RU2299877C2 - Производные алкилмочевины, обладающие свойствами ретиноидных агонистов (i), фармацевтическая композиция и лекарственное средство - Google Patents

Производные алкилмочевины, обладающие свойствами ретиноидных агонистов (i), фармацевтическая композиция и лекарственное средство Download PDF

Info

Publication number
RU2299877C2
RU2299877C2 RU2004111787/04A RU2004111787A RU2299877C2 RU 2299877 C2 RU2299877 C2 RU 2299877C2 RU 2004111787/04 A RU2004111787/04 A RU 2004111787/04A RU 2004111787 A RU2004111787 A RU 2004111787A RU 2299877 C2 RU2299877 C2 RU 2299877C2
Authority
RU
Russia
Prior art keywords
compound
acid
compounds
alkyl
emphysema
Prior art date
Application number
RU2004111787/04A
Other languages
English (en)
Russian (ru)
Other versions
RU2004111787A (ru
Inventor
Пола Нанетте БЕЛЛОНИ (US)
Пола Нанетте БЕЛЛОНИ
Денис Джон КЕРТЕШ (US)
Денис Джон КЕРТЕШ
Михаэль КЛАУС (DE)
Михаэль КЛАУС
Жан-Марк ЛАПЬЕР (US)
Жан-Марк ЛАПЬЕР
Original Assignee
Ф.Хоффманн-Ля Рош Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ф.Хоффманн-Ля Рош Аг filed Critical Ф.Хоффманн-Ля Рош Аг
Publication of RU2004111787A publication Critical patent/RU2004111787A/ru
Application granted granted Critical
Publication of RU2299877C2 publication Critical patent/RU2299877C2/ru

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
RU2004111787/04A 2001-09-18 2002-09-11 Производные алкилмочевины, обладающие свойствами ретиноидных агонистов (i), фармацевтическая композиция и лекарственное средство RU2299877C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32296301P 2001-09-18 2001-09-18
US60/332,963 2001-09-18

Publications (2)

Publication Number Publication Date
RU2004111787A RU2004111787A (ru) 2005-10-20
RU2299877C2 true RU2299877C2 (ru) 2007-05-27

Family

ID=33130243

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2004111787/04A RU2299877C2 (ru) 2001-09-18 2002-09-11 Производные алкилмочевины, обладающие свойствами ретиноидных агонистов (i), фармацевтическая композиция и лекарственное средство

Country Status (13)

Country Link
US (1) US6844466B2 (https=)
EP (1) EP1430024A1 (https=)
JP (1) JP4421293B2 (https=)
KR (1) KR100896550B1 (https=)
CN (1) CN1283621C (https=)
AR (1) AR036533A1 (https=)
AU (1) AU2002329276B2 (https=)
BR (1) BR0212583A (https=)
CA (1) CA2460693C (https=)
MX (1) MXPA04002590A (https=)
PL (1) PL370361A1 (https=)
RU (1) RU2299877C2 (https=)
WO (1) WO2003024921A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2530581A1 (en) * 2003-06-23 2005-01-06 Auspex Pharmaceuticals Novel therapeautic agents for the treatment of cancer, metabolic diseases and skin disorders
WO2005108338A1 (en) * 2004-05-03 2005-11-17 Auspex Pharmaceuticals Novel therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders
US7803951B2 (en) * 2005-03-30 2010-09-28 Merck Sharp & Dohme Corp. Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
TW200821284A (en) * 2006-10-03 2008-05-16 Merck & Co Inc Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
EP4066826B1 (en) 2010-09-01 2024-03-06 Thomas Jefferson University Retinoic acid receptor gamma agonists for muscle repair and regeneration
CA2890424C (en) 2012-11-08 2020-11-17 Yamaguchi University Therapeutic agent for keratoconjunctive disorders
KR101426197B1 (ko) * 2013-02-20 2014-08-01 여윤영 주먹밥틀
RS58045B1 (sr) 2013-05-22 2019-02-28 Univ Yamaguchi Inhibitor za retinohoroidalne poremećaje
CN105294567B (zh) * 2015-10-29 2018-10-09 湖北新烯王生物科技有限公司 取代的3-氟苯基甲醇类化合物、药物组合物及用途
SG11201810658PA (en) 2016-06-08 2018-12-28 Clementia Pharmaceuticals Inc Methods for treating heterotopic ossification
MX379489B (es) 2016-11-16 2025-03-11 Clementia Pharmaceuticals Inc Metodos para tratar la osteocondromatosis multiple (mo).

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2144913C1 (ru) * 1992-04-22 2000-01-27 Лайджэнд Фармасьютикалз Инкорпорейтед Соединения, обладающие избирательностью в отношении рецепторов ретиноида, фармацевтическая композиция (варианты), способ модулирования процессов (варианты), способ подавления патологических состояний
WO2001030326A1 (en) * 1999-10-19 2001-05-03 F. Hoffmann-La Roche Ag Treatment of emphysema using rar selective retinoid agonists

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU87821A1 (fr) 1990-10-12 1992-05-25 Cird Galderma Composes bi-aromatiques,et leur utilisation en medecine humaine et veterinaire et en cosmetique
US6093742A (en) 1997-06-27 2000-07-25 Vertex Pharmaceuticals, Inc. Inhibitors of p38

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2144913C1 (ru) * 1992-04-22 2000-01-27 Лайджэнд Фармасьютикалз Инкорпорейтед Соединения, обладающие избирательностью в отношении рецепторов ретиноида, фармацевтическая композиция (варианты), способ модулирования процессов (варианты), способ подавления патологических состояний
WO2001030326A1 (en) * 1999-10-19 2001-05-03 F. Hoffmann-La Roche Ag Treatment of emphysema using rar selective retinoid agonists

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
WO 92/06948 A1 (CIRD), 30.04.1992. Chem. abstr. v.125, ref.316403, соединение RN 183059-31-06. Chem. abstr. v.109, ref.104166, соединение RN 116193-59-0. *

Also Published As

Publication number Publication date
KR20040035809A (ko) 2004-04-29
PL370361A1 (en) 2005-05-16
MXPA04002590A (es) 2004-06-18
EP1430024A1 (en) 2004-06-23
CN1283621C (zh) 2006-11-08
RU2004111787A (ru) 2005-10-20
AR036533A1 (es) 2004-09-15
US6844466B2 (en) 2005-01-18
CN1555359A (zh) 2004-12-15
KR100896550B1 (ko) 2009-05-07
CA2460693C (en) 2010-12-07
CA2460693A1 (en) 2003-03-27
BR0212583A (pt) 2004-10-13
JP2005505571A (ja) 2005-02-24
JP4421293B2 (ja) 2010-02-24
WO2003024921A1 (en) 2003-03-27
US20030158226A1 (en) 2003-08-21
AU2002329276B2 (en) 2008-04-24

Similar Documents

Publication Publication Date Title
RU2299877C2 (ru) Производные алкилмочевины, обладающие свойствами ретиноидных агонистов (i), фармацевтическая композиция и лекарственное средство
EP1324970B1 (en) Retinoids for the treatment of emphysema
US6794416B2 (en) Methods, compositions and modes of delivery for the treatment of emphysema using 13-cis-retinoic acid
AU2002329276A1 (en) Alkyl urea retinoid agonists I
RU2303027C2 (ru) Производные замещенной мочевины, фармацевтическая композиция и лекарственное средство на их основе, обладающие ретиноидной активностью
AU2002340886A1 (en) Substituted urea retinoid agonists II
US7354931B2 (en) Heterocyclic retinoid compounds
AU2002363170A1 (en) Heterocyclic retinoid compounds

Legal Events

Date Code Title Description
MM4A The patent is invalid due to non-payment of fees

Effective date: 20120912