JP2005502675A5 - - Google Patents
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- Publication number
- JP2005502675A5 JP2005502675A5 JP2003524562A JP2003524562A JP2005502675A5 JP 2005502675 A5 JP2005502675 A5 JP 2005502675A5 JP 2003524562 A JP2003524562 A JP 2003524562A JP 2003524562 A JP2003524562 A JP 2003524562A JP 2005502675 A5 JP2005502675 A5 JP 2005502675A5
- Authority
- JP
- Japan
- Prior art keywords
- mometasone furoate
- formoterol fumarate
- suspension formulation
- metered dose
- dose inhaler
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- OBRNDARFFFHCGE-PERKLWIXSA-N (S,S)-formoterol fumarate Chemical compound OC(=O)\C=C\C(O)=O.C1=CC(OC)=CC=C1C[C@H](C)NC[C@@H](O)C1=CC=C(O)C(NC=O)=C1.C1=CC(OC)=CC=C1C[C@H](C)NC[C@@H](O)C1=CC=C(O)C(NC=O)=C1 OBRNDARFFFHCGE-PERKLWIXSA-N 0.000 claims 31
- 229960000193 formoterol fumarate Drugs 0.000 claims 31
- 229960002744 mometasone furoate Drugs 0.000 claims 31
- WOFMFGQZHJDGCX-ZULDAHANSA-N mometasone furoate Chemical compound O([C@]1([C@@]2(C)C[C@H](O)[C@]3(Cl)[C@@]4(C)C=CC(=O)C=C4CC[C@H]3[C@@H]2C[C@H]1C)C(=O)CCl)C(=O)C1=CC=CO1 WOFMFGQZHJDGCX-ZULDAHANSA-N 0.000 claims 31
- 239000000203 mixture Substances 0.000 claims 30
- 238000009472 formulation Methods 0.000 claims 27
- 239000000443 aerosol Substances 0.000 claims 23
- 239000000725 suspension Substances 0.000 claims 23
- 229940071648 metered dose inhaler Drugs 0.000 claims 21
- 238000000034 method Methods 0.000 claims 6
- YFMFNYKEUDLDTL-UHFFFAOYSA-N 1,1,1,2,3,3,3-heptafluoropropane Chemical compound FC(F)(F)C(F)C(F)(F)F YFMFNYKEUDLDTL-UHFFFAOYSA-N 0.000 claims 4
- 239000004094 surface-active agent Substances 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 3
- 239000011859 microparticle Substances 0.000 claims 3
- 239000000843 powder Substances 0.000 claims 3
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 2
- 229960001664 mometasone Drugs 0.000 claims 2
- QLIIKPVHVRXHRI-CXSFZGCWSA-N mometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CCl)(O)[C@@]1(C)C[C@@H]2O QLIIKPVHVRXHRI-CXSFZGCWSA-N 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 235000021314 Palmitic acid Nutrition 0.000 claims 1
- 235000021355 Stearic acid Nutrition 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 239000004067 bulking agent Substances 0.000 claims 1
- KYKAJFCTULSVSH-UHFFFAOYSA-N chloro(fluoro)methane Chemical compound F[C]Cl KYKAJFCTULSVSH-UHFFFAOYSA-N 0.000 claims 1
- 238000002788 crimping Methods 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 150000002118 epoxides Chemical class 0.000 claims 1
- BPZSYCZIITTYBL-UHFFFAOYSA-N formoterol Chemical compound C1=CC(OC)=CC=C1CC(C)NCC(O)C1=CC=C(O)C(NC=O)=C1 BPZSYCZIITTYBL-UHFFFAOYSA-N 0.000 claims 1
- 229960002848 formoterol Drugs 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 229940067606 lecithin Drugs 0.000 claims 1
- 235000010445 lecithin Nutrition 0.000 claims 1
- 239000000787 lecithin Substances 0.000 claims 1
- 229940063002 magnesium palmitate Drugs 0.000 claims 1
- 235000019359 magnesium stearate Nutrition 0.000 claims 1
- BJZBHTNKDCBDNQ-UHFFFAOYSA-L magnesium;dodecanoate Chemical compound [Mg+2].CCCCCCCCCCCC([O-])=O.CCCCCCCCCCCC([O-])=O BJZBHTNKDCBDNQ-UHFFFAOYSA-L 0.000 claims 1
- ABSWXCXMXIZDSN-UHFFFAOYSA-L magnesium;hexadecanoate Chemical compound [Mg+2].CCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCC([O-])=O ABSWXCXMXIZDSN-UHFFFAOYSA-L 0.000 claims 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims 1
- 239000003380 propellant Substances 0.000 claims 1
- 210000002345 respiratory system Anatomy 0.000 claims 1
- 239000008117 stearic acid Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31538601P | 2001-08-28 | 2001-08-28 | |
| PCT/US2002/027336 WO2003020253A2 (en) | 2001-08-28 | 2002-08-27 | Pharmaceutical compositions for the treatment of asthma |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009126933A Division JP2009185075A (ja) | 2001-08-28 | 2009-05-26 | 喘息治療用の製薬組成物 |
| JP2010036706A Division JP5170789B2 (ja) | 2001-08-28 | 2010-02-22 | 喘息治療用の製薬組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005502675A JP2005502675A (ja) | 2005-01-27 |
| JP2005502675A5 true JP2005502675A5 (enExample) | 2006-01-05 |
Family
ID=23224164
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003524562A Pending JP2005502675A (ja) | 2001-08-28 | 2002-08-27 | 喘息治療用の製薬組成物 |
| JP2009126933A Pending JP2009185075A (ja) | 2001-08-28 | 2009-05-26 | 喘息治療用の製薬組成物 |
| JP2010036706A Expired - Fee Related JP5170789B2 (ja) | 2001-08-28 | 2010-02-22 | 喘息治療用の製薬組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009126933A Pending JP2009185075A (ja) | 2001-08-28 | 2009-05-26 | 喘息治療用の製薬組成物 |
| JP2010036706A Expired - Fee Related JP5170789B2 (ja) | 2001-08-28 | 2010-02-22 | 喘息治療用の製薬組成物 |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US20030114428A1 (enExample) |
| EP (3) | EP2092935B1 (enExample) |
| JP (3) | JP2005502675A (enExample) |
| KR (1) | KR100970531B1 (enExample) |
| CN (2) | CN1649568B (enExample) |
| AR (1) | AR036358A1 (enExample) |
| AT (2) | ATE430555T1 (enExample) |
| AU (1) | AU2002313828B2 (enExample) |
| BR (1) | BR0212089A (enExample) |
| CA (1) | CA2457926A1 (enExample) |
| CO (1) | CO5560551A2 (enExample) |
| CY (2) | CY1109212T1 (enExample) |
| DE (2) | DE60239648D1 (enExample) |
| DK (2) | DK2092935T3 (enExample) |
| ES (3) | ES2389480T3 (enExample) |
| HU (1) | HUP0401514A3 (enExample) |
| MX (1) | MXPA04001875A (enExample) |
| NO (1) | NO20041277L (enExample) |
| NZ (1) | NZ530987A (enExample) |
| PE (1) | PE20030390A1 (enExample) |
| PL (1) | PL209640B1 (enExample) |
| PT (2) | PT1420759E (enExample) |
| SI (2) | SI1420759T1 (enExample) |
| TW (1) | TWI324934B (enExample) |
| WO (1) | WO2003020253A2 (enExample) |
| ZA (1) | ZA200401419B (enExample) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9904919D0 (en) * | 1999-03-03 | 1999-04-28 | Novartis Ag | Organic compounds |
| CN100496608C (zh) * | 2001-03-30 | 2009-06-10 | 洁垢技术有限公司 | 药用气溶胶制剂 |
| GB0207906D0 (en) * | 2002-04-05 | 2002-05-15 | 3M Innovative Properties Co | Formoterol and mometasone aerosol formulations |
| ES2388537T3 (es) * | 2002-08-23 | 2012-10-16 | Merck Sharp & Dohme Corp. | Inhalador dosificador que contiene una formulación en suspensión de aerosol |
| EP1785156B1 (en) * | 2002-08-23 | 2012-06-27 | Schering Corporation | Metered dose inhaler containing an aerosol suspension formulation |
| SI1542904T1 (sl) * | 2002-08-27 | 2008-06-30 | Schering Corp | Postopek za izdelavo inhalacijskih formulacij z merjenim odmerkom |
| GB0323684D0 (en) | 2003-10-09 | 2003-11-12 | Jagotec Ag | Improvements in or relating to organic compounds |
| GB0323685D0 (en) * | 2003-10-09 | 2003-11-12 | Jagotec Ag | Improvements in or relating to organic compounds |
| JP2007509147A (ja) * | 2003-10-20 | 2007-04-12 | シェーリング コーポレイション | 薬学的エアロゾル組成物 |
| EP1925293A3 (en) * | 2003-10-20 | 2010-01-13 | Schering Corporation | Pharmaceutical aerosol compositions |
| ES2340777T3 (es) * | 2004-01-21 | 2010-06-09 | Schering Corporation | Metodo de tratamiento de la rinosinusitis aguda. |
| US20110053999A1 (en) * | 2004-03-03 | 2011-03-03 | Daley Thomas E | 4-methylpyrazole formulations for inhibiting ethanol intolerance |
| WO2006040598A2 (en) * | 2004-10-12 | 2006-04-20 | Generics (Uk) Limited | Process for the preparation of suspension aerosol formulations, wherein the particles are formed by precipitation inside an aerosol canister |
| EP2484382A1 (en) | 2005-03-30 | 2012-08-08 | Schering Corporation | Medicament comprising a phosphodiesterase IV inhibitor in an inhalable form |
| CA2641616A1 (en) * | 2006-02-09 | 2007-08-23 | Schering Corporation | Pharmaceutical formulations |
| KR20100004993A (ko) * | 2007-02-09 | 2010-01-13 | 쉐링 코포레이션 | 안정한 약제학적 약물 에어로졸 |
| US20080253970A1 (en) * | 2007-02-09 | 2008-10-16 | Schering Corporation | Stable Pharmaceutical Drug Products |
| GB0714239D0 (en) * | 2007-07-20 | 2007-08-29 | Glaxo Group Ltd | Method |
| EP2077132A1 (en) | 2008-01-02 | 2009-07-08 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dispensing device, storage device and method for dispensing a formulation |
| WO2009089422A2 (en) * | 2008-01-10 | 2009-07-16 | Schering Corporation | Inhalation drug products, systems and uses |
| GB0801876D0 (en) | 2008-02-01 | 2008-03-12 | Vectura Group Plc | Suspension formulations |
| EP2414560B1 (de) | 2009-03-31 | 2013-10-23 | Boehringer Ingelheim International GmbH | Verfahren zur beschichtung einer oberfläche eines bauteils |
| EP2432531B1 (de) | 2009-05-18 | 2019-03-06 | Boehringer Ingelheim International GmbH | Adapter, inhalationseinrichtung und zerstäuber |
| PT2435025T (pt) * | 2009-05-29 | 2016-11-11 | Pearl Therapeutics Inc | Administração, por via respiratória, de agentes activos |
| US8815258B2 (en) | 2009-05-29 | 2014-08-26 | Pearl Therapeutics, Inc. | Compositions, methods and systems for respiratory delivery of two or more active agents |
| WO2011027247A1 (en) | 2009-09-03 | 2011-03-10 | Sulur Subramaniam Vanangamudi | An antifungal cream comprising terbinafine hydrochloride |
| GB0918149D0 (en) | 2009-10-16 | 2009-12-02 | Jagotec Ag | Improved medicinal aerosol formulation |
| US10016568B2 (en) | 2009-11-25 | 2018-07-10 | Boehringer Ingelheim International Gmbh | Nebulizer |
| WO2011064163A1 (en) | 2009-11-25 | 2011-06-03 | Boehringer Ingelheim International Gmbh | Nebulizer |
| MX2012005961A (es) | 2009-11-25 | 2012-06-14 | Boehringer Ingelheim Int | Nebulizador. |
| PT2467136E (pt) * | 2009-12-07 | 2014-08-26 | Raptor Therapeutics Inc | Formulações de 4-metilpirazol |
| WO2011101830A1 (en) | 2010-02-22 | 2011-08-25 | Sulur Subramaniam Vanangamudi | A medicinal fusidic acid cream made using sodium fusidate and incorporating a biopolymer and clobetasone, and a process to make it |
| PH12012501666A1 (en) | 2010-02-22 | 2012-11-05 | Sulur Subramaniam Vanangamudi | A medicinal fusidic acid cream made using sodium fusidate and incorporating a biopolymer, a corticosteroid - betamethasone dipropionate, and a process to make it |
| EP2585151B1 (en) | 2010-06-24 | 2018-04-04 | Boehringer Ingelheim International GmbH | Nebulizer |
| WO2012017368A1 (en) | 2010-08-02 | 2012-02-09 | Sulur Subramaniam Vanangamudi | A medicinal fusidic acid cream made using sodium fusidate and incorporating a biopolymer, beclomethasone dipropionate and a process to make it |
| WO2012049543A1 (en) | 2010-10-15 | 2012-04-19 | Sulur Subramaniam Vanangamudi | A medicinal fusidic acid cream made using sodium fusidate and incorporating a biopolymer and a corticosteroid, and a process to make it |
| WO2012130757A1 (de) | 2011-04-01 | 2012-10-04 | Boehringer Ingelheim International Gmbh | Medizinisches gerät mit behälter |
| US9827384B2 (en) | 2011-05-23 | 2017-11-28 | Boehringer Ingelheim International Gmbh | Nebulizer |
| KR102017915B1 (ko) * | 2011-10-11 | 2019-09-03 | 키에시 파르마슈티시 엣스. 피. 에이. | 지방산으로 코팅된 베타-작용제의 결정미세입자 |
| WO2013152894A1 (de) | 2012-04-13 | 2013-10-17 | Boehringer Ingelheim International Gmbh | Zerstäuber mit kodiermitteln |
| JP6454323B2 (ja) | 2013-03-15 | 2019-01-16 | パール セラピューティクス，インコーポレイテッド | 粒子状結晶性材料のコンディショニングのための方法及びシステム |
| JP6643231B2 (ja) | 2013-08-09 | 2020-02-12 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ネブライザ |
| EP2835146B1 (en) | 2013-08-09 | 2020-09-30 | Boehringer Ingelheim International GmbH | Nebulizer |
| HUE058904T2 (hu) | 2014-05-07 | 2022-09-28 | Boehringer Ingelheim Int | Porlasztókészülék |
| US10722666B2 (en) | 2014-05-07 | 2020-07-28 | Boehringer Ingelheim International Gmbh | Nebulizer with axially movable and lockable container and indicator |
| CA2948071C (en) | 2014-05-07 | 2022-08-30 | Boehringer Ingelheim International Gmbh | Container, nebulizer and use |
| US9360400B2 (en) | 2014-06-30 | 2016-06-07 | Proveris Scientific Corporation | Sampling apparatus for determining the amount and uniformity of a delivered dose of drug and related methods |
| GB2545025A (en) * | 2015-12-04 | 2017-06-07 | Mexichem Fluor Sa De Cv | Pharmaceutical composition |
| CN112472689B (zh) | 2015-12-04 | 2023-01-17 | 墨西哥氟石股份公司 | 药物组合物 |
| CA3016890A1 (en) | 2016-03-09 | 2017-09-14 | Proveris Scientific Corporation | Methods for measuring dose content uniformity performance of inhaler and nasal devices |
| CN106619658B (zh) * | 2016-12-28 | 2022-02-08 | 四川普锐特药业有限公司 | 一种医用气溶胶制剂及定量吸入气雾剂 |
| WO2021219495A1 (en) | 2020-04-28 | 2021-11-04 | Dalcor Pharma Uk Ltd., Leatherhead, Zug Branch | Methods for treating or preventing a viral infection or inhibiting viral replication |
| EP4228725A4 (en) | 2020-10-15 | 2024-11-06 | Proveris Scientific Corporation | SYSTEMS AND METHODS FOR INHALATOR TESTING |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5874063A (en) * | 1991-04-11 | 1999-02-23 | Astra Aktiebolag | Pharmaceutical formulation |
| PT656206E (pt) * | 1991-06-10 | 2001-11-30 | Schering Corp | Formulacoes de aerossois sem clorofluorocarbonetos |
| US6250300B1 (en) * | 1992-12-11 | 2001-06-26 | Ab Astra | System for dispensing pharmaceutically active compounds |
| JP4155594B2 (ja) * | 1994-12-22 | 2008-09-24 | アストラゼネカ・アクチエボラーグ | エアゾール製剤 |
| GB9612297D0 (en) * | 1996-06-11 | 1996-08-14 | Minnesota Mining & Mfg | Medicinal aerosol formulations |
| CO4900027A1 (es) * | 1996-08-29 | 2000-03-27 | Schering Corp | Formulaciones en aerosol de furoato de mometasona sin cloro- fluorocarburos . |
| SE9700135D0 (sv) * | 1997-01-20 | 1997-01-20 | Astra Ab | New formulation |
| US6503537B2 (en) * | 1997-03-20 | 2003-01-07 | Schering Corporation | Preparation of powder agglomerates |
| US6495167B2 (en) * | 1997-03-20 | 2002-12-17 | Schering Corporation | Preparation of powder agglomerates |
| TW533865U (en) * | 1997-06-10 | 2003-05-21 | Glaxo Group Ltd | Dispenser for dispensing medicament and actuation indicating device |
| EP1133301A1 (en) * | 1998-11-26 | 2001-09-19 | Britannia Pharmaceuticals Limited | Anti-asthmatic combinations comprising surface active phospholipids |
| AR022695A1 (es) * | 1999-01-28 | 2002-09-04 | Schering Corp | PORTADOR SoLIDO PARTICULADO Y MÉTODO PARA PROVEER CONTROL DE LA PARTICULADA PARA LA DISTRIBUCIoN DE TAMANO DE PARTíCULAS Y DE CONTENIDO AMORFO CONVERTIBLE DURANTE SU PREPARACION |
| GB9904919D0 (en) * | 1999-03-03 | 1999-04-28 | Novartis Ag | Organic compounds |
| SE9900833D0 (sv) * | 1999-03-09 | 1999-03-09 | Astra Ab | Novel combination |
| US6156294A (en) * | 1999-11-28 | 2000-12-05 | Scientific Development And Research, Inc. | Composition and method for treatment of otitis media |
| BR0107764A (pt) * | 2000-01-20 | 2002-11-12 | Basilea Pharmaceutica Ag | Composições de peptìdeo cìclico nasalmente administráveis |
| GB0009612D0 (en) * | 2000-04-18 | 2000-06-07 | Glaxo Group Ltd | Therapeutic formulations |
| AU2001278115A1 (en) * | 2000-08-04 | 2002-02-18 | Longwood Pharmaceutical Research, Inc. | Formulations of mometasone and a bronchodilator for pulmonary administration |
| TW200301698A (en) * | 2001-12-21 | 2003-07-16 | Bristol Myers Squibb Co | Acridone inhibitors of IMPDH enzyme |
-
2002
- 2002-08-26 AR ARP020103194A patent/AR036358A1/es not_active Application Discontinuation
- 2002-08-26 TW TW091119250A patent/TWI324934B/zh not_active IP Right Cessation
- 2002-08-27 EP EP09006110A patent/EP2092935B1/en not_active Expired - Lifetime
- 2002-08-27 AU AU2002313828A patent/AU2002313828B2/en not_active Ceased
- 2002-08-27 MX MXPA04001875A patent/MXPA04001875A/es active IP Right Grant
- 2002-08-27 PL PL368897A patent/PL209640B1/pl not_active IP Right Cessation
- 2002-08-27 KR KR1020047002778A patent/KR100970531B1/ko not_active Expired - Fee Related
- 2002-08-27 JP JP2003524562A patent/JP2005502675A/ja active Pending
- 2002-08-27 DE DE60239648T patent/DE60239648D1/de not_active Expired - Lifetime
- 2002-08-27 SI SI200230839T patent/SI1420759T1/sl unknown
- 2002-08-27 ES ES10012751T patent/ES2389480T3/es not_active Expired - Lifetime
- 2002-08-27 PE PE2002000820A patent/PE20030390A1/es not_active Application Discontinuation
- 2002-08-27 HU HU0401514A patent/HUP0401514A3/hu unknown
- 2002-08-27 ES ES09006110T patent/ES2361805T3/es not_active Expired - Lifetime
- 2002-08-27 EP EP02753549A patent/EP1420759B1/en not_active Expired - Lifetime
- 2002-08-27 DK DK09006110.2T patent/DK2092935T3/da active
- 2002-08-27 AT AT02753549T patent/ATE430555T1/de active
- 2002-08-27 PT PT02753549T patent/PT1420759E/pt unknown
- 2002-08-27 BR BR0212089-5A patent/BR0212089A/pt not_active IP Right Cessation
- 2002-08-27 EP EP10012751A patent/EP2319494B1/en not_active Expired - Lifetime
- 2002-08-27 CN CN02816685XA patent/CN1649568B/zh not_active Expired - Fee Related
- 2002-08-27 PT PT09006110T patent/PT2092935E/pt unknown
- 2002-08-27 CA CA002457926A patent/CA2457926A1/en not_active Abandoned
- 2002-08-27 ES ES02753549T patent/ES2325316T3/es not_active Expired - Lifetime
- 2002-08-27 NZ NZ530987A patent/NZ530987A/en not_active IP Right Cessation
- 2002-08-27 AT AT09006110T patent/ATE503461T1/de active
- 2002-08-27 DE DE60232251T patent/DE60232251D1/de not_active Expired - Lifetime
- 2002-08-27 CN CN201010156400A patent/CN101856362A/zh active Pending
- 2002-08-27 SI SI200230943T patent/SI2092935T1/sl unknown
- 2002-08-27 DK DK02753549T patent/DK1420759T3/da active
- 2002-08-27 WO PCT/US2002/027336 patent/WO2003020253A2/en not_active Ceased
- 2002-08-28 US US10/229,855 patent/US20030114428A1/en not_active Abandoned
-
2004
- 2004-02-16 CO CO04012909A patent/CO5560551A2/es not_active Application Discontinuation
- 2004-02-20 ZA ZA2004/01419A patent/ZA200401419B/en unknown
- 2004-03-26 NO NO20041277A patent/NO20041277L/no not_active Application Discontinuation
-
2005
- 2005-03-03 US US11/071,078 patent/US20050147565A1/en not_active Abandoned
-
2009
- 2009-05-26 JP JP2009126933A patent/JP2009185075A/ja active Pending
- 2009-07-08 CY CY20091100723T patent/CY1109212T1/el unknown
- 2009-12-08 US US12/633,510 patent/US20100143269A1/en not_active Abandoned
-
2010
- 2010-02-22 JP JP2010036706A patent/JP5170789B2/ja not_active Expired - Fee Related
-
2011
- 2011-06-28 CY CY20111100617T patent/CY1111726T1/el unknown
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