JP2004534769A - 抗ウイルスヌクレオシド誘導体 - Google Patents

抗ウイルスヌクレオシド誘導体 Download PDF

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Publication number
JP2004534769A
JP2004534769A JP2002591006A JP2002591006A JP2004534769A JP 2004534769 A JP2004534769 A JP 2004534769A JP 2002591006 A JP2002591006 A JP 2002591006A JP 2002591006 A JP2002591006 A JP 2002591006A JP 2004534769 A JP2004534769 A JP 2004534769A
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JP
Japan
Prior art keywords
hcv
compound
formula
treatment
deoxy
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Pending
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JP2002591006A
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English (en)
Japanese (ja)
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JP2004534769A5 (https=
Inventor
デヴォス，レネ・ロバート
ホッブス，クリストファー・ジョン
チャン，ウェン−ロン
マーチン，ジョゼフ・アームストロング
メレット，ジョン・ハーバート
ナジェラ，イザベル
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of JP2004534769A publication Critical patent/JP2004534769A/ja
Publication of JP2004534769A5 publication Critical patent/JP2004534769A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
JP2002591006A 2001-05-23 2002-05-15 抗ウイルスヌクレオシド誘導体 Pending JP2004534769A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0112617.6A GB0112617D0 (en) 2001-05-23 2001-05-23 Antiviral nucleoside derivatives
PCT/EP2002/005340 WO2002094289A1 (en) 2001-05-23 2002-05-15 Antiviral nucleoside derivatives

Publications (2)

Publication Number Publication Date
JP2004534769A true JP2004534769A (ja) 2004-11-18
JP2004534769A5 JP2004534769A5 (https=) 2005-08-18

Family

ID=9915191

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002591006A Pending JP2004534769A (ja) 2001-05-23 2002-05-15 抗ウイルスヌクレオシド誘導体

Country Status (8)

Country Link
US (1) US6660721B2 (https=)
EP (1) EP1395266B1 (https=)
JP (1) JP2004534769A (https=)
CA (1) CA2445744C (https=)
DE (1) DE60215157T2 (https=)
ES (1) ES2272732T3 (https=)
GB (1) GB0112617D0 (https=)
WO (1) WO2002094289A1 (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010515680A (ja) * 2007-01-05 2010-05-13 メルク・シャープ・エンド・ドーム・コーポレイション Ｒｎａ依存性ｒｎａウイルス感染症の治療用としてのヌクレオシドアリールホスホロアミデート
JP2015509983A (ja) * 2012-03-13 2015-04-02 ギリアード サイエンシーズ， インコーポレイテッド 抗ウイルス処置のための２’−置換カルバヌクレオシド類似体
WO2017155082A1 (ja) * 2016-03-11 2017-09-14 国立大学法人鹿児島大学 抗肝腫瘍ウイルス剤
WO2020158951A1 (ja) * 2019-02-01 2020-08-06 ダイキン工業株式会社 抗ｃ型肝炎ウイルス剤

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JP2015509983A (ja) * 2012-03-13 2015-04-02 ギリアード サイエンシーズ， インコーポレイテッド 抗ウイルス処置のための２’−置換カルバヌクレオシド類似体
JP2017206528A (ja) * 2012-03-13 2017-11-24 ギリアード サイエンシーズ， インコーポレイテッド 抗ウイルス処置のための２’−置換カルバヌクレオシド類似体
WO2017155082A1 (ja) * 2016-03-11 2017-09-14 国立大学法人鹿児島大学 抗肝腫瘍ウイルス剤
JPWO2017155082A1 (ja) * 2016-03-11 2019-01-31 国立大学法人 鹿児島大学 抗肝腫瘍ウイルス剤
US10987372B2 (en) 2016-03-11 2021-04-27 Kagoshima University Anti-hepatoma-virus agent
WO2020158951A1 (ja) * 2019-02-01 2020-08-06 ダイキン工業株式会社 抗ｃ型肝炎ウイルス剤
JP2020125245A (ja) * 2019-02-01 2020-08-20 ダイキン工業株式会社 抗ｃ型肝炎ウイルス剤

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US6660721B2 (en) 2003-12-09
EP1395266A1 (en) 2004-03-10
DE60215157T2 (de) 2007-08-23
CA2445744C (en) 2007-12-04
WO2002094289A1 (en) 2002-11-28
CA2445744A1 (en) 2002-11-28
ES2272732T3 (es) 2007-05-01
GB0112617D0 (en) 2001-07-18
US20030083307A1 (en) 2003-05-01
DE60215157D1 (de) 2006-11-16

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