JP2005502712A5 - - Google Patents
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- JP2005502712A5 JP2005502712A5 JP2003528119A JP2003528119A JP2005502712A5 JP 2005502712 A5 JP2005502712 A5 JP 2005502712A5 JP 2003528119 A JP2003528119 A JP 2003528119A JP 2003528119 A JP2003528119 A JP 2003528119A JP 2005502712 A5 JP2005502712 A5 JP 2005502712A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- adipose tissue
- separating
- matrix material
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004027 cell Anatomy 0.000 claims description 56
- 210000000130 stem cell Anatomy 0.000 claims description 51
- 238000000034 method Methods 0.000 claims description 43
- 210000000577 adipose tissue Anatomy 0.000 claims description 30
- 239000011159 matrix material Substances 0.000 claims description 23
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 22
- 239000000463 material Substances 0.000 claims description 20
- 238000001816 cooling Methods 0.000 claims description 13
- 238000005138 cryopreservation Methods 0.000 claims description 13
- 239000002577 cryoprotective agent Substances 0.000 claims description 13
- 230000001225 therapeutic effect Effects 0.000 claims description 12
- 238000010257 thawing Methods 0.000 claims description 11
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 230000003204 osmotic effect Effects 0.000 claims description 6
- 239000000654 additive Substances 0.000 claims description 5
- 230000008569 process Effects 0.000 claims description 5
- 238000012545 processing Methods 0.000 claims description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 4
- 239000002537 cosmetic Substances 0.000 claims description 4
- 238000011282 treatment Methods 0.000 claims description 4
- 102000009027 Albumins Human genes 0.000 claims description 3
- 108010088751 Albumins Proteins 0.000 claims description 3
- 102000008100 Human Serum Albumin Human genes 0.000 claims description 3
- 108091006905 Human Serum Albumin Proteins 0.000 claims description 3
- 229920001612 Hydroxyethyl starch Polymers 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 230000000959 cryoprotective effect Effects 0.000 claims description 3
- 229940050526 hydroxyethylstarch Drugs 0.000 claims description 3
- 239000012071 phase Substances 0.000 claims description 3
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 claims description 2
- 241000124008 Mammalia Species 0.000 claims description 2
- 230000000996 additive effect Effects 0.000 claims description 2
- 230000003833 cell viability Effects 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 2
- 229910052757 nitrogen Inorganic materials 0.000 claims description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 2
- 235000013772 propylene glycol Nutrition 0.000 claims description 2
- 239000000243 solution Substances 0.000 claims description 2
- 210000001789 adipocyte Anatomy 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 8
- 239000006285 cell suspension Substances 0.000 claims 3
- 239000000725 suspension Substances 0.000 claims 3
- 238000005119 centrifugation Methods 0.000 claims 2
- 238000010828 elution Methods 0.000 claims 2
- 150000002632 lipids Chemical class 0.000 claims 2
- 230000000717 retained effect Effects 0.000 claims 2
- 238000000926 separation method Methods 0.000 claims 2
- 239000007790 solid phase Substances 0.000 claims 2
- 238000009987 spinning Methods 0.000 claims 2
- 238000010792 warming Methods 0.000 claims 2
- 102000029816 Collagenase Human genes 0.000 claims 1
- 108060005980 Collagenase Proteins 0.000 claims 1
- 108010053770 Deoxyribonucleases Proteins 0.000 claims 1
- 102000016911 Deoxyribonucleases Human genes 0.000 claims 1
- 239000004367 Lipase Substances 0.000 claims 1
- 102000004882 Lipase Human genes 0.000 claims 1
- 108090001060 Lipase Proteins 0.000 claims 1
- 108090000526 Papain Proteins 0.000 claims 1
- 108091005804 Peptidases Proteins 0.000 claims 1
- 102000035195 Peptidases Human genes 0.000 claims 1
- 239000004365 Protease Substances 0.000 claims 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 1
- 208000007536 Thrombosis Diseases 0.000 claims 1
- 102000004142 Trypsin Human genes 0.000 claims 1
- 108090000631 Trypsin Proteins 0.000 claims 1
- 239000011324 bead Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 229960002424 collagenase Drugs 0.000 claims 1
- 238000005188 flotation Methods 0.000 claims 1
- 238000001943 fluorescence-activated cell sorting Methods 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 235000019421 lipase Nutrition 0.000 claims 1
- 229940055729 papain Drugs 0.000 claims 1
- 235000019834 papain Nutrition 0.000 claims 1
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 1
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 238000010008 shearing Methods 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 230000008961 swelling Effects 0.000 claims 1
- 239000012588 trypsin Substances 0.000 claims 1
- 229960001322 trypsin Drugs 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
- 238000012360 testing method Methods 0.000 description 6
- 238000007710 freezing Methods 0.000 description 5
- 230000008014 freezing Effects 0.000 description 5
- 230000035899 viability Effects 0.000 description 4
- 238000013459 approach Methods 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 229920003023 plastic Polymers 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 238000011084 recovery Methods 0.000 description 3
- 230000008439 repair process Effects 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 239000012620 biological material Substances 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 238000004113 cell culture Methods 0.000 description 2
- 210000002808 connective tissue Anatomy 0.000 description 2
- 239000002826 coolant Substances 0.000 description 2
- 238000009413 insulation Methods 0.000 description 2
- 239000000644 isotonic solution Substances 0.000 description 2
- 230000000149 penetrating effect Effects 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 208000026350 Inborn Genetic disease Diseases 0.000 description 1
- 230000000735 allogeneic effect Effects 0.000 description 1
- 230000003466 anti-cipated effect Effects 0.000 description 1
- 230000003409 anti-rejection Effects 0.000 description 1
- 238000010009 beating Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 230000005779 cell damage Effects 0.000 description 1
- 208000037887 cell injury Diseases 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000003021 clonogenic effect Effects 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 230000001066 destructive effect Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 208000037765 diseases and disorders Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 208000016361 genetic disease Diseases 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 210000002064 heart cell Anatomy 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 238000007443 liposuction Methods 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000002107 myocardial effect Effects 0.000 description 1
- 230000006911 nucleation Effects 0.000 description 1
- 238000010899 nucleation Methods 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000011164 ossification Effects 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000003211 trypan blue cell staining Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32207001P | 2001-09-14 | 2001-09-14 | |
| US10/242,094 US20030054331A1 (en) | 2001-09-14 | 2002-09-12 | Preservation of non embryonic cells from non hematopoietic tissues |
| PCT/US2002/029207 WO2003024215A1 (en) | 2001-09-14 | 2002-09-13 | Preservation of non embryonic cells from non hematopoietic tissues |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009189198A Division JP2009269930A (ja) | 2001-09-14 | 2009-08-18 | 非造血組織由来の非胚性細胞の保存 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005502712A JP2005502712A (ja) | 2005-01-27 |
| JP2005502712A5 true JP2005502712A5 (enExample) | 2006-08-17 |
Family
ID=26934818
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003528119A Pending JP2005502712A (ja) | 2001-09-14 | 2002-09-13 | 非造血組織由来の非胚性細胞の保存 |
| JP2009189198A Pending JP2009269930A (ja) | 2001-09-14 | 2009-08-18 | 非造血組織由来の非胚性細胞の保存 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009189198A Pending JP2009269930A (ja) | 2001-09-14 | 2009-08-18 | 非造血組織由来の非胚性細胞の保存 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20030054331A1 (enExample) |
| EP (1) | EP1427279A1 (enExample) |
| JP (2) | JP2005502712A (enExample) |
| KR (1) | KR100779812B1 (enExample) |
| CN (1) | CN1585602A (enExample) |
| AU (1) | AU2002326901B2 (enExample) |
| CA (1) | CA2460402A1 (enExample) |
| WO (1) | WO2003024215A1 (enExample) |
Families Citing this family (153)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002019092A1 (en) * | 2000-08-28 | 2002-03-07 | Ebox.Com Inc. | A high security wireless key for asynchronous delivery drop boxes |
| US7585670B2 (en) | 2001-12-07 | 2009-09-08 | Cytori Therapeutics, Inc. | Automated methods for isolating and using clinically safe adipose derived regenerative cells |
| US7514075B2 (en) | 2001-12-07 | 2009-04-07 | Cytori Therapeutics, Inc. | Systems and methods for separating and concentrating adipose derived stem cells from tissue |
| US7771716B2 (en) * | 2001-12-07 | 2010-08-10 | Cytori Therapeutics, Inc. | Methods of using regenerative cells in the treatment of musculoskeletal disorders |
| US9597395B2 (en) | 2001-12-07 | 2017-03-21 | Cytori Therapeutics, Inc. | Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions |
| US20050095228A1 (en) | 2001-12-07 | 2005-05-05 | Fraser John K. | Methods of using regenerative cells in the treatment of peripheral vascular disease and related disorders |
| US7651684B2 (en) | 2001-12-07 | 2010-01-26 | Cytori Therapeutics, Inc. | Methods of using adipose tissue-derived cells in augmenting autologous fat transfer |
| US8105580B2 (en) | 2001-12-07 | 2012-01-31 | Cytori Therapeutics, Inc. | Methods of using adipose derived stem cells to promote wound healing |
| US7595043B2 (en) | 2001-12-07 | 2009-09-29 | Cytori Therapeutics, Inc. | Method for processing and using adipose-derived stem cells |
| CA2469370C (en) * | 2001-12-07 | 2014-07-08 | Macropore Biosurgery, Inc. | Adipose-derived cell processing unit |
| KR20040094910A (ko) * | 2002-04-03 | 2004-11-10 | 아르테셀 사이언스, 인크. | 개선된 지방세포 분화된 지방 유래 성체 줄기세포 및 이의용도 |
| US20030205538A1 (en) | 2002-05-03 | 2003-11-06 | Randel Dorian | Methods and apparatus for isolating platelets from blood |
| US7992725B2 (en) | 2002-05-03 | 2011-08-09 | Biomet Biologics, Llc | Buoy suspension fractionation system |
| US7832566B2 (en) | 2002-05-24 | 2010-11-16 | Biomet Biologics, Llc | Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles |
| AU2003249642A1 (en) | 2002-05-24 | 2003-12-12 | Biomet Manufacturing Corp. | Apparatus and method for separating and concentrating fluids containing multiple components |
| US20060278588A1 (en) | 2002-05-24 | 2006-12-14 | Woodell-May Jennifer E | Apparatus and method for separating and concentrating fluids containing multiple components |
| US7845499B2 (en) | 2002-05-24 | 2010-12-07 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
| ATE524070T1 (de) * | 2003-02-20 | 2011-09-15 | Cytori Therapeutics Inc | Verfahren zur verwendung von aus fettgewebe stammenden zellen bei der behandlung von herz- kreislauf-leiden |
| US20040193274A1 (en) * | 2003-03-28 | 2004-09-30 | Trieu Hai H. | Materials and methods for augmenting and/or repairing intervertebral discs |
| WO2004091637A2 (en) * | 2003-04-07 | 2004-10-28 | Neostem, Inc. | System capable of treating and defining various diseases using stem cells |
| KR101127305B1 (ko) * | 2003-06-25 | 2012-04-23 | 사이토리 테라퓨틱스, 인크. | 조직으로부터 재생성 세포를 분리하고 농축시키기 위한시스템 및 방법 |
| SG146666A1 (en) * | 2003-09-17 | 2008-10-30 | Macropore Biosurgery Inc | Methods of using regenerative cells in the treatment of peripheral vascular disease and related disorders |
| US7840646B2 (en) * | 2003-10-08 | 2010-11-23 | Yahoo! Inc. | Learned upload time estimate module |
| AU2004280616A1 (en) * | 2003-10-08 | 2005-04-21 | Vet-Stem Inc. | Methods of preparing and using stem cell compositions and kits comprising the same |
| WO2005095583A1 (en) * | 2004-03-03 | 2005-10-13 | Life-Sciences Ag | Large scale storage of viable somatic stem and/or progenitor cells |
| EP1743021B1 (en) * | 2004-03-19 | 2014-03-26 | Cytori Therapeutics, Inc. | Method of preparing regenerative cells on a cell carrier and cell carrier containment device |
| WO2006014162A2 (en) | 2004-07-01 | 2006-02-09 | Macropore Biosurgery Inc. | Methods of using regenerative cells in the treatment of renal diseases and disorders |
| EP2980206A1 (en) * | 2004-07-01 | 2016-02-03 | Cytori Therapeutics, Inc. | Methods of using regenerative cells in the treatment of musculoskeletal disorders |
| US20060045872A1 (en) | 2004-08-25 | 2006-03-02 | Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco | Use of adipose tissue-derived stromal stem cells in treating fistula |
| US20060134781A1 (en) * | 2004-12-07 | 2006-06-22 | Bacterin International, Inc. | Three-dimensional cell culture system |
| AU2005322873B2 (en) * | 2004-12-30 | 2011-09-01 | Primegen Biotech, Llc | Adipose-derived stem cells for tissue regeneration and wound healing |
| US7866485B2 (en) | 2005-02-07 | 2011-01-11 | Hanuman, Llc | Apparatus and method for preparing platelet rich plasma and concentrates thereof |
| WO2006086201A2 (en) | 2005-02-07 | 2006-08-17 | Hanuman Llc | Platelet rich plasma concentrate apparatus and method |
| JP4961354B2 (ja) * | 2005-02-07 | 2012-06-27 | ハヌマン リミテッド ライアビリティ カンパニー | 多血小板血漿濃縮装置および方法 |
| US20070032774A1 (en) * | 2005-05-17 | 2007-02-08 | Clifford Glade | Container for transporting blood and blood products |
| JP4907908B2 (ja) * | 2005-06-29 | 2012-04-04 | ルネサスエレクトロニクス株式会社 | 駆動回路及び表示装置 |
| SG10202001007TA (en) | 2005-09-23 | 2020-03-30 | Tigenix Sau | Cell populations having immunoregulatory activity, method for isolation and uses |
| EP1957633B1 (en) * | 2005-10-13 | 2013-12-18 | Anthrogenesis Corporation | Immunomodulation using placental stem cells |
| US20070227547A1 (en) * | 2006-02-14 | 2007-10-04 | Sdgi Holdings, Inc. | Treatment of the vertebral column |
| US20070213822A1 (en) * | 2006-02-14 | 2007-09-13 | Sdgi Holdings, Inc. | Treatment of the vertebral column |
| US20070213717A1 (en) * | 2006-02-14 | 2007-09-13 | Sdgi Holdings, Inc. | Biological fusion in the vertebral column |
| US20070213718A1 (en) * | 2006-02-14 | 2007-09-13 | Sdgi Holdings, Inc. | Treatment of the vertebral column |
| US8567609B2 (en) | 2006-05-25 | 2013-10-29 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
| US20090304644A1 (en) * | 2006-05-30 | 2009-12-10 | Cytori Therapeutics, Inc. | Systems and methods for manipulation of regenerative cells separated and concentrated from adipose tissue |
| KR100803576B1 (ko) * | 2006-06-14 | 2008-02-15 | 주식회사 인피트론 | 지방줄기세포 및 지방세포를 포함한 이식용 조성물 |
| US20100015104A1 (en) * | 2006-07-26 | 2010-01-21 | Cytori Therapeutics, Inc | Generation of adipose tissue and adipocytes |
| US8034014B2 (en) | 2007-03-06 | 2011-10-11 | Biomet Biologics, Llc | Angiogenesis initation and growth |
| US8328024B2 (en) | 2007-04-12 | 2012-12-11 | Hanuman, Llc | Buoy suspension fractionation system |
| JP5479319B2 (ja) | 2007-04-12 | 2014-04-23 | バイオメット・バイオロジックス・リミテッド・ライアビリティ・カンパニー | ブイ式懸濁液分画システム |
| US20090192528A1 (en) * | 2008-01-29 | 2009-07-30 | Biomet Biologics, Inc. | Method and device for hernia repair |
| WO2009108890A1 (en) | 2008-02-27 | 2009-09-03 | Biomet Biologics, Llc | Methods and compositions for delivering interleukin-1 receptor antagonist |
| WO2009111338A1 (en) | 2008-02-29 | 2009-09-11 | Biomet Manufacturing Corp. | A system and process for separating a material |
| US8481253B2 (en) | 2008-03-19 | 2013-07-09 | Cryo-Save Ag | Cryopreservation of adipose tissue for the isolation of mesenchymal stem cells |
| US8012077B2 (en) | 2008-05-23 | 2011-09-06 | Biomet Biologics, Llc | Blood separating device |
| MX2011001730A (es) | 2008-08-14 | 2011-03-24 | Osiris Therapeutics Inc | Composiciones purificadas de celulas madre mesenquimales y metodos para purificar composiciones de celulas madre mesenquimales. |
| WO2010021993A1 (en) * | 2008-08-19 | 2010-02-25 | Cytori Therapeutics, Inc. | Methods of using adipose tissue-derived cells in the treatment of the lymphatic system and malignant disease |
| AU2011247866C9 (en) * | 2008-08-22 | 2014-02-13 | Regeneus Ltd. | Allogeneic therapeutic methods using adipose tissue-derived cell suspensions |
| AU2009201915C1 (en) | 2008-08-22 | 2015-02-26 | Regeneus Ltd | Therapeutic methods |
| US8187475B2 (en) | 2009-03-06 | 2012-05-29 | Biomet Biologics, Llc | Method and apparatus for producing autologous thrombin |
| US8313954B2 (en) | 2009-04-03 | 2012-11-20 | Biomet Biologics, Llc | All-in-one means of separating blood components |
| EP2424463B1 (en) * | 2009-05-01 | 2016-12-28 | Bimini Technologies LLC | Systems, methods and compositions for optimizing tissue and cell enriched grafts |
| US20100291534A1 (en) * | 2009-05-12 | 2010-11-18 | National Central University | Methods and Systems for Isolating, Ex Vivo Expanding and Harvesting Hematopoietic Stem Cells |
| US9011800B2 (en) | 2009-07-16 | 2015-04-21 | Biomet Biologics, Llc | Method and apparatus for separating biological materials |
| US8591391B2 (en) | 2010-04-12 | 2013-11-26 | Biomet Biologics, Llc | Method and apparatus for separating a material |
| US9352003B1 (en) | 2010-05-14 | 2016-05-31 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US8883210B1 (en) | 2010-05-14 | 2014-11-11 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US10130736B1 (en) | 2010-05-14 | 2018-11-20 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| AU2011279250B2 (en) | 2010-07-12 | 2014-12-04 | California Institute Of Technology | Biocompatible substrate for facilitating interconnections between stem cells and target tissues and methods for implanting same |
| US9725689B2 (en) | 2010-10-08 | 2017-08-08 | Terumo Bct, Inc. | Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system |
| WO2012083260A2 (en) * | 2010-12-16 | 2012-06-21 | Alt Eckhard U | Methods and apparatus for enhanced recovery of cells and of cell-enriched matrix from tissue samples |
| US8877489B2 (en) | 2011-12-05 | 2014-11-04 | California Institute Of Technology | Ultrathin parylene-C semipermeable membranes for biomedical applications |
| WO2012149468A2 (en) | 2011-04-29 | 2012-11-01 | University Of Southern California | Instruments and methods for the implantation of cell-seeded substrates |
| EP2702135B1 (en) | 2011-04-29 | 2019-04-17 | University of Southern California | Method of cryopreservation of stem cell-derived retinal pigment epithelial cells on polymeric substrate |
| US9109198B2 (en) | 2011-04-29 | 2015-08-18 | General Electric Company | Automated systems and methods for isolating regenerative cells from adipose tissue |
| US8834928B1 (en) | 2011-05-16 | 2014-09-16 | Musculoskeletal Transplant Foundation | Tissue-derived tissugenic implants, and methods of fabricating and using same |
| SG10201606745XA (en) | 2011-09-23 | 2016-10-28 | Cell Ideas Pty Ltd | Therapeutics using adipose cells and cell secretions |
| US10154664B2 (en) * | 2011-10-06 | 2018-12-18 | David K Moscatello | Systems and methods for the digestion of adipose tissue samples obtained from a client for cryopreservation |
| US8932805B1 (en) | 2011-10-31 | 2015-01-13 | BioDlogics, LLC | Birth tissue material and method of preparation |
| AU2012335746B2 (en) | 2011-11-08 | 2017-04-27 | Auxocell Laboratories, Inc. | Systems and methods for processing cells |
| ES2377796B8 (es) * | 2011-11-25 | 2012-12-28 | Banc De Sang I Teixits | Procedimiento para preparar productos de terapia celular o ingeniería tisular. |
| US9248013B2 (en) | 2011-12-05 | 2016-02-02 | California Institute Of Technology | 3-Dimensional parylene scaffold cage |
| AU2012347741B2 (en) * | 2011-12-07 | 2016-01-14 | Cytovera, Inc. | Method and device for sample processing |
| EP3338645B1 (en) * | 2012-01-17 | 2022-01-12 | Nico Corporation | Tissue preservation, cooling and tissue sample retrieval and preservation systems |
| CN104487567B (zh) * | 2012-06-07 | 2018-09-25 | 保信亚太生物科技（深圳）有限公司 | 用于自体脂肪转移手术的组合物及方法 |
| EP2864472A4 (en) * | 2012-06-20 | 2015-12-30 | Celula Inc | MATERIALS AND METHOD FOR PROCESSING CELL POPULATIONS |
| CN102907416B (zh) * | 2012-08-01 | 2016-08-03 | 西比曼生物科技（上海）有限公司 | 一种可维持细胞活性的组织冻存液 |
| US9642956B2 (en) | 2012-08-27 | 2017-05-09 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
| US10143725B2 (en) | 2013-03-15 | 2018-12-04 | Biomet Biologics, Llc | Treatment of pain using protein solutions |
| US20140271589A1 (en) | 2013-03-15 | 2014-09-18 | Biomet Biologics, Llc | Treatment of collagen defects using protein solutions |
| US10208095B2 (en) | 2013-03-15 | 2019-02-19 | Biomet Manufacturing, Llc | Methods for making cytokine compositions from tissues using non-centrifugal methods |
| TWI656839B (zh) * | 2013-03-15 | 2019-04-21 | 健臻公司 | 高密度細胞儲存方法 |
| US9950035B2 (en) | 2013-03-15 | 2018-04-24 | Biomet Biologics, Llc | Methods and non-immunogenic compositions for treating inflammatory disorders |
| US9895418B2 (en) | 2013-03-15 | 2018-02-20 | Biomet Biologics, Llc | Treatment of peripheral vascular disease using protein solutions |
| AU2014278178B2 (en) | 2013-06-11 | 2021-01-21 | President And Fellows Of Harvard College | SC-beta cells and compositions and methods for generating the same |
| US9580678B2 (en) | 2013-06-21 | 2017-02-28 | The Regents Of The University Of California | Microfluidic tumor tissue dissociation device |
| EP3019599B1 (en) * | 2013-07-10 | 2018-06-13 | Agency For Science, Technology And Research | Method for isolating stromal vascular fraction |
| WO2015017500A1 (en) | 2013-07-30 | 2015-02-05 | Musculoskeletal Transplant Foundation | Acellular soft tissue-derived matrices and methods for preparing same |
| KR20160073382A (ko) * | 2013-10-04 | 2016-06-24 | 셀 아이디어스 피티와이 엘티디 | 세포 치료를 위한 바이오마커들 |
| EP3068867B1 (en) | 2013-11-16 | 2018-04-18 | Terumo BCT, Inc. | Expanding cells in a bioreactor |
| US10077423B2 (en) | 2014-02-05 | 2018-09-18 | Muffin Incorporated | Compartmented cryopreservation container and uses thereof |
| US11008547B2 (en) | 2014-03-25 | 2021-05-18 | Terumo Bct, Inc. | Passive replacement of media |
| US9993748B2 (en) | 2014-08-11 | 2018-06-12 | Auxocell Laboratories, Inc. | Centrifuge clip and method |
| USD748462S1 (en) | 2014-08-11 | 2016-02-02 | Auxocell Laboratories, Inc. | Centrifuge clip |
| EP3957173A1 (en) | 2014-09-18 | 2022-02-23 | Genzyme Corporation | Ultra-high density cell banking methods |
| EP3198006B1 (en) | 2014-09-26 | 2021-03-24 | Terumo BCT, Inc. | Scheduled feed |
| US10201573B1 (en) | 2014-10-27 | 2019-02-12 | Brahm Holdings, Llc | Human birth tissue material composition and methods for the treatment of damage associated with a cerebral vascular accident |
| US10265438B1 (en) | 2014-11-03 | 2019-04-23 | BioDlogics, LLC | Methods and compositions for the repair and replacement of connective tissue |
| US9713810B2 (en) | 2015-03-30 | 2017-07-25 | Biomet Biologics, Llc | Cell washing plunger using centrifugal force |
| FR3035407B1 (fr) | 2015-04-23 | 2022-06-17 | Francais Du Sang Ets | Procede de conservation de cellules, tissus ou organes en hypothermie |
| US9757721B2 (en) | 2015-05-11 | 2017-09-12 | Biomet Biologics, Llc | Cell washing plunger using centrifugal force |
| CA2986702C (en) | 2015-05-21 | 2023-04-04 | David Wang | Modified demineralized cortical bone fibers |
| WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
| US10912864B2 (en) | 2015-07-24 | 2021-02-09 | Musculoskeletal Transplant Foundation | Acellular soft tissue-derived matrices and methods for preparing same |
| US11052175B2 (en) | 2015-08-19 | 2021-07-06 | Musculoskeletal Transplant Foundation | Cartilage-derived implants and methods of making and using same |
| US12551509B2 (en) | 2015-11-18 | 2026-02-17 | Lucina Patent Holdco, Llc | Acellular regenerative products and methods of their manufacture |
| CN108289915A (zh) * | 2015-11-24 | 2018-07-17 | 日本乐敦制药株式会社 | 包含脂肪组织来源基质细胞的肝病治疗剂及其制造方法 |
| CN105613484B (zh) * | 2015-12-16 | 2018-10-26 | 华南生物医药研究院 | 巨核祖细胞冻存液及其应用 |
| US10722540B1 (en) | 2016-02-01 | 2020-07-28 | The Regents Of The University Of California | Microfluidic device and method for shear stress-induced transformation of cells |
| WO2017141831A1 (ja) * | 2016-02-16 | 2017-08-24 | ロート製薬株式会社 | 脂肪組織由来間質細胞を含む虚血性疾患治療剤およびその製造方法 |
| GB201604304D0 (en) | 2016-03-14 | 2016-04-27 | Tigenix S A U | Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease |
| WO2017205667A1 (en) | 2016-05-25 | 2017-11-30 | Terumo Bct, Inc. | Cell expansion |
| US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
| US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
| CA3051051A1 (en) | 2016-06-08 | 2017-12-14 | The Regents Of The University Of California | Method and device for processing tissues and cells |
| JP2019146487A (ja) * | 2016-06-16 | 2019-09-05 | 株式会社ワンビシアーカイブズ | クライオボックス運搬および保管用容器 |
| CN106465710B (zh) * | 2016-08-19 | 2020-04-14 | 杭州易文赛生物技术有限公司 | 脂肪组织冻存液及脂肪组织冻存方法 |
| US12234441B2 (en) | 2017-03-31 | 2025-02-25 | Terumo Bct, Inc. | Cell expansion |
| US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
| JP7393945B2 (ja) | 2017-03-31 | 2023-12-07 | テルモ ビーシーティー、インコーポレーテッド | 細胞増殖 |
| CN108925548A (zh) * | 2017-05-24 | 2018-12-04 | 西比曼生物科技（香港）有限公司 | 一种冻存细胞制剂及细胞复苏方式 |
| WO2018218061A1 (en) | 2017-05-24 | 2018-11-29 | President And Fellows Of Harvard College | Satellite cells and compositions and methods for producing the same |
| CN108402032B (zh) * | 2018-03-14 | 2021-01-05 | 重庆奥纳思生物科技有限公司 | 一种脐带血干细胞储藏方法 |
| CN108477141B (zh) * | 2018-03-14 | 2021-01-05 | 重庆奥纳思生物科技有限公司 | 一种脐带血干细胞医用储藏箱 |
| ES2738956B2 (es) * | 2018-07-26 | 2022-01-17 | Disentropic S L | Dispositivo para el procesado del tejido graso y sus usos |
| KR20250058061A (ko) | 2018-09-07 | 2025-04-29 | 유니버시티 오브 써던 캘리포니아 | 세포 시딩된 기질로부터의 치료적 상층액 및 관련 방법 |
| KR102146379B1 (ko) * | 2019-03-04 | 2020-08-21 | 고려대학교 산학협력단 | 조직의 급속동결 보관장치 및 조직의 급속동결 보관방법 |
| US11697799B2 (en) | 2019-04-15 | 2023-07-11 | Ossium Health, Inc. | System and method for extraction and cryopreservation of bone marrow |
| EP3994245A1 (en) | 2019-07-05 | 2022-05-11 | Case Western Reserve University | Priming media and methods for stem cell culture and therapy |
| WO2021177344A1 (ja) * | 2020-03-05 | 2021-09-10 | 積水メディカル株式会社 | 細胞含有液用保存容器及び保存液 |
| KR20260116298A (ko) | 2020-05-11 | 2026-07-28 | 신틀 헬스 테크놀로지스 인코포레이티드 | 조직 및 세포 처리 방법 및 장치 |
| EP4181675A4 (en) | 2020-07-18 | 2024-04-24 | Ossium Health, Inc. | PERMEATION OF WHOLE VERTEBRATE BODIES WITH A CRYOPRETECTIVE AGENT USING VACUUM-ASSISTED DIFFUSION |
| US12426594B2 (en) | 2020-09-24 | 2025-09-30 | Everest Medical Innovation GmbH | Cryoprotective compositions and methods for protection of a surgical site during cryosurgery |
| US12453805B2 (en) | 2020-09-24 | 2025-10-28 | Everest Medical Innovation GmbH | Cryoprotective compositions, surgical kits, and methods for protection of a surgical site during cryosurgery |
| EP4229183A4 (en) | 2020-10-14 | 2024-12-11 | Ossium Health, Inc. | Compositions and methods for extraction of mesenchymal stem cells |
| EP4228406A4 (en) | 2020-10-14 | 2024-11-13 | Ossium Health, Inc. | SYSTEMS AND METHODS FOR BONE MARROW EXTRACTION AND CRYOPRESERVATION |
| DE102020127787B4 (de) * | 2020-10-22 | 2025-08-14 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eingetragener Verein | Verfahren und Kryokonservierungsvorrichtung zur Kryokonservierung einer Vielzahl von Zellverbänden aus biologischen Zellen |
| EP4262831A4 (en) | 2020-12-18 | 2025-01-01 | Ossium Health, Inc. | CELLULAR THERAPY PROCESSES |
| EP4314244B1 (en) | 2021-03-23 | 2025-07-23 | Terumo BCT, Inc. | Cell capture and expansion |
| US20250188417A1 (en) | 2021-04-11 | 2025-06-12 | President And Fellows Of Harvard College | Cardiomyocytes and compositions and methods for producing the same |
| CN114916534A (zh) * | 2022-02-11 | 2022-08-19 | 南京艾拓生命科技有限公司 | 一种间充质干细胞活性因子包装结构 |
| US12152699B2 (en) | 2022-02-28 | 2024-11-26 | Terumo Bct, Inc. | Multiple-tube pinch valve assembly |
| USD1099116S1 (en) | 2022-09-01 | 2025-10-21 | Terumo Bct, Inc. | Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device |
| US12636393B1 (en) * | 2024-11-12 | 2026-05-26 | Automated Systems of Tacoma, LLC | Automated systems for sterility testing of pharmaceutical fluid products |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4458678A (en) * | 1981-10-26 | 1984-07-10 | Massachusetts Institute Of Technology | Cell-seeding procedures involving fibrous lattices |
| US5372945A (en) * | 1985-06-06 | 1994-12-13 | Alchas; Paul G. | Device and method for collecting and processing fat tissue and procuring microvessel endothelial cells to produce endothelial cell product |
| US5312380A (en) * | 1985-06-06 | 1994-05-17 | Thomas Jefferson University | Endothelial cell procurement and deposition kit |
| US4820626A (en) * | 1985-06-06 | 1989-04-11 | Thomas Jefferson University | Method of treating a synthetic or naturally occuring surface with microvascular endothelial cells, and the treated surface itself |
| US5035708A (en) * | 1985-06-06 | 1991-07-30 | Thomas Jefferson University | Endothelial cell procurement and deposition kit |
| US5436135A (en) * | 1985-09-02 | 1995-07-25 | Pasteur Merieux Serums Et Vaccins | New preparation of placenta collagen, their extraction method and their applications |
| US4963489A (en) * | 1987-04-14 | 1990-10-16 | Marrow-Tech, Inc. | Three-dimensional cell and tissue culture system |
| US5158867A (en) * | 1987-08-21 | 1992-10-27 | Cryolife Inc. | Method for cryopreserving blood vessels |
| US4883755A (en) * | 1987-10-28 | 1989-11-28 | Thomas Jefferson University | Method of reendothelializing vascular linings |
| US4834703A (en) * | 1987-11-23 | 1989-05-30 | Dubrul Will R | Liposuction filter and lipoplasty device |
| US5092883A (en) * | 1988-12-28 | 1992-03-03 | Eppley Barry L | Method for promoting soft connective tissue growth and repair in mammals |
| EP0446450B1 (en) * | 1990-02-09 | 1995-03-29 | Thomas Jefferson University | Device for collecting and processing fat tissue to produce endothelial cell product |
| JPH0413700A (ja) * | 1990-05-08 | 1992-01-17 | Katsuya Takasu | コラーゲンの分離方法 |
| US5641622A (en) * | 1990-09-13 | 1997-06-24 | Baxter International Inc. | Continuous centrifugation process for the separation of biological components from heterogeneous cell populations |
| US5837539A (en) * | 1990-11-16 | 1998-11-17 | Osiris Therapeutics, Inc. | Monoclonal antibodies for human mesenchymal stem cells |
| US5226914A (en) * | 1990-11-16 | 1993-07-13 | Caplan Arnold I | Method for treating connective tissue disorders |
| US5486359A (en) * | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| NZ242533A (en) * | 1991-05-03 | 1995-05-26 | Becton Dickinson Co | Device for collecting and processing fat tissue; vessel with rinsing and digesting chamber, drain chamber and isolation chamber |
| US5261612A (en) * | 1991-10-09 | 1993-11-16 | Newman-Ftaiha, Inc. | Method and apparatus for extracting injectable collagen from adipose tissue |
| US5316942A (en) * | 1993-06-16 | 1994-05-31 | Battelle Memorial Institute | Process for the production of low-cost soluble high-molecular weight collagen |
| US5409833A (en) * | 1993-07-01 | 1995-04-25 | Baxter International Inc. | Microvessel cell isolation apparatus |
| US5470307A (en) * | 1994-03-16 | 1995-11-28 | Lindall; Arnold W. | Catheter system for controllably releasing a therapeutic agent at a remote tissue site |
| JPH07255469A (ja) * | 1994-03-17 | 1995-10-09 | Kurabo Ind Ltd | 動物細胞の凍結保存液 |
| WO1996001641A1 (de) * | 1994-07-08 | 1996-01-25 | Sulzer Medizinaltechnik Ag | Verfahren zur herstellung von implantationsmaterialien |
| JPH0892001A (ja) * | 1994-09-26 | 1996-04-09 | Asahi Medical Co Ltd | 細胞集団の保存方法 |
| DE4439480C1 (de) * | 1994-11-08 | 1996-06-05 | Asta Medica Ag | Verwendung von D,L- alpha-Liponsäure und/oder ihren Enantiomeren, und/oder ihren Derivaten als Zusatz bei Erythrozyten-Flüssigkonserven für homologe und autologe Erythrozyten-Konzentrate und als Zusatz bei Erythrozyten-Kryokonserven für homologe und autologe Erythrozytenkonzentrate |
| DE19519887C1 (de) * | 1995-05-31 | 1996-06-13 | Henkel Kgaa | Verfahren zur Epoxidierung olefinisch ungesättigter Verbindungen |
| US5783408A (en) * | 1995-06-07 | 1998-07-21 | Hamilton; Bradford S. | Method for screening potential anti-obesity agents |
| US6200606B1 (en) * | 1996-01-16 | 2001-03-13 | Depuy Orthopaedics, Inc. | Isolation of precursor cells from hematopoietic and nonhematopoietic tissues and their use in vivo bone and cartilage regeneration |
| JP4609807B2 (ja) * | 1996-03-28 | 2011-01-12 | 雪印乳業株式会社 | 骨強化用医薬、飲食品及び飼料 |
| JPH1017310A (ja) * | 1996-07-03 | 1998-01-20 | Ehime Pref Gov | コラーゲン、ヒドロキシアパタイトの製造方法及びその生成物 |
| US5980887A (en) * | 1996-11-08 | 1999-11-09 | St. Elizabeth's Medical Center Of Boston | Methods for enhancing angiogenesis with endothelial progenitor cells |
| US5830741A (en) * | 1996-12-06 | 1998-11-03 | Boehringer Mannheim Corporation | Composition for tissue dissociation containing collagenase I and II from clostridium histolyticum and a neutral protease |
| US5786207A (en) * | 1997-05-28 | 1998-07-28 | University Of Pittsburgh | Tissue dissociating system and method |
| JPH114682A (ja) * | 1997-06-16 | 1999-01-12 | Asahi Medical Co Ltd | 有核細胞保存方法、有核細胞保存用組成物及び有核細胞分離方法 |
| US6030836A (en) * | 1998-06-08 | 2000-02-29 | Osiris Therapeutics, Inc. | Vitro maintenance of hematopoietic stem cells |
| US6090121A (en) * | 1998-12-02 | 2000-07-18 | Weber; Paul J. | Highly flexible, reinforced swan neck liposuction cannulas |
| US6777231B1 (en) * | 1999-03-10 | 2004-08-17 | The Regents Of The University Of California | Adipose-derived stem cells and lattices |
| RU2306335C2 (ru) * | 1999-03-10 | 2007-09-20 | Юниверсити Оф Питтсбург Оф Дзе Коммонвелт Систем Оф Хайер Эдьюкейшн | Стволовые клетки и решетки, полученные из жировой ткани |
| US6316247B1 (en) * | 1999-06-15 | 2001-11-13 | University Of Pittsburgh | System and method for refining liposuctioned adipose tissue |
-
2002
- 2002-09-12 US US10/242,094 patent/US20030054331A1/en not_active Abandoned
- 2002-09-13 AU AU2002326901A patent/AU2002326901B2/en not_active Ceased
- 2002-09-13 CN CNA028226283A patent/CN1585602A/zh active Pending
- 2002-09-13 WO PCT/US2002/029207 patent/WO2003024215A1/en not_active Ceased
- 2002-09-13 EP EP02761654A patent/EP1427279A1/en not_active Withdrawn
- 2002-09-13 KR KR1020047003710A patent/KR100779812B1/ko not_active Expired - Fee Related
- 2002-09-13 JP JP2003528119A patent/JP2005502712A/ja active Pending
- 2002-09-13 CA CA002460402A patent/CA2460402A1/en not_active Abandoned
-
2009
- 2009-08-18 JP JP2009189198A patent/JP2009269930A/ja active Pending
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