US20070213822A1 - Treatment of the vertebral column - Google Patents

Treatment of the vertebral column Download PDF

Info

Publication number
US20070213822A1
US20070213822A1 US11353323 US35332306A US2007213822A1 US 20070213822 A1 US20070213822 A1 US 20070213822A1 US 11353323 US11353323 US 11353323 US 35332306 A US35332306 A US 35332306A US 2007213822 A1 US2007213822 A1 US 2007213822A1
Authority
US
Grant status
Application
Patent type
Prior art keywords
biological treatment
method
facet joint
biological
comprises
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US11353323
Inventor
Hai Trieu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warsaw Orthopedic Inc
Original Assignee
SDGI Holdings Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/70Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
    • A61B17/7061Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant for stabilising vertebrae or discs by improving the condition of their tissues, e.g. using implanted medication or fluid exchange
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/70Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
    • A61B17/7094Solid vertebral fillers; devices for inserting such fillers
    • A61B17/7095Solid vertebral fillers; devices for inserting such fillers the filler comprising unlinked macroscopic particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/34Trocars; Puncturing needles
    • A61B17/3478Endoscopic needles, e.g. for infusion
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/70Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
    • A61B17/7001Screws or hooks combined with longitudinal elements which do not contact vertebrae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/70Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
    • A61B17/7059Cortical plates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/70Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
    • A61B17/7062Devices acting on, attached to, or simulating the effect of, vertebral processes, vertebral facets or ribs ; Tools for such devices
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/70Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
    • A61B17/7062Devices acting on, attached to, or simulating the effect of, vertebral processes, vertebral facets or ribs ; Tools for such devices
    • A61B17/7064Devices acting on, attached to, or simulating the effect of, vertebral facets; Tools therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/44Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/442Intervertebral or spinal discs, e.g. resilient
    • A61F2/4425Intervertebral or spinal discs, e.g. resilient made of articulated components
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/44Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/442Intervertebral or spinal discs, e.g. resilient
    • A61F2002/444Intervertebral or spinal discs, e.g. resilient for replacing the nucleus pulposus

Abstract

A method is provided for treating a spinal condition. The method includes introducing a biological treatment into an area of a vertebral column, and mechanically unloading the treated area by applying a load-bearing device to the anterior region, the anterior column region, the posterior region, or the spinous process region of the vertebral column.

Description

    BACKGROUND
  • The present application relates generally to treatment of the vertebral column, for example, repairing or regenerating an area of the vertebral column, or reducing or preventing degeneration of an area of the vertebral column.
  • Disease, degradation, and trauma of the spine can lead to various conditions that require treatment to maintain, stabilize, or reconstruct the vertebral column. For example, degeneration of the facet joints and/or the intervertebral discs due to aging and/or trauma can lead to pain, neurological deficit and/or loss of motions that require treatment to maintain, stabilize, reconstruct and/or regenerate the degenerated levels. Repair/regeneration of such levels via a biological approach is technically challenging at least in part because of the high loading environment present in such levels. Reducing or preventing degeneration of an area of the vertebral column can be similarly challenging.
  • SUMMARY
  • The present application relates generally to treatment of the vertebral column, for example, repairing or regenerating an area of the vertebral column, or reducing or preventing degeneration of an area of the vertebral column.
  • In one embodiment, a method of treating a vertebral column includes introducing a biological treatment into an area of a vertebral column, and at least partially mechanically unloading the treated area. In one aspect, the treated area is mechanically unloaded by applying a load-bearing device to at least one region of the vertebral column. In certain aspects, the load-bearing device is applied to an anterior region, an anterior column region, a posterior region, or a spinous process region of the vertebral column.
  • In another embodiment, a method of treating a vertebral column includes introducing a biological treatment into a facet joint in a vertebral column, and at least partially mechanically unloading the treated facet joint. In one aspect, the treated facet joint is at least partially mechanically unloaded by applying a load-bearing device to an anterior column region adjacent to the treated area.
  • In another embodiment, a method of treating a vertebral column includes introducing a biological treatment into a disc space in a vertebral column, and at least partially mechanically unloading the treated disc space. In one aspect, the treated disc space is unloaded by applying a load-bearing device to an anterior column region adjacent to the treated area.
  • In another embodiment, a method for treating a motion segment of a vertebral column includes accessing a portion of the patient's spinal column, implanting a load-bearing device into the motion segment, and injecting a biological treatment into the motion segment. The load-bearing device at least partially mechanically unloads the motion segment. In one such embodiment, the motion segment of the vertebral column is intact.
  • Additional embodiments are provided in the following description and the attached drawings.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • FIG. 1 is a sagittal view of a motion segment of a vertebral column.
  • FIG. 2 is a superior view of a vertebral body depicted in FIG. 1.
  • FIGS. 3-4 illustrate methods for applying a biological treatment to a facet joint in a vertebral column.
  • FIGS. 5-6 illustrate methods for applying a biological treatment to a disc space in a vertebral column.
  • FIGS. 7A-7F illustrate methods for applying a biological treatment to a vertebral body and/or an endplate.
  • FIGS. 8A-8C illustrate alternative methods for applying a biological treatment to a disc space in a vertebral column.
  • FIGS. 9-10 are sagittal views of a motion segment of a vertebral column to which a biological treatment has been applied in combination with a mechanical unloading device.
  • DETAILED DESCRIPTION
  • The present disclosure relates generally to treatment of the vertebral column, for example, repairing or regenerating an area of the vertebral column, or reducing or preventing degeneration of an area of the vertebral column.
  • Certain embodiments describe methods for treating motion segments of the spinal column and components thereof. Such embodiments include but are not limited to treating facet joints, intervertebral discs, vertebral bodies and endplates using a biological approach in combination with a mechanical unloading device that is at least partially load-bearing with respect to the treated area such that it at least partially unloads the treated area.
  • For the purposes of promoting an understanding of the principles of the invention, reference will now be made to the embodiments, or examples, illustrated in the drawings and specific language will be used to describe the same. It will nevertheless be understood that no limitation of the scope of the invention is thereby intended. Any alterations and further modifications in the described embodiments, and any further applications of the principles of the invention as described herein are contemplated as would normally occur to one skilled in the art to which the invention relates.
  • Referring now to FIGS. 1 and 2, the reference numeral 10 refers to a motion segment of a vertebral column. Motion segment 10 comprises an intervertebral disc 25 and a facet joint 26. Motion segment 10 may be considered as having several regions extending from anterior to posterior. These regions include an anterior region 12, an anterior column region 14, a posterior region 16, and a spinous process region 18. The anterior column region 14 may be further considered to have several regions extending longitudinally along the column. These regions include a vertebral body region 20, an endplate region 22, and a disc space region 24. Disc space region 24 includes the nucleus and annulus forming intervertebral disc 25.
  • Any of the regions illustrated in FIGS. 1 and 2 may benefit from a biological treatment as described herein. In certain embodiments, the biological treatment is non-load bearing. In certain aspects, a non-load bearing biological treatment comprises a composition that is applied without an associated support or structure. Treatment/treating of the vertebral column includes repair and/or regeneration of a degenerated area of the vertebral column, and/or reduction or prevention of degeneration of an area of the vertebral column. Methods for treating the vertebral column with a biological treatment and a device that is at least partially load-bearing with respect to the treated area such that the device at least partially mechanically unloads the treated area are described herein.
  • As used herein, a “biological treatment” includes but is not limited to a “biologically active component”, with or without a “biological additive”.
  • A “biologically active component” includes but is not limited to anti-cytokines; anti-interleukin-1 components (anti-IL-1); anti-TNF alpha; “growth factors”; LIM mineralization proteins; “stem cell material”, autogenic chondrocytes; allogenic chondrocytes, such as those described in U.S. Patent Application Publication No. 2005/0196387, the entire disclosure of which is incorporated herein by reference; autogenic chondrocytes with retroviral viral vector or plasmid viral vector; allogenic chondrocytes with retroviral viral vector or plasmid viral vector; and fibroblasts. The acronym “LIM” is derived from the three genes in which the LIM domain was first described. The LIM domain is a cysteine-rich motif defined by 50-60 amino acids with the consensus sequence CX2C16-23HX2CX2CX2CX16-21CX2(C/H/D), which contains two closely associated zinc-binding modules. LIM mineralization proteins include but are not limited to those described in U.S. Patent Application Publication No. 2003/0180266 A1, the disclosure of which is incorporated herein by reference. “Growth factors” include but are not limited to transforming growth factor (TGF)-beta 1, TGF-beta 2, TGF-beta 3, bone morphogenetic protein (BMP)-2, BMP-3, BMP-4, BMP-6, BMP-7, BMP-9, fibroblast growth factor (FGF), platelet derived growth factor (PDGF), insulin-like growth factor (ILGF); human endothelial cell growth factor (ECGF); epidermal growth factor (EGF); nerve growth factor (NGF); and vascular endothelial growth factor (VEGF). “Anti-IL-1” components include but are not limited to those described in U.S. Patent Application Publication Nos. 2003/0220283 and 2005/0260159, the entire disclosures of which are incorporated herein by reference. “Stem cell material” includes but is not limited to dedifferentiated stem cells, undifferentiated stem cells, and mesenchymal stem cells. “Stem cell material” also includes but is not limited to stem cells extracted from marrow, which may include lipo-derived stem cell material and adipose-derived stem cell material, such as described in U.S. Publication Nos. 2004/0193274 and 2005/0118228, each of which is incorporated herein by reference. “Stem cell material” also includes but is not limited to stem cells derived from adipose tissue as described in U.S. Patent Application Publication Nos. 2003/0161816, 2004/0097867 and 2004/0106196, each of which is incorporated herein by reference.
  • A “biologically active component” also includes but is not limited to cartilage derived morphogenetic protein (CDMP); cartilage inducing factor (CIP); proteoglycans; hormones; and matrix metalloproteinases (MMP) inhibitors, which act to inhibit the activity of MMPs, to prevent the MMPs from degrading the extracellular matrix (ECM) produced by cells within the nucleus pulposus of the disc. Exemplary MMP inhibitors include but are not limited to tissue inhibitors, such as TIMP-1 and TIMP-2. Certain MMP inhibitors are also described in U.S. Patent Application Publication No. 2004/0228853, the entire disclosure of which is incorporated herein by reference.
  • A “biologically active component” also includes but is not limited to allogenic or xenogenic disc annulus material, such as described in U.S. Patent Application Publication No. 2005/0043801, the entire disclosure of which is incorporated herein by reference; biologic tissues, such as those described in U.S. Patent Application Publication No. 2003/0004574, the entire disclosure of which is incorporated herein by reference; an activated tissue graft, such as described in U.S. Patent Application Publication No. 2005/0136042, the entire disclosure of which is incorporated herein by reference; an engineered cell comprising a nucleic acid for encoding a protein or variant thereof, such as a BMP, a LIM mineralization protein, or an SMAD protein as described in U.S. Patent Application Publication Nos. 2003/0219423 and 2003/0228292, the entire disclosures of which are incorporated herein by reference; and a recombinant human bone morphogenetic protein, such as described in U.S. Patent Application Publication No. 2004/0024081, the entire disclosure of which is incorporated herein by reference.
  • As used herein, a “biological additive” includes but is not limited to “biomaterial carriers”, “therapeutic agents”, “liquids” and “lubricants.”
  • “Biomaterial carriers” include but are not limited to collagen, gelatin, hyaluronic acid, fibrin, albumin, keratin, silk, elastin, glycosaminoglycans (GAGs), polyethylene glycol (PEG), polyethylene oxide (PEO), polyvinyl alcohol (PVA) hydrogel, polyvinyl pyrrolidone (PVP), co-polymers of PVA and PVP, other polysaccharides, platelet gel, peptides, carboxymethyl cellulose, and other modified starches and celluloses. Collagen includes but is not limited to collagen-based material, which may be autogenic, allogenic, xenogenic or of human-recombinant origin, such as the collagen-based material described in U.S. Patent Application Publication Nos. 2004/0054414 and 2004/0228901, the entire disclosures of which are incorporated herein by reference.
  • “Therapeutic agents” include but are not limited to nutrients, analgesics, antibiotics, anti-inflammatories, steroids, antiviricides, vitamins, amino acids and peptides. Nutrients include but are not limited to substances that promote disc cell survival, such as glucose and pH buffers, wherein the pH buffer provides a basic environment in the disc space, which preferably will be a pH of about 7.4. Analgesics include but are not limited to hydrophilic opoids, such as codeine, prodrugs, morphine, hydromorphone, propoxyphene, hydrocodone, oxycodone, meperidine and methadone, and lipophilic opoids, such as fentanyl. Antibiotics include but are not limited to erythromycin, bacitracin, neomycin, penicillin, polymyxin B, tetracyclines, viomycin, chloromycetin and streptomycins, cefazolin, ampicillin, azactam, tobramycin, clindamycin and gentamycin.
  • “Liquids” include but are not limited to water, saline and radio-contrast media. Radio-contrast media includes but is not limited to barium sulfate, or a radio contrast dye, such as sodium diatrizoate (HYPAQUE™).
  • “Lubricants” include but are not limited to hyaluronic acid, a salt of hyaluronic acid, sodium hyaluronate, glucosaminoglycan, dermatan sulfate, heparin sulfate, chondroitin sulfate, keratin sulfate, synovial fluid, a component of synovial fluid, vitronectin and rooster comb hyaluronate.
  • A biological treatment may be introduced to an area of a vertebral column, such as a motion segment, by any method and in any form appropriate for such introduction. For example, the biological treatment can be injected, deposited, or applied, as a solution, a suspension, emulsion, paste, a particulate material, a fibrous material, a plug, a solid, porous, woven or non-woven material, or in a dehydrated or rehydrated state. Suitable forms for a biological treatment and suitable methods for injecting a biological treatment include those described in U.S. Patent Application Publication Nos. 2005/0267577, 2005/0031666, 2004/0054414, and 2004/0228901, each of which is incorporated herein by reference.
  • For example, referring now to FIG. 3, a biological treatment 30 may be injected into the joint capsule 32 of a facet joint 34 through a hypodermic needle 36 attached to a syringe 38. The syringe 38 is inserted into the joint capsule 32, and the syringe plunger 40 is depressed, thereby releasing the biological treatment into the joint capsule of the facet joint. As illustrated by the arrows in FIG. 3, the needle/syringe assembly may be moved around within the joint capsule, sweeping from side to side and back and forth, to ensure uniform distribution of the biological treatment within the facet joint. It is preferred, however, that the tip of the needle be maintained near the center of the joint capsule to ensure deposition of the material within the desired area, and to minimize potential leakage.
  • Referring now to FIG. 4, another method for injecting a biological treatment into a facet joint is illustrated. According to the embodiment illustrated in FIG. 4, a biological treatment 42 is provided in the form of microspheres, powders, particulates, pellets, granules, a plug, a solid, porous, woven or non-woven material. Biological treatment 42 may be compressed into a size suitable for delivery through a cannula 44 by pressure and/or heat and/or insertion through a small diameter tube. The delivery cannula 44 is attached to a dilator 46. The biological treatment 42 is inserted into a facet joint 48 by penetrating the capsule 50 of the facet joint with a guide needle 52. Dilator 46, preferably with delivery cannula 44 already attached, is inserted over guide needle 52. A plunger 54 may be used to push the biological treatment from the cannula into the facet joint. The form of the biological treatment may expand upon exiting the dilator, and may further expand as it hydrates or rehydrates in the facet joint.
  • Referring now to FIG. 5, a method for injecting a biological treatment into a disc space is illustrated. According to the embodiment illustrated in FIG. 5, a biological treatment 56 may be injected into the nucleus pulposus 58 contained within a disc annulus 60 in an intervertebral disc space 62. Biological treatment 56 is injected through a hypodermic needle 64 attached to a syringe 66. The syringe 66 is inserted into the nucleus pulposus, and the syringe plunger 68 is depressed, thereby releasing the biological treatment into the disc space 62. As illustrated by the arrows in FIG. 5, the needle/syringe assembly may be moved around, sweeping from side to side and back and forth, to ensure uniform distribution of the biological treatment within the disc space. It is preferred, however, that the tip of the needle be maintained near the center of the disc space to ensure deposition of the material within the nucleus of the disc, and to minimize potential leakage.
  • Referring now to FIG. 6, another method for injecting a biological treatment into a disc space is illustrated. According to the embodiment illustrated in FIG. 6, a biological treatment 68 is provided in the form of granules, a plug, a solid, porous, woven or non-woven material. Biological treatment 68 may be compressed into a size suitable for gdelivery through a cannula 70 by pressure and/or heat and/or insertion through a small diameter tube. The delivery cannula 70 is attached to a dilator 72. The biological treatment 68 is inserted into the nucleus pulposus 74 by penetrating the annulus 76 of the disc with a guide needle 78. Dilator 72, preferably with delivery cannula 70 already attached, is inserted over guide needle 78. A plunger 80 may be used to push the biological treatment from the cannula into the nucleus pulposus. The form of the biological treatment may expand upon exiting the dilator, and may further expand as it hydrates or rehydrates.
  • Referring now to FIGS. 7A-7F, a method of injecting a biological treatment into a vertebral body and/or an endplate is illustrated.
  • With reference now to FIG. 7A, a channel 86 can be created in vertebral body 84 through the pedicle using a suitable bone-penetrating implement such as a trocar needle 88. A sheath 90 (FIG. 7B) can be inserted into channel 86 through which various procedures can be implemented. FIG. 7C shows a subsequent step in which a flexible or otherwise steerable device 92, such as a needle or drill, is positioned through sheath 90 to access regions nearing the endplate of vertebral body 84. Although FIG. 7C illustrates positioning sheath 90 to access regions near the endplate of vertebral body 84, sheath 90 could also be positioned so as to access regions more central to the vertebral body itself, as opposed to the endplate.
  • Referring still to FIG. 7C, several directional passes of the steerable device 92 may be used in order to create access to a broader volume of bone. The tip 93 of steerable device 92 can be designed so as to be steerable, for instance by rotation of steerable device 92. As illustrated in FIG. 7D, after accessing near the endplate, (or to the vertebral body itself in other embodiments), the steerable device 92 can be withdrawn, and a delivery device 94 can be inserted through sheath 90. Delivery device 94 can have delivery tip 95, which is curved or otherwise steerable. Delivery device 94 can also include a reservoir 96 and a plunger 97, allowing for the delivery of a biological treatment 98 out of delivery tip 93. FIG. 7E shows an intermediate stage of the delivery process in which additional amounts of the biological treatment 98 are delivered as the sheath 90 and the delivery device 94 are withdrawn from the access channel 86. In this manner, the access channel 86 can be backfilled with the biological treatment 98 as the implements are withdrawn. Finally, shown in FIG. 7F is the biological treatment 98 occupying a volume overlying an endplate of the vertebral body 84, and also backfilled into the access channel 86.
  • Referring now to FIGS. 8A-8C, another method of injecting a biological treatment into a vertebral body and/or an endplate is illustrated.
  • With reference now to FIG. 8A, an access channel 200 is created in vertebral body 202 just above the endplate using a bone-penetrating implement 204, for example, a needle. After this access, a sheath 206 is provided into channel 200. A delivery device 208 is then inserted through the lumen of sheath 206 and is used to deliver a biological treatment 210 into the vertebral body in a volume overlying the endplate. If desired or needed, a steerable needle or drill can be used to create access to a broader volume of bone, generally as described in conjunction with FIGS. 7A through 7F above. As well, a backfilling procedure can be used to fill the access channel 200 as the delivery device 208 and sheath 206 are removed. As shown in FIG. 8C, ultimately, a volume of the biological treatment 210 is delivered into the vertebral body overlying the endplate.
  • In other embodiments, a biological treatment may be introduced into an area of a vertebral column, such as a motion segment, through a needle/trocar assembly, as described in the above-referenced U.S. Patent Application Publication Nos. 2005/0031666. In still other embodiments, a biological treatment may be introduced into an area of a vertebral column by extrusion through a dilated annular opening, infusion through a catheter, insertion through an opening created by trauma or surgical incision, or by other means of invasive or minimally invasive deposition of materials into the area receiving the biological treatment.
  • According to certain embodiments described herein, when treating a vertebral column with a biological treatment, the load to be imposed on the treated area and/or on surrounding areas is also considered. For example, it can be noted whether the load imposed on a motion segment being treated would adversely affect the success of a biological treatment applied to the motion segment in achieving the desired repair, regeneration, reduction or prevention. By reducing the load imposed on the treated motion segment, the biological treatment is provided an opportunity to perform its function in an area that is less stressed, and therefore more receptive to the intended function of the biological treatment.
  • Thus, to achieve an improved clinical outcome and a stable result, biological treatments are applied in one or more of the anterior region, anterior column region, posterior region, and spinous process region of a vertebral column, while load-bearing devices and systems for treatment of one or more of the anterior region, anterior column region, posterior region, and spinous process region are also applied to provide a mechanical unloading of the region receiving the biological treatment.
  • Biological Treatment of Facet Joint and/or Disc Space Combined with Anterior Systems
  • Referring now to FIG. 9, a combined treatment of a vertebral motion segment 100 with a biological treatment and a load-bearing device for treatment of the anterior region 120 of the spine is illustrated.
  • A biological treatment 102 has been applied to facet joint 104 by injection with an appropriately sized syringe/hypodermic needle assembly 106. Selection of an appropriately sized syringe/hypodermic needle assembly for injection into the facet joints of a spine is within the purview of one of ordinary skill in the art. Suitable methods for injecting the biological treatment 102 into the facet joint 104 are described above with respect to FIGS. 3 and 4. Other methods as described herein and as are known to those of ordinary skill in the art may also be used.
  • In the embodiment illustrated in FIG. 9, a biological treatment 108 has also been applied to disc space 110, which could include treatment of either or both of the nucleus pulposus and the annulus, with an appropriately sized hypodermic needle 112. Selection of an appropriately sized hypodermic needle for injection into the disc space of a spine is within the purview of one of ordinary skill in the art. Suitable methods for injecting the biological treatment 108 into the disc space 116 are described above with respect to FIGS. 5 and 6. Other methods as described herein and as are known to those of ordinary skill in the art may also be used.
  • Although two biological treatments 102 and 108 are illustrated, the present disclosure contemplates and includes application of just one biological treatment, or of two or more biological treatments. Moreover, biological treatments can be applied in one or more of the anterior longitudinal ligament, the vertebral bodies, and the endplates of the vertebral bodies.
  • According to the embodiment illustrated in FIG. 9, the treatment of facet joint 104 and the disc space 110 with biological treatments 102 and 108 is combined with an anterior device designed for treatment of the anterior region 120 of the vertebral motion segment 100. The anterior device is represented in FIG. 9 by anterior device 114, however the appearance of anterior device 114 is illustrative only, and it is understood that a wide variety of anterior devices could be used with the present embodiments. Further, it is contemplated that separately or in combination with biological treatment 108, an interbody spacer (not shown) may be placed in the disc space to at least partially mechanically unload the facet and/or a portion of the disc space.
  • Anterior device 114 may be an elastic anterior tension band, attachable to the adjacent vertebral bodies with bone screws 115. In other embodiments, anterior device 114 could comprise any synthetic or natural tissue based prostheses for replacing or supplementing the anterior longitudinal ligament. In still other embodiments, anterior device 114 could comprise anterior bone fixation plates for the cervical, thoracic, or lumbar vertebral regions. Such plates may include those offered by or developed by Medtronic, Inc. of Minneapolis, Minn. under brand names such as the ATLANTIS plate, PREMIER plate, ZEPHIR plate, MYSTIC plate, PYRAMID plate, or DYNALOK CLASSIC plate, CD HORIZON ECLIPSE.
  • Suitable anterior devices may be formed from a biocompatible material selected from metals, polymers, ceramics, and tissue, and combinations thereof. A suitable configuration could be a metal plate, such as titanium, titanium alloy, nickel titanium, tantalum, or stainless steel plate. Alternatively, anterior devices may be formed of elastomer-based devices, or polymeric composite-based devices that connect with two or more vertebrae. Anterior devices may also be formed of less rigid or more flexible materials such as polyaryletherketone (PAEK)-based materials, which includes polyetheretherketone (PEEK), polyetherketoneketone (PEKK), PEEK-carbon composite, polyetherimide, polyimide, polysulfone, polyethylene, polyester, polylactide, copolymers of poly L-lactide and poly D-lactide, polyorthoester, tyrosine polycarbonate, polypolyurethane, silicone, polyolefin rubber, etc., and combinations thereof. In some embodiments, the anterior device may be bioresorbable or partially resorbable.
  • Anterior devices may also be formed of inelastic material, such as braided tethers or woven textiles, for example polyester or polyethylene, or of elastic material, such as rubber banding or plates, sheets, rods, or tubing made of silicone or polyurethane. In still another alternative, an anterior device may include annulus repair or replacement devices for the anterior portion of the annulus.
  • The selected anterior device may be connected to two or more vertebral bodies or vertebral endplates through the use of any connection mechanism such as bone screws, staples, sutures, or adhesives, or other applicable devices. The anterior device may be loaded in compression or tension depending upon the patient's indication or the performance of biological treatments, such as biological treatments 102 and/or 108. For example, an anterior plate may be installed in tension to be load-bearing with respect to facet joint 104, thereby reducing the load on facet joint 104 where the biological treatment 102 was introduced. Such a technique can be further enhanced with the use of an interbody spacer.
  • Biological Treatment of Facet Joint and/or Vertebral Body and/or Endplate Combined with Anterior Column Systems
  • Referring now to FIG. 10, a combined treatment of a vertebral motion segment 130 with a biological treatment and a load-bearing device for treatment of the anterior column region 142 of the spine is illustrated.
  • A biological treatment 132 has been introduced into facet joint 134 by injection with an appropriately sized hypodermic needle 136. Selection of an appropriately sized hypodermic needle for injection into the facet joints of a spine is within the purview of one of ordinary skill in the art. Suitable methods for introducing biological treatment 132 into the facet joint 134 are described above with respect to FIGS. 3 and 4. Other methods as described herein and as are known to those of ordinary skill in the art may also be used.
  • In the embodiment illustrated in FIG. 10, biological treatments 138 and 140 have also been applied to the vertebral bodies and endplates, respectively. Suitable methods for introducing biological treatments 138 and 140 into the vertebral bodies and endplates are described above with respect to FIGS. 7A-7F and 8A-8C. Other methods as described herein and as are known to those of ordinary skill in the art may also be used.
  • Although three biological treatments 132, 138 and 140 are illustrated, the present disclosure contemplates and includes application of just one biological treatment, or of two or more biological treatments. Moreover, biological treatments can be applied in other areas of the spine, for example, biological treatments can be applied to the disc space, including the nucleus and/or the annulus of the disc, and the anterior longitudinal ligament.
  • According to the embodiment illustrated in FIG. 10, the treatment of facet joint, the endplates and the vertebral bodies with biological treatments is combined with an anterior column device designed for treatment of the anterior column region 142 of the vertebral motion segment 130. The anterior column device is represented in FIG. 10 by an anterior column device 146 designed for treatment of disc space 144, however the appearance of anterior column device 146 is illustrative only, and it is understood that a wide variety of anterior column devices could be used with the present embodiments.
  • Anterior column device 146 may be a prosthetic motion-preserving disc, such as those offered by or developed by Medtronic, Inc. under brand names such as MAVERICK, BRYAN, PRESTIGE, or PRESTIGE LP. Single articulating surface motion preserving discs may be disclosed more fully in U.S. Pat. Nos. 6,740,118; 6,113,637; or 6,540,785, each of which is incorporated by reference herein. Double articulating surface motion preserving discs may be disclosed more fully in U.S. Pat. Nos. 5,674,296; 6,156,067; or 5,865,846, each of which is incorporated by reference herein.
  • In some embodiments, anterior column device 146 may be a motion-preserving interbody device that extends posteriorly from the interbody space and includes features for providing posterior motion. These types of bridged systems may be disclosed in U.S. Pub. Pat. App. Nos. 2005/0171610; 2005/0171609; 2005/0171608; 2005/0154467; 2005/0154466; 2005/0154465; 2005/0154464; 2005/0154461, each of which is incorporated by reference herein.
  • According to other embodiments, anterior column device 146 may include rigid fusion devices, such as those offered by or developed by Medtronic, Inc. of Minneapolis, Minn. under brand names such as INTERFIX cage, INTERFIX RP cage, LT cage, CORNERSTONE spacer, TELAMON spacer, MDII and MDIII threaded bone dowels, PRECISION GRAFT and PERIMETER ring spacers, etc.
  • According to still other embodiments, anterior column device 146 may include a spherical, ellipsoidal or similarly shaped disc replacement device, which may be installed in the interbody space. Such devices may include the SATELLITE system offered by or developed by Medtronic, Inc. This type of device may be described in detail, for example, in U.S. Pat. No. 6,478,822, which is incorporated by reference herein.
  • In still another embodiment, anterior column device 146 may be an elastically deformable device comprising a resilient or an elastomeric material such as silicone, polyurethane, polyolefin rubber or a resilient polymer, and/or may comprise a mechanical spring component. Such elastically deformable devices include those with an elastomeric core disposed between rigid outer plates, as described for example, in U.S. Pat. Nos. 6,669,732; 6,592,664 and 6,162252, each of which is incorporated by reference. Such devices may also include the ACROFLEX lumber disc offered by or developed by Depuy-Acromed, Inc. In some embodiments, the anterior column device may be bioresorbable or partially resorbable.
  • In still other embodiments, anterior column device 146 may include interbody motion-preserving devices, such as nucleus replacement implants that work in conjunction with all or portions of the natural annulus. Such nucleus replacement implants may include those offered by or developed by Medtronic, Inc under a brand name such as NAUTILUS or offered by or developed by Raymedica, Inc. of Minneapolis, Minn. under brand names such as PDN-SOLO® and PDN-SOLO XL™. These types of nucleus replacement implants may be described in detail in, for example, U.S. Pat. Nos. 6,620,196 and 5,674,295, each. of which is incorporated by reference herein. Injectable nucleus replacement material including a polymer based system such as DASCOR™ by Disc Dynamics of Eden Prairie, Minn. or a protein polymer system such as NuCore™ Injectable Nucleus by Spine Wave, Inc. of Shelton, Conn. may be alternatives for preserving interbody motion.
  • In still other embodiments, anterior column device 146 comprises a device for treating a vertebral body in the anterior column region of the spine. Devices for treating a vertebral body that are suitable for combination with the methods described herein include void creation devices and vertebral compression fracture realignment devices for vertebral body repair, such as balloon expansion systems offered by or developed by Kyphon, Inc. of Glendale, Calif. Examples of such balloon expansion systems are disclosed in U.S. Pub. Nos. 2004/0102774 and 20040133280 and U.S. Pat. Nos. 4,969,888 and 5,108,404, all of which are incorporated by reference herein. Other void creation devices that utilize expandable cages or displacement systems may also be used for vertebral body repair. Such additional void creation systems may be disclosed in U.S. Published Pat. App. No. 2004/0153064 and 2005/0182417 and are incorporated by reference herein. In still another alternative, vertebral body replacement devices or corpectomy devices may be used to replace an entire vertebrae or series of vertebrae. Such corpectomy systems may be of the type disclosed, for example, in U.S. Pat. Nos. 5,702,453; 5,776,197; 5,5776,198; or 6,344,057, each of which is incorporated by reference herein.
  • In still further embodiments, anterior column device 146 comprises a device for treating an endplate of a vertebral body in the anterior column region of the spine. Devices for treating an endplate that are suitable for combination with the methods described herein include but are not limited to endplate supplementation systems that use rigid or flexible devices such as metal plates with spikes or other attachment mechanisms to anchor the plates to existing bony tissue.
  • Anterior column device 146 may be formed from biocompatible materials such as metals, polymers, ceramics, and tissue, and combinations thereof. In certain embodiments, anterior column device 146 may be resorbable or partially resorbable.
  • Any of the foregoing anterior column devices may be combined with any biological treatment. For example, in certain embodiments, a biological treatment comprising injectable collagen containing stem cells and BMP-6 is applied to a facet joint in a vertebral column. A nucleus replacement implant such as a NAUTILUS brand implant (Medtronic, Inc.) is inserted into the nucleus of a disc adjacent to the facet joint receiving the biological treatment to provide a mechanical unloading to the treated facet joint.
  • In other embodiments, a biological treatment comprising an injectable polyvinyl alcohol hydrogel containing chondrocytes and TGF-beta 2 is applied to a facet joint. A prosthetic motion-preserving disc, such as a MAVERICK brand implant (Medtronic, Inc.) is inserted into the disc space adjacent to the facet joint receiving the biological treatment to provide a mechanical unloading to the treated facet joint.
  • In still other embodiments, a biological treatment comprising injectable polyethylene glycol gel containing fibroblasts and TGF-beta is applied to a facet joint. An injectable collagen is inserted into the disc space adjacent to the facet joint receiving the biological treatment to provide a mechanical unloading to the treated facet joint.
  • In yet other embodiments, a biological treatment comprising an injectable porcine-based collagen containing anti-TNF alpha and ILGF is applied to a facet joint. An injectable nucleus replacement material, such as the polymer based system DASCOR™ (Disc Dynamics) is applied to the disc space adjacent to the facet joint receiving the biological treatment to provide a mechanical unloading to the treated facet joint.
  • Anterior column device 146 may be loaded in compression or tension depending upon the patient's indication or the performance of other implanted systems or treatments. These interbody systems may provide a desired level of intervertebral disc space distraction, depending upon the patient's indication. For example, an interbody device or system may be sized or filled to reduce the load on the facet joint 134 where the biological treatment 132 was introduced.
  • According to one embodiment, a procedure for performing the methods described herein includes surgically accessing at least a portion of a patient's spine, and implanting a load-bearing device in the patient's spine. In one aspect, the load-bearing device is implanted so as to mechanically unload all or a portion of the facet joint and/or the disc space, which receives a biological treatment. In another aspect, the load-bearing device is implanted into an area of the spine that is intact, for example, a motion segment where the anatomy has not been surgically disrupted. In another aspect, the anatomy of the area of the spine in which the load-bearing device is being implanted has been surgically disrupted, for example, a resection of the facet or the spinous process, or even a discectomy, has been performed.
  • Whether the spinal anatomy is intact or has been disrupted, the load-bearing device is device is implanted in to the spine in a position so as to be at least partially load-bearing with respect to the area that is to receive a biological treatment. The device thus mechanically unloads all or a portion of the area to receive the biological treatment. For example, a motion-preserving device may be placed in the disc space located in the anterior column portion of the spine to transfer load away from the disc space and/or the facets. In one aspect, the facet joints and/or the adjacent vertebral bodies surrounding the disc space are mechanically moved by placement of the mechanical unloading device to align the facet joint and/or increase the distance between the adjacent vertebral bodies. After application of the mechanical unloading device, a biological treatment is applied to at least one facet and/or the disc space. In another aspect, the above-described steps may be reversed such that the biological treatment of the facet joint and/or the disc space occurs first, and the mechanical unloading occurs later.
  • Although only a few exemplary embodiments have been described in detail above, those skilled in the art will readily appreciate that many modifications are possible in the exemplary embodiments without materially departing from the novel teachings and advantages of this disclosure. Accordingly, all such modifications and alternative are intended to be included within the scope of the invention as defined in the following claims. Those skilled in the art should also realize that such modifications and equivalent constructions or methods do not depart from the spirit and scope of the present disclosure, and that they may make various changes, substitutions, and alterations herein without departing from the spirit and scope of the present disclosure.
  • For example, each of the following patent applications are incorporated herein by reference, as each describes spinal devices that can be applied to the anterior, anterior column, posterior, or spinous process regions of the vertebral column, and that can be used to unload an area treated with a biological treatment as described herein.
    Attorney
    Docket
    Title No. Filing Date Inventor(s)
    Materials, Devices, and P22656.00 Jan. 13, 2006 Hai H. Trieu
    Methods for Treating 31132.378
    Multiple Spinal Regions
    Including The Interbody
    Region
    Materials, Devices, and P22578.00 Jan. 13, 2006 Hai H. Trieu
    Methods for Treating 31132.376
    Multiple Spinal Regions
    Including The Posterior
    and Spinous
    Process Regions
    Materials, Devices, and P22615.00 Jan. 13, 2006 Hai H. Trieu
    Methods for Treating 31132.377
    Multiple Spinal Regions
    Including The Anterior
    Region.
    Materials, Devices, and P22681.00 Jan. 13, 2006 Hai H. Trieu
    Methods for Treating 31132.379
    Multiple Spinal Regions
    Including Vertebral Body
    and Endplate Regions
    Use Of A Posterior P22397.00 Jan. 13, 2006 Aure Bruneau et
    Dynamic Stabilization 31132.420 al.
    System With An
    Interdiscal Device
  • In addition, each of the following applications describes suitable biological treatments that can be applied to an area of the vertebral column, and spinal devices that can be applied to the anterior, anterior column, posterior, or spinous process regions of the vertebral column to unload the treated area. Each of the following applications was filed concurrently with the present application, assigned to the same assignee, and each is hereby incorporated by reference.
    Attorney Docket
    Title No. Filing Date Inventor(s)
    Treatment of the P23558.00 concurrent with Hai H. Trieu
    Vertebral Column 31132.476 the present
    application
    Treatment of the P23556.00 concurrent with Hai H. Trieu
    Vertebral Column 31132.474 the present
    application
    Treatment of the P23557.00 concurrent with Hai H. Trieu
    Vertebral Column 31132.475 the present
    application
    Biological Fusion P23568.00 concurrent with Hai H. Trieu
    in the Vertebral 31132.478 the present Mike Sherman
    Column application
    Treatment of the P23559.00 concurrent with Hai H. Trieu
    Vertebral Column 31132.477 the present
    application
  • It is understood that all spatial references, such as “horizontal,” “vertical,” “top,” “inner,” “outer,” “bottom,” “left,” “right,” “anterior,” “posterior,” “superior,” “inferior,” “upper,” and “lower” are for illustrative purposes only and can be varied within the scope of the disclosure. In the claims, means-plus-function clauses are intended to cover the elements described herein as performing the recited function and not only structural equivalents, but also equivalent elements.

Claims (25)

  1. 1. A method of treating a vertebral column comprising:
    introducing a biological treatment into at least one area of a vertebral column selected from a facet joint, a disc space, a vertebral body and an endplate; and
    at least partially mechanically unloading the treated area by applying a load-bearing device to at least an anterior column region of the vertebral column.
  2. 2. The method of claim 1 wherein the biological treatment comprises a biologically active component.
  3. 3. The method of claim 2 wherein the biological treatment further comprises a biological additive.
  4. 4. The method of claim 3 wherein the biological additive comprises at least one of a biomaterial carrier, a therapeutic agent, a liquid and a lubricant.
  5. 5. The method of claim 3 wherein the biological additive is selected from autogenic collagen, allogenic collagen, xenogenic collagen, human recombinant collagen, gelatin, hyaluronic acid, fibrin, albumin, keratin, silk, elastin, glycosaminoglycans (GAGs), polyethylene glycol (PEG), polyethylene oxide (PEO), polyvinyl alcohol (PVA) hydrogel, polyvinyl pyrrolidone (PVP), co-polymers of PVA and PVP, polysaccharides, platelet gel, peptides, carboxymethyl cellulose, modified starches and celluloses.
  6. 6. The method of claim 3 wherein the biological additive is selected from nutrients, analgesics, antibiotics, anti-inflammatories, steroids, antiviricides, vitamins, amino acids and peptides.
  7. 7. The method of claim 6 wherein the biological additive comprises at least one of:
    an analgesic selected from codeine, prodrugs, morphine, hydromorphone, propoxyphene, hydrocodone, oxycodone, meperidine, methadone, and fentanyl; and
    an antibiotic selected from erythromycin, bacitracin, neomycin, penicillin, polymyxin B, tetracyclines, viomycin, chloromycetin, streptomycins, cefazolin, ampicillin, azactam, tobramycin, clindamycin and gentamycin.
  8. 8. The method of claim 3 wherein the biological additive is selected from water, saline, radio-contrast media, hyaluronic acid, a salt of hyaluronic acid, sodium hyaluronate, glucosaminoglycan, dermatan sulfate, heparin sulfate, chondroitin sulfate, keratin sulfate, synovial fluid, a component of synovial fluid, vitronectin and rooster comb hyaluronate.
  9. 9. The method of claim 1 wherein the biological treatment comprises a biologically active component selected from anti-cytokines; anti-interleukin-1 components (anti-IL-1); anti-TNF alpha; growth factors; LIM mineralization proteins; stem cell material, autogenic chondrocytes; allogenic chondrocytes, autogenic chondrocytes with one of a retroviral viral vector or a plasmid viral vector; allogenic chondrocytes with one of a retroviral viral vector or a plasmid viral vector; and fibroblasts;
  10. 10. The method of claim 1 wherein the biological treatment comprises a biologically active component selected from transforming growth factors, bone morphogenetic proteins, fibroblast growth factors, platelet derived growth factor (PDGF), insulin-like growth factor (ILGF); human endothelial cell growth factor (ECGF); epidermal growth factor (EGF); nerve growth factor (NGF); and vascular endothelial growth factor (VEGF).
  11. 11. The method of claim 10 wherein the biologically active component comprises at least one of a transforming growth factor selected from TGF-beta 1, TGF-beta 2, and TGF-beta 3, and a bone morphogenetic protein selected from BMP-2, BMP-3, BMP-4, BMP-6, BMP-7, and BMP-9.
  12. 12. The method of claim 1 wherein the biological treatment comprises stem cell material selected from dedifferentiated stem cells, undifferentiated stem cells, mesenchymal stem cells, marrow-extracted stem cell material and adipose-derived stem cell material.
  13. 13. The method of claim 1 wherein the biological treatment comprises a biologically active component selected from cartilage derived morphogenetic protein (CDMP); cartilage inducing factor (CIP); proteoglycans; hormones; and matrix metalloproteinases (MMP) inhibitors.
  14. 14. The method of claim 1 wherein the biological treatment comprises a biologically active component selected from allogenic disc annulus material, xenogenic disc annulus material, biologic tissues, activated tissue grafts, engineered cells comprising a nucleic acid for encoding a protein or variant thereof, and a recombinant human bone morphogenetic protein.
  15. 15. The method of claim 1 wherein the load-bearing device is bioresorbable or partially resorbable.
  16. 16. The method of claim 1 wherein the treated area comprises a facet joint.
  17. 17. The method of claim 1 wherein the spinal device comprises at least one of a prosthetic motion-preserving system, a fusion system, a disc replacement system, a disc nucleus replacement system, vertebral body repair system and an endplate supplementation system.
  18. 18. The method of claim 1 wherein:
    the area of the vertebral column receiving the biological treatment comprises a facet joint;
    the biological treatment comprises collagen containing stem cells and BMP-6; and
    the spinal device comprises a nucleus replacement implant inserted into the nucleus of a disc adjacent to the facet joint receiving the biological treatment.
  19. 19. The method of claim 1 wherein:
    the area of the vertebral column receiving the biological treatment comprises a facet joint;
    the biological treatment comprises a polyvinyl alcohol hydrogel containing chondrocytes and TGF-beta 2; and
    the spinal device comprises a prosthetic motion-preserving disc inserted into the disc space adjacent to the facet joint receiving the biological treatment.
  20. 20. The method of claim 1 wherein:
    the area of the vertebral column receiving the biological treatment comprises a facet joint;
    the biological treatment comprises a polyethylene glycol gel containing fibroblasts and TGF-beta; and
    the spinal device comprises collagen inserted into the disc space adjacent to the facet joint receiving the biological treatment.
  21. 21. The method of claim 1 wherein:
    the area of the vertebral column receiving the biological treatment comprises a facet joint;
    the biological treatment comprises a porcine-based collagen containing anti-TNF alpha and ILGF; and
    the spinal device comprises a nucleus replacement material applied to the disc space adjacent to the facet joint receiving the biological treatment.
  22. 22. The method of claim 1 wherein the biological treatment is non load-bearing.
  23. 23. A method for treating a motion segment of a spinal column comprising:
    accessing a portion of a patient's spinal column;
    implanting a load-bearing device in an anterior column region of the spinal column to at least partially mechanically unload an intact motion segment in the spinal column, wherein the intact motion segment comprises a facet joint; and
    injecting a biological treatment into the facet joint.
  24. 24. The method of claim 23 wherein the load-bearing device is implanted at a location in the spine that is spaced from the motion segment receiving the biological treatment.
  25. 25. The method of claim 23 wherein the load-bearing device is implanted at a location in the spine that is adjacent to the motion segment receiving the biological treatment.
US11353323 2006-02-14 2006-02-14 Treatment of the vertebral column Abandoned US20070213822A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US11353517 US8163018B2 (en) 2006-02-14 2006-02-14 Treatment of the vertebral column
US11353323 US20070213822A1 (en) 2006-02-14 2006-02-14 Treatment of the vertebral column

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11353323 US20070213822A1 (en) 2006-02-14 2006-02-14 Treatment of the vertebral column

Publications (1)

Publication Number Publication Date
US20070213822A1 true true US20070213822A1 (en) 2007-09-13

Family

ID=38479961

Family Applications (3)

Application Number Title Priority Date Filing Date
US11353323 Abandoned US20070213822A1 (en) 2006-02-14 2006-02-14 Treatment of the vertebral column
US11353517 Active 2028-11-22 US8163018B2 (en) 2006-02-14 2006-02-14 Treatment of the vertebral column
US11353520 Active 2027-03-03 US7520888B2 (en) 2006-02-14 2006-02-14 Treatment of the vertebral column

Family Applications After (2)

Application Number Title Priority Date Filing Date
US11353517 Active 2028-11-22 US8163018B2 (en) 2006-02-14 2006-02-14 Treatment of the vertebral column
US11353520 Active 2027-03-03 US7520888B2 (en) 2006-02-14 2006-02-14 Treatment of the vertebral column

Country Status (1)

Country Link
US (3) US20070213822A1 (en)

Cited By (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080172059A1 (en) * 2007-01-12 2008-07-17 Warsaw Orthopedic, Inc. System and Method for Forming Porous Bone Filling Material
US20080172131A1 (en) * 2007-01-12 2008-07-17 Warsaw Orthopedic, Inc. System and Method for Forming Bone Filling Materials With Microparticles
US20080269897A1 (en) * 2007-04-26 2008-10-30 Abhijeet Joshi Implantable device and methods for repairing articulating joints for using the same
US20080268056A1 (en) * 2007-04-26 2008-10-30 Abhijeet Joshi Injectable copolymer hydrogel useful for repairing vertebral compression fractures
US20090054994A1 (en) * 2007-08-21 2009-02-26 James Rogan Methods and kits for prophylactically reinforcing degenerated spinal discs and facet joints near a surgically treated spinal section
US20090297603A1 (en) * 2008-05-29 2009-12-03 Abhijeet Joshi Interspinous dynamic stabilization system with anisotropic hydrogels
US7682540B2 (en) 2004-02-06 2010-03-23 Georgia Tech Research Corporation Method of making hydrogel implants
US7815648B2 (en) 2004-06-02 2010-10-19 Facet Solutions, Inc Surgical measurement systems and methods
US20100268155A1 (en) * 2009-04-20 2010-10-21 Warsaw Orthopedic, Inc. Method For Stabilizing An Intervertebral Disc Device
US7910124B2 (en) 2004-02-06 2011-03-22 Georgia Tech Research Corporation Load bearing biocompatible device
US7914560B2 (en) 2004-02-17 2011-03-29 Gmedelaware 2 Llc Spinal facet implant with spherical implant apposition surface and bone bed and methods of use
US20110245804A1 (en) * 2008-12-05 2011-10-06 Regenerative Sciences, Llc Methods and Compositions to Facilitate Repair of Avascular Tissue
US8088163B1 (en) 2008-02-06 2012-01-03 Kleiner Jeffrey B Tools and methods for spinal fusion
USD656610S1 (en) 2009-02-06 2012-03-27 Kleiner Jeffrey B Spinal distraction instrument
US8206418B2 (en) 2007-01-10 2012-06-26 Gmedelaware 2 Llc System and method for facet joint replacement with detachable coupler
US8366748B2 (en) 2008-12-05 2013-02-05 Kleiner Jeffrey Apparatus and method of spinal implant and fusion
US8394072B2 (en) 2004-10-29 2013-03-12 Spinal Restoration, Inc. Injection of fibrin sealant including an anesthetic in spinal applications
US20130190879A1 (en) * 2009-07-24 2013-07-25 Zyga Technology, Inc. Methods for facet joint treatment
US8685031B2 (en) 2009-09-18 2014-04-01 Spinal Surgical Strategies, Llc Bone graft delivery system
US8777994B2 (en) 2004-06-02 2014-07-15 Gmedelaware 2 Llc System and method for multiple level facet joint arthroplasty and fusion
US8834928B1 (en) 2011-05-16 2014-09-16 Musculoskeletal Transplant Foundation Tissue-derived tissugenic implants, and methods of fabricating and using same
US8864654B2 (en) 2010-04-20 2014-10-21 Jeffrey B. Kleiner Method and apparatus for performing retro peritoneal dissection
US8883210B1 (en) 2010-05-14 2014-11-11 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US8906028B2 (en) 2009-09-18 2014-12-09 Spinal Surgical Strategies, Llc Bone graft delivery device and method of using the same
USD723682S1 (en) 2013-05-03 2015-03-03 Spinal Surgical Strategies, Llc Bone graft delivery tool
US8986304B2 (en) 2004-10-29 2015-03-24 Bsnc Holding, Llc Injection of fibrin sealant using reconstituted components in spinal applications
US8998905B2 (en) 2011-04-29 2015-04-07 Warsaw Orthopedic, Inc. Methods and instruments for use in vertebral treatment
US9060877B2 (en) 2009-09-18 2015-06-23 Spinal Surgical Strategies, Llc Fusion cage with combined biological delivery system
US9155543B2 (en) 2011-05-26 2015-10-13 Cartiva, Inc. Tapered joint implant and related tools
US9173694B2 (en) 2009-09-18 2015-11-03 Spinal Surgical Strategies, Llc Fusion cage with combined biological delivery system
US9186193B2 (en) 2009-09-18 2015-11-17 Spinal Surgical Strategies, Llc Fusion cage with combined biological delivery system
US9220554B2 (en) 2010-02-18 2015-12-29 Globus Medical, Inc. Methods and apparatus for treating vertebral fractures
US9247943B1 (en) 2009-02-06 2016-02-02 Kleiner Intellectual Property, Llc Devices and methods for preparing an intervertebral workspace
US9259507B2 (en) 2009-04-21 2016-02-16 Warsaw Orthopedic, Inc. Tissue augmentation with active agent for wound healing
USD750249S1 (en) 2014-10-20 2016-02-23 Spinal Surgical Strategies, Llc Expandable fusion cage
US9352003B1 (en) 2010-05-14 2016-05-31 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US9492444B2 (en) 2013-12-17 2016-11-15 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
US9629729B2 (en) 2009-09-18 2017-04-25 Spinal Surgical Strategies, Llc Biological delivery system with adaptable fusion cage interface
US9707184B2 (en) 2014-07-17 2017-07-18 Pharmaceutical Manufacturing Research Services, Inc. Immediate release abuse deterrent liquid fill dosage form
US9717403B2 (en) 2008-12-05 2017-08-01 Jeffrey B. Kleiner Method and apparatus for performing retro peritoneal dissection
USD797290S1 (en) 2015-10-19 2017-09-12 Spinal Surgical Strategies, Llc Bone graft delivery tool
US9907663B2 (en) 2015-03-31 2018-03-06 Cartiva, Inc. Hydrogel implants with porous materials and methods
US10080671B2 (en) 2016-11-01 2018-09-25 Warsaw Orhtopedic, Inc. Trial and method for use thereof
US10092600B2 (en) 2016-12-22 2018-10-09 Musculoskeletal Transplant Foundation Method of preparing an adipose tissue derived matrix

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2363254C (en) 1999-03-07 2009-05-05 Discure Ltd. Method and apparatus for computerized surgery
US6793678B2 (en) 2002-06-27 2004-09-21 Depuy Acromed, Inc. Prosthetic intervertebral motion disc having dampening
CA2735334A1 (en) * 2002-11-05 2004-05-21 Spineology, Inc. A semi-biological intervertebral disc replacement system
US7988735B2 (en) * 2005-06-15 2011-08-02 Matthew Yurek Mechanical apparatus and method for delivering materials into the inter-vertebral body space for nucleus replacement
US20060247634A1 (en) * 2005-05-02 2006-11-02 Warner Kenneth D Spinous Process Spacer Implant and Technique
US20070042326A1 (en) * 2005-06-01 2007-02-22 Osseous Technologies Of America Collagen antral membrane expander
US8361116B2 (en) 2006-03-24 2013-01-29 U.S. Spine, Inc. Non-pedicle based interspinous spacer
US7666211B2 (en) * 2006-12-28 2010-02-23 Mi4Spine, Llc Vertebral disc annular fibrosis tensioning and lengthening device
WO2008106140A3 (en) 2007-02-26 2008-11-20 M Samy Abdou Spinal stabilization systems and methods of use
US8900307B2 (en) 2007-06-26 2014-12-02 DePuy Synthes Products, LLC Highly lordosed fusion cage
US20090110637A1 (en) * 2007-10-26 2009-04-30 Warsaw Orthopedic, Inc. LMP and Regulation of Tissue Growth
US8343190B1 (en) 2008-03-26 2013-01-01 Nuvasive, Inc. Systems and methods for spinous process fixation
WO2009124269A1 (en) 2008-04-05 2009-10-08 Synthes Usa, Llc Expandable intervertebral implant
EP2430995B1 (en) * 2008-08-08 2016-03-30 Alphatec Spine, Inc. Spinous process device
US9149319B2 (en) * 2008-09-23 2015-10-06 Lanx, Llc Methods and compositions for stabilization of a vertebra
US8852201B2 (en) * 2009-03-30 2014-10-07 Arthrex, Inc. Microfracture instrument
US20110040332A1 (en) * 2009-08-11 2011-02-17 Interventional Spine, Inc. Spinous process spacer and implantation procedure
US8926552B2 (en) * 2009-08-12 2015-01-06 Medtronic, Inc. Particle delivery
WO2011057131A1 (en) 2009-11-09 2011-05-12 Spotlight Technology Partners Llc Polysaccharide based hydrogels
EP2498764B1 (en) 2009-11-09 2017-09-06 Spotlight Technology Partners LLC Fragmented hydrogels
US8876870B2 (en) 2010-04-27 2014-11-04 Adnan Iqbal Qureshi Intraspinal device deployed through percutaneous approach into subarachnoid or intradural space of vertebral canal to protect spinal cord from external compression
US8979860B2 (en) 2010-06-24 2015-03-17 DePuy Synthes Products. LLC Enhanced cage insertion device
US9884909B2 (en) 2010-12-01 2018-02-06 Alderbio Holdings Llc Anti-NGF compositions and use thereof
US9067988B2 (en) 2010-12-01 2015-06-30 Alderbio Holdings Llc Methods of preventing or treating pain using anti-NGF antibodies
US9539324B2 (en) 2010-12-01 2017-01-10 Alderbio Holdings, Llc Methods of preventing inflammation and treating pain using anti-NGF compositions
WO2012075340A3 (en) 2010-12-01 2012-11-01 Alderbio Holdings Llc Anti-ngf compositions and use thereof
US9078878B2 (en) 2010-12-01 2015-07-14 Alderbio Holdings Llc Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75
US8496689B2 (en) * 2011-02-23 2013-07-30 Farzad Massoudi Spinal implant device with fusion cage and fixation plates and method of implanting
US8425560B2 (en) * 2011-03-09 2013-04-23 Farzad Massoudi Spinal implant device with fixation plates and lag screws and method of implanting
US20120323276A1 (en) * 2011-06-17 2012-12-20 Bryan Okamoto Expandable interspinous device
US9149306B2 (en) 2011-06-21 2015-10-06 Seaspine, Inc. Spinous process device
USD757943S1 (en) 2011-07-14 2016-05-31 Nuvasive, Inc. Spinous process plate
US8882805B1 (en) 2011-08-02 2014-11-11 Lawrence Maccree Spinal fixation system
US8961570B2 (en) 2012-01-24 2015-02-24 Warsaw Othopedic, Inc. Spinal correction system and method
US20130282121A1 (en) * 2012-03-22 2013-10-24 Ann Prewett Spinal facet augmentation implant and method
US8998906B2 (en) 2012-07-09 2015-04-07 X-Spine Systems, Inc. Surgical implant inserter compressor
WO2014018098A1 (en) 2012-07-26 2014-01-30 DePuy Synthes Products, LLC Expandable implant
US20140067069A1 (en) 2012-08-30 2014-03-06 Interventional Spine, Inc. Artificial disc
US9522070B2 (en) 2013-03-07 2016-12-20 Interventional Spine, Inc. Intervertebral implant
US20160113772A1 (en) * 2014-10-24 2016-04-28 Warsaw Orthopedic, Inc. Spinal implant system and method
US9913727B2 (en) 2015-07-02 2018-03-13 Medos International Sarl Expandable implant
USD816844S1 (en) 2017-06-29 2018-05-01 American Medical Ortho Systems LLC Lumbar interbody implant

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5769899A (en) * 1994-08-12 1998-06-23 Matrix Biotechnologies, Inc. Cartilage repair unit
US20010029399A1 (en) * 1997-05-05 2001-10-11 Ku David N. Poly (vinyl alcohol) hydrogel
US20040054414A1 (en) * 2002-09-18 2004-03-18 Trieu Hai H. Collagen-based materials and methods for augmenting intervertebral discs
US6773699B1 (en) * 2001-10-09 2004-08-10 Tissue Adhesive Technologies, Inc. Light energized tissue adhesive conformal patch
US20040156878A1 (en) * 2003-02-11 2004-08-12 Alireza Rezania Implantable medical device seeded with mammalian cells and methods of treatment
US20040167617A1 (en) * 2001-01-26 2004-08-26 Voellmicke John C. Graft delivery system
US20040199252A1 (en) * 2003-04-03 2004-10-07 William Sears Apparatus and method for supporting vertebral bodies
US20040225292A1 (en) * 2003-05-05 2004-11-11 Sasso Ricardo C. Bone anchor and methods of using the same
US20050043814A1 (en) * 2003-08-20 2005-02-24 Akihiko Kusanagi Acellular matrix implanted into an articular cartilage or osteochondral lesion protected with a biodegradable polymer modified to have extended polymerization time and methods for preparation and use thereof
US20060004367A1 (en) * 2004-06-17 2006-01-05 Alamin Todd F Facet joint fusion devices and methods

Family Cites Families (189)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6004548A (en) 1985-08-23 1999-12-21 Amgen, Inc. Analogs of pluripotent granulocyte colony-stimulating factor
US4772287A (en) * 1987-08-20 1988-09-20 Cedar Surgical, Inc. Prosthetic disc and method of implanting
US5015247A (en) 1988-06-13 1991-05-14 Michelson Gary K Threaded spinal implant
US4969888A (en) 1989-02-09 1990-11-13 Arie Scholten Surgical protocol for fixation of osteoporotic bone using inflatable device
US5062845A (en) 1989-05-10 1991-11-05 Spine-Tech, Inc. Method of making an intervertebral reamer
CA2007210C (en) 1989-05-10 1996-07-09 Stephen D. Kuslich Intervertebral reamer
US6159464A (en) 1990-12-20 2000-12-12 University Of Pittsburgh Of The Commonwealth System Of Higher Education Viral vectors to inhibit leukocyte infiltration or cartilage degradation of joints
FR2676911B1 (en) 1991-05-30 1998-03-06 Psi Ste Civile Particuliere Device intervertebral stabilization dampers.
US5171279A (en) 1992-03-17 1992-12-15 Danek Medical Method for subcutaneous suprafascial pedicular internal fixation
US6344057B1 (en) 1994-11-22 2002-02-05 Sdgi Holdings, Inc. Adjustable vertebral body replacement
FR2692952B1 (en) 1992-06-25 1996-04-05 Psi IMPROVED Shock has limit of displacement.
FR2701650B1 (en) 1993-02-17 1995-05-24 Psi Double damper for intervertebral stabilization.
US6333168B1 (en) 1993-05-20 2001-12-25 The Trustees Of Columbia University In The City Of New York Cloning, expression and uses of dorsalin-1
US6719773B1 (en) 1998-06-01 2004-04-13 Kyphon Inc. Expandable structures for deployment in interior body regions
US6248110B1 (en) 1994-01-26 2001-06-19 Kyphon, Inc. Systems and methods for treating fractured or diseased bone using expandable bodies
US5888220A (en) 1994-05-06 1999-03-30 Advanced Bio Surfaces, Inc. Articulating joint repair
US6248131B1 (en) 1994-05-06 2001-06-19 Advanced Bio Surfaces, Inc. Articulating joint repair
DE69532856D1 (en) 1994-10-17 2004-05-13 Raymedica Inc Intervertebral prosthetic spinal disc nucleus
US5674296A (en) 1994-11-14 1997-10-07 Spinal Dynamics Corporation Human spinal disc prosthesis
DE69534042T2 (en) 1994-12-09 2006-04-13 SDGI Holdings, Inc., Wilmington Adjustable vertebral body replacement
US5776197A (en) 1994-12-09 1998-07-07 Sdgi Holdings, Inc. Adjustable vertebral body replacement
US20050186673A1 (en) 1995-02-22 2005-08-25 Ed. Geistlich Soehne Ag Fuer Chemistrie Industrie Collagen carrier of therapeutic genetic material, and method
DE69737756D1 (en) 1995-03-27 2007-07-05 Warsaw Orthopedic Inc Spinal fusion implant
US5782919A (en) 1995-03-27 1998-07-21 Sdgi Holdings, Inc. Interbody fusion device and method for restoration of normal spinal anatomy
US5645084A (en) 1995-06-07 1997-07-08 Danek Medical, Inc. Method for spinal fusion without decortication
US6152871A (en) 1996-03-22 2000-11-28 Sdgi Holdings, Inc. Apparatus for percutaneous surgery
EP1466564B1 (en) 1996-03-22 2010-10-20 Warsaw Orthopedic, Inc. Devices for percutaneous surgery related applications
US5792044A (en) 1996-03-22 1998-08-11 Danek Medical, Inc. Devices and methods for percutaneous surgery
US20030054376A1 (en) 1997-07-07 2003-03-20 Mullis Kary Banks Dual bead assays using cleavable spacers and/or ligation to improve specificity and sensitivity including related methods and apparatus
US6126682A (en) 1996-08-13 2000-10-03 Oratec Interventions, Inc. Method for treating annular fissures in intervertebral discs
US5980504A (en) 1996-08-13 1999-11-09 Oratec Interventions, Inc. Method for manipulating tissue of an intervertebral disc
US6007570A (en) 1996-08-13 1999-12-28 Oratec Interventions, Inc. Apparatus with functional element for performing function upon intervertebral discs
DE69728424T2 (en) 1996-10-23 2005-02-17 SDGI Holdings, Inc., Wilmington Spacer for invertebrates
US5836948A (en) 1997-01-02 1998-11-17 Saint Francis Medical Technologies, Llc Spine distraction implant and method
US5860977A (en) 1997-01-02 1999-01-19 Saint Francis Medical Technologies, Llc Spine distraction implant and method
US7789841B2 (en) 1997-02-06 2010-09-07 Exogen, Inc. Method and apparatus for connective tissue treatment
US6033438A (en) 1997-06-03 2000-03-07 Sdgi Holdings, Inc. Open intervertebral spacer
US7923250B2 (en) 1997-07-30 2011-04-12 Warsaw Orthopedic, Inc. Methods of expressing LIM mineralization protein in non-osseous cells
US6048346A (en) * 1997-08-13 2000-04-11 Kyphon Inc. Systems and methods for injecting flowable materials into bones
US5824094A (en) 1997-10-17 1998-10-20 Acromed Corporation Spinal disc
US6090998A (en) 1997-10-27 2000-07-18 University Of Florida Segmentally demineralized bone implant
US6648916B1 (en) 1997-12-10 2003-11-18 Sdgi Holdings, Inc. Osteogenic fusion device
US6162252A (en) 1997-12-12 2000-12-19 Depuy Acromed, Inc. Artificial spinal disc
FR2775183B1 (en) * 1998-02-20 2000-08-04 Jean Taylor Inter-thorny Prothese
US5928239A (en) 1998-03-16 1999-07-27 University Of Washington Percutaneous surgical cavitation device and method
US6440138B1 (en) 1998-04-06 2002-08-27 Kyphon Inc. Structures and methods for creating cavities in interior body regions
US6716216B1 (en) 1998-08-14 2004-04-06 Kyphon Inc. Systems and methods for treating vertebral bodies
US6241734B1 (en) 1998-08-14 2001-06-05 Kyphon, Inc. Systems and methods for placing materials into bone
DE69927512T2 (en) 1998-10-06 2006-07-06 Stryker Corp., Kalamazoo Use of OP-1 for preparing a pharmaceutical composition for repair of non-defective articular cartilage of a mammal
US6113637A (en) 1998-10-22 2000-09-05 Sofamor Danek Holdings, Inc. Artificial intervertebral joint permitting translational and rotational motion
US6436143B1 (en) * 1999-02-22 2002-08-20 Anthony C. Ross Method and apparatus for treating intervertebral disks
US20050153442A1 (en) 1999-03-10 2005-07-14 Adam Katz Adipose-derived stem cells and lattices
KR100979664B1 (en) 1999-03-10 2010-09-02 더 리전츠 오브 더 유니버시티 오브 캘리포니아 Adipose-derived stem cells and lattices
US6777231B1 (en) 1999-03-10 2004-08-17 The Regents Of The University Of California Adipose-derived stem cells and lattices
US20030082152A1 (en) * 1999-03-10 2003-05-01 Hedrick Marc H. Adipose-derived stem cells and lattices
US6770079B2 (en) 1999-03-16 2004-08-03 American Osteomedix, Inc. Apparatus and method for fixation of osteoporotic bone
US6582446B1 (en) 1999-05-06 2003-06-24 J. Alexander Marchosky Method and apparatus for percutaneous osteoplasty
US6969404B2 (en) 1999-10-08 2005-11-29 Ferree Bret A Annulus fibrosis augmentation methods and apparatus
US7273497B2 (en) 1999-05-28 2007-09-25 Anova Corp. Methods for treating a defect in the annulus fibrosis
US6224604B1 (en) 1999-07-30 2001-05-01 Loubert Suddaby Expandable orthopedic drill for vertebral interbody fusion techniques
US20030004574A1 (en) * 1999-10-08 2003-01-02 Ferree Bret A. Disc and annulus augmentation using biologic tissue
US6793677B2 (en) 1999-08-13 2004-09-21 Bret A. Ferree Method of providing cells and other biologic materials for transplantation
US6419702B1 (en) * 1999-08-13 2002-07-16 Bret A. Ferree Treating degenerative disc disease through transplantation of the nucleus pulposis
US7220281B2 (en) * 1999-08-18 2007-05-22 Intrinsic Therapeutics, Inc. Implant for reinforcing and annulus fibrosis
WO2002054978A3 (en) * 1999-08-18 2002-11-07 Intrinsic Therapeutics, Inc. Devices and method for nucleus pulposus augmentation and retention
DE19943064B4 (en) 1999-09-09 2013-01-31 Robert Bosch Gmbh A method for epitaxial deposition of atoms or molecules from a reactive gas on a deposition surface of a substrate
FR2799640B1 (en) 1999-10-15 2002-01-25 Spine Next Sa intervetebral implant
US6575919B1 (en) 1999-10-19 2003-06-10 Kyphon Inc. Hand-held instruments that access interior body regions
US6592625B2 (en) 1999-10-20 2003-07-15 Anulex Technologies, Inc. Spinal disc annulus reconstruction method and spinal disc annulus stent
JP4326134B2 (en) 1999-10-20 2009-09-02 ウォーソー・オーソペディック・インコーポレーテッド Method and apparatus for performing surgical procedures
US6610091B1 (en) 1999-10-22 2003-08-26 Archus Orthopedics Inc. Facet arthroplasty devices and methods
DE60030313D1 (en) 1999-12-01 2006-10-05 Henry Graf A device for intervertebral stabilization
US6558390B2 (en) 2000-02-16 2003-05-06 Axiamed, Inc. Methods and apparatus for performing therapeutic procedures in the spine
US6575979B1 (en) 2000-02-16 2003-06-10 Axiamed, Inc. Method and apparatus for providing posterior or anterior trans-sacral access to spinal vertebrae
US6558386B1 (en) 2000-02-16 2003-05-06 Trans1 Inc. Axial spinal implant and method and apparatus for implanting an axial spinal implant within the vertebrae of the spine
US20030191474A1 (en) 2000-02-16 2003-10-09 Cragg Andrew H. Apparatus for performing a discectomy through a trans-sacral axial bore within the vertebrae of the spine
US7014633B2 (en) 2000-02-16 2006-03-21 Trans1, Inc. Methods of performing procedures in the spine
US6899716B2 (en) 2000-02-16 2005-05-31 Trans1, Inc. Method and apparatus for spinal augmentation
WO2001076514A3 (en) * 2000-04-05 2002-05-02 Joseph J Basista Methods and devices for treating fractured and/or diseased bone
US6723335B1 (en) * 2000-04-07 2004-04-20 Jeffrey William Moehlenbruck Methods and compositions for treating intervertebral disc degeneration
US6675048B2 (en) 2000-05-08 2004-01-06 International Rehabilitative Sciences, Inc. Electro-medical device for use with biologics
WO2002000126A1 (en) * 2000-06-23 2002-01-03 University Of Southern California Percutaneous vertebral fusion system
EP1294324A1 (en) 2000-06-27 2003-03-26 Kyphon Inc. Systems and methods for injecting flowable materials into bones
US7144414B2 (en) 2000-06-27 2006-12-05 Smith & Nephew, Inc. Surgical procedures and instruments
US20040083001A1 (en) 2000-06-29 2004-04-29 Rita Kandel Intervertebral disc
EP1303236B1 (en) 2000-07-14 2008-12-03 Kyphon SARL Systems for treating vertebral bodies
US6939540B1 (en) * 2000-07-31 2005-09-06 Cornell Research Foundation, Inc. Method of enhancing bone density
CA2419196A1 (en) 2000-08-11 2002-02-21 Sdgi Holdings, Inc. Surgical instrumentation and method for treatment of the spine
US20020029082A1 (en) 2000-08-29 2002-03-07 Muhanna Nabil L. Vertebral spacer and method of use
US6620196B1 (en) 2000-08-30 2003-09-16 Sdgi Holdings, Inc. Intervertebral disc nucleus implants and methods
US6679886B2 (en) 2000-09-01 2004-01-20 Synthes (Usa) Tools and methods for creating cavities in bone
US6824565B2 (en) 2000-09-08 2004-11-30 Nabil L. Muhanna System and methods for inserting a vertebral spacer
US20040101957A1 (en) 2001-09-14 2004-05-27 Emini Emilio A. Enhanced first generation adenovirus vaccines expressing codon optimized hiv1-gag, pol.nef and modifications
US6733993B2 (en) * 2000-09-15 2004-05-11 Merck & Co., Inc. Enhanced first generation adenovirus vaccines expressing codon optimized HIV1-gag, pol, nef and modifications
US20020045942A1 (en) 2000-10-16 2002-04-18 Ham Michael J. Procedure for repairing damaged discs
US6599291B1 (en) 2000-10-20 2003-07-29 Sdgi Holdings, Inc. Methods and instruments for interbody surgical techniques
EP1328304B1 (en) * 2000-10-24 2005-02-09 Osteotech, Inc., Vertebral augmentation composition
EP1330216B1 (en) 2000-10-24 2006-06-21 SDGI Holdings, Inc. Osteogenic packing device and method
US8002775B2 (en) 2001-10-24 2011-08-23 Warsaw Orthopedic, Inc. Methods and instruments for treating pseudoarthrosis
US7153306B2 (en) 2000-10-25 2006-12-26 Kyphon Inc. Systems and methods for reducing fractured bone using a fracture reduction cannula
US6582467B1 (en) 2000-10-31 2003-06-24 Vertelink Corporation Expandable fusion cage
US6666891B2 (en) 2000-11-13 2003-12-23 Frank H. Boehm, Jr. Device and method for lumbar interbody fusion
CA2429168C (en) 2000-11-15 2010-06-08 Bio Syntech Canada Inc. Method for restoring a damaged or degenerated intervertebral disc
CA2468041A1 (en) 2001-11-20 2003-05-30 Burstein Technologies, Inc. Optical bio-discs and microfluidic devices for analysis of cells
US20030129665A1 (en) 2001-08-30 2003-07-10 Selvan Gowri Pyapali Methods for qualitative and quantitative analysis of cells and related optical bio-disc systems
US20030082568A1 (en) * 2000-11-27 2003-05-01 Phan Brigitte Chau Use of restriction enzymes and other chemical methods to decrease non-specific binding in dual bead assays and related bio-discs, methods, and system apparatus for detecting medical targets
US20030003464A1 (en) * 2000-11-27 2003-01-02 Phan Brigitte C. Dual bead assays including optical biodiscs and methods relating thereto
US20020172980A1 (en) 2000-11-27 2002-11-21 Phan Brigitte Chau Methods for decreasing non-specific binding of beads in dual bead assays including related optical biodiscs and disc drive systems
FR2817461B1 (en) 2000-12-01 2003-08-15 Henry Graf Device for intervertebral stabilization
US6786930B2 (en) * 2000-12-04 2004-09-07 Spineco, Inc. Molded surgical implant and method
US20020168663A1 (en) 2001-02-27 2002-11-14 Phan Brigitte Chau Methods for DNA conjugation onto solid phase including related optical biodiscs and disc drive systems
US20020150971A1 (en) 2001-02-08 2002-10-17 Johansen Jeanette Elisabeth Nucleic acids and polypeptides for controlling food intake and/or body weight
US7008433B2 (en) 2001-02-15 2006-03-07 Depuy Acromed, Inc. Vertebroplasty injection device
US6613018B2 (en) 2001-02-20 2003-09-02 Vita Licensing, Inc. System and kit for delivery of restorative materials
US7544196B2 (en) * 2001-02-20 2009-06-09 Orthovita, Inc. System and kit for delivery of restorative materials
US20020115742A1 (en) 2001-02-22 2002-08-22 Trieu Hai H. Bioactive nanocomposites and methods for their use
US6572619B2 (en) 2001-02-23 2003-06-03 Albert N. Santilli Cage plate for spinal fusion and method of operation
US6673075B2 (en) 2001-02-23 2004-01-06 Albert N. Santilli Porous intervertebral spacer
US6478822B1 (en) 2001-03-20 2002-11-12 Spineco, Inc. Spherical spinal implant
US20030069639A1 (en) 2001-04-14 2003-04-10 Tom Sander Methods and compositions for repair or replacement of joints and soft tissues
EP1389121B1 (en) * 2001-04-24 2012-02-22 Purdue Research Foundation Method and compositions for treating mammalian nerve tissue injuries
US6746451B2 (en) 2001-06-01 2004-06-08 Lance M. Middleton Tissue cavitation device and method
US6620162B2 (en) 2001-07-20 2003-09-16 Spineology, Inc. Device for inserting fill material particles into body cavities
FR2828398B1 (en) * 2001-08-08 2003-09-19 Jean Taylor vertebrae stabilization assembly
US7435722B2 (en) 2001-08-31 2008-10-14 University Of Southern California Non-toxic crosslinking reagents to resist curve progression in scoliosis and increase disc permeability
US6736815B2 (en) 2001-09-06 2004-05-18 Core Medical, Inc. Apparatus and methods for treating spinal discs
US20030054331A1 (en) 2001-09-14 2003-03-20 Stemsource, Inc. Preservation of non embryonic cells from non hematopoietic tissues
US6805715B2 (en) 2001-10-09 2004-10-19 Pmt Corporation Method and device for treating intervertebral disc herniations
US7595043B2 (en) 2001-12-07 2009-09-29 Cytori Therapeutics, Inc. Method for processing and using adipose-derived stem cells
US7585670B2 (en) 2001-12-07 2009-09-08 Cytori Therapeutics, Inc. Automated methods for isolating and using clinically safe adipose derived regenerative cells
US20050048035A1 (en) 2001-12-07 2005-03-03 Fraser John K. Methods of using regenerative cells in the treatment of stroke and related diseases and disorders
US8404229B2 (en) 2001-12-07 2013-03-26 Cytori Therapeutics, Inc. Methods of using adipose derived stem cells to treat acute tubular necrosis
US7771716B2 (en) * 2001-12-07 2010-08-10 Cytori Therapeutics, Inc. Methods of using regenerative cells in the treatment of musculoskeletal disorders
EP1572071B1 (en) 2001-12-07 2018-10-03 Cytori Therapeutics, Inc. Methods for preparing fresh adipose tissue-derived cells and uses in treating patients
US7651684B2 (en) * 2001-12-07 2010-01-26 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in augmenting autologous fat transfer
US20050008626A1 (en) * 2001-12-07 2005-01-13 Fraser John K. Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions
US20050048036A1 (en) 2001-12-07 2005-03-03 Hedrick Marc H. Methods of using regenerative cells in the treatment of inherited and acquired disorders of the bone, bone marrow, liver, and other tissues
EP1467746A4 (en) 2001-12-20 2006-10-04 Macropore Inc Systems and methods for treating patients with collagen-rich material extracted from adipose tissue
US20030219843A1 (en) 2001-12-20 2003-11-27 Welsch Dean J. Methods of diagnosing and treating abnormal growth
WO2003059932A3 (en) 2001-12-27 2004-01-29 Yissum Res Dev Co Methods of inducing or enhancing connective tissue repair
US7504099B2 (en) 2001-12-27 2009-03-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Methods of inducing or enhancing connective tissue repair
US6582439B1 (en) 2001-12-28 2003-06-24 Yacmur Llc Vertebroplasty system
US6780191B2 (en) 2001-12-28 2004-08-24 Yacmur Llc Cannula system
US6740118B2 (en) 2002-01-09 2004-05-25 Sdgi Holdings, Inc. Intervertebral prosthetic joint
US20030195630A1 (en) 2002-04-10 2003-10-16 Ferree Bret A. Disc augmentation using materials that expand in situ
US6878167B2 (en) 2002-04-24 2005-04-12 Bret A. Ferree Methods and apparatus for placing intradiscal devices
US7048736B2 (en) 2002-05-17 2006-05-23 Sdgi Holdings, Inc. Device for fixation of spinous processes
US6740188B2 (en) * 2002-05-29 2004-05-25 Johns Manville International, Inc. Compression-cutting and facing method
US6730095B2 (en) 2002-06-26 2004-05-04 Scimed Life Systems, Inc. Retrograde plunger delivery system
US20050020945A1 (en) 2002-07-02 2005-01-27 Tosaya Carol A. Acoustically-aided cerebrospinal-fluid manipulation for neurodegenerative disease therapy
US7901407B2 (en) 2002-08-02 2011-03-08 Boston Scientific Scimed, Inc. Media delivery device for bone structures
EP1536743A2 (en) * 2002-08-27 2005-06-08 SDGI Holdings, Inc. Systems and methods for intravertebral reduction
US20040087947A1 (en) 2002-08-28 2004-05-06 Roy Lim Minimally invasive expanding spacer and method
CA2735334A1 (en) * 2002-11-05 2004-05-21 Spineology, Inc. A semi-biological intervertebral disc replacement system
WO2004043271A1 (en) * 2002-11-08 2004-05-27 Sdgi Holdings, Inc. Transpedicular intervertebral disk access methods and devices
WO2004047689A1 (en) * 2002-11-21 2004-06-10 Sdgi Holdings, Inc. Systems and techniques for intravertebral spinal stablization with expandable devices
CA2505468A1 (en) 2002-11-21 2004-06-10 Sdgi Holdings, Inc. Systems and techniques for interbody spinal stablization with expandable devices
EP1594421A4 (en) * 2003-01-17 2006-02-08 Psinergi Corp Artificial nucleus pulposus and method of injecting same
US20040193274A1 (en) 2003-03-28 2004-09-30 Trieu Hai H. Materials and methods for augmenting and/or repairing intervertebral discs
US7429378B2 (en) 2003-05-13 2008-09-30 Depuy Spine, Inc. Transdiscal administration of high affinity anti-MMP inhibitors
US20050015150A1 (en) 2003-07-17 2005-01-20 Lee Casey K. Intervertebral disk and nucleus prosthesis
US20050088632A1 (en) * 2003-07-21 2005-04-28 Sadi Sonja J. Vitasolve dissolving film strips with supplements pharmaceutical drug(RX), +vitamins
US7169405B2 (en) * 2003-08-06 2007-01-30 Warsaw Orthopedic, Inc. Methods and devices for the treatment of intervertebral discs
EP1660663A4 (en) 2003-08-12 2007-07-11 Brigham & Womens Hospital Methods and compositions for tissue repair
US7309359B2 (en) 2003-08-21 2007-12-18 Warsaw Orthopedic, Inc. Allogenic/xenogenic implants and methods for augmenting or repairing intervertebral discs
CA2537048C (en) * 2003-09-03 2010-01-12 Kyphon Inc. Devices for creating voids in interior body regions and related methods
US7824412B2 (en) * 2003-09-05 2010-11-02 Medical Design Instruments LLC Cement/biologics inserter and method for bone-fastener fixation augmentation
US20050113923A1 (en) 2003-10-03 2005-05-26 David Acker Prosthetic spinal disc nucleus
US20050164969A1 (en) 2003-11-19 2005-07-28 Massachusetts Institute Of Technology Method of extending life span
US7553320B2 (en) * 2003-12-10 2009-06-30 Warsaw Orthopedic, Inc. Method and apparatus for replacing the function of facet joints
US20050154467A1 (en) 2004-01-09 2005-07-14 Sdgi Holdings, Inc. Interconnected spinal device and method
US7166110B2 (en) 2004-01-09 2007-01-23 Yundt Kent D Method, system and apparatus for interbody fusion
US7556651B2 (en) 2004-01-09 2009-07-07 Warsaw Orthopedic, Inc. Posterior spinal device and method
US20050153849A1 (en) 2004-01-09 2005-07-14 Mishra Munmaya K. Graft copolymers, method of making and compositions containing the same
US20050171608A1 (en) 2004-01-09 2005-08-04 Sdgi Holdings, Inc. Centrally articulating spinal device and method
US20050171610A1 (en) 2004-01-09 2005-08-04 Sdgi Holdings, Inc. Mobile bearing spinal device and method
US7901459B2 (en) 2004-01-09 2011-03-08 Warsaw Orthopedic, Inc. Split spinal device and method
US7875077B2 (en) 2004-01-09 2011-01-25 Warsaw Orthopedic, Inc. Support structure device and method
US7771479B2 (en) 2004-01-09 2010-08-10 Warsaw Orthopedic, Inc. Dual articulating spinal device and method
KR20070004656A (en) * 2004-01-30 2007-01-09 오스테오테크, 인코포레이티드 Stacking implants for spinal fusion
US7597694B2 (en) 2004-01-30 2009-10-06 Warsaw Orthopedic, Inc. Instruments and methods for minimally invasive spinal stabilization
US7641664B2 (en) 2004-02-12 2010-01-05 Warsaw Orthopedic, Inc. Surgical instrumentation and method for treatment of a spinal structure
WO2005081870A3 (en) 2004-02-20 2006-12-14 Iv H Davis Adkisson Intervertebral disc repair, methods and devices therefor
US7485145B2 (en) 2004-02-23 2009-02-03 Alphatec Spine, Incorporated Artificial intervertebral disc assembly
WO2005086695A3 (en) 2004-03-04 2006-10-12 Univ Tennessee Res Foundation Intracellular interleukin-1 receptor antagonist and uses thereof
US7524324B2 (en) * 2004-04-28 2009-04-28 Kyphon Sarl System and method for an interspinous process implant as a supplement to a spine stabilization implant
FR2870718B1 (en) * 2004-05-25 2006-09-22 Spine Next Sa processing the complete degeneration of an intervertebral disc
US7749268B2 (en) 2004-05-26 2010-07-06 Warsaw Orthopedic, Inc. Methods for treating the spine
US20060247623A1 (en) * 2005-04-29 2006-11-02 Sdgi Holdings, Inc. Local delivery of an active agent from an orthopedic implant

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5769899A (en) * 1994-08-12 1998-06-23 Matrix Biotechnologies, Inc. Cartilage repair unit
US20010029399A1 (en) * 1997-05-05 2001-10-11 Ku David N. Poly (vinyl alcohol) hydrogel
US20040167617A1 (en) * 2001-01-26 2004-08-26 Voellmicke John C. Graft delivery system
US6773699B1 (en) * 2001-10-09 2004-08-10 Tissue Adhesive Technologies, Inc. Light energized tissue adhesive conformal patch
US20040054414A1 (en) * 2002-09-18 2004-03-18 Trieu Hai H. Collagen-based materials and methods for augmenting intervertebral discs
US20040228901A1 (en) * 2002-09-18 2004-11-18 Trieu Hai H. Collagen-based materials and methods for treating synovial joints
US20040156878A1 (en) * 2003-02-11 2004-08-12 Alireza Rezania Implantable medical device seeded with mammalian cells and methods of treatment
US20040199252A1 (en) * 2003-04-03 2004-10-07 William Sears Apparatus and method for supporting vertebral bodies
US20040225292A1 (en) * 2003-05-05 2004-11-11 Sasso Ricardo C. Bone anchor and methods of using the same
US20050043814A1 (en) * 2003-08-20 2005-02-24 Akihiko Kusanagi Acellular matrix implanted into an articular cartilage or osteochondral lesion protected with a biodegradable polymer modified to have extended polymerization time and methods for preparation and use thereof
US20060004367A1 (en) * 2004-06-17 2006-01-05 Alamin Todd F Facet joint fusion devices and methods

Cited By (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7682540B2 (en) 2004-02-06 2010-03-23 Georgia Tech Research Corporation Method of making hydrogel implants
US8002830B2 (en) 2004-02-06 2011-08-23 Georgia Tech Research Corporation Surface directed cellular attachment
US7910124B2 (en) 2004-02-06 2011-03-22 Georgia Tech Research Corporation Load bearing biocompatible device
US8895073B2 (en) 2004-02-06 2014-11-25 Georgia Tech Research Corporation Hydrogel implant with superficial pores
US8142808B2 (en) 2004-02-06 2012-03-27 Georgia Tech Research Corporation Method of treating joints with hydrogel implants
US8486436B2 (en) 2004-02-06 2013-07-16 Georgia Tech Research Corporation Articular joint implant
US8318192B2 (en) 2004-02-06 2012-11-27 Georgia Tech Research Corporation Method of making load bearing hydrogel implants
US8906063B2 (en) 2004-02-17 2014-12-09 Gmedelaware 2 Llc Spinal facet joint implant
US7914560B2 (en) 2004-02-17 2011-03-29 Gmedelaware 2 Llc Spinal facet implant with spherical implant apposition surface and bone bed and methods of use
US7998177B2 (en) 2004-02-17 2011-08-16 Gmedelaware 2 Llc Linked bilateral spinal facet implants and methods of use
US7998178B2 (en) 2004-02-17 2011-08-16 Gmedelaware 2 Llc Linked bilateral spinal facet implants and methods of use
US7815648B2 (en) 2004-06-02 2010-10-19 Facet Solutions, Inc Surgical measurement systems and methods
US8777994B2 (en) 2004-06-02 2014-07-15 Gmedelaware 2 Llc System and method for multiple level facet joint arthroplasty and fusion
US8403895B2 (en) 2004-10-29 2013-03-26 Spinal Restoration, Inc. Injection of fibrin sealant including an anesthetic in spinal applications
US8986304B2 (en) 2004-10-29 2015-03-24 Bsnc Holding, Llc Injection of fibrin sealant using reconstituted components in spinal applications
US8394072B2 (en) 2004-10-29 2013-03-12 Spinal Restoration, Inc. Injection of fibrin sealant including an anesthetic in spinal applications
US8211147B2 (en) 2007-01-10 2012-07-03 Gmedelaware 2 Llc System and method for facet joint replacement
US8252027B2 (en) 2007-01-10 2012-08-28 Gmedelaware 2 Llc System and method for facet joint replacement
US8206418B2 (en) 2007-01-10 2012-06-26 Gmedelaware 2 Llc System and method for facet joint replacement with detachable coupler
US20080172131A1 (en) * 2007-01-12 2008-07-17 Warsaw Orthopedic, Inc. System and Method for Forming Bone Filling Materials With Microparticles
US20080172059A1 (en) * 2007-01-12 2008-07-17 Warsaw Orthopedic, Inc. System and Method for Forming Porous Bone Filling Material
US8926623B2 (en) 2007-01-12 2015-01-06 Warsaw Orthopedic, Inc. System and method for forming porous bone filling material
US8268010B2 (en) * 2007-01-12 2012-09-18 Warsaw Orthopedic, Inc. System and method for forming bone filling materials with microparticles
US9283016B2 (en) 2007-01-12 2016-03-15 Warsaw Orthopedic, Inc. System and method for forming porous bone filling material
US8702759B2 (en) 2007-04-17 2014-04-22 Gmedelaware 2 Llc System and method for bone anchorage
US9050144B2 (en) 2007-04-17 2015-06-09 Gmedelaware 2 Llc System and method for implant anchorage with anti-rotation features
US20080268056A1 (en) * 2007-04-26 2008-10-30 Abhijeet Joshi Injectable copolymer hydrogel useful for repairing vertebral compression fractures
US20080269897A1 (en) * 2007-04-26 2008-10-30 Abhijeet Joshi Implantable device and methods for repairing articulating joints for using the same
US20090054994A1 (en) * 2007-08-21 2009-02-26 James Rogan Methods and kits for prophylactically reinforcing degenerated spinal discs and facet joints near a surgically treated spinal section
US8808305B2 (en) 2008-02-06 2014-08-19 Jeffrey B. Kleiner Spinal fusion cage system with inserter
US8088163B1 (en) 2008-02-06 2012-01-03 Kleiner Jeffrey B Tools and methods for spinal fusion
USD700322S1 (en) 2008-02-06 2014-02-25 Jeffrey B. Kleiner Intervertebral surgical tool
USD696399S1 (en) 2008-02-06 2013-12-24 Kleiner Intellectual Property, Llc Spinal distraction instrument
US8277510B2 (en) 2008-02-06 2012-10-02 Kleiner Intellectual Property, Llc Tools and methods for spinal fusion
US8292960B2 (en) 2008-02-06 2012-10-23 Kleiner Intellectual Property, Llc Spinal fusion cage with removable planar elements
US9439782B2 (en) 2008-02-06 2016-09-13 Jeffrey B. Kleiner Spinal fusion cage system with inserter
US8715355B2 (en) 2008-02-06 2014-05-06 Nuvasive, Inc. Spinal fusion cage with removable planar elements
US20090297603A1 (en) * 2008-05-29 2009-12-03 Abhijeet Joshi Interspinous dynamic stabilization system with anisotropic hydrogels
US8366748B2 (en) 2008-12-05 2013-02-05 Kleiner Jeffrey Apparatus and method of spinal implant and fusion
US20110245804A1 (en) * 2008-12-05 2011-10-06 Regenerative Sciences, Llc Methods and Compositions to Facilitate Repair of Avascular Tissue
US9427264B2 (en) 2008-12-05 2016-08-30 Jeffrey KLEINER Apparatus and method of spinal implant and fusion
US8870882B2 (en) 2008-12-05 2014-10-28 Jeffrey KLEINER Apparatus and method of spinal implant and fusion
US9861496B2 (en) 2008-12-05 2018-01-09 Jeffrey B. Kleiner Apparatus and method of spinal implant and fusion
US9717403B2 (en) 2008-12-05 2017-08-01 Jeffrey B. Kleiner Method and apparatus for performing retro peritoneal dissection
US9247943B1 (en) 2009-02-06 2016-02-02 Kleiner Intellectual Property, Llc Devices and methods for preparing an intervertebral workspace
USD656610S1 (en) 2009-02-06 2012-03-27 Kleiner Jeffrey B Spinal distraction instrument
USD667542S1 (en) 2009-02-06 2012-09-18 Kleiner Jeffrey B Spinal distraction instrument
US9826988B2 (en) 2009-02-06 2017-11-28 Kleiner Intellectual Property, Llc Devices and methods for preparing an intervertebral workspace
US8377136B2 (en) 2009-04-20 2013-02-19 Warsaw Orthopedic, Inc. Method for stabilizing an intervertebral disc device
US20100268155A1 (en) * 2009-04-20 2010-10-21 Warsaw Orthopedic, Inc. Method For Stabilizing An Intervertebral Disc Device
US9259507B2 (en) 2009-04-21 2016-02-16 Warsaw Orthopedic, Inc. Tissue augmentation with active agent for wound healing
US9017389B2 (en) * 2009-07-24 2015-04-28 Zyga Technology, Inc. Methods for facet joint treatment
US20130190879A1 (en) * 2009-07-24 2013-07-25 Zyga Technology, Inc. Methods for facet joint treatment
US9060877B2 (en) 2009-09-18 2015-06-23 Spinal Surgical Strategies, Llc Fusion cage with combined biological delivery system
US8709088B2 (en) 2009-09-18 2014-04-29 Spinal Surgical Strategies, Llc Fusion cage with combined biological delivery system
US8906028B2 (en) 2009-09-18 2014-12-09 Spinal Surgical Strategies, Llc Bone graft delivery device and method of using the same
US9186193B2 (en) 2009-09-18 2015-11-17 Spinal Surgical Strategies, Llc Fusion cage with combined biological delivery system
US9173694B2 (en) 2009-09-18 2015-11-03 Spinal Surgical Strategies, Llc Fusion cage with combined biological delivery system
US8685031B2 (en) 2009-09-18 2014-04-01 Spinal Surgical Strategies, Llc Bone graft delivery system
US9629729B2 (en) 2009-09-18 2017-04-25 Spinal Surgical Strategies, Llc Biological delivery system with adaptable fusion cage interface
US9220554B2 (en) 2010-02-18 2015-12-29 Globus Medical, Inc. Methods and apparatus for treating vertebral fractures
US8864654B2 (en) 2010-04-20 2014-10-21 Jeffrey B. Kleiner Method and apparatus for performing retro peritoneal dissection
US8883210B1 (en) 2010-05-14 2014-11-11 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US9352003B1 (en) 2010-05-14 2016-05-31 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US8998905B2 (en) 2011-04-29 2015-04-07 Warsaw Orthopedic, Inc. Methods and instruments for use in vertebral treatment
US9504480B2 (en) 2011-04-29 2016-11-29 Warsaw Orthopedic, Inc. Methods and instruments for use in vertebral treatment
US8834928B1 (en) 2011-05-16 2014-09-16 Musculoskeletal Transplant Foundation Tissue-derived tissugenic implants, and methods of fabricating and using same
US9155543B2 (en) 2011-05-26 2015-10-13 Cartiva, Inc. Tapered joint implant and related tools
US9526632B2 (en) 2011-05-26 2016-12-27 Cartiva, Inc. Methods of repairing a joint using a wedge-shaped implant
USD723682S1 (en) 2013-05-03 2015-03-03 Spinal Surgical Strategies, Llc Bone graft delivery tool
US9492444B2 (en) 2013-12-17 2016-11-15 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
US9707184B2 (en) 2014-07-17 2017-07-18 Pharmaceutical Manufacturing Research Services, Inc. Immediate release abuse deterrent liquid fill dosage form
USD750249S1 (en) 2014-10-20 2016-02-23 Spinal Surgical Strategies, Llc Expandable fusion cage
US9907663B2 (en) 2015-03-31 2018-03-06 Cartiva, Inc. Hydrogel implants with porous materials and methods
USD797290S1 (en) 2015-10-19 2017-09-12 Spinal Surgical Strategies, Llc Bone graft delivery tool
US10080671B2 (en) 2016-11-01 2018-09-25 Warsaw Orhtopedic, Inc. Trial and method for use thereof
US10092600B2 (en) 2016-12-22 2018-10-09 Musculoskeletal Transplant Foundation Method of preparing an adipose tissue derived matrix

Also Published As

Publication number Publication date Type
US20070213824A1 (en) 2007-09-13 application
US20070213823A1 (en) 2007-09-13 application
US7520888B2 (en) 2009-04-21 grant
US8163018B2 (en) 2012-04-24 grant

Similar Documents

Publication Publication Date Title
US7507243B2 (en) Devices and method for augmenting a vertebral disc
US7066960B1 (en) Intervertebral disk replacement
US7267687B2 (en) Spinal implant and method of use
US8052728B2 (en) Method for stabilizing a facet joint
US6645247B2 (en) Supplementing engineered annulus tissues with autograft of allograft tendons
US7879103B2 (en) Vertebral disc repair
US7867278B2 (en) Intervertebral disc anulus implant
US20050209696A1 (en) Implant frames for use with settable materials and related methods of use
US20110054408A1 (en) Delivery systems, devices, tools, and methods of use
US20040044412A1 (en) Devices and method for augmenting a vertebral disc
US6344058B1 (en) Treating degenerative disc disease through transplantation of allograft disc and vertebral endplates
US7435260B2 (en) Use of morphogenetic proteins to treat human disc disease
US20050182414A1 (en) Apparatus and method for injecting fluent material at a distracted tissue site
US20010020188A1 (en) Selective uptake of materials by bone implants
US6761739B2 (en) Cortical and cancellous allograft spacer
US8241363B2 (en) Expandable corpectomy spinal fusion cage
US20060280768A1 (en) Meniscal repair device and method
US20050234549A1 (en) Meniscal repair scaffold
US20050055096A1 (en) Functional spinal unit prosthetic
US20060200246A1 (en) Method of monitoring characteristics of an intervertebral disc and implantable prosthetic
US20030033022A1 (en) Cartilage repair and regeneration device and method
US6419702B1 (en) Treating degenerative disc disease through transplantation of the nucleus pulposis
US20120310352A1 (en) In-situ intervertebral fusion device and method
US7323011B2 (en) Cortical and cancellous allograft cervical fusion block
US20050074481A1 (en) Device for regeneration of articular cartilage and other tissue

Legal Events

Date Code Title Description
AS Assignment

Owner name: SDGI HOLDINGS, INC., DELAWARE

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:TRIEU, HAI H.;REEL/FRAME:017577/0104

Effective date: 20060210

AS Assignment

Owner name: WARSAW ORTHOPEDIC, INC., INDIANA

Free format text: MERGER;ASSIGNOR:SDGI HOLDINGS, INC.;REEL/FRAME:020558/0116

Effective date: 20060428

Owner name: WARSAW ORTHOPEDIC, INC.,INDIANA

Free format text: MERGER;ASSIGNOR:SDGI HOLDINGS, INC.;REEL/FRAME:020558/0116

Effective date: 20060428