JP2005501082A5 - - Google Patents
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- Publication number
- JP2005501082A5 JP2005501082A5 JP2003518614A JP2003518614A JP2005501082A5 JP 2005501082 A5 JP2005501082 A5 JP 2005501082A5 JP 2003518614 A JP2003518614 A JP 2003518614A JP 2003518614 A JP2003518614 A JP 2003518614A JP 2005501082 A5 JP2005501082 A5 JP 2005501082A5
- Authority
- JP
- Japan
- Prior art keywords
- aerosol pharmaceutical
- pentafluorooctyl
- oxy
- acetic acid
- physiologically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000443 aerosol Substances 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 6
- 239000011780 sodium chloride Substances 0.000 claims 6
- PRPBZMJTJYWVAN-UHFFFAOYSA-N 2-(7,7,8,8,8-pentafluorooctoxy)acetic acid Chemical compound OC(=O)COCCCCCCC(F)(F)C(F)(F)F PRPBZMJTJYWVAN-UHFFFAOYSA-N 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 239000012453 solvate Substances 0.000 claims 5
- 239000003380 propellant Substances 0.000 claims 4
- LVGUZGTVOIAKKC-UHFFFAOYSA-N 1,1,1,2-Tetrafluoroethane Chemical group FCC(F)(F)F LVGUZGTVOIAKKC-UHFFFAOYSA-N 0.000 claims 2
- NBVXSUQYWXRMNV-UHFFFAOYSA-N Fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 claims 2
- WMWTYOKRWGGJOA-CENSZEJFSA-N Fluticasone propionate Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(OC(=O)CC)[C@@]2(C)C[C@@H]1O WMWTYOKRWGGJOA-CENSZEJFSA-N 0.000 claims 2
- GIIZNNXWQWCKIB-UHFFFAOYSA-N Serevent Chemical compound C1=C(O)C(CO)=CC(C(O)CNCCCCCCOCCCCC=2C=CC=CC=2)=C1 GIIZNNXWQWCKIB-UHFFFAOYSA-N 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 229960000289 fluticasone propionate Drugs 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 229960004017 salmeterol Drugs 0.000 claims 2
- YFMFNYKEUDLDTL-UHFFFAOYSA-N 1,1,1,2,3,3,3-Heptafluoropropane Chemical compound FC(F)(F)C(F)C(F)(F)F YFMFNYKEUDLDTL-UHFFFAOYSA-N 0.000 claims 1
- YAQLSKVCTLCIIE-UHFFFAOYSA-M 2-bromobutanoate Chemical compound CCC(Br)C([O-])=O YAQLSKVCTLCIIE-UHFFFAOYSA-M 0.000 claims 1
- JVIIYFXMBLZGQO-UHFFFAOYSA-N 7,7,8,8,8-pentafluorooctan-1-ol Chemical compound OCCCCCCC(F)(F)C(F)(F)F JVIIYFXMBLZGQO-UHFFFAOYSA-N 0.000 claims 1
- 229940023808 Albuterol Drugs 0.000 claims 1
- NDAUXUAQIAJITI-UHFFFAOYSA-N Salbutamol Chemical group CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- KYKAJFCTULSVSH-UHFFFAOYSA-N chloro(fluoro)methane Chemical compound F[C]Cl KYKAJFCTULSVSH-UHFFFAOYSA-N 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drugs Drugs 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000007971 pharmaceutical suspension Substances 0.000 claims 1
- 229960002052 salbutamol Drugs 0.000 claims 1
- 239000000375 suspending agent Substances 0.000 claims 1
Claims (10)
- 粒子状の薬剤と、1個以上のフルオロカーボン噴射剤もしくは水素含有クロロフルオロカーボン噴射剤と、[(7,7,8,8,8-ペンタフルオロオクチル)オキシ]酢酸またはその塩もしくは溶媒和物とを含む、エアロゾル医薬製剤。
- [(7,7,8,8,8-ペンタフルオロオクチル)オキシ]酢酸が遊離酸として存在する、請求項１記載のエアロゾル医薬製剤。
- フルオロカーボン噴射剤が、1,1,1,2-テトラフルオロエタン、または1,1,1,2,3,3,3-ヘプタフルオロ-n-プロパン、またはそれらの混合物から選択される、請求項１または２記載のエアロゾル医薬製剤。
- 噴射剤が1,1,1,2-テトラフルオロエタンである、請求項３に記載のエアロゾル医薬製剤。
- 粒子状の薬剤が、アルブテロールもしくはその生理学的に許容される塩、フルチカゾンプロピオネートもしくはその生理学的に許容される溶媒和物、サルメテロールもしくはその生理学的に許容される塩から選択される、請求項１〜４のいずれか一項に記載のエアロゾル医薬製剤。
- 更なる薬剤を含む、請求項1〜５のいずれか一項に記載のエアロゾル医薬製剤。
- サルメテロールもしくはその生理学的に許容される塩とフルチカゾンプロピオネートもしくはその生理学的に許容される溶媒和物とを組み合わせて含む、請求項６に記載のエアロゾル医薬製剤。
- [(7,7,8,8,8-ペンタフルオロオクチル)オキシ]酢酸またはその塩もしくは溶媒和物。
- 定量噴霧式吸入器における使用に適合させたエアロゾル医薬懸濁剤における懸濁化剤としての、[(7,7,8,8,8-ペンタフルオロオクチル)オキシ]酢酸またはその塩もしくは溶媒和の使用。
- 6-(ペンタフルオロエチル)ヘキサン-1-オールとブロモ酢酸エチルとを反応させることを含む、[(7,7,8,8,8-ペンタフルオロオクチル)オキシ]酢酸の製造方法。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0118994A GB0118994D0 (en) | 2001-08-03 | 2001-08-03 | Compounds |
| GB0206892A GB0206892D0 (en) | 2002-03-23 | 2002-03-23 | Compounds |
| PCT/GB2002/003586 WO2003013610A2 (en) | 2001-08-03 | 2002-08-02 | Surfactant compounds and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005206725A Division JP2006008695A (ja) | 2001-08-03 | 2005-07-15 | 界面活性剤化合物およびその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005501082A JP2005501082A (ja) | 2005-01-13 |
| JP2005501082A5 true JP2005501082A5 (ja) | 2006-01-05 |
Family
ID=26246403
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003518614A Pending JP2005501082A (ja) | 2001-08-03 | 2002-08-02 | 界面活性剤化合物およびその使用 |
| JP2005206725A Pending JP2006008695A (ja) | 2001-08-03 | 2005-07-15 | 界面活性剤化合物およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005206725A Pending JP2006008695A (ja) | 2001-08-03 | 2005-07-15 | 界面活性剤化合物およびその使用 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7195752B2 (ja) |
| EP (2) | EP1486203B1 (ja) |
| JP (2) | JP2005501082A (ja) |
| KR (1) | KR20040025738A (ja) |
| CN (1) | CN1279893C (ja) |
| AT (2) | ATE320795T1 (ja) |
| AU (1) | AU2002321422B2 (ja) |
| BR (1) | BR0211656A (ja) |
| CA (1) | CA2456052A1 (ja) |
| CO (1) | CO5550416A2 (ja) |
| DE (2) | DE60210102T2 (ja) |
| ES (2) | ES2293157T3 (ja) |
| HU (1) | HUP0401194A2 (ja) |
| IL (1) | IL160114A0 (ja) |
| MX (1) | MXPA04001049A (ja) |
| NO (1) | NO20040462L (ja) |
| NZ (1) | NZ530828A (ja) |
| PL (1) | PL368805A1 (ja) |
| RU (1) | RU2004103075A (ja) |
| WO (1) | WO2003013610A2 (ja) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0125127D0 (en) | 2001-10-19 | 2001-12-12 | Glaxo Group Ltd | Compounds |
| PL372106A1 (en) | 2002-02-13 | 2005-07-11 | Glaxo Group Limited | Carboxylic acid compounds for use as surfactants |
| GB0323701D0 (en) * | 2003-10-09 | 2003-11-12 | Glaxo Group Ltd | Formulations |
| EP1740189B1 (en) * | 2004-04-19 | 2012-06-13 | Centre National De La Recherche Scientifique -Cnrs- | Lung surfactant supplements |
| EP1773979B1 (en) | 2004-08-04 | 2016-06-29 | Acea Biosciences, Inc. | Dynamic monitoring of activation of g-protein (gpcr) in living cells using real-time microelectronic cell sensing technology |
| DE102005000858A1 (de) * | 2005-01-05 | 2006-07-20 | Merck Patent Gmbh | Fluortenside |
| PL240578B1 (pl) * | 2018-10-26 | 2022-05-02 | Nanosanguis | Związek chemiczny będący solą amoniową częściowo fluorowanych kwasów organicznych oraz jego zastosowania |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3250808A (en) * | 1963-10-31 | 1966-05-10 | Du Pont | Fluorocarbon ethers derived from hexafluoropropylene epoxide |
| US3498923A (en) * | 1966-10-18 | 1970-03-03 | Us Navy | Surface-active compositions and method for displacing liquid organic films from solid surfaces |
| JPS5331582A (en) * | 1976-09-04 | 1978-03-24 | Daikin Ind Ltd | Aerosol composition |
| US4346235A (en) * | 1979-06-15 | 1982-08-24 | Okamura Oil Mill Limited | Fluorine-containing compounds |
| JPS62297478A (ja) | 1986-06-18 | 1987-12-24 | Nippon Soda Co Ltd | 表面処理剤およびその製造方法 |
| FR2613357B1 (fr) * | 1987-04-06 | 1989-06-16 | Atochem | Trifluoromethylation de composes organiques insatures |
| IL97065A (en) | 1990-02-02 | 1994-01-25 | Fisons Plc | Repellent preparations for aerosol |
| DE69131867T2 (de) | 1990-03-23 | 2000-05-18 | Minnesota Mining & Mfg | Anwendung von löslichen fluorhaltigen Tensiden zur Herstellung von Aerosol-Präparaten mit dosierter Abgabe |
| WO1992000107A1 (en) | 1990-06-28 | 1992-01-09 | Glaxo Inc. | Aerosol drug formulations |
| JPH04283538A (ja) | 1991-03-13 | 1992-10-08 | Neos Co Ltd | 含フッ素カルボン酸誘導体 |
| JP2668760B2 (ja) | 1992-06-02 | 1997-10-27 | スカイアルミニウム 株式会社 | アルカリ化学粗面化用アルミニウム合金展伸材およびその製造方法 |
| GB9419536D0 (en) * | 1994-09-28 | 1994-11-16 | Glaxo Inc | Medicaments |
| DE19603033A1 (de) * | 1996-01-19 | 1997-07-24 | Schering Ag | Perfluoralkylhaltige Metallkomplexe, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik |
| DE19608278A1 (de) | 1996-02-23 | 1997-08-28 | Schering Ag | Pharmazeutische Mittel enthaltend perfluoralkylhaltige Metallkomplexe, und ihre Verwendung in der Tumortherapie und interventioniellen Radiologie |
| DE19731300C1 (de) | 1997-07-11 | 1999-01-21 | Schering Ag | Perfluoralkylgruppenhaltige Trijodaromaten, Verfahren zu deren Herstellung und deren Verwendung als Kontrastmittel |
| DE19731591C2 (de) | 1997-07-17 | 1999-09-16 | Schering Ag | Pharmazeutische Mittel enthaltend perfluoralkylgruppenhaltige Trijodaromaten und ihre Verwendung in der Tumortherapie und interventionellen Radiologie |
| US6309623B1 (en) * | 1997-09-29 | 2001-10-30 | Inhale Therapeutic Systems, Inc. | Stabilized preparations for use in metered dose inhalers |
-
2002
- 2002-08-02 WO PCT/GB2002/003586 patent/WO2003013610A2/en active IP Right Grant
- 2002-08-02 AU AU2002321422A patent/AU2002321422B2/en not_active Ceased
- 2002-08-02 CN CNB028193539A patent/CN1279893C/zh not_active Expired - Fee Related
- 2002-08-02 BR BR0211656-1A patent/BR0211656A/pt not_active IP Right Cessation
- 2002-08-02 CA CA002456052A patent/CA2456052A1/en not_active Abandoned
- 2002-08-02 DE DE60210102T patent/DE60210102T2/de not_active Expired - Fee Related
- 2002-08-02 RU RU2004103075/15A patent/RU2004103075A/ru not_active Application Discontinuation
- 2002-08-02 EP EP04077076A patent/EP1486203B1/en not_active Expired - Lifetime
- 2002-08-02 DE DE60222591T patent/DE60222591T2/de not_active Expired - Fee Related
- 2002-08-02 HU HU0401194A patent/HUP0401194A2/hu unknown
- 2002-08-02 NZ NZ530828A patent/NZ530828A/en unknown
- 2002-08-02 AT AT02755124T patent/ATE320795T1/de not_active IP Right Cessation
- 2002-08-02 EP EP02755124A patent/EP1411896B1/en not_active Expired - Lifetime
- 2002-08-02 MX MXPA04001049A patent/MXPA04001049A/es unknown
- 2002-08-02 JP JP2003518614A patent/JP2005501082A/ja active Pending
- 2002-08-02 ES ES04077076T patent/ES2293157T3/es not_active Expired - Lifetime
- 2002-08-02 KR KR10-2004-7001720A patent/KR20040025738A/ko not_active Application Discontinuation
- 2002-08-02 PL PL02368805A patent/PL368805A1/xx unknown
- 2002-08-02 IL IL16011402A patent/IL160114A0/xx unknown
- 2002-08-02 US US10/485,595 patent/US7195752B2/en not_active Expired - Fee Related
- 2002-08-02 AT AT04077076T patent/ATE373469T1/de not_active IP Right Cessation
- 2002-08-02 ES ES02755124T patent/ES2260468T3/es not_active Expired - Lifetime
-
2004
- 2004-02-02 NO NO20040462A patent/NO20040462L/no not_active Application Discontinuation
- 2004-02-03 CO CO04008339A patent/CO5550416A2/es not_active Application Discontinuation
-
2005
- 2005-07-15 JP JP2005206725A patent/JP2006008695A/ja active Pending
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