004-10-18 2010-01-13 Polymun Scientific Immunbiologische Forschung GmbH Liposomale zusammensetzung einen wirkstoff zur relaxierung glatter muskulatur enthaltend, die herstellung dieser zusammensetzung und deren therapeutische verwendung
US20080213352A1 (en) * 2007-03-02 2008-09-04 Luna Innovations Incorporated Liposome carriers for in vivo delivery of fullerenes
DE102007036294A1 (de) 2007-07-31 2009-02-05 Gea Westfaliasurge Gmbh Vorrichtung und ein Verfahren zum Bereitstellen von Informationen über Tiere beim Durchlaufen eines Tierdurchganges
US9713591B2 (en) 2008-10-07 2017-07-25 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. Composition of matter comprising liposomes embedded in a polymeric matrix and methods of using same
WO2010058840A1 (ja) * 2008-11-20 2010-05-27 テルモ株式会社 リポソームからの薬物放出手段および放出性評価法
US20100129430A1 (en) * 2008-11-24 2010-05-27 Stavroula Sofou Liposome drug carriers with ph-sensitivity
BR112013016365A2 (pt) * 2010-12-27 2018-06-26 Terumo Corp composição de lipossoma e processo para produção do mesmo
KR101494594B1 (ko) 2011-08-30 2015-02-23 주식회사 종근당 약리학적 활성물질의 서방성 지질 초기제제 및 이를 포함하는 약제학적 조성물
KR101586791B1 (ko) 2012-12-28 2016-01-19 주식회사 종근당 ＧｎＲＨ 유도체의 서방성 지질 초기제제 및 이를 포함하는 약제학적 조성물
WO2014121235A2 (en) * 2013-02-01 2014-08-07 Zoneone Pharma, Inc. Transformation of drug cyclodextrin complex compositions into compositions of mixtures of lipid vesicle encapsulated drug and cyclodextrin drug complexes
WO2014121211A2 (en) * 2013-02-01 2014-08-07 Zoneone Pharma, Inc. Remote loading of sparingly water-soluble drugs into liposomes
WO2014153192A1 (en) * 2013-03-14 2014-09-25 Zoneone Pharma, Inc. Pharmaceutical formulations of chelating agents as a metal removal treatment system
CN106999419A (zh) 2014-08-04 2017-08-01 佐尼奥尼制药股份有限公司 远程装载略微水溶性药物至脂质膜泡
JP2020111523A (ja) * 2019-01-09 2020-07-27 国立研究開発法人理化学研究所 機能性ナノ構造体
GB202200962D0 (en) * 2022-01-25 2022-03-09 Cytoseek Ltd Polymer additives

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02196713A (ja) * 1988-09-28 1990-08-03 Yissum Res Dev Co Of Hebrew Univ Of Jerusalem 両親媒性分子を有効に充填かつ制御放出するリポソーム
JPH02502458A (ja) * 1987-03-05 1990-08-09 ザ　リポソーム　カンパニー，インコーポレイテッド リポソーム性抗腫瘍剤の高薬剤：脂質調剤
US5939096A (en) * 1995-04-18 1999-08-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Liposome drug-loading method and composition
WO2000066126A2 (en) * 1999-04-29 2000-11-09 Alza Corporation Liposome compositions for improved drug retention

Family Cites Families (2)

* Cited by examiner, † Cited by third party
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US5972379A (en) * 1995-02-14 1999-10-26 Sequus Pharmaceuticals, Inc. Liposome composition and method for administering a quinolone
IL140892A0 (en) * 1998-08-12 2002-02-10 Yissum Res Dev Co Liposomal bupivacaine compositions prepared using an ammonium sulfate gradient

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02502458A (ja) * 1987-03-05 1990-08-09 ザ　リポソーム　カンパニー，インコーポレイテッド リポソーム性抗腫瘍剤の高薬剤：脂質調剤
JPH02196713A (ja) * 1988-09-28 1990-08-03 Yissum Res Dev Co Of Hebrew Univ Of Jerusalem 両親媒性分子を有効に充填かつ制御放出するリポソーム
US5939096A (en) * 1995-04-18 1999-08-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Liposome drug-loading method and composition
WO2000066126A2 (en) * 1999-04-29 2000-11-09 Alza Corporation Liposome compositions for improved drug retention

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
ANALYTICAL BIOCHEMISTRY, vol. 1998, Vol.259, JPN7009002183, pages 104 - 111, ISSN: 0001314675 *
BIOCHIMICA ET BIOPHYSICA ACTA, BIOMEMBRANES, vol. 1993, Vol.1151, JPN6009021213, pages 201 - 215, ISSN: 0001314674 *
BIOCHIMICA ET BIOPHYSICA ACTA, BIOMEMBRANES, vol. 1995, Vol.1239, JPN6009021206, pages 145 - 156, ISSN: 0001314672 *
BIOCHIMICA ET BIOPHYSICA ACTA, BIOMEMBRANES, vol. 1995, Vol.1240, JPN6009021217, pages 257 - 265, ISSN: 0001314676 *
BIOCHIMICA ET BIOPHYSICA ACTA, BIOMEMBRANES, vol. 1998, Vol.1415, JPN6009021209, pages 23 - 40, ISSN: 0001314673 *
CURRENT OPINION IN COLLID & INTERFACE SCIENCE, vol. 2001, Vol.6, JPN6009021219, pages 66 - 77, ISSN: 0001314677 *
JOURNAL OF LIPOSOME RESEARCH, vol. 1999, Vol.9, No.1, JPN7009002184, pages 53 - 79, ISSN: 0001314678 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016504352A (ja) * 2012-12-28 2016-02-12 チョン クン ダン ファーマシューティカル コーポレーション アニオン性薬理学的活性物質の徐放性脂質初期製剤およびこれを含む薬剤学的組成物
JP2020505451A (ja) * 2017-01-18 2020-02-20 テマセク・ライフ・サイエンシーズ・ラボラトリー・リミテッドＴｅｍａｓｅｋ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌａｂｏｒａｔｏｒｙ Ｌｉｍｉｔｅｄ 超安定リポソームによる有糸分裂細胞の標的化の増加
JP7232530B2 (ja) 2017-01-18 2023-03-03 テマセク・ライフ・サイエンシーズ・ラボラトリー・リミテッド 超安定リポソームによる有糸分裂細胞の標的化の増加

Also Published As

Publication number Publication date
US20080213353A1 (en) 2008-09-04
CA2460209A1 (en) 2003-04-24
AU2002334358B2 (en) 2008-02-07
US20060165766A1 (en) 2006-07-27
EP1429726A2 (en) 2004-06-23
IL160350A0 (en) 2004-07-25
WO2003032947A2 (en) 2003-04-24
WO2003032947A3 (en) 2003-09-25

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