JP2005503782A5 - - Google Patents
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- Publication number
- JP2005503782A5 JP2005503782A5 JP2003510683A JP2003510683A JP2005503782A5 JP 2005503782 A5 JP2005503782 A5 JP 2005503782A5 JP 2003510683 A JP2003510683 A JP 2003510683A JP 2003510683 A JP2003510683 A JP 2003510683A JP 2005503782 A5 JP2005503782 A5 JP 2005503782A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- peptide
- synthetic polypeptide
- purified synthetic
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 248
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 130
- 150000001413 amino acids Chemical class 0.000 claims description 115
- 229920001184 polypeptide Polymers 0.000 claims description 108
- 239000012528 membrane Substances 0.000 claims description 17
- 241001524679 Escherichia virus M13 Species 0.000 claims description 16
- 230000004927 fusion Effects 0.000 claims description 15
- 239000002773 nucleotide Substances 0.000 claims description 6
- 125000003729 nucleotide group Chemical group 0.000 claims description 6
- 238000013519 translation Methods 0.000 claims description 6
- 230000004572 zinc-binding Effects 0.000 claims description 6
- 239000003814 drug Substances 0.000 claims description 5
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 229940079593 drug Drugs 0.000 claims description 4
- 102000039446 nucleic acids Human genes 0.000 claims description 4
- 108020004707 nucleic acids Proteins 0.000 claims description 4
- 150000007523 nucleic acids Chemical class 0.000 claims description 4
- 241000282465 Canis Species 0.000 claims description 3
- 239000002502 liposome Substances 0.000 claims description 3
- 239000011859 microparticle Substances 0.000 claims description 3
- 239000002105 nanoparticle Substances 0.000 claims description 3
- 239000000427 antigen Substances 0.000 claims 5
- 102000036639 antigens Human genes 0.000 claims 5
- 108091007433 antigens Proteins 0.000 claims 5
- 230000015572 biosynthetic process Effects 0.000 claims 4
- 238000003786 synthesis reaction Methods 0.000 claims 4
- 241000894006 Bacteria Species 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 238000000746 purification Methods 0.000 claims 3
- 241000700605 Viruses Species 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 244000052769 pathogen Species 0.000 claims 1
- 230000001717 pathogenic effect Effects 0.000 claims 1
- 108700010839 phage proteins Proteins 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 description 55
- 239000003446 ligand Substances 0.000 description 28
- 210000004027 cell Anatomy 0.000 description 18
- 239000012634 fragment Substances 0.000 description 11
- 210000004379 membrane Anatomy 0.000 description 11
- 241000700159 Rattus Species 0.000 description 10
- 230000027455 binding Effects 0.000 description 10
- 241000282472 Canis lupus familiaris Species 0.000 description 7
- 241000699666 Mus <mouse, genus> Species 0.000 description 7
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 4
- 241000282898 Sus scrofa Species 0.000 description 3
- 238000011990 functional testing Methods 0.000 description 3
- VQPRNSWQIAHPMS-HNNXBMFYSA-N N(6)-dansyl-L-lysine Chemical group C1=CC=C2C(N(C)C)=CC=CC2=C1S(=O)(=O)NCCCC[C@H](N)C(O)=O VQPRNSWQIAHPMS-HNNXBMFYSA-N 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 229960002685 biotin Drugs 0.000 description 2
- 235000020958 biotin Nutrition 0.000 description 2
- 239000011616 biotin Substances 0.000 description 2
- 210000001986 peyer's patch Anatomy 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 101710132601 Capsid protein Proteins 0.000 description 1
- 101710094648 Coat protein Proteins 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 102100021181 Golgi phosphoprotein 3 Human genes 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 101710125418 Major capsid protein Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 101710141454 Nucleoprotein Proteins 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 108010067902 Peptide Library Proteins 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 101710083689 Probable capsid protein Proteins 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000007413 biotinylation Methods 0.000 description 1
- 230000006287 biotinylation Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000004899 c-terminal region Anatomy 0.000 description 1
- 108091006116 chimeric peptides Proteins 0.000 description 1
- 239000013599 cloning vector Substances 0.000 description 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 210000004347 intestinal mucosa Anatomy 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 125000001151 peptidyl group Chemical group 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 235000019833 protease Nutrition 0.000 description 1
- 238000000159 protein binding assay Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 241001515965 unidentified phage Species 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30259101P | 2001-07-02 | 2001-07-02 | |
| PCT/IB2002/003401 WO2003004517A2 (en) | 2001-07-02 | 2002-06-28 | Peyers's patch and/or m-celle targeting ligands |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005503782A JP2005503782A (ja) | 2005-02-10 |
| JP2005503782A5 true JP2005503782A5 (https=) | 2008-12-18 |
| JP4383855B2 JP4383855B2 (ja) | 2009-12-16 |
Family
ID=23168408
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003510683A Expired - Fee Related JP4383855B2 (ja) | 2001-07-02 | 2002-06-28 | パイエル板および／またはｍ細胞を標的とするリガンド |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US6916789B2 (https=) |
| EP (1) | EP1432729B1 (https=) |
| JP (1) | JP4383855B2 (https=) |
| AT (1) | ATE414100T1 (https=) |
| AU (1) | AU2002326070A1 (https=) |
| CA (1) | CA2451741C (https=) |
| DE (1) | DE60229867D1 (https=) |
| WO (1) | WO2003004517A2 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6521737B1 (en) * | 1995-11-10 | 2003-02-18 | Elan Corporation, Plc | Peptides which enhance transport across tissues and methods of identifying and using the same |
| ATE414100T1 (de) * | 2001-07-02 | 2008-11-15 | Merrion Res Iii Ltd | Zielgerichtete ligande gegen peyer's flecke- und/oder m-zellen |
| WO2004108755A2 (en) * | 2003-06-10 | 2004-12-16 | University Of Saskatchewan | Chimeric adenovirus capsid proteins |
| AU2012201102B2 (en) * | 2004-06-23 | 2014-05-08 | Ferguson, Ian Andrew | Agents and methods for early diagnosis and monitoring of Alzheimer's disease and other neurological disorders |
| DE102005031755B9 (de) * | 2005-07-01 | 2010-04-08 | Technische Universität Dresden | Salmonella spp. bindende Peptide, dafür kodierende Nukleinsäuren, deren Verwendungen und Verfahren und Kits zur Anreicherung, Immobilisierung und zum Nachweis von Salmonella spp. |
| WO2007137174A2 (en) * | 2006-05-18 | 2007-11-29 | The Ohio State University Research Foundation | Compositions and methods for the detection of vulnerable plaque |
| CN104884065B (zh) | 2012-09-21 | 2019-01-01 | 强烈治疗剂公司 | 治疗癌症的方法 |
| JP6618892B2 (ja) | 2013-04-23 | 2019-12-11 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 細菌バイオフィルムの遺伝的リプログラミング |
| EP3280397A4 (en) | 2015-04-06 | 2018-08-22 | President and Fellows of Harvard College | Biosynthetic amyloid-based materials displaying functional protein sequences |
| US11098133B2 (en) | 2016-05-19 | 2021-08-24 | President And Fellows Of Harvard College | Methods of making gels and films using curli nanofibers |
| TW201829470A (zh) | 2016-10-26 | 2018-08-16 | 廖朝暐 | 用於免疫增強的融合胜肽及使用其增強誘發免疫反應的方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1986004608A1 (en) * | 1985-02-05 | 1986-08-14 | Synergen Biologicals, Inc. | Metalloproteinase inhibitor sequence recombinant vector system for using same and recombinant-dna method for the manufacture of same |
| IL84167A (en) * | 1986-10-24 | 1991-04-15 | Southern Res Inst | Oral delivery of bioactive agents to and through the peyer's patch by use of microencapsulation |
| US5254342A (en) | 1991-09-30 | 1993-10-19 | University Of Southern California | Compositions and methods for enhanced transepithelial and transendothelial transport or active agents |
| GB9201139D0 (en) * | 1992-01-20 | 1992-03-11 | Connaught Lab | Synthetic peptides for a rubella vaccine |
| WO1993020834A1 (en) | 1992-04-10 | 1993-10-28 | Brigham And Women's Hospital | Methods and compositions for oral delivery of therapeutic agents |
| US5534496A (en) | 1992-07-07 | 1996-07-09 | University Of Southern California | Methods and compositions to enhance epithelial drug transport |
| EP0750630A4 (en) * | 1994-03-11 | 1998-01-07 | Ariad Pharma Inc | METHOD AND MATERIALS FOR IDENTIFYING INHIBITORS OF MOLECULAR INTERACTIONS, WHICH ARE BROUGHT BY THE SH3 DOMAINS |
| US5831008A (en) * | 1994-08-18 | 1998-11-03 | La Jolla Cancer Research Foundation | Retinoblastoma protein-interacting zinc finger proteins |
| US6086875A (en) | 1995-01-17 | 2000-07-11 | The Brigham And Women's Hospital, Inc. | Receptor specific transepithelial transport of immunogens |
| US6030613A (en) | 1995-01-17 | 2000-02-29 | The Brigham And Women's Hospital, Inc. | Receptor specific transepithelial transport of therapeutics |
| IE80466B1 (en) | 1995-11-10 | 1998-07-29 | Elan Corp Plc | Peptides which enhance transport across tissues and methods of identifying and using the same |
| NZ322175A (en) * | 1995-11-10 | 1999-02-25 | Elan Corp Plc | Peptides which enhance transport across tissues and methods of identifying the same |
| US6261787B1 (en) | 1996-06-03 | 2001-07-17 | Case Western Reserve University | Bifunctional molecules for delivery of therapeutics |
| US6060082A (en) | 1997-04-18 | 2000-05-09 | Massachusetts Institute Of Technology | Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery |
| WO1998051325A2 (en) * | 1997-05-15 | 1998-11-19 | Cytogen Corporation | Random peptides that bind to gastro-intestinal tract (git) transport receptors and related methods |
| JP4799790B2 (ja) * | 1999-09-27 | 2011-10-26 | メリオン リサーチ スリー リミテッド | 膜転位ペプチド、同ペプチドを含有する組成物、同ペプチドを含有する医薬製剤及び同ペプチドの製剤の調製における使用 |
| JP2001245675A (ja) * | 1999-12-28 | 2001-09-11 | Kyogo Ito | 腫瘍抗原 |
| CN1323825A (zh) * | 2000-05-16 | 2001-11-28 | 上海博德基因开发有限公司 | 一种新的多肽——人网格蛋白轻链9和编码这种多肽的多核苷酸 |
| AU2002254161A1 (en) * | 2001-03-12 | 2002-09-24 | Montana State University-Bozeman | M cell directed vaccines |
| EP1419252A2 (en) * | 2001-04-04 | 2004-05-19 | Merrion Research I Limited | Genetic analysis of peyers's patches and m cells and methods and compositions targeting peyer's patches and m cell receptors |
| ATE414100T1 (de) * | 2001-07-02 | 2008-11-15 | Merrion Res Iii Ltd | Zielgerichtete ligande gegen peyer's flecke- und/oder m-zellen |
-
2002
- 2002-06-28 AT AT02760458T patent/ATE414100T1/de not_active IP Right Cessation
- 2002-06-28 US US10/185,815 patent/US6916789B2/en not_active Expired - Fee Related
- 2002-06-28 JP JP2003510683A patent/JP4383855B2/ja not_active Expired - Fee Related
- 2002-06-28 AU AU2002326070A patent/AU2002326070A1/en not_active Abandoned
- 2002-06-28 EP EP02760458A patent/EP1432729B1/en not_active Expired - Lifetime
- 2002-06-28 DE DE60229867T patent/DE60229867D1/de not_active Expired - Lifetime
- 2002-06-28 WO PCT/IB2002/003401 patent/WO2003004517A2/en not_active Ceased
- 2002-06-28 CA CA2451741A patent/CA2451741C/en not_active Expired - Fee Related
-
2005
- 2005-06-07 US US11/147,083 patent/US7485321B2/en not_active Expired - Fee Related
-
2008
- 2008-12-19 US US12/340,019 patent/US20100016549A1/en not_active Abandoned
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