JP2005503782A5 - - Google Patents
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- Publication number
- JP2005503782A5 JP2005503782A5 JP2003510683A JP2003510683A JP2005503782A5 JP 2005503782 A5 JP2005503782 A5 JP 2005503782A5 JP 2003510683 A JP2003510683 A JP 2003510683A JP 2003510683 A JP2003510683 A JP 2003510683A JP 2005503782 A5 JP2005503782 A5 JP 2005503782A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- peptide
- synthetic polypeptide
- purified synthetic
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 248
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 130
- 150000001413 amino acids Chemical class 0.000 claims description 115
- 229920001184 polypeptide Polymers 0.000 claims description 108
- 239000012528 membrane Substances 0.000 claims description 17
- 241001524679 Escherichia virus M13 Species 0.000 claims description 16
- 230000004927 fusion Effects 0.000 claims description 15
- 239000002773 nucleotide Substances 0.000 claims description 6
- 125000003729 nucleotide group Chemical group 0.000 claims description 6
- 238000013519 translation Methods 0.000 claims description 6
- 230000004572 zinc-binding Effects 0.000 claims description 6
- 239000003814 drug Substances 0.000 claims description 5
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 229940079593 drug Drugs 0.000 claims description 4
- 102000039446 nucleic acids Human genes 0.000 claims description 4
- 108020004707 nucleic acids Proteins 0.000 claims description 4
- 150000007523 nucleic acids Chemical class 0.000 claims description 4
- 241000282465 Canis Species 0.000 claims description 3
- 239000002502 liposome Substances 0.000 claims description 3
- 239000011859 microparticle Substances 0.000 claims description 3
- 239000002105 nanoparticle Substances 0.000 claims description 3
- 239000000427 antigen Substances 0.000 claims 5
- 102000036639 antigens Human genes 0.000 claims 5
- 108091007433 antigens Proteins 0.000 claims 5
- 230000015572 biosynthetic process Effects 0.000 claims 4
- 238000003786 synthesis reaction Methods 0.000 claims 4
- 241000894006 Bacteria Species 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 238000000746 purification Methods 0.000 claims 3
- 241000700605 Viruses Species 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 244000052769 pathogen Species 0.000 claims 1
- 230000001717 pathogenic effect Effects 0.000 claims 1
- 108700010839 phage proteins Proteins 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 description 55
- 239000003446 ligand Substances 0.000 description 28
- 210000004027 cell Anatomy 0.000 description 18
- 239000012634 fragment Substances 0.000 description 11
- 210000004379 membrane Anatomy 0.000 description 11
- 241000700159 Rattus Species 0.000 description 10
- 230000027455 binding Effects 0.000 description 10
- 241000282472 Canis lupus familiaris Species 0.000 description 7
- 241000699666 Mus <mouse, genus> Species 0.000 description 7
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 4
- 241000282898 Sus scrofa Species 0.000 description 3
- 238000011990 functional testing Methods 0.000 description 3
- VQPRNSWQIAHPMS-HNNXBMFYSA-N N(6)-dansyl-L-lysine Chemical group C1=CC=C2C(N(C)C)=CC=CC2=C1S(=O)(=O)NCCCC[C@H](N)C(O)=O VQPRNSWQIAHPMS-HNNXBMFYSA-N 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 229960002685 biotin Drugs 0.000 description 2
- 235000020958 biotin Nutrition 0.000 description 2
- 239000011616 biotin Substances 0.000 description 2
- 210000001986 peyer's patch Anatomy 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 101710132601 Capsid protein Proteins 0.000 description 1
- 101710094648 Coat protein Proteins 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 102100021181 Golgi phosphoprotein 3 Human genes 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 101710125418 Major capsid protein Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 101710141454 Nucleoprotein Proteins 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 108010067902 Peptide Library Proteins 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 101710083689 Probable capsid protein Proteins 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000007413 biotinylation Methods 0.000 description 1
- 230000006287 biotinylation Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000004899 c-terminal region Anatomy 0.000 description 1
- 108091006116 chimeric peptides Proteins 0.000 description 1
- 239000013599 cloning vector Substances 0.000 description 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 210000004347 intestinal mucosa Anatomy 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 125000001151 peptidyl group Chemical group 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 235000019833 protease Nutrition 0.000 description 1
- 238000000159 protein binding assay Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 241001515965 unidentified phage Species 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30259101P | 2001-07-02 | 2001-07-02 | |
| PCT/IB2002/003401 WO2003004517A2 (en) | 2001-07-02 | 2002-06-28 | Peyers's patch and/or m-celle targeting ligands |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005503782A JP2005503782A (ja) | 2005-02-10 |
| JP2005503782A5 true JP2005503782A5 (https=) | 2008-12-18 |
| JP4383855B2 JP4383855B2 (ja) | 2009-12-16 |
Family
ID=23168408
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003510683A Expired - Fee Related JP4383855B2 (ja) | 2001-07-02 | 2002-06-28 | パイエル板および／またはｍ細胞を標的とするリガンド |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US6916789B2 (https=) |
| EP (1) | EP1432729B1 (https=) |
| JP (1) | JP4383855B2 (https=) |
| AT (1) | ATE414100T1 (https=) |
| AU (1) | AU2002326070A1 (https=) |
| CA (1) | CA2451741C (https=) |
| DE (1) | DE60229867D1 (https=) |
| WO (1) | WO2003004517A2 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6521737B1 (en) * | 1995-11-10 | 2003-02-18 | Elan Corporation, Plc | Peptides which enhance transport across tissues and methods of identifying and using the same |
| DE60229867D1 (de) * | 2001-07-02 | 2008-12-24 | Merrion Res Iii Ltd | Zielgerichtete ligande gegen peyer's flecke- und/oder m-zellen |
| EP1631582A2 (en) * | 2003-06-10 | 2006-03-08 | University of Saskatchewan | Chimeric adenovirus capsid proteins |
| AU2012201102B2 (en) * | 2004-06-23 | 2014-05-08 | Ferguson, Ian Andrew | Agents and methods for early diagnosis and monitoring of Alzheimer's disease and other neurological disorders |
| DE102005031755B9 (de) * | 2005-07-01 | 2010-04-08 | Technische Universität Dresden | Salmonella spp. bindende Peptide, dafür kodierende Nukleinsäuren, deren Verwendungen und Verfahren und Kits zur Anreicherung, Immobilisierung und zum Nachweis von Salmonella spp. |
| WO2007137174A2 (en) * | 2006-05-18 | 2007-11-29 | The Ohio State University Research Foundation | Compositions and methods for the detection of vulnerable plaque |
| PL2897620T3 (pl) | 2012-09-21 | 2020-11-02 | Intensity Therapeutics, Inc | Sposób leczenia nowotworu złośliwego |
| JP6618892B2 (ja) | 2013-04-23 | 2019-12-11 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 細菌バイオフィルムの遺伝的リプログラミング |
| EP3280397A4 (en) * | 2015-04-06 | 2018-08-22 | President and Fellows of Harvard College | Biosynthetic amyloid-based materials displaying functional protein sequences |
| WO2017201428A1 (en) | 2016-05-19 | 2017-11-23 | President And Fellows Of Harvard College | Methods of making gels and film using curli nanofibers |
| TW201829470A (zh) | 2016-10-26 | 2018-08-16 | 廖朝暐 | 用於免疫增強的融合胜肽及使用其增強誘發免疫反應的方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR940010862B1 (ko) * | 1985-02-05 | 1994-11-18 | 씨네겐 바이오로지칼즈, 인코포레이티드 | 유용한 메탈로프로테이나제 억제제 씨퀀스 재조합 벡터계의 제조를 위한 dna 재조합 방법 |
| IL84167A (en) * | 1986-10-24 | 1991-04-15 | Southern Res Inst | Oral delivery of bioactive agents to and through the peyer's patch by use of microencapsulation |
| US5254342A (en) | 1991-09-30 | 1993-10-19 | University Of Southern California | Compositions and methods for enhanced transepithelial and transendothelial transport or active agents |
| GB9201139D0 (en) * | 1992-01-20 | 1992-03-11 | Connaught Lab | Synthetic peptides for a rubella vaccine |
| AU3937693A (en) | 1992-04-10 | 1993-11-18 | Brigham And Women's Hospital | Methods and compositions for oral delivery of therapeutic agents |
| US5534496A (en) | 1992-07-07 | 1996-07-09 | University Of Southern California | Methods and compositions to enhance epithelial drug transport |
| AU2159895A (en) * | 1994-03-11 | 1995-09-25 | Ariad Pharmaceuticals, Inc. | Methods and materials for identifying inhibitors of molecular interactions mediated by sh3 domains |
| US5831008A (en) * | 1994-08-18 | 1998-11-03 | La Jolla Cancer Research Foundation | Retinoblastoma protein-interacting zinc finger proteins |
| US6030613A (en) | 1995-01-17 | 2000-02-29 | The Brigham And Women's Hospital, Inc. | Receptor specific transepithelial transport of therapeutics |
| US6086875A (en) | 1995-01-17 | 2000-07-11 | The Brigham And Women's Hospital, Inc. | Receptor specific transepithelial transport of immunogens |
| IE80466B1 (en) | 1995-11-10 | 1998-07-29 | Elan Corp Plc | Peptides which enhance transport across tissues and methods of identifying and using the same |
| AU705688B2 (en) * | 1995-11-10 | 1999-05-27 | Cytogen Corporation | Peptides which enhance transport across tissues and methods of identifying and using the same |
| US6261787B1 (en) | 1996-06-03 | 2001-07-17 | Case Western Reserve University | Bifunctional molecules for delivery of therapeutics |
| US6060082A (en) | 1997-04-18 | 2000-05-09 | Massachusetts Institute Of Technology | Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery |
| JP4129298B2 (ja) * | 1997-05-15 | 2008-08-06 | サイトジェン コーポレーション | 胃腸管（ｇｉｔ）輸送受容体に結合するランダムペプチド、及び関連した方法 |
| WO2001027154A2 (en) * | 1999-09-27 | 2001-04-19 | Mahony Daniel J O | Membrane translocating peptide drug delivery system |
| JP2001245675A (ja) * | 1999-12-28 | 2001-09-11 | Kyogo Ito | 腫瘍抗原 |
| CN1323825A (zh) * | 2000-05-16 | 2001-11-28 | 上海博德基因开发有限公司 | 一种新的多肽——人网格蛋白轻链9和编码这种多肽的多核苷酸 |
| AU2002254161A1 (en) * | 2001-03-12 | 2002-09-24 | Montana State University-Bozeman | M cell directed vaccines |
| CA2443644A1 (en) * | 2001-04-04 | 2003-01-16 | Elan Corporation, Plc | Genetic analysis of peyers's patches and m cells and methods and compositions targeting peyer's patches and m cell receptors |
| DE60229867D1 (de) * | 2001-07-02 | 2008-12-24 | Merrion Res Iii Ltd | Zielgerichtete ligande gegen peyer's flecke- und/oder m-zellen |
-
2002
- 2002-06-28 DE DE60229867T patent/DE60229867D1/de not_active Expired - Lifetime
- 2002-06-28 AU AU2002326070A patent/AU2002326070A1/en not_active Abandoned
- 2002-06-28 US US10/185,815 patent/US6916789B2/en not_active Expired - Fee Related
- 2002-06-28 JP JP2003510683A patent/JP4383855B2/ja not_active Expired - Fee Related
- 2002-06-28 AT AT02760458T patent/ATE414100T1/de not_active IP Right Cessation
- 2002-06-28 EP EP02760458A patent/EP1432729B1/en not_active Expired - Lifetime
- 2002-06-28 WO PCT/IB2002/003401 patent/WO2003004517A2/en not_active Ceased
- 2002-06-28 CA CA2451741A patent/CA2451741C/en not_active Expired - Fee Related
-
2005
- 2005-06-07 US US11/147,083 patent/US7485321B2/en not_active Expired - Fee Related
-
2008
- 2008-12-19 US US12/340,019 patent/US20100016549A1/en not_active Abandoned
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