JP2005505571A5 - - Google Patents
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- Publication number
- JP2005505571A5 JP2005505571A5 JP2003528769A JP2003528769A JP2005505571A5 JP 2005505571 A5 JP2005505571 A5 JP 2005505571A5 JP 2003528769 A JP2003528769 A JP 2003528769A JP 2003528769 A JP2003528769 A JP 2003528769A JP 2005505571 A5 JP2005505571 A5 JP 2005505571A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- alkyl
- compound according
- hydrogen
- solvate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 19
- 229910052739 hydrogen Inorganic materials 0.000 claims 8
- 239000001257 hydrogen Substances 0.000 claims 8
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 150000002431 hydrogen Chemical class 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 239000012453 solvate Substances 0.000 claims 6
- 206010014561 Emphysema Diseases 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 5
- 208000017520 skin disease Diseases 0.000 claims 5
- 125000003710 aryl alkyl group Chemical group 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 229940002612 prodrug Drugs 0.000 claims 2
- 239000000651 prodrug Substances 0.000 claims 2
- 239000013543 active substance Substances 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000003136 n-heptyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 claims 1
- -1 n-octyl Chemical group 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32296301P | 2001-09-18 | 2001-09-18 | |
| PCT/EP2002/010179 WO2003024921A1 (en) | 2001-09-18 | 2002-09-11 | Alkyl urea retinoid agonists i |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005505571A JP2005505571A (ja) | 2005-02-24 |
| JP2005505571A5 true JP2005505571A5 (https=) | 2006-01-05 |
| JP4421293B2 JP4421293B2 (ja) | 2010-02-24 |
Family
ID=33130243
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003528769A Expired - Fee Related JP4421293B2 (ja) | 2001-09-18 | 2002-09-11 | アルキル尿素レチノイドアゴニストｉ |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6844466B2 (https=) |
| EP (1) | EP1430024A1 (https=) |
| JP (1) | JP4421293B2 (https=) |
| KR (1) | KR100896550B1 (https=) |
| CN (1) | CN1283621C (https=) |
| AR (1) | AR036533A1 (https=) |
| AU (1) | AU2002329276B2 (https=) |
| BR (1) | BR0212583A (https=) |
| CA (1) | CA2460693C (https=) |
| MX (1) | MXPA04002590A (https=) |
| PL (1) | PL370361A1 (https=) |
| RU (1) | RU2299877C2 (https=) |
| WO (1) | WO2003024921A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2530581A1 (en) * | 2003-06-23 | 2005-01-06 | Auspex Pharmaceuticals | Novel therapeautic agents for the treatment of cancer, metabolic diseases and skin disorders |
| WO2005108338A1 (en) * | 2004-05-03 | 2005-11-17 | Auspex Pharmaceuticals | Novel therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders |
| US7803951B2 (en) * | 2005-03-30 | 2010-09-28 | Merck Sharp & Dohme Corp. | Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use |
| TW200821284A (en) * | 2006-10-03 | 2008-05-16 | Merck & Co Inc | Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use |
| EP4066826B1 (en) | 2010-09-01 | 2024-03-06 | Thomas Jefferson University | Retinoic acid receptor gamma agonists for muscle repair and regeneration |
| CA2890424C (en) | 2012-11-08 | 2020-11-17 | Yamaguchi University | Therapeutic agent for keratoconjunctive disorders |
| KR101426197B1 (ko) * | 2013-02-20 | 2014-08-01 | 여윤영 | 주먹밥틀 |
| RS58045B1 (sr) | 2013-05-22 | 2019-02-28 | Univ Yamaguchi | Inhibitor za retinohoroidalne poremećaje |
| CN105294567B (zh) * | 2015-10-29 | 2018-10-09 | 湖北新烯王生物科技有限公司 | 取代的3-氟苯基甲醇类化合物、药物组合物及用途 |
| SG11201810658PA (en) | 2016-06-08 | 2018-12-28 | Clementia Pharmaceuticals Inc | Methods for treating heterotopic ossification |
| MX379489B (es) | 2016-11-16 | 2025-03-11 | Clementia Pharmaceuticals Inc | Metodos para tratar la osteocondromatosis multiple (mo). |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LU87821A1 (fr) | 1990-10-12 | 1992-05-25 | Cird Galderma | Composes bi-aromatiques,et leur utilisation en medecine humaine et veterinaire et en cosmetique |
| DE10199033I2 (de) * | 1992-04-22 | 2003-01-09 | Ligand Parmaceuticals Inc | Retinoid-x Rezeptor selektive Verbindungen |
| US6093742A (en) | 1997-06-27 | 2000-07-25 | Vertex Pharmaceuticals, Inc. | Inhibitors of p38 |
| JO2178B1 (en) | 1999-10-19 | 2003-04-23 | اف . هوفمان لاروش ايه جي | Treatment of emphysema using rar selective retinoid antagonists |
-
2002
- 2002-09-11 MX MXPA04002590A patent/MXPA04002590A/es active IP Right Grant
- 2002-09-11 CA CA2460693A patent/CA2460693C/en not_active Expired - Fee Related
- 2002-09-11 EP EP02764881A patent/EP1430024A1/en not_active Withdrawn
- 2002-09-11 WO PCT/EP2002/010179 patent/WO2003024921A1/en not_active Ceased
- 2002-09-11 AU AU2002329276A patent/AU2002329276B2/en not_active Ceased
- 2002-09-11 KR KR1020047003931A patent/KR100896550B1/ko not_active Expired - Fee Related
- 2002-09-11 BR BR0212583-8A patent/BR0212583A/pt not_active Application Discontinuation
- 2002-09-11 CN CNB028181522A patent/CN1283621C/zh not_active Expired - Fee Related
- 2002-09-11 RU RU2004111787/04A patent/RU2299877C2/ru not_active IP Right Cessation
- 2002-09-11 PL PL02370361A patent/PL370361A1/xx not_active IP Right Cessation
- 2002-09-11 JP JP2003528769A patent/JP4421293B2/ja not_active Expired - Fee Related
- 2002-09-16 AR ARP020103490A patent/AR036533A1/es unknown
- 2002-09-17 US US10/245,133 patent/US6844466B2/en not_active Expired - Fee Related