JP2005505571A5 - - Google Patents

Claims (20)

Structural formula (I):

(Where
n is an integer from 0 to 2;
X is S, O or NR ³ R ⁴ ;
R ³ and R ⁴ are independently hydrogen, alkyl, aryl, arylalkyl, cycloalkyl or cycloalkyl-alkyl, or together with the nitrogen atom to which they are attached, form a heterocyclyl ring. ;
Y is —OR ⁵ , —SR ⁵ or —NR ⁶ R ⁷ ;
R ⁵ is hydrogen, alkyl, aryl, arylalkyl, cycloalkyl or cycloalkyl-alkyl;
R ⁶ and R ⁷ , independently of one another, are hydrogen, alkyl, aryl, arylalkyl, cycloalkyl or cycloalkyl-alkyl or together with the nitrogen atom to which they are attached form a heterocyclyl ring And
R ¹ is (C ₂ -C ₈ ) alkyl;
R ² is hydrogen, alkyl, hydroxy or oxo; and R ⁹ is hydrogen, alkyl, haloalkyl, halo, cyano, nitro or alkoxy)
Or a salt, solvate or hydrate thereof.   The compound according to claim 1, wherein n is 1. The compound of claim 1, wherein R ² is hydrogen.   The compound of claim 1, wherein X is O.   The compound of claim 1, wherein Y is OH. The compound of claim 1, wherein R ¹ is (C ₄ -C ₈ ) alkyl. The compound according to claim 2, wherein R ² and R ⁹ are hydrogen.   8. A compound according to claim 7, wherein X is O. Y is OR ^5, wherein compound of claim 8. R ⁵ is hydrogen, compound of claim 9. 11. A compound according to claim 10, wherein R < ¹ > is n-butyl, n-pentyl, n-hexyl, n-heptyl, n-octyl or i-butyl. 12. A compound according to claim 11 wherein R < ¹ > is n-pentyl.   13. A compound according to any one of claims 1 to 12, or a salt, solvate or hydrate thereof for use as a therapeutically active substance.   A pharmaceutical composition comprising a compound according to any one of claims 1 to 12, or a salt, solvate or hydrate thereof, especially for the treatment of emphysema, cancer or skin disorders.   Use of a compound according to any one of claims 1 to 12, or a salt, solvate or hydrate thereof for the manufacture of a medicament for the treatment of emphysema, cancer or skin disorders.   A pharmaceutical composition comprising a compound according to any one of claims 1 to 12, or a salt, solvate or hydrate thereof, and a therapeutically inert carrier.   A compound based on a compound according to any one of claims 1 to 12, or a salt, solvate or hydrate thereof, for the treatment of emphysema, cancer or skin disorders.   18. A medicament according to claim 17 for local or systemic application.   A pharmaceutical composition for treating emphysema, cancer or skin disorders in a mammal comprising a therapeutically effective amount of the compound of claim 1 or a pro-drug thereof.   A composition for treating emphysema and related disorders, cancer or skin disorders, characterized in that it comprises a compound according to claim 1 or a pro-drug thereof and is delivered to the lungs of a mammal.