JP2004535456A5 - - Google Patents

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Publication number
JP2004535456A5
JP2004535456A5 JP2003510039A JP2003510039A JP2004535456A5 JP 2004535456 A5 JP2004535456 A5 JP 2004535456A5 JP 2003510039 A JP2003510039 A JP 2003510039A JP 2003510039 A JP2003510039 A JP 2003510039A JP 2004535456 A5 JP2004535456 A5 JP 2004535456A5
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JP
Japan
Prior art keywords
trimethylquinoline
tetrahydro
acetyl
phenyl
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2003510039A
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English (en)
Other versions
JP4523273B2 (ja
JP2004535456A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2002/007053 external-priority patent/WO2003004028A1/en
Publication of JP2004535456A publication Critical patent/JP2004535456A/ja
Publication of JP2004535456A5 publication Critical patent/JP2004535456A5/ja
Application granted granted Critical
Publication of JP4523273B2 publication Critical patent/JP4523273B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Description

１−アセチル−４−フェニル−１，２，３，４−テトラヒドロ−６−（ −トルエンスルホニル）アミノ−２，２，４−トリメチルキノリン
実施例６で説明したアシル化法にしたがって、テトラヒドロフラン（２５ｍｌ）中において、１−アセチル−６−アミノ−４−フェニル−１，２，３，４−テトラヒドロ−２，２，４−トリメチルキノリン（１０ｍｇ）を、−トルエンスルホニルクロリド（１２ｍｇ）及びＮ，Ｎ−ジイソプロピルエチルアミン（２２ ｌ）でスルホニル化した。
JP2003510039A 2001-07-02 2002-06-25 テトラヒドロキノリン誘導体 Expired - Fee Related JP4523273B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01202531 2001-07-02
PCT/EP2002/007053 WO2003004028A1 (en) 2001-07-02 2002-06-25 Tetrahydroquinoline derivatives

Publications (3)

Publication Number Publication Date
JP2004535456A JP2004535456A (ja) 2004-11-25
JP2004535456A5 true JP2004535456A5 (ja) 2009-07-16
JP4523273B2 JP4523273B2 (ja) 2010-08-11

Family

ID=8180574

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003510039A Expired - Fee Related JP4523273B2 (ja) 2001-07-02 2002-06-25 テトラヒドロキノリン誘導体

Country Status (32)

Country Link
US (2) US8058441B2 (ja)
EP (1) EP1406628B1 (ja)
JP (1) JP4523273B2 (ja)
KR (1) KR100908468B1 (ja)
CN (1) CN1261099C (ja)
AR (1) AR034669A1 (ja)
AT (1) ATE319451T1 (ja)
AU (1) AU2002317848B2 (ja)
BR (1) BR0210645A (ja)
CA (1) CA2452606C (ja)
CY (1) CY1106087T1 (ja)
CZ (1) CZ20042A3 (ja)
DE (1) DE60209734T2 (ja)
DK (1) DK1406628T3 (ja)
EC (1) ECSP034932A (ja)
ES (1) ES2260458T3 (ja)
HK (1) HK1061810A1 (ja)
HR (1) HRP20031080A2 (ja)
HU (1) HUP0400390A2 (ja)
IL (1) IL159288A0 (ja)
IS (1) IS2418B (ja)
MX (1) MXPA03011908A (ja)
NO (1) NO325516B1 (ja)
NZ (1) NZ530198A (ja)
PE (1) PE20030273A1 (ja)
PL (1) PL367638A1 (ja)
PT (1) PT1406628E (ja)
RU (1) RU2347570C2 (ja)
SA (1) SA02230260B1 (ja)
SK (1) SK286759B6 (ja)
WO (1) WO2003004028A1 (ja)
ZA (1) ZA200309921B (ja)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
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DE60325025D1 (de) * 2002-02-15 2009-01-15 Glaxo Group Ltd Modulatoren des vanilloidrezeptors
FR2836620B1 (fr) * 2002-02-28 2004-04-16 Snecma Services Instrument de projection thermique
SE0200920D0 (sv) * 2002-03-25 2002-03-25 Astrazeneca Ab Novel compounds
TWI322012B (en) * 2002-12-20 2010-03-21 Organon Nv Tetrahydroquinoline derivatives
TWI306855B (en) * 2002-12-20 2009-03-01 Organon Nv Tetrahydroquinoline derivatives
SE0300480D0 (sv) * 2003-02-21 2003-02-21 Astrazeneca Ab Novel compounds
EP1644042A1 (en) * 2003-05-29 2006-04-12 AstraZeneca AB A pharmaceutical composition containing a p2x7 receptor antagonist and methotrexate
WO2004105797A1 (en) * 2003-05-29 2004-12-09 Astrazeneca Ab A pharmaceutical composition comprising a p2x7 antagonist and sulfasalazine
BRPI0410739A (pt) * 2003-05-29 2006-06-27 Astrazeneca Ab composição farmacêutica compreendendo um antagonista do receptor p2x7 e um fator de necrose tumoral (alfa)
GB0312609D0 (en) * 2003-06-02 2003-07-09 Astrazeneca Ab Novel compounds
KR100554155B1 (ko) * 2003-06-09 2006-02-22 학교법인 포항공과대학교 금속/반도체 나노막대 이종구조를 이용한 전극 구조물 및그 제조 방법
SE0302139D0 (sv) * 2003-07-28 2003-07-28 Astrazeneca Ab Novel compounds
SE0302192D0 (sv) * 2003-08-08 2003-08-08 Astrazeneca Ab Novel compounds
SE0302488D0 (sv) * 2003-09-18 2003-09-18 Astrazeneca Ab New combination
SA05260265A (ar) * 2004-08-30 2005-12-03 استرازينيكا ايه بي مركبات جديدة
SE0402925D0 (sv) * 2004-11-30 2004-11-30 Astrazeneca Ab Novel Compounds
US7691848B2 (en) 2005-03-02 2010-04-06 Wyeth Pyrrolobenzodiazepine arylcarboxamides and derivatives thereof as follicle-stimulating hormone receptor antagonists
MX2007013745A (es) 2005-05-04 2008-01-24 Organon Nv Derivados de dihidropiridina.
UA92009C2 (ru) * 2005-05-04 2010-09-27 Н.В. Органон Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодия
UA92007C2 (ru) 2005-05-04 2010-09-27 Н.В. Органон Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодности
UA92008C2 (en) * 2005-05-04 2010-09-27 Н.В. Органон 4-PHENYL-5-OXO-l,4,5,6,7,8-HEXAHYDROQUINOLINE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF INFERTILITY
CN101213197A (zh) 2005-05-12 2008-07-02 惠氏公司 作为促卵泡激素受体(fsh－r)拮抗剂的吡咯并苯并二氮杂䓬以及杂环甲酰胺衍生物
US7678787B2 (en) 2005-06-09 2010-03-16 Wyeth Pyrrolobenzodiazepine pyridine carboxamides and derivatives as follicle-stimulating hormone receptor antagonists
JP2009504597A (ja) * 2005-08-10 2009-02-05 バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト アシルトリプトファノール
US20070060573A1 (en) * 2005-08-10 2007-03-15 Lars Wortmann Acyltryptophanols
US20080221195A1 (en) * 2006-12-13 2008-09-11 Lars Wortmann 1,2-diarylacetylene derivatives of acyltryptophanols
EP1932831A1 (en) * 2006-12-13 2008-06-18 Bayer Schering Pharma Aktiengesellschaft 1,2-Diarylacetylene Derivatives of Acyltryptophanols
TWI410422B (zh) * 2007-01-15 2013-10-01 Mitsubishi Tanabe Pharma Corp 縮合四氫喹啉衍生物及其醫藥用途
TW200848021A (en) 2007-03-06 2008-12-16 Wyeth Corp Sulfonylated heterocycles useful for modulation of the progesterone receptor
MX2009010059A (es) * 2007-03-22 2009-10-12 Astrazeneca Ab Derivados de quinolina para el tratamiento de enfermedades inflamatorias.
TW200918058A (en) * 2007-08-31 2009-05-01 Organon Nv TSH receptor antagonizing tetrahydroquinoline compounds
US8106073B2 (en) 2007-11-30 2012-01-31 Astrazeneca Ab Quinoline derivatives 057
TW200944523A (en) 2008-02-08 2009-11-01 Organon Nv (Dihydro)pyrrolo[2,1-a]isoquinolines
US20100061976A1 (en) * 2008-07-24 2010-03-11 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Method for treating or preventing osteoporosis by reducing follicle stimulating hormone to cyclic physiological levels in a mammalian subject
US8071587B2 (en) 2009-05-27 2011-12-06 N. V. Organon (Dihydro)imidazoiso[5,1-A]quinolines
TWI461426B (zh) * 2009-05-27 2014-11-21 Merck Sharp & Dohme （二氫）咪唑並異〔５，１－ａ〕喹啉類
US8431564B2 (en) 2009-07-29 2013-04-30 Merck Sharp & Dohme B.V. Ring-annulated dihydropyrrolo[2,1-α]isoquinolines
TW201116531A (en) 2009-07-29 2011-05-16 Organon Nv Ring-annulated dihydropyrrolo[2,1-a]isoquinolines
TW201116515A (en) 2009-07-31 2011-05-16 Organon Nv Dihydrobenzoindazoles
US8921562B2 (en) * 2010-10-08 2014-12-30 N30 Pharmaceuticals, Inc. Substituted quinoline compounds as S-nitrosoglutathione reductase inhibitors
US8546427B2 (en) * 2010-10-20 2013-10-01 Hoffmann-La Roche Inc. Tetrahydroquinoline derivatives
EP3174932B1 (en) 2014-07-30 2021-06-09 Henkel IP & Holding GmbH Cure accelerators for anaerobic curable compositions
EP3703692A4 (en) * 2017-11-01 2021-04-28 Merck Sharp & Dohme Corp. NEW SUBSTITUTED TETRAHYDROQUINOLINE COMPOUNDS USED AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) INHIBITORS

Family Cites Families (9)

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Publication number Priority date Publication date Assignee Title
US2686182A (en) 1950-12-07 1954-08-10 Basf Ag O-hydroxy-dihydro-quinoline carboxylic acids
ES2054784T3 (es) 1987-08-08 1994-08-16 Akzo Nv Un metodo para la fabricacion de un implante.
EP1043326A1 (en) 1994-12-22 2000-10-11 Ligand Pharmaceuticals Incorporated Steroid receptor modulator compounds and methods
IL141063A (en) * 1998-08-07 2005-06-19 Applied Research Systems Derivatives of pyrrolidine-2-carboxylic acid and piperidine-2-carboxylic acids and pharmaceutical compositions comprising said derivatives for treating infertility
JP2000143636A (ja) * 1998-09-02 2000-05-26 Sumitomo Pharmaceut Co Ltd アミノ誘導体
US6200963B1 (en) * 1999-03-31 2001-03-13 American Home Products Corporation Aryl sulfonic acids as FSH antagonists
CA2452606C (en) 2001-07-02 2011-09-13 Akzo Nobel N.V. Tetrahydroquinoline derivatives
TWI322012B (en) 2002-12-20 2010-03-21 Organon Nv Tetrahydroquinoline derivatives
TWI306855B (en) 2002-12-20 2009-03-01 Organon Nv Tetrahydroquinoline derivatives

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