JP2005504507A5 - - Google Patents

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Publication number
JP2005504507A5
JP2005504507A5 JP2002570676A JP2002570676A JP2005504507A5 JP 2005504507 A5 JP2005504507 A5 JP 2005504507A5 JP 2002570676 A JP2002570676 A JP 2002570676A JP 2002570676 A JP2002570676 A JP 2002570676A JP 2005504507 A5 JP2005504507 A5 JP 2005504507A5
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JP
Japan
Prior art keywords
human
cells
gene
ungulate
cell
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JP2002570676A
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English (en)
Japanese (ja)
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JP2005504507A (ja
JP3797974B2 (ja
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Priority claimed from PCT/US2001/043128 external-priority patent/WO2002070648A2/en
Publication of JP2005504507A publication Critical patent/JP2005504507A/ja
Publication of JP2005504507A5 publication Critical patent/JP2005504507A5/ja
Application granted granted Critical
Publication of JP3797974B2 publication Critical patent/JP3797974B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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JP2002570676A 2000-11-17 2001-11-16 クローン化トランスジェニック有蹄動物における異種(ヒト)免疫グロブリンの発現 Expired - Fee Related JP3797974B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US71418500A 2000-11-17 2000-11-17
US25645800P 2000-12-20 2000-12-20
US31162501P 2001-08-09 2001-08-09
PCT/US2001/043128 WO2002070648A2 (en) 2000-11-17 2001-11-16 Expression of xenogenous (human) immunoglobulins in cloned, transgenic ungulates

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2005136675A Division JP2005224250A (ja) 2000-11-17 2005-05-09 クローン化トランスジェニック有蹄動物における異種(ヒト)免疫グロブリンの発現

Publications (3)

Publication Number Publication Date
JP2005504507A JP2005504507A (ja) 2005-02-17
JP2005504507A5 true JP2005504507A5 (https=) 2005-09-02
JP3797974B2 JP3797974B2 (ja) 2006-07-19

Family

ID=27400960

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2002570676A Expired - Fee Related JP3797974B2 (ja) 2000-11-17 2001-11-16 クローン化トランスジェニック有蹄動物における異種(ヒト)免疫グロブリンの発現
JP2005136675A Pending JP2005224250A (ja) 2000-11-17 2005-05-09 クローン化トランスジェニック有蹄動物における異種(ヒト)免疫グロブリンの発現

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2005136675A Pending JP2005224250A (ja) 2000-11-17 2005-05-09 クローン化トランスジェニック有蹄動物における異種(ヒト)免疫グロブリンの発現

Country Status (11)

Country Link
EP (2) EP1343880B1 (https=)
JP (2) JP3797974B2 (https=)
KR (2) KR100882029B1 (https=)
CN (1) CN1486365B (https=)
AT (2) ATE503012T1 (https=)
AU (2) AU2001297523B2 (https=)
CA (1) CA2428053C (https=)
DE (2) DE60138832D1 (https=)
MX (1) MXPA03004313A (https=)
NZ (1) NZ525664A (https=)
WO (1) WO2002070648A2 (https=)

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CA2501068C (en) * 2002-10-04 2014-12-16 Kirin Beer Kabushiki Kaisha Human artificial chromosome (hac) vector
US7429690B2 (en) 2002-11-08 2008-09-30 Kirin Holdings Kabushiki Kaisha Transgenic bovines having reduced prion protein production
JP2007528721A (ja) 2003-08-14 2007-10-18 ダイアックス コーポレイション エンドセリアーゼ−2リガンド
US7807862B2 (en) * 2003-09-30 2010-10-05 Sterrenbeld Biotechnologie North America, Inc. Transgenic bovine comprising human growth hormone in its serum and methods of making
AU2005237494B2 (en) * 2004-04-22 2010-06-10 Kyowa Hakko Kirin Co., Ltd Transgenic animals and uses thereof
US20080026457A1 (en) 2004-10-22 2008-01-31 Kevin Wells Ungulates with genetically modified immune systems
CA2958259C (en) * 2004-10-22 2020-06-30 Revivicor, Inc. Ungulates with genetically modified immune systems
US20090041783A1 (en) 2005-04-28 2009-02-12 Mochida Pharmaceutical Co., Ltd. Anti-platelet membrane glycoprotein vi monoclonal antibody
DK2348827T3 (en) 2008-10-27 2015-07-20 Revivicor Inc IMMUNICIPLY COMPROMATED PETS
JP5827127B2 (ja) * 2008-12-18 2015-12-02 エラスムス・ユニヴァーシティ・メディカル・センター・ロッテルダム ヒト化抗体を発現する非ヒトトランスジェニック動物及びその使用
US9445581B2 (en) 2012-03-28 2016-09-20 Kymab Limited Animal models and therapeutic molecules
DK3622815T3 (da) 2009-07-08 2023-06-26 Kymab Ltd Gnavermodeller og terapeutiske molekyler
EP2502993B1 (en) 2009-11-17 2017-07-26 Sanford Applied Biosciences L.L.C. Human artificial chromosome vector
BR112014006394A2 (pt) 2011-09-19 2017-03-28 Kymab Ltd manipulação de diversidade genética de imunoglobulina e terapêuticos multi-anticorpos
JP6156144B2 (ja) 2011-09-21 2017-07-05 富士レビオ株式会社 親和性複合体に対する抗体
WO2013045916A1 (en) 2011-09-26 2013-04-04 Kymab Limited Chimaeric surrogate light chains (slc) comprising human vpreb
US9253965B2 (en) 2012-03-28 2016-02-09 Kymab Limited Animal models and therapeutic molecules
ES2791758T3 (es) * 2011-12-22 2020-11-05 Hoffmann La Roche Organización de vectores de expresión, procedimientos de generación de células de producción novedosos y su uso para la producción recombinante de polipéptidos
GB2502127A (en) 2012-05-17 2013-11-20 Kymab Ltd Multivalent antibodies and in vivo methods for their production
US10251377B2 (en) 2012-03-28 2019-04-09 Kymab Limited Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies
AU2013296182B2 (en) * 2012-08-03 2018-03-08 Sab, Llc Complex chromosome engineering for production of human antibodies in transgenic animals
US9788534B2 (en) 2013-03-18 2017-10-17 Kymab Limited Animal models and therapeutic molecules
US9783618B2 (en) 2013-05-01 2017-10-10 Kymab Limited Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics
US11707056B2 (en) 2013-05-02 2023-07-25 Kymab Limited Animals, repertoires and methods
US9783593B2 (en) 2013-05-02 2017-10-10 Kymab Limited Antibodies, variable domains and chains tailored for human use
AU2014330922A1 (en) 2013-10-01 2016-03-03 Kymab Limited Animal models and therapeutic molecules
CN116059378A (zh) 2014-12-10 2023-05-05 明尼苏达大学董事会 用于治疗疾病的遗传修饰的细胞、组织和器官
KR20230110373A (ko) * 2016-06-14 2023-07-21 리전츠 오브 더 유니버스티 오브 미네소타 질환을 치료하기 위한 유전적으로 변형된 세포, 조직,및 장기
EP3533867A4 (en) 2016-10-31 2020-07-22 National University Corporation Tottori University NON-HUMAN ANIMAL PRODUCING HUMAN ANTIBODIES AND PROCESS FOR THE PREPARATION OF HUMAN ANTIBODIES USING IT
CN115362172A (zh) * 2020-02-12 2022-11-18 Sab有限责任公司 抗胸腺细胞球蛋白

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