JP2004534769A5 - - Google Patents

Info

Publication number

JP2004534769A5

JP2004534769A5 JP2002591006A JP2002591006A JP2004534769A5 JP 2004534769 A5 JP2004534769 A5 JP 2004534769A5 JP 2002591006 A JP2002591006 A JP 2002591006A JP 2002591006 A JP2002591006 A JP 2002591006A JP 2004534769 A5 JP2004534769 A5 JP 2004534769A5

Authority

JP

Japan

Prior art keywords

compound

formula

treatment

pharmaceutically acceptable

hcv

Prior art date

2002-05-15

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 150000001875 compounds Chemical class 0.000 claims 9
• 241000711549 Hepacivirus C Species 0.000 claims 8
• 150000003839 salts Chemical class 0.000 claims 7
• 201000010099 disease Diseases 0.000 claims 4
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
• 230000001404 mediated effect Effects 0.000 claims 4
• -1 1-pyrimidinyl Chemical group 0.000 claims 3
• 239000003814 drug Substances 0.000 claims 3
• 238000004519 manufacturing process Methods 0.000 claims 3
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• MHWHYOFBOWTAHZ-DXTOWSMRSA-N (2r,3r,4r,5r)-5-(2,6-diaminopurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol Chemical compound C12=NC(N)=NC(N)=C2N=CN1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1F MHWHYOFBOWTAHZ-DXTOWSMRSA-N 0.000 claims 1
• UXUZARPLRQRNNX-DXTOWSMRSA-N 2-amino-9-[(2r,3r,4r,5r)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3h-purin-6-one Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1F UXUZARPLRQRNNX-DXTOWSMRSA-N 0.000 claims 1
• NVZFZMCNALTPBY-XVFCMESISA-N 4-amino-1-[(2r,3r,4r,5r)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@H](F)[C@H](O)[C@@H](CO)O1 NVZFZMCNALTPBY-XVFCMESISA-N 0.000 claims 1
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
• 229910019142 PO4 Inorganic materials 0.000 claims 1
• 229910052739 hydrogen Inorganic materials 0.000 claims 1
• 239000001257 hydrogen Substances 0.000 claims 1
• FUDCDANFNOFIDL-IAIGYFSYSA-M lithium [(2R,3R,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-4-fluoro-3-hydroxyoxolan-2-yl]methyl [hydroxy(phosphonooxy)phosphoryl] phosphate Chemical compound [Li+].O=C1N=C(N)C=CN1[C@H]1[C@H](F)[C@H](O)[C@@H](COP([O-])(=O)OP(O)(=O)OP(O)(O)=O)O1 FUDCDANFNOFIDL-IAIGYFSYSA-M 0.000 claims 1
• NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
• 239000010452 phosphate Substances 0.000 claims 1