CN1283621C - 烷基脲的类维生素a激动剂ⅰ - Google Patents

烷基脲的类维生素a激动剂ⅰ Download PDF

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Publication number
CN1283621C
CN1283621C CNB028181522A CN02818152A CN1283621C CN 1283621 C CN1283621 C CN 1283621C CN B028181522 A CNB028181522 A CN B028181522A CN 02818152 A CN02818152 A CN 02818152A CN 1283621 C CN1283621 C CN 1283621C
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CN
China
Prior art keywords
compounds
alkyl
acid
compound
emphysema
Prior art date
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Expired - Fee Related
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CNB028181522A
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English (en)
Chinese (zh)
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CN1555359A (zh
Inventor
保拉·南妮特·贝洛尼
丹尼斯·约翰·凯尔泰斯
米夏埃尔·克劳斯
让－马克·拉皮埃尔
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication of CN1555359A publication Critical patent/CN1555359A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CNB028181522A 2001-09-18 2002-09-11 烷基脲的类维生素a激动剂ⅰ Expired - Fee Related CN1283621C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32296301P 2001-09-18 2001-09-18
US60/332,963 2001-09-18

Publications (2)

Publication Number Publication Date
CN1555359A CN1555359A (zh) 2004-12-15
CN1283621C true CN1283621C (zh) 2006-11-08

Family

ID=33130243

Family Applications (1)

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CNB028181522A Expired - Fee Related CN1283621C (zh) 2001-09-18 2002-09-11 烷基脲的类维生素a激动剂ⅰ

Country Status (13)

Country Link
US (1) US6844466B2 (https=)
EP (1) EP1430024A1 (https=)
JP (1) JP4421293B2 (https=)
KR (1) KR100896550B1 (https=)
CN (1) CN1283621C (https=)
AR (1) AR036533A1 (https=)
AU (1) AU2002329276B2 (https=)
BR (1) BR0212583A (https=)
CA (1) CA2460693C (https=)
MX (1) MXPA04002590A (https=)
PL (1) PL370361A1 (https=)
RU (1) RU2299877C2 (https=)
WO (1) WO2003024921A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005000233A2 (en) * 2003-06-23 2005-01-06 Auspex Pharmaceuticals Novel therapeautic agents for the treatment of cancer, metabolic diseases and skin disorders
WO2005108338A1 (en) * 2004-05-03 2005-11-17 Auspex Pharmaceuticals Novel therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders
JP2008534593A (ja) * 2005-03-30 2008-08-28 メルク エンド カムパニー インコーポレーテッド グルカゴン受容体アンタゴニスト化合物、そのような化合物を含む組成物、及びその使用方法
TW200821284A (en) * 2006-10-03 2008-05-16 Merck & Co Inc Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
EP3721880B1 (en) 2010-09-01 2022-02-02 Thomas Jefferson University Composition and method for muscle repair and regeneration
US9492431B2 (en) 2012-11-08 2016-11-15 Yamaguchi University Therapeutic agent for keratoconjunctive disorders
KR101426197B1 (ko) * 2013-02-20 2014-08-01 여윤영 주먹밥틀
ES2694831T3 (es) 2013-05-22 2018-12-27 Yamaguchi University Inhibidor para trastornos retinocoroideos
CN105294567B (zh) * 2015-10-29 2018-10-09 湖北新烯王生物科技有限公司 取代的3-氟苯基甲醇类化合物、药物组合物及用途
JP7023868B2 (ja) 2016-06-08 2022-02-22 クレメンティア ファーマシューティカルズ，インコーポレイテッド 異所性骨化を治療するための方法
CA3043807A1 (en) 2016-11-16 2018-05-24 Clementia Pharmaceuticals Inc. Methods for treating multiple osteochondroma (mo)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU87821A1 (fr) 1990-10-12 1992-05-25 Cird Galderma Composes bi-aromatiques,et leur utilisation en medecine humaine et veterinaire et en cosmetique
ATE195716T1 (de) * 1992-04-22 2000-09-15 Ligand Pharm Inc Retinoid-x rezeptor selektive verbindungen
US6093742A (en) 1997-06-27 2000-07-25 Vertex Pharmaceuticals, Inc. Inhibitors of p38
JO2178B1 (en) 1999-10-19 2003-04-23 اف . هوفمان لاروش ايه جي Treatment of emphysema using rar selective retinoid antagonists

Also Published As

Publication number Publication date
MXPA04002590A (es) 2004-06-18
US20030158226A1 (en) 2003-08-21
KR100896550B1 (ko) 2009-05-07
KR20040035809A (ko) 2004-04-29
EP1430024A1 (en) 2004-06-23
RU2004111787A (ru) 2005-10-20
PL370361A1 (en) 2005-05-16
AR036533A1 (es) 2004-09-15
US6844466B2 (en) 2005-01-18
CA2460693A1 (en) 2003-03-27
BR0212583A (pt) 2004-10-13
CN1555359A (zh) 2004-12-15
RU2299877C2 (ru) 2007-05-27
AU2002329276B2 (en) 2008-04-24
JP2005505571A (ja) 2005-02-24
WO2003024921A1 (en) 2003-03-27
JP4421293B2 (ja) 2010-02-24
CA2460693C (en) 2010-12-07

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SE01 Entry into force of request for substantive examination
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GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20061108

Termination date: 20120911