JP2005502615A5 - - Google Patents
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- Publication number
- JP2005502615A5 JP2005502615A5 JP2003508369A JP2003508369A JP2005502615A5 JP 2005502615 A5 JP2005502615 A5 JP 2005502615A5 JP 2003508369 A JP2003508369 A JP 2003508369A JP 2003508369 A JP2003508369 A JP 2003508369A JP 2005502615 A5 JP2005502615 A5 JP 2005502615A5
- Authority
- JP
- Japan
- Prior art keywords
- polymer according
- polymer
- group
- pharmaceutically acceptable
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920000642 polymer Polymers 0.000 claims 30
- -1 Amino alkyl polyols Chemical class 0.000 claims 9
- 150000003839 salts Chemical class 0.000 claims 7
- 125000002947 alkylene group Chemical group 0.000 claims 6
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical group OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 claims 6
- 229920005862 polyol Polymers 0.000 claims 6
- 125000001931 aliphatic group Chemical group 0.000 claims 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 4
- 239000000178 monomer Substances 0.000 claims 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 3
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical group C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 3
- 239000005977 Ethylene Substances 0.000 claims 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims 3
- 125000005647 linker group Chemical group 0.000 claims 3
- 150000003077 polyols Chemical class 0.000 claims 3
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Chemical group CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 claims 3
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 claims 3
- VVJKKWFAADXIJK-UHFFFAOYSA-N Allylamine Chemical compound NCC=C VVJKKWFAADXIJK-UHFFFAOYSA-N 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 2
- 229920001577 copolymer Polymers 0.000 claims 2
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 2
- 150000002632 lipids Chemical class 0.000 claims 2
- UZUMQQZPGOFJBQ-UHFFFAOYSA-N 1-aminopropane-1,2-diol Chemical group CC(O)C(N)O UZUMQQZPGOFJBQ-UHFFFAOYSA-N 0.000 claims 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 206010011091 Coronary artery thrombosis Diseases 0.000 claims 1
- 208000002705 Glucose Intolerance Diseases 0.000 claims 1
- 201000005569 Gout Diseases 0.000 claims 1
- 208000034991 Hiatal Hernia Diseases 0.000 claims 1
- 206010020028 Hiatus hernia Diseases 0.000 claims 1
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 102000004877 Insulin Human genes 0.000 claims 1
- 108090001061 Insulin Proteins 0.000 claims 1
- 208000000913 Kidney Calculi Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 206010029148 Nephrolithiasis Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 claims 1
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 claims 1
- 208000021017 Weight Gain Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 201000001883 cholelithiasis Diseases 0.000 claims 1
- 208000002528 coronary thrombosis Diseases 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 150000002009 diols Chemical class 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000001130 gallstones Diseases 0.000 claims 1
- 208000021302 gastroesophageal reflux disease Diseases 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- 201000001421 hyperglycemia Diseases 0.000 claims 1
- 208000006575 hypertriglyceridemia Diseases 0.000 claims 1
- 208000000509 infertility Diseases 0.000 claims 1
- 230000036512 infertility Effects 0.000 claims 1
- 231100000535 infertility Toxicity 0.000 claims 1
- 229940125396 insulin Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 230000007935 neutral effect Effects 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 235000006408 oxalic acid Nutrition 0.000 claims 1
- 208000000689 peptic esophagitis Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 201000009104 prediabetes syndrome Diseases 0.000 claims 1
- 230000035935 pregnancy Effects 0.000 claims 1
- 208000002815 pulmonary hypertension Diseases 0.000 claims 1
- 201000002859 sleep apnea Diseases 0.000 claims 1
- 208000001162 steatorrhea Diseases 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 229920001897 terpolymer Polymers 0.000 claims 1
- 229940116269 uric acid Drugs 0.000 claims 1
- 230000004584 weight gain Effects 0.000 claims 1
- 235000019786 weight gain Nutrition 0.000 claims 1
- 230000004580 weight loss Effects 0.000 claims 1
- 0 CCC(C)(*)N*C=C=C Chemical compound CCC(C)(*)N*C=C=C 0.000 description 3
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30208101P | 2001-06-29 | 2001-06-29 | |
| US30222101P | 2001-06-29 | 2001-06-29 | |
| US35947402P | 2002-02-22 | 2002-02-22 | |
| US35947302P | 2002-02-22 | 2002-02-22 | |
| US35946702P | 2002-02-22 | 2002-02-22 | |
| PCT/US2002/020922 WO2003002130A1 (en) | 2001-06-29 | 2002-07-01 | Fat-binding polymers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005502615A JP2005502615A (ja) | 2005-01-27 |
| JP2005502615A5 true JP2005502615A5 (enExample) | 2006-01-05 |
Family
ID=27540878
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003508369A Pending JP2005502615A (ja) | 2001-06-29 | 2002-07-01 | 脂肪結合ポリマー |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7049345B2 (enExample) |
| EP (1) | EP1404349B1 (enExample) |
| JP (1) | JP2005502615A (enExample) |
| AT (1) | ATE411808T1 (enExample) |
| AU (1) | AU2002346034B2 (enExample) |
| CA (1) | CA2490219A1 (enExample) |
| DE (1) | DE60229523D1 (enExample) |
| WO (1) | WO2003002130A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003291567A1 (en) * | 2002-11-19 | 2004-06-15 | Genzyme Corporation | Polymeric boronic acid derivatives as lipase inhibitors |
| US20080107748A1 (en) * | 2006-11-06 | 2008-05-08 | Krishan Kumar Singal | Microcapsules for removing and absorbing a chemical from a mixture |
| US8317808B2 (en) | 2008-02-18 | 2012-11-27 | Covidien Lp | Device and method for rolling and inserting a prosthetic patch into a body cavity |
| US9034002B2 (en) | 2008-02-18 | 2015-05-19 | Covidien Lp | Lock bar spring and clip for implant deployment device |
| US8758373B2 (en) | 2008-02-18 | 2014-06-24 | Covidien Lp | Means and method for reversibly connecting a patch to a patch deployment device |
| US9393002B2 (en) | 2008-02-18 | 2016-07-19 | Covidien Lp | Clip for implant deployment device |
| US9044235B2 (en) | 2008-02-18 | 2015-06-02 | Covidien Lp | Magnetic clip for implant deployment device |
| US9833240B2 (en) | 2008-02-18 | 2017-12-05 | Covidien Lp | Lock bar spring and clip for implant deployment device |
| US9301826B2 (en) | 2008-02-18 | 2016-04-05 | Covidien Lp | Lock bar spring and clip for implant deployment device |
| US8808314B2 (en) | 2008-02-18 | 2014-08-19 | Covidien Lp | Device and method for deploying and attaching an implant to a biological tissue |
| US9393093B2 (en) | 2008-02-18 | 2016-07-19 | Covidien Lp | Clip for implant deployment device |
| US9398944B2 (en) | 2008-02-18 | 2016-07-26 | Covidien Lp | Lock bar spring and clip for implant deployment device |
| WO2009104182A2 (en) | 2008-02-18 | 2009-08-27 | Polytouch Medical Ltd | A device and method for deploying and attaching a patch to a biological tissue |
| WO2010046893A1 (en) | 2008-10-20 | 2010-04-29 | Polytouch Medical Ltd. | A device for attaching a patch to a biological tissue |
| CA2769666C (en) | 2009-08-17 | 2018-02-13 | Arie Levy | Means and method for reversibly connecting an implant to a deployment device |
| CA2769707A1 (en) | 2009-08-17 | 2011-02-24 | Tyco Healthcare Group Lp | Articulating patch deployment device and method of use |
| TWI614017B (zh) | 2012-12-21 | 2018-02-11 | 財團法人國家衛生研究院 | 包含中孔洞矽奈米粒子之組成物的用途 |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7017227A (enExample) * | 1969-12-27 | 1971-06-29 | ||
| US4211765A (en) * | 1971-10-12 | 1980-07-08 | Monsanto Company | Method for controlling obesity |
| US3923972A (en) * | 1971-10-12 | 1975-12-02 | Monsanto Co | Method of lowering blood cholesterol level |
| IT1052819B (it) * | 1975-12-12 | 1981-07-20 | Fargal Pharmasint Lab Biochim | Preparato inibitore dell assorbimento dei lipidi a base di dietilamminoetildestrano |
| US4265879A (en) * | 1977-09-13 | 1981-05-05 | Monsanto Company | Method for controlling blood triglycerides |
| US4302450A (en) * | 1979-01-15 | 1981-11-24 | Hoffmann-La Roche Inc. | Polyether ionophores as antiobesity and hypotriglyceridemic agents |
| US4218443A (en) * | 1979-01-15 | 1980-08-19 | Hoffmann-La Roche Inc. | Polyether ionophores as antiobesity and hypotriglyceridemic agents |
| CA1213397A (en) | 1980-10-20 | 1986-10-28 | Judith L. Page | Weight control with alkyl styrene polymers |
| US4432968A (en) * | 1980-10-20 | 1984-02-21 | The Dow Chemical Company | Weight control with fat imbibing polymers |
| IT1133979B (it) | 1980-10-22 | 1986-07-24 | Ponteggi Est Spa | Testata di ancoraggio per trefoli o cavi atti a mettere in tensione strutture metalliche o in calcestruzzo |
| CA1247547A (en) * | 1983-06-22 | 1988-12-28 | Paul Hadvary | Leucine derivatives |
| US5597810A (en) * | 1984-12-27 | 1997-01-28 | Hoffman; Allan S. | Method for reducing absorption of undesired lipids in the gastrointestinal tract |
| US5200183A (en) * | 1987-11-19 | 1993-04-06 | Oklahoma Medical Research Foundation | Recombinant bile salt activated lipases |
| JPH02503205A (ja) | 1988-02-12 | 1990-10-04 | ドゥ ツァープフェル，ブリギット | 医用及びパラメディカル用の架橋親水性コポリマー |
| US5089163A (en) * | 1989-01-30 | 1992-02-18 | Lever Brothers Company, Division Of Conopco, Inc. | Enzymatic liquid detergent composition |
| US4959179A (en) | 1989-01-30 | 1990-09-25 | Lever Brothers Company | Stabilized enzymes liquid detergent composition containing lipase and protease |
| US5484777A (en) * | 1989-04-20 | 1996-01-16 | Lange, Iii; Louis G. | Pancreatic cholesterol esterase inhibitor |
| US5063210A (en) * | 1989-04-20 | 1991-11-05 | Lange Iii Louis G | Use of sulfated polysaccharides to decrease cholesterol and fatty acid absorption |
| WO1991003544A1 (en) * | 1989-08-29 | 1991-03-21 | The Regents Of The University Of California | Novel hydrolytic enzyme inhibitors and substrates and assays, methods and kits embodying same |
| US5308766A (en) * | 1989-08-29 | 1994-05-03 | The Regents Of The University Of California | Hydrolytic enzyme inhibitors/inactivators and methods for using same |
| US5260310A (en) * | 1990-02-26 | 1993-11-09 | Hoffmann-La Roche Inc. | Oxetanone compounds and pharmaceutical compositions containing them |
| US5137716A (en) * | 1990-11-15 | 1992-08-11 | Weisenfeld Michael S | Method of reducing weight in mammals |
| JP2709658B2 (ja) | 1991-04-30 | 1998-02-04 | 第一工業製薬株式会社 | ロジン系エマルジョンサイズ剤用乳化分散剤及びサイズ剤 |
| EP0622078B1 (en) * | 1992-01-14 | 1999-09-01 | Hisamitsu Pharmaceutical Co., Inc. | Cholesterol level depressant |
| JP2667351B2 (ja) * | 1992-03-24 | 1997-10-27 | 麒麟麦酒株式会社 | 食餌脂質消化吸収阻害剤および飲食品 |
| DK0563731T3 (da) * | 1992-03-28 | 1996-03-18 | Hoechst Ag | Lægemidler indeholdende polyhydromethylenderivater, fremgangsmåde til deres fremstilling og deres anvendelse |
| JP3507523B2 (ja) | 1993-05-12 | 2004-03-15 | 積水化学工業株式会社 | 糖質吸収抑制剤 |
| US5900475A (en) * | 1994-06-10 | 1999-05-04 | Geltex Pharmaceuticals, Inc. | Hydrophobic sequestrant for cholesterol depletion |
| US5703188A (en) * | 1993-06-02 | 1997-12-30 | Geltex Pharmaceuticals, Inc. | Process for removing bile salts from a patient and compositions therefor |
| US5618530A (en) * | 1994-06-10 | 1997-04-08 | Geltex Pharmaceuticals, Inc. | Hydrophobic amine polymer sequestrant and method of cholesterol depletion |
| US5624963A (en) * | 1993-06-02 | 1997-04-29 | Geltex Pharmaceuticals, Inc. | Process for removing bile salts from a patient and compositions therefor |
| US5607669A (en) * | 1994-06-10 | 1997-03-04 | Geltex Pharmaceuticals, Inc. | Amine polymer sequestrant and method of cholesterol depletion |
| US5569452A (en) * | 1993-08-31 | 1996-10-29 | Tsrl, Inc. | Pharmaceutical formulation having enhanced bile acid binding affinity |
| US5414068A (en) * | 1994-01-24 | 1995-05-09 | Rohm And Haas Company | Crosslinked anion exchange particles and method for producing the particles |
| TW474813B (en) * | 1994-06-10 | 2002-02-01 | Geltex Pharma Inc | Alkylated composition for removing bile salts from a patient |
| US5474993A (en) * | 1994-06-14 | 1995-12-12 | Sterling Winthrop, Inc. | Lactam inhibitors of cholesterol esterase |
| JPH0859458A (ja) * | 1994-08-25 | 1996-03-05 | Zeria Pharmaceut Co Ltd | インダン誘導体を含有する高脂血症治療剤 |
| US5900233A (en) * | 1997-10-16 | 1999-05-04 | Day; Charles E. | Epichlorohydrin and 1-(3-aminopropyl) imidazole copolymer and its use in treating irritable bowel syndrome |
| US6299868B1 (en) * | 1999-07-14 | 2001-10-09 | Geltex Pharmaceuticals, Inc. | Fat-binding polymers |
| US6264937B1 (en) * | 1998-01-09 | 2001-07-24 | Geltex Pharmaceuticals, Inc. | Fat-binding polymers |
| AU759388B2 (en) * | 1998-08-14 | 2003-04-10 | Cheplapharm Arzneimittel Gmbh | Pharmaceutical compositions containing lipase inhibitors and chitosan |
| TR200100471T2 (tr) * | 1998-08-14 | 2001-07-23 | F.Hoffmann-La Roche Ag | Lipaz inhibitörleri içeren farmasötik bileşimler |
| IL147361A0 (en) | 1999-07-14 | 2002-08-14 | Geltex Pharma Inc | Fat-binding polymers, optionally combined with lipase inhibitors |
-
2002
- 2002-06-27 US US10/187,315 patent/US7049345B2/en not_active Expired - Lifetime
- 2002-07-01 EP EP02744787A patent/EP1404349B1/en not_active Expired - Lifetime
- 2002-07-01 WO PCT/US2002/020922 patent/WO2003002130A1/en not_active Ceased
- 2002-07-01 DE DE60229523T patent/DE60229523D1/de not_active Expired - Lifetime
- 2002-07-01 AU AU2002346034A patent/AU2002346034B2/en not_active Ceased
- 2002-07-01 CA CA002490219A patent/CA2490219A1/en not_active Abandoned
- 2002-07-01 JP JP2003508369A patent/JP2005502615A/ja active Pending
- 2002-07-01 AT AT02744787T patent/ATE411808T1/de not_active IP Right Cessation
-
2006
- 2006-02-06 US US11/349,357 patent/US20060127353A1/en not_active Abandoned
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