JP2005162745A - 高血圧改善剤 - Google Patents
高血圧改善剤 Download PDFInfo
- Publication number
- JP2005162745A JP2005162745A JP2004327310A JP2004327310A JP2005162745A JP 2005162745 A JP2005162745 A JP 2005162745A JP 2004327310 A JP2004327310 A JP 2004327310A JP 2004327310 A JP2004327310 A JP 2004327310A JP 2005162745 A JP2005162745 A JP 2005162745A
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- Prior art keywords
- hypertension
- angiotensin
- decrease
- administered
- blood pressure
- Prior art date
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Abstract
【解決手段】 ヒハツを配合したことを特徴とする高血圧改善剤、アンジオテンシン活性阻害剤。
【選択図】 なし
Description
精製水 全100ml
上記各成分を混合溶解し、水酸化ナトリウムでpH4.5に調節後80℃30分滅菌して、試験溶液を得た。
ヒハツ乾燥エキス 620mg(原生薬換算量5.0g)
クエン酸 1000mg
精製水 全100ml
上記各成分を混合溶解し、水酸化ナトリウムでpH4.5に調節後80℃30分滅菌して、試験溶液を得た。
乳糖 200g
微結晶セルロース 50g
ステアリン酸マグネシウム 3g
上記各成分を秤量し均一に混合した後、得られた混合粉末を2号硬カプセルに200mgずつ充填し、カプセル剤を得た。
ジオウエキス(地黄300mgに相当) 150g
乳糖 50g
低置換度ヒドロキシプロピルセルロース 166.4g
ステアリン酸マグネシウム 10g
硬化ヒマシ油 10g
上記の各成分を秤量し均一に混合した後、得られた混合粉末を直打法により1錠重量200mgになるように打錠し、錠剤を得た。
試験例1 ラットを用いた観血式血圧の測定
試験動物としてSD系ラット(雄、体重:300g〜400g、チャールスリバー)を用いた。なお、動物は全実験期間を通して、室温25±2℃、湿度55±15%で照明(約200ルックス)が12時間サイクルに設定された実験室で水洗ケージにて飼育した。食餌は市販固形飼料、水は滅菌水を用い、それぞれ、自由摂取とし、実験18時間前に絶食とした。
Claims (3)
- ヒハツを配合したことを特徴とするアンジオテンシン活性阻害剤。
- ヒハツを配合したことを特徴とするアンジオテンシンII活性阻害剤。
- ヒハツを配合したことを特徴とする高血圧症の治療または予防剤。
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Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005298429A (ja) * | 2004-04-14 | 2005-10-27 | Maruzen Pharmaceut Co Ltd | 血管内皮型一酸化窒素合成酵素活性促進剤 |
WO2013119605A1 (en) * | 2012-02-07 | 2013-08-15 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Promoting sleep using at1 receptor blockers |
JP2016164193A (ja) * | 2011-05-10 | 2016-09-08 | 丸善製薬株式会社 | Tie2活性化剤、血管新生抑制剤、血管の成熟化剤、血管の正常化剤、及び血管の安定化剤、並びに医薬品組成物、及び飲食品 |
JP2017025056A (ja) * | 2015-07-27 | 2017-02-02 | 大正製薬株式会社 | ピペリン含有経口組成物 |
JP2018002658A (ja) * | 2016-07-01 | 2018-01-11 | 株式会社東洋新薬 | 経口組成物 |
WO2022162633A1 (en) * | 2021-02-01 | 2022-08-04 | Rath Matthias W | Micronutrient composition and method to reduce high blood pressure |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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JPS62178517A (ja) * | 1986-02-03 | 1987-08-05 | Mitsubishi Chem Ind Ltd | 冠血管拡張薬 |
JPH11500725A (ja) * | 1995-02-24 | 1999-01-19 | サビンサ コーポレーション | ピペリンのバイオアベイラビリティ増強剤としての使用 |
JP2002080356A (ja) * | 2000-09-05 | 2002-03-19 | Kao Corp | 高血圧症予防・治療剤 |
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- 2004-11-11 JP JP2004327310A patent/JP4797363B2/ja active Active
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JPS62178517A (ja) * | 1986-02-03 | 1987-08-05 | Mitsubishi Chem Ind Ltd | 冠血管拡張薬 |
JPH11500725A (ja) * | 1995-02-24 | 1999-01-19 | サビンサ コーポレーション | ピペリンのバイオアベイラビリティ増強剤としての使用 |
JP2002080356A (ja) * | 2000-09-05 | 2002-03-19 | Kao Corp | 高血圧症予防・治療剤 |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005298429A (ja) * | 2004-04-14 | 2005-10-27 | Maruzen Pharmaceut Co Ltd | 血管内皮型一酸化窒素合成酵素活性促進剤 |
JP2016164193A (ja) * | 2011-05-10 | 2016-09-08 | 丸善製薬株式会社 | Tie2活性化剤、血管新生抑制剤、血管の成熟化剤、血管の正常化剤、及び血管の安定化剤、並びに医薬品組成物、及び飲食品 |
WO2013119605A1 (en) * | 2012-02-07 | 2013-08-15 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Promoting sleep using at1 receptor blockers |
US10813915B2 (en) | 2012-02-07 | 2020-10-27 | University of Pittsburgh—of the Commonwealth System of Higher Education | Promoting sleep using AT1 receptor blockers |
US11439624B2 (en) | 2012-02-07 | 2022-09-13 | University of Pittsburgh—of the Commonwealth System of Higher Education | Promoting sleep using AT1 receptor blockers |
JP2017025056A (ja) * | 2015-07-27 | 2017-02-02 | 大正製薬株式会社 | ピペリン含有経口組成物 |
JP2018002658A (ja) * | 2016-07-01 | 2018-01-11 | 株式会社東洋新薬 | 経口組成物 |
WO2022162633A1 (en) * | 2021-02-01 | 2022-08-04 | Rath Matthias W | Micronutrient composition and method to reduce high blood pressure |
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