JP2005504532A5 - - Google Patents
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- Publication number
- JP2005504532A5 JP2005504532A5 JP2003525596A JP2003525596A JP2005504532A5 JP 2005504532 A5 JP2005504532 A5 JP 2005504532A5 JP 2003525596 A JP2003525596 A JP 2003525596A JP 2003525596 A JP2003525596 A JP 2003525596A JP 2005504532 A5 JP2005504532 A5 JP 2005504532A5
- Authority
- JP
- Japan
- Prior art keywords
- medicament according
- medicament
- cancer
- antagonist
- endothelial cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 claims 21
- 239000005557 antagonist Substances 0.000 claims 9
- 210000002889 endothelial cell Anatomy 0.000 claims 8
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 230000000365 steroidogenetic effect Effects 0.000 claims 4
- 208000026062 Tissue disease Diseases 0.000 claims 3
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 3
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 3
- 230000033115 angiogenesis Effects 0.000 claims 3
- 230000004663 cell proliferation Effects 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 230000001850 reproductive effect Effects 0.000 claims 3
- 230000004083 survival effect Effects 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 230000001419 dependent effect Effects 0.000 claims 2
- 230000035558 fertility Effects 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 210000000056 organ Anatomy 0.000 claims 2
- 210000001550 testis Anatomy 0.000 claims 2
- 208000034431 Adrenal hypoplasia congenita Diseases 0.000 claims 1
- 208000005676 Adrenogenital syndrome Diseases 0.000 claims 1
- 208000005875 Alternating hemiplegia of childhood Diseases 0.000 claims 1
- 208000008448 Congenital adrenal hyperplasia Diseases 0.000 claims 1
- 208000010255 Familial Hypoadrenocorticism Diseases 0.000 claims 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 1
- 206010059594 Secondary hypogonadism Diseases 0.000 claims 1
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 1
- 206010057644 Testis cancer Diseases 0.000 claims 1
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- 201000010869 X-linked adrenal hypoplasia congenita Diseases 0.000 claims 1
- 239000003098 androgen Substances 0.000 claims 1
- 210000003372 endocrine gland Anatomy 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- 229960002897 heparin Drugs 0.000 claims 1
- 229920000669 heparin Polymers 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 208000000509 infertility Diseases 0.000 claims 1
- 230000036512 infertility Effects 0.000 claims 1
- 231100000535 infertility Toxicity 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 201000007700 organ system cancer Diseases 0.000 claims 1
- 208000001061 polyostotic fibrous dysplasia Diseases 0.000 claims 1
- 208000006155 precocious puberty Diseases 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 230000035938 sexual maturation Effects 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- 201000003120 testicular cancer Diseases 0.000 claims 1
- 206010046766 uterine cancer Diseases 0.000 claims 1
- 210000004291 uterus Anatomy 0.000 claims 1
- 210000003556 vascular endothelial cell Anatomy 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31618401P | 2001-08-29 | 2001-08-29 | |
| PCT/US2002/027571 WO2003020892A2 (en) | 2001-08-29 | 2002-08-27 | Bv8 NUCLEIC ACIDS AND POLYPEPTIDES WITH MITOGENIC ACTIVITY |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005504532A JP2005504532A (ja) | 2005-02-17 |
| JP2005504532A5 true JP2005504532A5 (https=) | 2006-01-05 |
| JP4361791B2 JP4361791B2 (ja) | 2009-11-11 |
Family
ID=23227889
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003525596A Expired - Fee Related JP4361791B2 (ja) | 2001-08-29 | 2002-08-27 | マイトジェン活性を有するＢｖ８核酸及びポリペプチド |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US7060278B2 (https=) |
| EP (2) | EP1427830B1 (https=) |
| JP (1) | JP4361791B2 (https=) |
| KR (3) | KR100942880B1 (https=) |
| CN (2) | CN1575338B (https=) |
| AT (1) | ATE557092T1 (https=) |
| AU (1) | AU2002332732B2 (https=) |
| BR (1) | BR0212070A (https=) |
| CA (1) | CA2458670C (https=) |
| DK (1) | DK1427830T3 (https=) |
| ES (1) | ES2386346T3 (https=) |
| HU (1) | HU230373B1 (https=) |
| IL (4) | IL160422A0 (https=) |
| IS (1) | IS2889B (https=) |
| MX (1) | MXPA04001720A (https=) |
| NO (2) | NO332445B1 (https=) |
| NZ (2) | NZ530985A (https=) |
| PL (1) | PL368972A1 (https=) |
| SI (1) | SI1427830T1 (https=) |
| WO (1) | WO2003020892A2 (https=) |
| ZA (1) | ZA200401001B (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL368972A1 (en) * | 2001-08-29 | 2005-04-04 | Genentech, Inc. | Bv8 nucleic acids and polypeptides with mitogenic activity |
| WO2003040326A2 (en) * | 2001-11-02 | 2003-05-15 | Nuvelo, Inc. | Methods and materials relating to prokineticin-like polypeptides and polynucleotides |
| JP4912144B2 (ja) * | 2003-03-12 | 2012-04-11 | ジェネンテック， インコーポレイテッド | 造血促進のためのｂｖ８及び／又はｅｇ−ｖｅｇｆの使用 |
| GB0320238D0 (en) | 2003-08-29 | 2003-10-01 | Medical Res Council | Treatment of disease |
| WO2005042717A2 (en) * | 2003-10-31 | 2005-05-12 | The Regents Of The University Of California | Primate prokineticin and prokineticin receptor polypeptides, related compositions and methods |
| EP1756153A2 (en) * | 2004-03-29 | 2007-02-28 | Janssen Pharmaceutica N.V. | Prokineticin 2beta peptide and its use |
| US7872430B2 (en) * | 2005-11-18 | 2011-01-18 | Cree, Inc. | Solid state lighting panels with variable voltage boost current sources |
| US20070243584A1 (en) * | 2006-04-13 | 2007-10-18 | West James W | Tetramerizing polypeptides and methods of use |
| US20100075377A1 (en) * | 2006-04-13 | 2010-03-25 | West James W | Tetramerizing polypeptides and methods of use |
| EP2004682A2 (en) * | 2006-04-13 | 2008-12-24 | Zymogenetics, Inc. | Tetramerizing polypeptides and methods of use |
| CL2008002782A1 (es) * | 2007-09-21 | 2009-07-31 | Genentech Inc | Anticuerpo anti-bv8 neutralizante; composicion que lo comprende; y su uso para tratar tumores en humanos previamente tratados con un antagonista del factor de crecimiento endotelial vascular. |
| KR101044874B1 (ko) * | 2008-12-02 | 2011-06-28 | 주식회사 동호 | 흡인식 쓰레기 설비의 이송관로 막힘 검출 시스템 |
| RU2559542C2 (ru) | 2009-12-23 | 2015-08-10 | Дженентек, Инк. | Антитела против bv8 и их применение |
| KR101040724B1 (ko) * | 2010-08-16 | 2011-06-10 | 주식회사 에스더블 테크 | 공기이송 더스트 배출장치 |
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| US4263428A (en) | 1978-03-24 | 1981-04-21 | The Regents Of The University Of California | Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same |
| JPS6023084B2 (ja) | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
| US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| ZA811368B (en) | 1980-03-24 | 1982-04-28 | Genentech Inc | Bacterial polypedtide expression employing tryptophan promoter-operator |
| EP0052322B1 (de) | 1980-11-10 | 1985-03-27 | Gersonde, Klaus, Prof. Dr. | Verfahren zur Herstellung von Lipid-Vesikeln durch Ultraschallbehandlung, Anwendung des Verfahrens und Vorrichtung zur Durchführung des Verfahrens |
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| PL368972A1 (en) * | 2001-08-29 | 2005-04-04 | Genentech, Inc. | Bv8 nucleic acids and polypeptides with mitogenic activity |
| JP4912144B2 (ja) | 2003-03-12 | 2012-04-11 | ジェネンテック， インコーポレイテッド | 造血促進のためのｂｖ８及び／又はｅｇ−ｖｅｇｆの使用 |
| CL2008002782A1 (es) * | 2007-09-21 | 2009-07-31 | Genentech Inc | Anticuerpo anti-bv8 neutralizante; composicion que lo comprende; y su uso para tratar tumores en humanos previamente tratados con un antagonista del factor de crecimiento endotelial vascular. |
-
2002
- 2002-08-27 PL PL02368972A patent/PL368972A1/xx not_active Application Discontinuation
- 2002-08-27 AU AU2002332732A patent/AU2002332732B2/en not_active Ceased
- 2002-08-27 WO PCT/US2002/027571 patent/WO2003020892A2/en not_active Ceased
- 2002-08-27 DK DK02797786.7T patent/DK1427830T3/da active
- 2002-08-27 KR KR1020047002640A patent/KR100942880B1/ko not_active Expired - Fee Related
- 2002-08-27 MX MXPA04001720A patent/MXPA04001720A/es active IP Right Grant
- 2002-08-27 ES ES02797786T patent/ES2386346T3/es not_active Expired - Lifetime
- 2002-08-27 IL IL16042202A patent/IL160422A0/xx unknown
- 2002-08-27 CN CN028209664A patent/CN1575338B/zh not_active Expired - Fee Related
- 2002-08-27 SI SI200230990T patent/SI1427830T1/sl unknown
- 2002-08-27 JP JP2003525596A patent/JP4361791B2/ja not_active Expired - Fee Related
- 2002-08-27 NZ NZ530985A patent/NZ530985A/xx not_active IP Right Cessation
- 2002-08-27 KR KR1020107002333A patent/KR101008785B1/ko not_active Expired - Fee Related
- 2002-08-27 KR KR1020097012101A patent/KR101008734B1/ko not_active Expired - Fee Related
- 2002-08-27 NZ NZ543755A patent/NZ543755A/en not_active IP Right Cessation
- 2002-08-27 CA CA2458670A patent/CA2458670C/en not_active Expired - Fee Related
- 2002-08-27 HU HU0401584A patent/HU230373B1/hu not_active IP Right Cessation
- 2002-08-27 US US10/231,411 patent/US7060278B2/en not_active Expired - Lifetime
- 2002-08-27 AT AT02797786T patent/ATE557092T1/de active
- 2002-08-27 BR BR0212070-4A patent/BR0212070A/pt not_active Application Discontinuation
- 2002-08-27 EP EP02797786A patent/EP1427830B1/en not_active Expired - Lifetime
- 2002-08-27 CN CN201010227537.3A patent/CN101884784B/zh not_active Expired - Fee Related
- 2002-08-27 EP EP10009859A patent/EP2311960A3/en not_active Withdrawn
-
2004
- 2004-02-06 ZA ZA200401001A patent/ZA200401001B/en unknown
- 2004-02-06 NO NO20040553A patent/NO332445B1/no not_active IP Right Cessation
- 2004-02-13 IS IS7154A patent/IS2889B/is unknown
- 2004-02-16 IL IL160422A patent/IL160422A/en not_active IP Right Cessation
-
2006
- 2006-03-17 US US11/384,222 patent/US20060204510A1/en not_active Abandoned
- 2006-09-29 US US11/536,880 patent/US7811984B2/en not_active Expired - Fee Related
-
2009
- 2009-03-11 IL IL197539A patent/IL197539A/en not_active IP Right Cessation
-
2010
- 2010-03-16 IL IL204543A patent/IL204543A/en not_active IP Right Cessation
-
2012
- 2012-05-24 NO NO20120612A patent/NO334713B1/no not_active IP Right Cessation
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