JP2005330266A5 - - Google Patents
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- JP2005330266A5 JP2005330266A5 JP2005113726A JP2005113726A JP2005330266A5 JP 2005330266 A5 JP2005330266 A5 JP 2005330266A5 JP 2005113726 A JP2005113726 A JP 2005113726A JP 2005113726 A JP2005113726 A JP 2005113726A JP 2005330266 A5 JP2005330266 A5 JP 2005330266A5
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- JP
- Japan
- Prior art keywords
- group
- substituted
- halogen
- unsubstituted
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 71
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 63
- 125000005843 halogen group Chemical group 0.000 claims 45
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 40
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 22
- -1 phenylcarbamoyl group Chemical group 0.000 claims 17
- 125000001424 substituent group Chemical group 0.000 claims 11
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 9
- 125000003277 amino group Chemical group 0.000 claims 7
- 125000004043 oxo group Chemical group O=* 0.000 claims 7
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 7
- 125000002252 acyl group Chemical group 0.000 claims 6
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 5
- 125000003545 alkoxy group Chemical group 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 5
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 4
- 125000004093 cyano group Chemical group *C#N 0.000 claims 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims 3
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 3
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 125000004076 pyridyl group Chemical group 0.000 claims 3
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 2
- IANQTJSKSUMEQM-UHFFFAOYSA-N 1-benzofuran Chemical group C1=CC=C2OC=CC2=C1 IANQTJSKSUMEQM-UHFFFAOYSA-N 0.000 claims 2
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical group N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 claims 2
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical group C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims 2
- 125000005092 alkenyloxycarbonyl group Chemical group 0.000 claims 2
- 125000005530 alkylenedioxy group Chemical group 0.000 claims 2
- 125000005225 alkynyloxycarbonyl group Chemical group 0.000 claims 2
- 125000002883 imidazolyl group Chemical group 0.000 claims 2
- PQNFLJBBNBOBRQ-UHFFFAOYSA-N indane Chemical group C1=CC=C2CCCC2=C1 PQNFLJBBNBOBRQ-UHFFFAOYSA-N 0.000 claims 2
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 2
- 125000004193 piperazinyl group Chemical group 0.000 claims 2
- 125000005936 piperidyl group Chemical group 0.000 claims 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 2
- CXWXQJXEFPUFDZ-UHFFFAOYSA-N tetralin Chemical group C1=CC=C2CCCCC2=C1 CXWXQJXEFPUFDZ-UHFFFAOYSA-N 0.000 claims 2
- LYOIGYXSILNCGD-HSZRJFAPSA-N (2r)-2-[[4-[4-(4-chlorophenyl)piperazin-1-yl]phenoxy]methyl]-2-methyl-6-nitro-3h-imidazo[2,1-b][1,3]oxazole Chemical compound C([C@]1(C)OC2=NC(=CN2C1)[N+]([O-])=O)OC(C=C1)=CC=C1N(CC1)CCN1C1=CC=C(Cl)C=C1 LYOIGYXSILNCGD-HSZRJFAPSA-N 0.000 claims 1
- GFILILIJROUKQX-XMMPIXPASA-N (2r)-2-[[4-[4-[(4-chlorophenyl)methyl]piperazin-1-yl]phenoxy]methyl]-2-methyl-6-nitro-3h-imidazo[2,1-b][1,3]oxazole Chemical compound C([C@]1(C)OC2=NC(=CN2C1)[N+]([O-])=O)OC(C=C1)=CC=C1N(CC1)CCN1CC1=CC=C(Cl)C=C1 GFILILIJROUKQX-XMMPIXPASA-N 0.000 claims 1
- ZMQUUTLDDPXMNF-HSZRJFAPSA-N (2r)-2-methyl-6-nitro-2-[[4-[4-[4-(trifluoromethyl)phenyl]piperazin-1-yl]phenoxy]methyl]-3h-imidazo[2,1-b][1,3]oxazole Chemical compound C([C@]1(C)OC2=NC(=CN2C1)[N+]([O-])=O)OC(C=C1)=CC=C1N(CC1)CCN1C1=CC=C(C(F)(F)F)C=C1 ZMQUUTLDDPXMNF-HSZRJFAPSA-N 0.000 claims 1
- GZEWSZWWEUTZIP-XMMPIXPASA-N (2r)-2-methyl-6-nitro-2-[[4-[4-[[4-(trifluoromethoxy)phenyl]methyl]piperazin-1-yl]phenoxy]methyl]-3h-imidazo[2,1-b][1,3]oxazole Chemical compound C([C@]1(C)OC2=NC(=CN2C1)[N+]([O-])=O)OC(C=C1)=CC=C1N(CC1)CCN1CC1=CC=C(OC(F)(F)F)C=C1 GZEWSZWWEUTZIP-XMMPIXPASA-N 0.000 claims 1
- JMBCEUCFQUVBIJ-XMMPIXPASA-N (2r)-2-methyl-6-nitro-2-[[4-[4-[[4-(trifluoromethyl)phenyl]methyl]piperazin-1-yl]phenoxy]methyl]-3h-imidazo[2,1-b][1,3]oxazole Chemical compound C([C@]1(C)OC2=NC(=CN2C1)[N+]([O-])=O)OC(C=C1)=CC=C1N(CC1)CCN1CC1=CC=C(C(F)(F)F)C=C1 JMBCEUCFQUVBIJ-XMMPIXPASA-N 0.000 claims 1
- UCWWPISVZMWAJC-OAQYLSRUSA-N (2r)-6-nitro-2-[[4-[4-[4-(trifluoromethoxy)phenoxy]piperidin-1-yl]phenoxy]methyl]-2,3-dihydroimidazo[2,1-b][1,3]oxazole Chemical compound C([C@H]1CN2C=C(N=C2O1)[N+](=O)[O-])OC(C=C1)=CC=C1N(CC1)CCC1OC1=CC=C(OC(F)(F)F)C=C1 UCWWPISVZMWAJC-OAQYLSRUSA-N 0.000 claims 1
- XDAOLTSRNUSPPH-DEOSSOPVSA-N (2s)-2-methyl-6-nitro-2-[[4-[4-[4-(trifluoromethoxy)phenoxy]piperidin-1-yl]phenoxy]methyl]-3h-imidazo[2,1-b][1,3]oxazole Chemical compound C([C@@]1(C)OC2=NC(=CN2C1)[N+]([O-])=O)OC(C=C1)=CC=C1N(CC1)CCC1OC1=CC=C(OC(F)(F)F)C=C1 XDAOLTSRNUSPPH-DEOSSOPVSA-N 0.000 claims 1
- 125000004844 (C1-C6) alkoxyimino group Chemical group 0.000 claims 1
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 1
- UGUHFDPGDQDVGX-UHFFFAOYSA-N 1,2,3-thiadiazole Chemical group C1=CSN=N1 UGUHFDPGDQDVGX-UHFFFAOYSA-N 0.000 claims 1
- 125000004511 1,2,3-thiadiazolyl group Chemical group 0.000 claims 1
- 125000001376 1,2,4-triazolyl group Chemical group N1N=C(N=C1)* 0.000 claims 1
- AIUOUEPKBRDPLG-UHFFFAOYSA-N 1,3-benzoxathiole Chemical group C1=CC=C2SCOC2=C1 AIUOUEPKBRDPLG-UHFFFAOYSA-N 0.000 claims 1
- FCEHBMOGCRZNNI-UHFFFAOYSA-N 1-benzothiophene Chemical group C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 claims 1
- HBEDSQVIWPRPAY-UHFFFAOYSA-N 2,3-dihydrobenzofuran Chemical group C1=CC=C2OCCC2=C1 HBEDSQVIWPRPAY-UHFFFAOYSA-N 0.000 claims 1
- GFILILIJROUKQX-UHFFFAOYSA-N 2-[[4-[4-[(4-chlorophenyl)methyl]piperazin-1-yl]phenoxy]methyl]-2-methyl-6-nitro-3h-imidazo[2,1-b][1,3]oxazole Chemical compound C1N2C=C([N+]([O-])=O)N=C2OC1(C)COC(C=C1)=CC=C1N(CC1)CCN1CC1=CC=C(Cl)C=C1 GFILILIJROUKQX-UHFFFAOYSA-N 0.000 claims 1
- XDAOLTSRNUSPPH-UHFFFAOYSA-N 2-methyl-6-nitro-2-[[4-[4-[4-(trifluoromethoxy)phenoxy]piperidin-1-yl]phenoxy]methyl]-3h-imidazo[2,1-b][1,3]oxazole Chemical compound C1N2C=C([N+]([O-])=O)N=C2OC1(C)COC(C=C1)=CC=C1N(CC1)CCC1OC1=CC=C(OC(F)(F)F)C=C1 XDAOLTSRNUSPPH-UHFFFAOYSA-N 0.000 claims 1
- ZMQUUTLDDPXMNF-UHFFFAOYSA-N 2-methyl-6-nitro-2-[[4-[4-[4-(trifluoromethyl)phenyl]piperazin-1-yl]phenoxy]methyl]-3h-imidazo[2,1-b][1,3]oxazole Chemical compound C1N2C=C([N+]([O-])=O)N=C2OC1(C)COC(C=C1)=CC=C1N(CC1)CCN1C1=CC=C(C(F)(F)F)C=C1 ZMQUUTLDDPXMNF-UHFFFAOYSA-N 0.000 claims 1
- GZEWSZWWEUTZIP-UHFFFAOYSA-N 2-methyl-6-nitro-2-[[4-[4-[[4-(trifluoromethoxy)phenyl]methyl]piperazin-1-yl]phenoxy]methyl]-3h-imidazo[2,1-b][1,3]oxazole Chemical compound C1N2C=C([N+]([O-])=O)N=C2OC1(C)COC(C=C1)=CC=C1N(CC1)CCN1CC1=CC=C(OC(F)(F)F)C=C1 GZEWSZWWEUTZIP-UHFFFAOYSA-N 0.000 claims 1
- JMBCEUCFQUVBIJ-UHFFFAOYSA-N 2-methyl-6-nitro-2-[[4-[4-[[4-(trifluoromethyl)phenyl]methyl]piperazin-1-yl]phenoxy]methyl]-3h-imidazo[2,1-b][1,3]oxazole Chemical compound C1N2C=C([N+]([O-])=O)N=C2OC1(C)COC(C=C1)=CC=C1N(CC1)CCN1CC1=CC=C(C(F)(F)F)C=C1 JMBCEUCFQUVBIJ-UHFFFAOYSA-N 0.000 claims 1
- RTWPOMOFGYHVAF-GZNOUCQFSA-N 4-methylbenzenesulfonic acid;(2r)-2-methyl-6-nitro-2-[[4-[3-[4-(trifluoromethoxy)phenoxy]-8-azabicyclo[3.2.1]octan-8-yl]phenoxy]methyl]-3h-imidazo[2,1-b][1,3]oxazole Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1.C([C@]1(C)OC2=NC(=CN2C1)[N+]([O-])=O)OC(C=C1)=CC=C1N1C(C2)CCC1CC2OC1=CC=C(OC(F)(F)F)C=C1 RTWPOMOFGYHVAF-GZNOUCQFSA-N 0.000 claims 1
- QISRGAUYEHQMJV-UHFFFAOYSA-N 6-nitro-2,3-dihydroimidazo[2,1-b][1,3]oxazole Chemical class C1COC2=NC([N+](=O)[O-])=CN21 QISRGAUYEHQMJV-UHFFFAOYSA-N 0.000 claims 1
- UCWWPISVZMWAJC-UHFFFAOYSA-N 6-nitro-2-[[4-[4-[4-(trifluoromethoxy)phenoxy]piperidin-1-yl]phenoxy]methyl]-2,3-dihydroimidazo[2,1-b][1,3]oxazole Chemical compound O1C2=NC([N+](=O)[O-])=CN2CC1COC(C=C1)=CC=C1N(CC1)CCC1OC1=CC=C(OC(F)(F)F)C=C1 UCWWPISVZMWAJC-UHFFFAOYSA-N 0.000 claims 1
- DGGKXQQCVPAUEA-UHFFFAOYSA-N 8-azabicyclo[3.2.1]octane Chemical group C1CCC2CCC1N2 DGGKXQQCVPAUEA-UHFFFAOYSA-N 0.000 claims 1
- KYNSBQPICQTCGU-UHFFFAOYSA-N Benzopyrane Chemical group C1=CC=C2C=CCOC2=C1 KYNSBQPICQTCGU-UHFFFAOYSA-N 0.000 claims 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical group C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 1
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 claims 1
- WYNCHZVNFNFDNH-UHFFFAOYSA-N Oxazolidine Chemical group C1COCN1 WYNCHZVNFNFDNH-UHFFFAOYSA-N 0.000 claims 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical group C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims 1
- ZQJDWBXBOUAVET-UHFFFAOYSA-N [4-(trifluoromethoxy)phenyl]methyl 4-[4-[(2-methyl-6-nitro-3h-imidazo[2,1-b][1,3]oxazol-2-yl)methoxy]phenyl]piperazine-1-carboxylate Chemical compound C1N2C=C([N+]([O-])=O)N=C2OC1(C)COC(C=C1)=CC=C1N(CC1)CCN1C(=O)OCC1=CC=C(OC(F)(F)F)C=C1 ZQJDWBXBOUAVET-UHFFFAOYSA-N 0.000 claims 1
- ZQJDWBXBOUAVET-RUZDIDTESA-N [4-(trifluoromethoxy)phenyl]methyl 4-[4-[[(2r)-2-methyl-6-nitro-3h-imidazo[2,1-b][1,3]oxazol-2-yl]methoxy]phenyl]piperazine-1-carboxylate Chemical compound C([C@]1(C)OC2=NC(=CN2C1)[N+]([O-])=O)OC(C=C1)=CC=C1N(CC1)CCN1C(=O)OCC1=CC=C(OC(F)(F)F)C=C1 ZQJDWBXBOUAVET-RUZDIDTESA-N 0.000 claims 1
- 125000004423 acyloxy group Chemical group 0.000 claims 1
- 125000005115 alkyl carbamoyl group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical group C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 claims 1
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 claims 1
- 125000001589 carboacyl group Chemical group 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- XDAOLTSRNUSPPH-XMMPIXPASA-N delamanid Chemical compound C([C@]1(C)OC2=NC(=CN2C1)[N+]([O-])=O)OC(C=C1)=CC=C1N(CC1)CCC1OC1=CC=C(OC(F)(F)F)C=C1 XDAOLTSRNUSPPH-XMMPIXPASA-N 0.000 claims 1
- 229940072185 drug for treatment of tuberculosis Drugs 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000000842 isoxazolyl group Chemical group 0.000 claims 1
- HRDXJKGNWSUIBT-UHFFFAOYSA-N methoxybenzene Chemical group [CH2]OC1=CC=CC=C1 HRDXJKGNWSUIBT-UHFFFAOYSA-N 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 125000005186 naphthyloxy group Chemical group C1(=CC=CC2=CC=CC=C12)O* 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 125000000160 oxazolidinyl group Chemical group 0.000 claims 1
- 125000006678 phenoxycarbonyl group Chemical group 0.000 claims 1
- 125000003356 phenylsulfanyl group Chemical group [*]SC1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000004194 piperazin-1-yl group Chemical group [H]N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 125000005554 pyridyloxy group Chemical group 0.000 claims 1
- 125000000168 pyrrolyl group Chemical group 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 125000003831 tetrazolyl group Chemical group 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 125000005505 thiomorpholino group Chemical group 0.000 claims 1
- 229930192474 thiophene Natural products 0.000 claims 1
- 125000001425 triazolyl group Chemical group 0.000 claims 1
- 239000000814 tuberculostatic agent Substances 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005113726A JP4787529B2 (ja) | 2004-04-09 | 2005-04-11 | 医薬組成物 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004114975 | 2004-04-09 | ||
| JP2004114975 | 2004-04-09 | ||
| JP2004125055 | 2004-04-21 | ||
| JP2004125055 | 2004-04-21 | ||
| JP2005113726A JP4787529B2 (ja) | 2004-04-09 | 2005-04-11 | 医薬組成物 |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008103907A Division JP4789966B2 (ja) | 2004-04-09 | 2008-04-11 | 医薬組成物 |
| JP2011101480A Division JP5345174B2 (ja) | 2004-04-09 | 2011-04-28 | 医薬組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005330266A JP2005330266A (ja) | 2005-12-02 |
| JP2005330266A5 true JP2005330266A5 (https=) | 2008-05-29 |
| JP4787529B2 JP4787529B2 (ja) | 2011-10-05 |
Family
ID=35485163
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005113726A Expired - Lifetime JP4787529B2 (ja) | 2004-04-09 | 2005-04-11 | 医薬組成物 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP4787529B2 (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007297305A (ja) * | 2006-04-28 | 2007-11-15 | Daiso Co Ltd | Ｎ−（２，３−エポキシ−２−メチルプロピル）フタルイミドの製造法 |
| US7638541B2 (en) | 2006-12-28 | 2009-12-29 | Metabolex Inc. | 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine |
| AR070301A1 (es) * | 2007-05-08 | 2010-03-31 | Otsuka Pharma Co Ltd | Compuesto epoxi y metodo para producir el mismo |
| JP5464709B2 (ja) | 2007-06-08 | 2014-04-09 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ピペリジン／ピペラジン誘導体 |
| ES2536406T3 (es) | 2007-06-08 | 2015-05-25 | Janssen Pharmaceutica, N.V. | Derivados de piperidina/piperazina |
| JO2972B1 (en) | 2007-06-08 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Piperidine / piperazine derivatives |
| EP2152271B1 (en) | 2007-06-08 | 2015-10-21 | Janssen Pharmaceutica, N.V. | Piperidine/piperazine derivatives |
| RU2010142937A (ru) * | 2008-03-20 | 2012-04-27 | Форест Лабораториес Холдингс Лимитед (Bm) | НОВЫЕ ПРОИЗВОДНЫЕ ПИПЕРИДИНА В КАЧЕСТВЕ ИНГИБИТОРОВ СТЕАРОИЛ-КоА ДЕСАТУРАЗЫ |
| JP5613656B2 (ja) * | 2008-03-26 | 2014-10-29 | グローバル、アライアンス、フォア、ティービー、ドラッグ、ディベロップメント | 置換されたフェニルオキサゾリジノンと共有結合した二環式ニトロイミダゾール |
| PE20100083A1 (es) | 2008-06-05 | 2010-02-17 | Janssen Pharmaceutica Nv | Combinaciones de drogas que comprenden un inhibidor de dgat y un agonista de ppar |
| CA2727174A1 (en) * | 2008-06-20 | 2010-01-21 | Jiangao Song | Aryl gpr119 agonists and uses thereof |
| BR112012002214B1 (pt) | 2009-07-31 | 2022-01-25 | Global Alliance For Tb Drug Development | Análogos de nitroimidazooxazina e nitroimidazooxazol, seus usos e composição farmacêutica |
| JP5909185B2 (ja) | 2009-10-01 | 2016-04-26 | シマベイ セラピューティクス， インコーポレーテッド | 置換テトラゾール−１−イルフェノキシメチルチアゾール−２−イルピペリジニルピリミジン塩 |
| JP5770096B2 (ja) | 2009-10-26 | 2015-08-26 | 富士フイルムＲｉファーマ株式会社 | 感染症診断薬 |
| WO2014014845A1 (en) | 2012-07-18 | 2014-01-23 | Vertex Pharmaceuticals Incorporated | Combination therapy comprising|1 -ethyl-3-[5-[2-{1 -hydroxy-1 -methyl-ethyl}pyrimidin-5-yl]-7-(tetra hydrofuran-2-|yl}-1 h-benzimidazol-2-yl]urea and derivatives thereof to treat mycobacterium|diseases |
| IN2013DE02954A (https=) * | 2013-10-04 | 2015-04-10 | Council Scient Ind Res | |
| EP3209669B1 (en) * | 2014-10-21 | 2018-11-07 | Council of Scientific and Industrial Research | Substituted 1,2,3-triazol-1-yl-methyl-2,3-dihydro-2-methyl-6-nitroimidazo[2,1-b]oxazoles as anti-mycobacterial agents and a process for the preparation thereof |
| WO2016119706A1 (zh) * | 2015-01-29 | 2016-08-04 | 南京明德新药研发股份有限公司 | 抗肺结核病的硝基咪唑衍生物 |
| EA201792154A1 (ru) * | 2015-03-27 | 2018-02-28 | Оцука Фармасьютикал Ко., Лтд. | Способ получения 1-(4-гидроксифенил)-4-(4- трифторметоксифенокси)пиперидина или его соли |
| CN106317072B (zh) * | 2015-06-17 | 2020-03-17 | 盟科医药技术(上海)有限公司 | 用于分枝杆菌感染治疗的杂环化合物及其应用 |
| US20190276475A1 (en) * | 2016-07-22 | 2019-09-12 | Medshine Discovery Inc. | Crystal and salt of nitroimidazole, and manufacturing method thereof |
| AU2017305392A1 (en) | 2016-08-03 | 2019-02-21 | Cymabay Therapeutics, Inc. | Oxymethylene aryl compounds for treating inflammatory gastrointestinal diseases or gastrointestinal conditions |
| GB201617758D0 (en) * | 2016-10-20 | 2016-12-07 | Almac Discovery Limited | Pharmaceutical compounds |
| US11339147B2 (en) | 2017-05-26 | 2022-05-24 | Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. | Lactam compound as FXR receptor agonist |
| WO2019128963A1 (zh) * | 2017-12-26 | 2019-07-04 | 南京明德新药研发股份有限公司 | 抗肺结核病的硝基咪唑衍生物 |
| WO2020202205A1 (en) * | 2019-04-01 | 2020-10-08 | Council Of Scientific And Industrial Research | Process for the preparation of derivatives of 1,1-dialkylethane-1,2-diols as useful intermediates |
| CN112300192B (zh) * | 2019-08-02 | 2023-08-11 | 南京长澳医药科技有限公司 | 硝基咪唑类化合物及其制备方法和用途 |
| CN115368252B (zh) * | 2022-09-19 | 2024-01-12 | 西北农林科技大学 | 一种4-胺基酚类衍生物及应用 |
| CN116570592B (zh) * | 2023-04-17 | 2025-01-14 | 首都医科大学附属北京胸科医院 | Gsk1292263在制备抑制结核分枝杆菌药物中的应用 |
| CN119059990B (zh) * | 2024-11-01 | 2025-02-07 | 安徽昊帆生物有限公司 | 1-氨基甲酸叔丁酯哌嗪的制备方法 |
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| US5668127A (en) * | 1995-06-26 | 1997-09-16 | Pathogenesis Corporation | Nitroimidazole antibacterial compounds and methods of use thereof |
| AR041198A1 (es) * | 2002-10-11 | 2005-05-04 | Otsuka Pharma Co Ltd | Compuesto 2,3-dihidro-6-nitroimidazo[2,1-b] oxaxol, y composiciones farmaceuticas que lo contienen |
| JP4258630B2 (ja) * | 2002-10-15 | 2009-04-30 | 大塚製薬株式会社 | １位置換−４−ニトロイミダゾール化合物及びその製造法 |
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