EA201792154A1 - Способ получения 1-(4-гидроксифенил)-4-(4- трифторметоксифенокси)пиперидина или его соли - Google Patents

Способ получения 1-(4-гидроксифенил)-4-(4- трифторметоксифенокси)пиперидина или его соли

Info

Publication number
EA201792154A1
EA201792154A1 EA201792154A EA201792154A EA201792154A1 EA 201792154 A1 EA201792154 A1 EA 201792154A1 EA 201792154 A EA201792154 A EA 201792154A EA 201792154 A EA201792154 A EA 201792154A EA 201792154 A1 EA201792154 A1 EA 201792154A1
Authority
EA
Eurasian Patent Office
Prior art keywords
piperidine
hydroxyphenyl
salt
triftormetoxyphenoxy
obtaining
Prior art date
Application number
EA201792154A
Other languages
English (en)
Inventor
Масахиро Мияке
Ая Асахина
Такахиро ОКАДА
Original Assignee
Оцука Фармасьютикал Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Оцука Фармасьютикал Ко., Лтд. filed Critical Оцука Фармасьютикал Ко., Лтд.
Publication of EA201792154A1 publication Critical patent/EA201792154A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4465—Non condensed piperidines, e.g. piperocaine only substituted in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B37/00—Reactions without formation or introduction of functional groups containing hetero atoms, involving either the formation of a carbon-to-carbon bond between two carbon atoms not directly linked already or the disconnection of two directly linked carbon atoms
    • C07B37/04—Substitution

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

В настоящем изобретении обеспечивается способ получения 1-(4-гидроксифенил)-4-(4-трифторметоксифенокси)пиперидина или его соли, при этом способ включает стадию нагревания гидрохинона и 4-(4-трифторметоксифенокси)пиперидина. Посредством данного способа можно получать 1-(4-гидроксифенил)-4-(4-трифторметоксифенокси)пиперидин или его соль целесообразным в промышленном масштабе способом.
EA201792154A 2015-03-27 2016-03-25 Способ получения 1-(4-гидроксифенил)-4-(4- трифторметоксифенокси)пиперидина или его соли EA201792154A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2015065824 2015-03-27
JP2016036290 2016-02-26
PCT/JP2016/059599 WO2016158737A1 (ja) 2015-03-27 2016-03-25 １－（４－ヒドロキシフェニル）－４－（４－トリフルオロメトキシフェノキシ）ピペリジン又はその塩の製造方法

Publications (1)

Publication Number Publication Date
EA201792154A1 true EA201792154A1 (ru) 2018-02-28

Family

ID=57004670

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201792154A EA201792154A1 (ru) 2015-03-27 2016-03-25 Способ получения 1-(4-гидроксифенил)-4-(4- трифторметоксифенокси)пиперидина или его соли

Country Status (8)

Country Link
US (1) US10252995B2 (ru)
EP (1) EP3275862B1 (ru)
JP (1) JP6776226B2 (ru)
KR (1) KR102597449B1 (ru)
CN (1) CN107406386B (ru)
EA (1) EA201792154A1 (ru)
LT (1) LT3275862T (ru)
WO (1) WO2016158737A1 (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109705022A (zh) * 2018-12-28 2019-05-03 上海彩迩文生化科技有限公司 一种芳香胺中间体的制备方法
WO2020202205A1 (en) * 2019-04-01 2020-10-08 Council Of Scientific And Industrial Research Process for the preparation of derivatives of 1,1-dialkylethane-1,2-diols as useful intermediates

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5138245B2 (ru) * 1973-05-22 1976-10-20
DE2437929A1 (de) * 1974-08-07 1976-02-19 Hoechst Ag Verfahren zur herstellung von hydrochinon
JPS5673048A (en) * 1979-11-20 1981-06-17 Mitsui Petrochem Ind Ltd Amination of dihydric phenol
JPS58118545A (ja) * 1981-12-29 1983-07-14 Toyo Soda Mfg Co Ltd ４−ヒドロキシジフエニルアミンの製造法
JPH0585994A (ja) 1991-09-30 1993-04-06 Mitsui Petrochem Ind Ltd Ｎ，ｎ−ジアルキルアミノフエノール類の製造方法
JP2003096030A (ja) * 2001-09-27 2003-04-03 Sumitomo Chem Co Ltd Ｎ、ｎ−ジアルキルアミノフェノール類の製造方法
TWI347946B (en) 2002-10-11 2011-09-01 Otsuka Pharma Co Ltd 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound
TWI380975B (zh) * 2004-03-25 2013-01-01 Otsuka Pharma Co Ltd 製造胺基酚類化合物的方法
JP4761802B2 (ja) * 2004-03-25 2011-08-31 大塚製薬株式会社 アミノフェノール化合物の製造法
JP4787529B2 (ja) * 2004-04-09 2011-10-05 大塚製薬株式会社 医薬組成物
AR070301A1 (es) * 2007-05-08 2010-03-31 Otsuka Pharma Co Ltd Compuesto epoxi y metodo para producir el mismo
TW201200523A (en) * 2010-01-29 2012-01-01 Otsuka Pharma Co Ltd Synthetic intermediate of oxazole compound and method for producing the same

Also Published As

Publication number Publication date
JPWO2016158737A1 (ja) 2018-01-18
LT3275862T (lt) 2020-09-25
CN107406386B (zh) 2021-06-01
CN107406386A (zh) 2017-11-28
US20180065931A1 (en) 2018-03-08
JP6776226B2 (ja) 2020-10-28
EP3275862A4 (en) 2018-12-05
KR102597449B1 (ko) 2023-11-03
WO2016158737A1 (ja) 2016-10-06
EP3275862B1 (en) 2020-08-12
US10252995B2 (en) 2019-04-09
KR20170129898A (ko) 2017-11-27
EP3275862A1 (en) 2018-01-31

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