JP2005504100A - 肥満の治療のための１，５，６，７−テトラヒドロピロロ［３，２−ｃ］ピリジン誘導体の製造法および使用 - Google Patents
肥満の治療のための１，５，６，７−テトラヒドロピロロ［３，２−ｃ］ピリジン誘導体の製造法および使用 Download PDFInfo
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- JP2005504100A JP2005504100A JP2003530702A JP2003530702A JP2005504100A JP 2005504100 A JP2005504100 A JP 2005504100A JP 2003530702 A JP2003530702 A JP 2003530702A JP 2003530702 A JP2003530702 A JP 2003530702A JP 2005504100 A JP2005504100 A JP 2005504100A
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- Prior art keywords
- alkyl
- alkoxy
- optionally substituted
- trifluoromethyl
- phenyl
- Prior art date
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- 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 claims description 10
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- VMNFCTDOMRUEJN-UHFFFAOYSA-N 1-(2-chlorophenyl)-2-(4-methoxyphenyl)-3-methyl-5-piperidin-1-yl-6,7-dihydropyrrolo[3,2-c]pyridin-4-one;hydrochloride Chemical compound Cl.C1=CC(OC)=CC=C1C(N1C=2C(=CC=CC=2)Cl)=C(C)C(C2=O)=C1CCN2N1CCCCC1 VMNFCTDOMRUEJN-UHFFFAOYSA-N 0.000 claims description 3
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- Engineering & Computer Science (AREA)
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- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
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- Neurology (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32444301P | 2001-09-24 | 2001-09-24 | |
| PCT/US2002/030541 WO2003027114A1 (en) | 2001-09-24 | 2002-09-24 | Preparation and use of 1,5,6,7-tetrahydropyrrolo[3,2-c]pyridine derivatives for treatment of obesity |
Publications (2)
| Publication Number | Publication Date |
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| JP2005504100A true JP2005504100A (ja) | 2005-02-10 |
| JP2005504100A5 JP2005504100A5 (enExample) | 2006-01-05 |
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| JP2003530702A Withdrawn JP2005504100A (ja) | 2001-09-24 | 2002-09-24 | 肥満の治療のための１，５，６，７−テトラヒドロピロロ［３，２−ｃ］ピリジン誘導体の製造法および使用 |
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| Country | Link |
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| US (2) | US7071207B2 (enExample) |
| EP (1) | EP1432708B1 (enExample) |
| JP (1) | JP2005504100A (enExample) |
| AT (1) | ATE311386T1 (enExample) |
| CA (1) | CA2461142A1 (enExample) |
| DE (1) | DE60207744T2 (enExample) |
| ES (1) | ES2252524T3 (enExample) |
| MX (1) | MXPA04002249A (enExample) |
| WO (1) | WO2003027114A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009524604A (ja) * | 2006-01-27 | 2009-07-02 | シャンハイ ヘンルイ ファーマシューティカル カンパニー リミテッド | ピロロ［３，２−ｃ］ピリジン−４−オン２−インドリノン（ｉｎｄｏｌｉｎｏｎｅ）プロテインキナーゼ阻害剤 |
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| NZ534757A (en) | 2002-03-12 | 2006-07-28 | Merck & Co Inc | Substituted amides |
| CA2494091C (en) | 2002-08-02 | 2011-02-01 | Richard B. Toupence | Substituted furo [2,3-b| pyridine derivatives |
| US7129239B2 (en) | 2002-10-28 | 2006-10-31 | Pfizer Inc. | Purine compounds and uses thereof |
| US7247628B2 (en) | 2002-12-12 | 2007-07-24 | Pfizer, Inc. | Cannabinoid receptor ligands and uses thereof |
| KR100704097B1 (ko) | 2003-01-02 | 2007-04-06 | 에프. 호프만-라 로슈 아게 | 신규 ｃｂ 1 수용체 역작용제 |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| US7329658B2 (en) | 2003-02-06 | 2008-02-12 | Pfizer Inc | Cannabinoid receptor ligands and uses thereof |
| US7176210B2 (en) | 2003-02-10 | 2007-02-13 | Pfizer Inc. | Cannabinoid receptor ligands and uses thereof |
| US7268133B2 (en) | 2003-04-23 | 2007-09-11 | Pfizer, Inc. Patent Department | Cannabinoid receptor ligands and uses thereof |
| US7141669B2 (en) | 2003-04-23 | 2006-11-28 | Pfizer Inc. | Cannabiniod receptor ligands and uses thereof |
| US7145012B2 (en) | 2003-04-23 | 2006-12-05 | Pfizer Inc. | Cannabinoid receptor ligands and uses thereof |
| US7232823B2 (en) | 2003-06-09 | 2007-06-19 | Pfizer, Inc. | Cannabinoid receptor ligands and uses thereof |
| EP1644335A4 (en) | 2003-07-11 | 2008-06-04 | Bristol Myers Squibb Co | TETRAHYDROQUINOLINE DERIVATIVES COMPRISING MODULATORS OF CANNABINOID RECEPTORS |
| US20050043346A1 (en) * | 2003-08-08 | 2005-02-24 | Pharmacia Italia S.P.A. | Pyridylpyrrole derivatives active as kinase inhibitors |
| BRPI0413438A (pt) * | 2003-08-08 | 2006-10-17 | Pharmacia Italia Spa | derivados de pirimidilpirrol ativos como inibidores de cinase |
| US7326706B2 (en) | 2003-08-15 | 2008-02-05 | Bristol-Myers Squibb Company | Pyrazine modulators of cannabinoid receptors |
| US7151097B2 (en) * | 2003-11-07 | 2006-12-19 | Pfizer Inc. | Bicyclic pyrazolyl and imidazolyl compounds and uses thereof |
| EP1734963A4 (en) | 2004-04-02 | 2008-06-18 | Merck & Co Inc | METHOD FOR TREATING PEOPLE WITH METABOLIC AND ANTHROPOMETRIC DISORDER |
| TW200602314A (en) | 2004-05-28 | 2006-01-16 | Tanabe Seiyaku Co | A novel pyrrolidine compound and a process for preparing the same |
| US7923465B2 (en) | 2005-06-02 | 2011-04-12 | Glenmark Pharmaceuticals S.A. | Cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation |
| PL1902034T3 (pl) | 2005-06-02 | 2011-09-30 | Glenmark Pharmaceuticals Sa | Nowe ligandy receptorów kanabinoidowych, kompozycja farmaceutyczna je zawierająca oraz proces ich wytwarzania |
| AR056560A1 (es) * | 2005-10-06 | 2007-10-10 | Astrazeneca Ab | Pirrolopiridinonas como moduladores cb1 |
| US7618982B2 (en) | 2005-12-19 | 2009-11-17 | Nerviano Medical Sciences S.R.L. | Heteroarylpyrrolopyridinones active as kinase inhibitors |
| CN101007815B (zh) * | 2006-01-27 | 2010-06-23 | 江苏恒瑞医药股份有限公司 | 吡咯并六元杂环化合物及其在医药上的用途 |
| JP5337717B2 (ja) | 2007-02-27 | 2013-11-06 | ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ | キナーゼ阻害剤として活性なイソキノリノピロロピリジノン |
| AR065909A1 (es) * | 2007-04-03 | 2009-07-08 | Astrazeneca Ab | Agentes terapeuticos 685 |
| AR066207A1 (es) * | 2007-04-03 | 2009-08-05 | Astrazeneca Ab | Agentes terapeuticos 684 |
| WO2008134354A1 (en) * | 2007-04-27 | 2008-11-06 | Array Biopharma, Inc. | TNF-α PRODUCTION INHIBITOR |
| US20100120694A1 (en) | 2008-06-04 | 2010-05-13 | Synergy Pharmaceuticals, Inc. | Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| JP5546451B2 (ja) | 2007-06-04 | 2014-07-09 | シナジー ファーマシューティカルズ インコーポレイテッド | 胃腸の障害、炎症、癌および他の障害の処置に有用なグアニル酸シクラーゼのアゴニスト |
| EP2003129B1 (en) | 2007-06-11 | 2017-08-09 | Nerviano Medical Sciences S.r.l. | 1H-Pyrido[3,4-B]indol-1-one and 2,3,4,9-Tetrahydro-1H-Beta-Carbolin-1-one Derivatives |
| EP3241839B1 (en) | 2008-07-16 | 2019-09-04 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| EP2348857B1 (en) | 2008-10-22 | 2016-02-24 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| AU2009309037A1 (en) | 2008-10-31 | 2010-05-06 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| US8895596B2 (en) | 2010-02-25 | 2014-11-25 | Merck Sharp & Dohme Corp | Cyclic benzimidazole derivatives useful as anti-diabetic agents |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| MY159058A (en) | 2011-02-25 | 2016-12-15 | Merck Sharp & Dohme | Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agent |
| EP2880028B1 (en) | 2012-08-02 | 2020-09-30 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| JP2016516004A (ja) | 2013-02-22 | 2016-06-02 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | 抗糖尿病二環式化合物 |
| WO2014139388A1 (en) | 2013-03-14 | 2014-09-18 | Merck Sharp & Dohme Corp. | Novel indole derivatives useful as anti-diabetic agents |
| HK1220696A1 (zh) | 2013-03-15 | 2017-05-12 | Bausch Health Ireland Limited | 鸟苷酸环化酶激动剂及其用途 |
| AU2014235209B2 (en) | 2013-03-15 | 2018-06-14 | Bausch Health Ireland Limited | Guanylate cyclase receptor agonists combined with other drugs |
| EP4424697A3 (en) | 2013-06-05 | 2024-12-25 | Bausch Health Ireland Limited | Ultra-pure agonists of guanylate cyclase c, method of making and using same |
| WO2015022073A1 (en) * | 2013-08-13 | 2015-02-19 | Grünenthal GmbH | Annelated pyrroles and their use as crac inhibitors |
| JO3442B1 (ar) | 2013-10-07 | 2019-10-20 | Takeda Pharmaceuticals Co | مضادات ذات نوع فرعي من مستقبل سوماتوستاتين 5 (sstr5) |
| WO2015051496A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| US11072602B2 (en) | 2016-12-06 | 2021-07-27 | Merck Sharp & Dohme Corp. | Antidiabetic heterocyclic compounds |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1484140A (en) | 1974-04-24 | 1977-08-24 | Wyeth John & Brother Ltd | Pyrrolopyridine derivatives |
| US4897390A (en) * | 1987-07-21 | 1990-01-30 | Ruhe Rodney C | Novel anti-obesity compounds and method of use |
| KR960705824A (ko) * | 1993-10-20 | 1996-11-08 | 아사이 이페이 | 인돌 유도체(Indole Derivative) |
| KR100251522B1 (ko) * | 1997-08-13 | 2000-08-01 | 김충섭 | 할로알콕시기를 함유하는 피롤[3,2-c]퀴놀린 유도체 및 약학적으로 허용되는 그의 염 |
| EP1147113B1 (en) | 1999-01-19 | 2006-06-07 | Neurosearch A/S | Fused heterocyclic compounds and their use in the treatment of neurodegenerative diseases |
| IL147485A0 (en) | 1999-07-06 | 2002-08-14 | Endorech Inc | Pharmaceutical compositions containing a selective estrogen receptor modulator |
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2002
- 2002-09-24 AT AT02780364T patent/ATE311386T1/de not_active IP Right Cessation
- 2002-09-24 ES ES02780364T patent/ES2252524T3/es not_active Expired - Lifetime
- 2002-09-24 WO PCT/US2002/030541 patent/WO2003027114A1/en not_active Ceased
- 2002-09-24 MX MXPA04002249A patent/MXPA04002249A/es active IP Right Grant
- 2002-09-24 EP EP02780364A patent/EP1432708B1/en not_active Expired - Lifetime
- 2002-09-24 JP JP2003530702A patent/JP2005504100A/ja not_active Withdrawn
- 2002-09-24 DE DE60207744T patent/DE60207744T2/de not_active Expired - Fee Related
- 2002-09-24 CA CA002461142A patent/CA2461142A1/en not_active Abandoned
- 2002-09-24 US US10/487,976 patent/US7071207B2/en not_active Expired - Fee Related
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2006
- 2006-01-18 US US11/335,349 patent/US20060122215A1/en not_active Abandoned
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009524604A (ja) * | 2006-01-27 | 2009-07-02 | シャンハイ ヘンルイ ファーマシューティカル カンパニー リミテッド | ピロロ［３，２−ｃ］ピリジン−４−オン２−インドリノン（ｉｎｄｏｌｉｎｏｎｅ）プロテインキナーゼ阻害剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1432708A1 (en) | 2004-06-30 |
| CA2461142A1 (en) | 2003-04-03 |
| ES2252524T3 (es) | 2006-05-16 |
| US20040224970A1 (en) | 2004-11-11 |
| ATE311386T1 (de) | 2005-12-15 |
| DE60207744D1 (de) | 2006-01-05 |
| US7071207B2 (en) | 2006-07-04 |
| EP1432708B1 (en) | 2005-11-30 |
| MXPA04002249A (es) | 2004-06-29 |
| DE60207744T2 (de) | 2006-08-03 |
| WO2003027114A1 (en) | 2003-04-03 |
| US20060122215A1 (en) | 2006-06-08 |
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