KR100896550B1 - 알킬 우레아 레티노이드 작용제 ｉ - Google Patents

알킬 우레아 레티노이드 작용제 ｉ Download PDF

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Publication number
KR100896550B1
KR100896550B1 KR1020047003931A KR20047003931A KR100896550B1 KR 100896550 B1 KR100896550 B1 KR 100896550B1 KR 1020047003931 A KR1020047003931 A KR 1020047003931A KR 20047003931 A KR20047003931 A KR 20047003931A KR 100896550 B1 KR100896550 B1 KR 100896550B1
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KR
South Korea
Prior art keywords
compounds
alkyl
acid
emphysema
tetrahydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020047003931A
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English (en)
Korean (ko)
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KR20040035809A (ko
Inventor
벨로니파울라나네트
커테스데니스존
클라우스미카엘
라피에르장-마크
Original Assignee
에프. 호프만-라 로슈 아게
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Publication of KR20040035809A publication Critical patent/KR20040035809A/ko
Application granted granted Critical
Publication of KR100896550B1 publication Critical patent/KR100896550B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020047003931A 2001-09-18 2002-09-11 알킬 우레아 레티노이드 작용제 ｉ Expired - Fee Related KR100896550B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US32296301P 2001-09-18 2001-09-18
US60/322,963 2001-09-18
US60/332,963 2001-09-18
PCT/EP2002/010179 WO2003024921A1 (en) 2001-09-18 2002-09-11 Alkyl urea retinoid agonists i

Publications (2)

Publication Number Publication Date
KR20040035809A KR20040035809A (ko) 2004-04-29
KR100896550B1 true KR100896550B1 (ko) 2009-05-07

Family

ID=33130243

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020047003931A Expired - Fee Related KR100896550B1 (ko) 2001-09-18 2002-09-11 알킬 우레아 레티노이드 작용제 ｉ

Country Status (13)

Country Link
US (1) US6844466B2 (https=)
EP (1) EP1430024A1 (https=)
JP (1) JP4421293B2 (https=)
KR (1) KR100896550B1 (https=)
CN (1) CN1283621C (https=)
AR (1) AR036533A1 (https=)
AU (1) AU2002329276B2 (https=)
BR (1) BR0212583A (https=)
CA (1) CA2460693C (https=)
MX (1) MXPA04002590A (https=)
PL (1) PL370361A1 (https=)
RU (1) RU2299877C2 (https=)
WO (1) WO2003024921A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2530581A1 (en) * 2003-06-23 2005-01-06 Auspex Pharmaceuticals Novel therapeautic agents for the treatment of cancer, metabolic diseases and skin disorders
WO2005108338A1 (en) * 2004-05-03 2005-11-17 Auspex Pharmaceuticals Novel therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders
US7803951B2 (en) * 2005-03-30 2010-09-28 Merck Sharp & Dohme Corp. Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
TW200821284A (en) * 2006-10-03 2008-05-16 Merck & Co Inc Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
EP4066826B1 (en) 2010-09-01 2024-03-06 Thomas Jefferson University Retinoic acid receptor gamma agonists for muscle repair and regeneration
CA2890424C (en) 2012-11-08 2020-11-17 Yamaguchi University Therapeutic agent for keratoconjunctive disorders
KR101426197B1 (ko) * 2013-02-20 2014-08-01 여윤영 주먹밥틀
RS58045B1 (sr) 2013-05-22 2019-02-28 Univ Yamaguchi Inhibitor za retinohoroidalne poremećaje
CN105294567B (zh) * 2015-10-29 2018-10-09 湖北新烯王生物科技有限公司 取代的3-氟苯基甲醇类化合物、药物组合物及用途
SG11201810658PA (en) 2016-06-08 2018-12-28 Clementia Pharmaceuticals Inc Methods for treating heterotopic ossification
MX379489B (es) 2016-11-16 2025-03-11 Clementia Pharmaceuticals Inc Metodos para tratar la osteocondromatosis multiple (mo).

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU87821A1 (fr) 1990-10-12 1992-05-25 Cird Galderma Composes bi-aromatiques,et leur utilisation en medecine humaine et veterinaire et en cosmetique
DE10199033I2 (de) * 1992-04-22 2003-01-09 Ligand Parmaceuticals Inc Retinoid-x Rezeptor selektive Verbindungen
US6093742A (en) 1997-06-27 2000-07-25 Vertex Pharmaceuticals, Inc. Inhibitors of p38
JO2178B1 (en) 1999-10-19 2003-04-23 اف . هوفمان لاروش ايه جي Treatment of emphysema using rar selective retinoid antagonists

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Biol. Pharm. Bull. 19(10), pp.1322-28, 1996*
J. Cancer Res. Clin. Oncol. 114(3):221-4, 1988*

Also Published As

Publication number Publication date
KR20040035809A (ko) 2004-04-29
PL370361A1 (en) 2005-05-16
MXPA04002590A (es) 2004-06-18
EP1430024A1 (en) 2004-06-23
CN1283621C (zh) 2006-11-08
RU2004111787A (ru) 2005-10-20
AR036533A1 (es) 2004-09-15
US6844466B2 (en) 2005-01-18
CN1555359A (zh) 2004-12-15
CA2460693C (en) 2010-12-07
RU2299877C2 (ru) 2007-05-27
CA2460693A1 (en) 2003-03-27
BR0212583A (pt) 2004-10-13
JP2005505571A (ja) 2005-02-24
JP4421293B2 (ja) 2010-02-24
WO2003024921A1 (en) 2003-03-27
US20030158226A1 (en) 2003-08-21
AU2002329276B2 (en) 2008-04-24

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