RU2299877C2 - Производные алкилмочевины, обладающие свойствами ретиноидных агонистов (i), фармацевтическая композиция и лекарственное средство - Google Patents

Производные алкилмочевины, обладающие свойствами ретиноидных агонистов (i), фармацевтическая композиция и лекарственное средство Download PDF

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Publication number
RU2299877C2
RU2299877C2 RU2004111787/04A RU2004111787A RU2299877C2 RU 2299877 C2 RU2299877 C2 RU 2299877C2 RU 2004111787/04 A RU2004111787/04 A RU 2004111787/04A RU 2004111787 A RU2004111787 A RU 2004111787A RU 2299877 C2 RU2299877 C2 RU 2299877C2
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RU
Russia
Prior art keywords
compound
acid
compounds
alkyl
emphysema
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RU2004111787/04A
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English (en)
Russian (ru)
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RU2004111787A (ru
Inventor
Пола Нанетте БЕЛЛОНИ (US)
Пола Нанетте БЕЛЛОНИ
Денис Джон КЕРТЕШ (US)
Денис Джон КЕРТЕШ
Михаэль КЛАУС (DE)
Михаэль КЛАУС
Жан-Марк ЛАПЬЕР (US)
Жан-Марк ЛАПЬЕР
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Ф.Хоффманн-Ля Рош Аг
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
RU2004111787/04A 2001-09-18 2002-09-11 Производные алкилмочевины, обладающие свойствами ретиноидных агонистов (i), фармацевтическая композиция и лекарственное средство RU2299877C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32296301P 2001-09-18 2001-09-18
US60/332,963 2001-09-18

Publications (2)

Publication Number Publication Date
RU2004111787A RU2004111787A (ru) 2005-10-20
RU2299877C2 true RU2299877C2 (ru) 2007-05-27

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RU2004111787/04A RU2299877C2 (ru) 2001-09-18 2002-09-11 Производные алкилмочевины, обладающие свойствами ретиноидных агонистов (i), фармацевтическая композиция и лекарственное средство

Country Status (13)

Country Link
US (1) US6844466B2 (https=)
EP (1) EP1430024A1 (https=)
JP (1) JP4421293B2 (https=)
KR (1) KR100896550B1 (https=)
CN (1) CN1283621C (https=)
AR (1) AR036533A1 (https=)
AU (1) AU2002329276B2 (https=)
BR (1) BR0212583A (https=)
CA (1) CA2460693C (https=)
MX (1) MXPA04002590A (https=)
PL (1) PL370361A1 (https=)
RU (1) RU2299877C2 (https=)
WO (1) WO2003024921A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005000233A2 (en) * 2003-06-23 2005-01-06 Auspex Pharmaceuticals Novel therapeautic agents for the treatment of cancer, metabolic diseases and skin disorders
WO2005108338A1 (en) * 2004-05-03 2005-11-17 Auspex Pharmaceuticals Novel therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders
JP2008534593A (ja) * 2005-03-30 2008-08-28 メルク エンド カムパニー インコーポレーテッド グルカゴン受容体アンタゴニスト化合物、そのような化合物を含む組成物、及びその使用方法
TW200821284A (en) * 2006-10-03 2008-05-16 Merck & Co Inc Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
EP3721880B1 (en) 2010-09-01 2022-02-02 Thomas Jefferson University Composition and method for muscle repair and regeneration
US9492431B2 (en) 2012-11-08 2016-11-15 Yamaguchi University Therapeutic agent for keratoconjunctive disorders
KR101426197B1 (ko) * 2013-02-20 2014-08-01 여윤영 주먹밥틀
ES2694831T3 (es) 2013-05-22 2018-12-27 Yamaguchi University Inhibidor para trastornos retinocoroideos
CN105294567B (zh) * 2015-10-29 2018-10-09 湖北新烯王生物科技有限公司 取代的3-氟苯基甲醇类化合物、药物组合物及用途
JP7023868B2 (ja) 2016-06-08 2022-02-22 クレメンティア ファーマシューティカルズ，インコーポレイテッド 異所性骨化を治療するための方法
CA3043807A1 (en) 2016-11-16 2018-05-24 Clementia Pharmaceuticals Inc. Methods for treating multiple osteochondroma (mo)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2144913C1 (ru) * 1992-04-22 2000-01-27 Лайджэнд Фармасьютикалз Инкорпорейтед Соединения, обладающие избирательностью в отношении рецепторов ретиноида, фармацевтическая композиция (варианты), способ модулирования процессов (варианты), способ подавления патологических состояний
WO2001030326A1 (en) * 1999-10-19 2001-05-03 F. Hoffmann-La Roche Ag Treatment of emphysema using rar selective retinoid agonists

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU87821A1 (fr) 1990-10-12 1992-05-25 Cird Galderma Composes bi-aromatiques,et leur utilisation en medecine humaine et veterinaire et en cosmetique
US6093742A (en) 1997-06-27 2000-07-25 Vertex Pharmaceuticals, Inc. Inhibitors of p38

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2144913C1 (ru) * 1992-04-22 2000-01-27 Лайджэнд Фармасьютикалз Инкорпорейтед Соединения, обладающие избирательностью в отношении рецепторов ретиноида, фармацевтическая композиция (варианты), способ модулирования процессов (варианты), способ подавления патологических состояний
WO2001030326A1 (en) * 1999-10-19 2001-05-03 F. Hoffmann-La Roche Ag Treatment of emphysema using rar selective retinoid agonists

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
WO 92/06948 A1 (CIRD), 30.04.1992. Chem. abstr. v.125, ref.316403, соединение RN 183059-31-06. Chem. abstr. v.109, ref.104166, соединение RN 116193-59-0. *

Also Published As

Publication number Publication date
MXPA04002590A (es) 2004-06-18
US20030158226A1 (en) 2003-08-21
KR100896550B1 (ko) 2009-05-07
KR20040035809A (ko) 2004-04-29
EP1430024A1 (en) 2004-06-23
RU2004111787A (ru) 2005-10-20
PL370361A1 (en) 2005-05-16
AR036533A1 (es) 2004-09-15
US6844466B2 (en) 2005-01-18
CA2460693A1 (en) 2003-03-27
BR0212583A (pt) 2004-10-13
CN1283621C (zh) 2006-11-08
CN1555359A (zh) 2004-12-15
AU2002329276B2 (en) 2008-04-24
JP2005505571A (ja) 2005-02-24
WO2003024921A1 (en) 2003-03-27
JP4421293B2 (ja) 2010-02-24
CA2460693C (en) 2010-12-07

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Effective date: 20120912