JP2004534541A5 - - Google Patents
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- JP2004534541A5 JP2004534541A5 JP2003505372A JP2003505372A JP2004534541A5 JP 2004534541 A5 JP2004534541 A5 JP 2004534541A5 JP 2003505372 A JP2003505372 A JP 2003505372A JP 2003505372 A JP2003505372 A JP 2003505372A JP 2004534541 A5 JP2004534541 A5 JP 2004534541A5
- Authority
- JP
- Japan
- Prior art keywords
- strand
- strands
- watson
- probe
- crick
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 238000000034 method Methods 0.000 claims 41
- 239000000523 sample Substances 0.000 claims 31
- 150000007523 nucleic acids Chemical class 0.000 claims 20
- 108020004707 nucleic acids Proteins 0.000 claims 16
- 102000039446 nucleic acids Human genes 0.000 claims 16
- 230000005855 radiation Effects 0.000 claims 9
- 239000000975 dye Substances 0.000 claims 6
- 239000000138 intercalating agent Substances 0.000 claims 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 4
- 238000012217 deletion Methods 0.000 claims 4
- 230000037430 deletion Effects 0.000 claims 4
- 238000009396 hybridization Methods 0.000 claims 4
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 claims 3
- QTANTQQOYSUMLC-UHFFFAOYSA-O Ethidium cation Chemical compound C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CC)=C1C1=CC=CC=C1 QTANTQQOYSUMLC-UHFFFAOYSA-O 0.000 claims 3
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 3
- DZBUGLKDJFMEHC-UHFFFAOYSA-N acridine Chemical compound C1=CC=CC2=CC3=CC=CC=C3N=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-N 0.000 claims 3
- 238000003556 assay Methods 0.000 claims 3
- 230000005284 excitation Effects 0.000 claims 3
- 229920000140 heteropolymer Polymers 0.000 claims 3
- 230000001678 irradiating effect Effects 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- CZVCGJBESNRLEQ-UHFFFAOYSA-N 7h-purine;pyrimidine Chemical class C1=CN=CN=C1.C1=NC=C2NC=NC2=N1 CZVCGJBESNRLEQ-UHFFFAOYSA-N 0.000 claims 2
- 229960002685 biotin Drugs 0.000 claims 2
- 235000020958 biotin Nutrition 0.000 claims 2
- 239000011616 biotin Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 238000009830 intercalation Methods 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 claims 2
- ANRHNWWPFJCPAZ-UHFFFAOYSA-M thionine Chemical class [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 claims 2
- VGIRNWJSIRVFRT-UHFFFAOYSA-N 2',7'-difluorofluorescein Chemical compound OC(=O)C1=CC=CC=C1C1=C2C=C(F)C(=O)C=C2OC2=CC(O)=C(F)C=C21 VGIRNWJSIRVFRT-UHFFFAOYSA-N 0.000 claims 1
- BGWLYQZDNFIFRX-UHFFFAOYSA-N 5-[3-[2-[3-(3,8-diamino-6-phenylphenanthridin-5-ium-5-yl)propylamino]ethylamino]propyl]-6-phenylphenanthridin-5-ium-3,8-diamine;dichloride Chemical compound [Cl-].[Cl-].C=1C(N)=CC=C(C2=CC=C(N)C=C2[N+]=2CCCNCCNCCC[N+]=3C4=CC(N)=CC=C4C4=CC=C(N)C=C4C=3C=3C=CC=CC=3)C=1C=2C1=CC=CC=C1 BGWLYQZDNFIFRX-UHFFFAOYSA-N 0.000 claims 1
- YXHLJMWYDTXDHS-IRFLANFNSA-N 7-aminoactinomycin D Chemical compound C[C@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]2CCCN2C(=O)[C@@H](C(C)C)NC(=O)[C@H]1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=C(N)C=C3C(=O)N[C@@H]4C(=O)N[C@@H](C(N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)=O)C(C)C)=C3N=C21 YXHLJMWYDTXDHS-IRFLANFNSA-N 0.000 claims 1
- 108700012813 7-aminoactinomycin D Proteins 0.000 claims 1
- IVRMZWNICZWHMI-UHFFFAOYSA-N Azide Chemical compound [N-]=[N+]=[N-] IVRMZWNICZWHMI-UHFFFAOYSA-N 0.000 claims 1
- TYBKADJAOBUHAD-UHFFFAOYSA-J BoBo-1 Chemical compound [I-].[I-].[I-].[I-].S1C2=CC=CC=C2[N+](C)=C1C=C1C=CN(CCC[N+](C)(C)CCC[N+](C)(C)CCCN2C=CC(=CC3=[N+](C4=CC=CC=C4S3)C)C=C2)C=C1 TYBKADJAOBUHAD-UHFFFAOYSA-J 0.000 claims 1
- UIZZRDIAIPYKJZ-UHFFFAOYSA-J BoBo-3 Chemical compound [I-].[I-].[I-].[I-].S1C2=CC=CC=C2[N+](C)=C1C=CC=C1C=CN(CCC[N+](C)(C)CCC[N+](C)(C)CCCN2C=CC(=CC=CC3=[N+](C4=CC=CC=C4S3)C)C=C2)C=C1 UIZZRDIAIPYKJZ-UHFFFAOYSA-J 0.000 claims 1
- QBKMWMZYHZILHF-UHFFFAOYSA-L Po-Pro-1 Chemical compound [I-].[I-].O1C2=CC=CC=C2[N+](C)=C1C=C1C=CN(CCC[N+](C)(C)C)C=C1 QBKMWMZYHZILHF-UHFFFAOYSA-L 0.000 claims 1
- CZQJZBNARVNSLQ-UHFFFAOYSA-L Po-Pro-3 Chemical compound [I-].[I-].O1C2=CC=CC=C2[N+](C)=C1C=CC=C1C=CN(CCC[N+](C)(C)C)C=C1 CZQJZBNARVNSLQ-UHFFFAOYSA-L 0.000 claims 1
- BOLJGYHEBJNGBV-UHFFFAOYSA-J PoPo-1 Chemical compound [I-].[I-].[I-].[I-].O1C2=CC=CC=C2[N+](C)=C1C=C1C=CN(CCC[N+](C)(C)CCC[N+](C)(C)CCCN2C=CC(=CC3=[N+](C4=CC=CC=C4O3)C)C=C2)C=C1 BOLJGYHEBJNGBV-UHFFFAOYSA-J 0.000 claims 1
- GYPIAQJSRPTNTI-UHFFFAOYSA-J PoPo-3 Chemical compound [I-].[I-].[I-].[I-].O1C2=CC=CC=C2[N+](C)=C1C=CC=C1C=CN(CCC[N+](C)(C)CCC[N+](C)(C)CCCN2C=CC(=CC=CC3=[N+](C4=CC=CC=C4O3)C)C=C2)C=C1 GYPIAQJSRPTNTI-UHFFFAOYSA-J 0.000 claims 1
- DPXHITFUCHFTKR-UHFFFAOYSA-L To-Pro-1 Chemical compound [I-].[I-].S1C2=CC=CC=C2[N+](C)=C1C=C1C2=CC=CC=C2N(CCC[N+](C)(C)C)C=C1 DPXHITFUCHFTKR-UHFFFAOYSA-L 0.000 claims 1
- QHNORJFCVHUPNH-UHFFFAOYSA-L To-Pro-3 Chemical compound [I-].[I-].S1C2=CC=CC=C2[N+](C)=C1C=CC=C1C2=CC=CC=C2N(CCC[N+](C)(C)C)C=C1 QHNORJFCVHUPNH-UHFFFAOYSA-L 0.000 claims 1
- MZZINWWGSYUHGU-UHFFFAOYSA-J ToTo-1 Chemical compound [I-].[I-].[I-].[I-].C12=CC=CC=C2C(C=C2N(C3=CC=CC=C3S2)C)=CC=[N+]1CCC[N+](C)(C)CCC[N+](C)(C)CCC[N+](C1=CC=CC=C11)=CC=C1C=C1N(C)C2=CC=CC=C2S1 MZZINWWGSYUHGU-UHFFFAOYSA-J 0.000 claims 1
- ULHRKLSNHXXJLO-UHFFFAOYSA-L Yo-Pro-1 Chemical compound [I-].[I-].C1=CC=C2C(C=C3N(C4=CC=CC=C4O3)C)=CC=[N+](CCC[N+](C)(C)C)C2=C1 ULHRKLSNHXXJLO-UHFFFAOYSA-L 0.000 claims 1
- ZVUUXEGAYWQURQ-UHFFFAOYSA-L Yo-Pro-3 Chemical compound [I-].[I-].O1C2=CC=CC=C2[N+](C)=C1C=CC=C1C2=CC=CC=C2N(CCC[N+](C)(C)C)C=C1 ZVUUXEGAYWQURQ-UHFFFAOYSA-L 0.000 claims 1
- GRRMZXFOOGQMFA-UHFFFAOYSA-J YoYo-1 Chemical group [I-].[I-].[I-].[I-].C12=CC=CC=C2C(C=C2N(C3=CC=CC=C3O2)C)=CC=[N+]1CCC[N+](C)(C)CCC[N+](C)(C)CCC[N+](C1=CC=CC=C11)=CC=C1C=C1N(C)C2=CC=CC=C2O1 GRRMZXFOOGQMFA-UHFFFAOYSA-J 0.000 claims 1
- JSBNEYNPYQFYNM-UHFFFAOYSA-J YoYo-3 Chemical compound [I-].[I-].[I-].[I-].C12=CC=CC=C2C(C=CC=C2N(C3=CC=CC=C3O2)C)=CC=[N+]1CCC(=[N+](C)C)CCCC(=[N+](C)C)CC[N+](C1=CC=CC=C11)=CC=C1C=CC=C1N(C)C2=CC=CC=C2O1 JSBNEYNPYQFYNM-UHFFFAOYSA-J 0.000 claims 1
- DPKHZNPWBDQZCN-UHFFFAOYSA-N acridine orange free base Chemical compound C1=CC(N(C)C)=CC2=NC3=CC(N(C)C)=CC=C3C=C21 DPKHZNPWBDQZCN-UHFFFAOYSA-N 0.000 claims 1
- 150000001251 acridines Chemical class 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 150000001768 cations Chemical class 0.000 claims 1
- 239000000539 dimer Substances 0.000 claims 1
- ZMMJGEGLRURXTF-UHFFFAOYSA-N ethidium bromide Chemical compound [Br-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CC)=C1C1=CC=CC=C1 ZMMJGEGLRURXTF-UHFFFAOYSA-N 0.000 claims 1
- 229960005542 ethidium bromide Drugs 0.000 claims 1
- 206010016256 fatigue Diseases 0.000 claims 1
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 claims 1
- 230000008014 freezing Effects 0.000 claims 1
- 238000007710 freezing Methods 0.000 claims 1
- 239000000833 heterodimer Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000178 monomer Substances 0.000 claims 1
- XJMOSONTPMZWPB-UHFFFAOYSA-M propidium iodide Chemical compound [I-].[I-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CCC[N+](C)(CC)CC)=C1C1=CC=CC=C1 XJMOSONTPMZWPB-UHFFFAOYSA-M 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- XJCQPMRCZSJDPA-UHFFFAOYSA-L trimethyl-[3-[4-[(e)-(3-methyl-1,3-benzothiazol-2-ylidene)methyl]pyridin-1-ium-1-yl]propyl]azanium;diiodide Chemical compound [I-].[I-].S1C2=CC=CC=C2N(C)\C1=C\C1=CC=[N+](CCC[N+](C)(C)C)C=C1 XJCQPMRCZSJDPA-UHFFFAOYSA-L 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/885,731 US6927027B2 (en) | 1999-12-21 | 2001-06-20 | Nucleic acid multiplex formation |
| PCT/IB2002/001972 WO2002103051A2 (en) | 2001-06-20 | 2002-05-31 | Nucleic acid triplex and quadruplex formation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004534541A JP2004534541A (ja) | 2004-11-18 |
| JP2004534541A5 true JP2004534541A5 (https=) | 2005-12-08 |
Family
ID=25387577
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003505372A Pending JP2004534541A (ja) | 2001-06-20 | 2002-05-31 | 核酸多重鎖の形成 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6927027B2 (https=) |
| EP (1) | EP1436415B1 (https=) |
| JP (1) | JP2004534541A (https=) |
| KR (1) | KR100699960B1 (https=) |
| CN (1) | CN1533441A (https=) |
| AU (1) | AU2002304318B2 (https=) |
| BR (1) | BR0210544A (https=) |
| CA (1) | CA2450831A1 (https=) |
| CO (1) | CO5550493A2 (https=) |
| IL (1) | IL159309A0 (https=) |
| MX (1) | MXPA03012071A (https=) |
| NZ (1) | NZ530647A (https=) |
| RU (1) | RU2304168C2 (https=) |
| WO (1) | WO2002103051A2 (https=) |
| ZA (1) | ZA200400372B (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6656692B2 (en) * | 1999-12-21 | 2003-12-02 | Ingeneus Corporation | Parallel or antiparallel, homologous or complementary binding of nucleic acids or analogues thereof to form duplex, triplex or quadruplex complexes |
| US7052844B2 (en) * | 1999-12-21 | 2006-05-30 | Ingeneus, Inc. | Purification of DS-DNA using heteropolymeric capture probes and a triplex, quadruplex or homologous duplex binding mechanism |
| JP4616988B2 (ja) * | 2000-12-20 | 2011-01-19 | 株式会社アイシン・コスモス研究所 | 三本鎖ｄｎａ形成技術を応用したｄｎａ多型検出方法 |
| CA2501144C (en) * | 2002-10-23 | 2015-10-06 | University Of Utah Research Foundation | Amplicon melting analysis with saturation dyes |
| US20040142329A1 (en) * | 2003-01-17 | 2004-07-22 | Ingeneus Corporation | Probe conjugation to increase multiplex binding motif preference |
| GB0310270D0 (en) * | 2003-05-03 | 2003-06-11 | Univ Edinburgh | Biomolecular devices |
| US20050249669A1 (en) * | 2003-10-22 | 2005-11-10 | Academia Sinica | Quadruplex stabilizer |
| AU2005218507A1 (en) * | 2004-02-28 | 2005-09-15 | Chang-Ning J. Wang | Nucleic acid complexes |
| US9657347B2 (en) | 2004-04-20 | 2017-05-23 | University of Utah Research Foundation and BioFire Defense, LLC | Nucleic acid melting analysis with saturation dyes |
| NZ554538A (en) | 2004-09-24 | 2009-12-24 | Ingeneus Inc | Genomic assay |
| WO2006124089A1 (en) * | 2005-05-12 | 2006-11-23 | The Arizona Board Of Regents, A Body Corporate Acting On Behalf Of Arizona State University | Self-assembled nucleic acid nanoarrays and uses therefor |
| WO2007084380A2 (en) * | 2006-01-13 | 2007-07-26 | California Institute Of Technology | Compounds and methods for nucleic acid mismatch detection |
| US7943591B2 (en) | 2007-05-11 | 2011-05-17 | Adynxx, Inc. | Gene expression and pain |
| CN101587066B (zh) * | 2008-05-23 | 2011-03-30 | 中国科学院化学研究所 | 菁染料在检测g-四链体结构dna中的新用途 |
| RU2429293C1 (ru) * | 2009-12-15 | 2011-09-20 | Общество С Ограниченной Ответственностью "Апто-Фарм" | Днк-аптамеры, ингибирующие тромбин, и способ стабилизации их структуры |
| PT2846839T (pt) | 2012-05-10 | 2019-05-29 | Adynxx Inc | Formulações para a administração de ingredientes ativos |
| RU2017108238A (ru) | 2014-08-15 | 2018-09-17 | Эйдинкс, Инк. | Олигонуклеотиды-приманки для лечения боли |
| WO2016057597A1 (en) * | 2014-10-09 | 2016-04-14 | Albert Einstein College Of Medicine, Inc. | Programmed cargo release using nucleic acid-stabilized micelles |
| CN105861682B (zh) * | 2016-05-05 | 2020-06-26 | 厦门多维生物医药科技有限公司 | 鸟嘌呤检测探针 |
| CN110951836B (zh) * | 2019-12-03 | 2023-05-23 | 华东师范大学 | 一种基于光化学调控核酸分子链置换动力学的方法 |
| CN114539422B (zh) * | 2020-11-25 | 2024-03-29 | 安升（上海）医药科技有限公司 | 核酸多聚化介导的多价蛋白药物和疫苗的构建方法及应用 |
| CN113862337B (zh) * | 2021-10-15 | 2023-09-19 | 华东师范大学 | 一种基于冻融循环提高dna链置换反应速率的调控方法 |
| JP7514460B2 (ja) * | 2022-03-31 | 2024-07-11 | 邦明 長峯 | ポリアミンの検出方法、ポリアミンの検出試薬及びアプタマ |
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| US6017709A (en) | 1998-04-29 | 2000-01-25 | University Of Houston | DNA replication templates stabilized by guanine quartets |
| US6255469B1 (en) | 1998-05-06 | 2001-07-03 | New York University | Periodic two and three dimensional nucleic acid structures |
| US6255050B1 (en) | 1998-05-22 | 2001-07-03 | Lorne Park Research, Inc. | Dynamic hybridization system |
| GB9812768D0 (en) | 1998-06-13 | 1998-08-12 | Zeneca Ltd | Methods |
| GB9821989D0 (en) | 1998-10-08 | 1998-12-02 | Hybaid Ltd | Detection of nucleic acid polymorphism |
| US6656692B2 (en) * | 1999-12-21 | 2003-12-02 | Ingeneus Corporation | Parallel or antiparallel, homologous or complementary binding of nucleic acids or analogues thereof to form duplex, triplex or quadruplex complexes |
| US6900300B1 (en) * | 2000-09-19 | 2005-05-31 | Ingeneus Corporation | Quadruplex DNA and duplex probe systems |
| US6420115B1 (en) * | 1999-12-21 | 2002-07-16 | Ingeneus Corporation | Cation mediated triplex hybridization assay |
| WO2000043543A1 (en) | 1999-01-19 | 2000-07-27 | Dade Behring Inc. | Detection of differences between polynucleotides |
| WO2001024046A2 (en) * | 1999-09-29 | 2001-04-05 | Xml-Global Technologies, Inc. | Authoring, altering, indexing, storing and retrieving electronic documents embedded with contextual markup |
| US6265170B1 (en) | 2000-01-24 | 2001-07-24 | Ingeneus Corporation | Homogenous assay of duplex of triplex hybridization by means of multiple measurements under varied conditions |
-
2001
- 2001-06-20 US US09/885,731 patent/US6927027B2/en not_active Expired - Fee Related
-
2002
- 2002-05-31 EP EP02733104A patent/EP1436415B1/en not_active Expired - Lifetime
- 2002-05-31 WO PCT/IB2002/001972 patent/WO2002103051A2/en not_active Ceased
- 2002-05-31 CN CNA028124103A patent/CN1533441A/zh active Pending
- 2002-05-31 MX MXPA03012071A patent/MXPA03012071A/es active IP Right Grant
- 2002-05-31 IL IL15930902A patent/IL159309A0/xx unknown
- 2002-05-31 KR KR1020037016650A patent/KR100699960B1/ko not_active Expired - Fee Related
- 2002-05-31 AU AU2002304318A patent/AU2002304318B2/en not_active Ceased
- 2002-05-31 RU RU2004101294/13A patent/RU2304168C2/ru not_active IP Right Cessation
- 2002-05-31 NZ NZ530647A patent/NZ530647A/en active IP Right Revival
- 2002-05-31 CA CA002450831A patent/CA2450831A1/en not_active Abandoned
- 2002-05-31 JP JP2003505372A patent/JP2004534541A/ja active Pending
- 2002-05-31 BR BR0210544-6A patent/BR0210544A/pt not_active IP Right Cessation
-
2004
- 2004-01-19 ZA ZA200400372A patent/ZA200400372B/en unknown
- 2004-01-20 CO CO04003755A patent/CO5550493A2/es not_active Application Discontinuation
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