JP2004534064A - アルツハイマー病の治療に有用な大環状分子 - Google Patents
アルツハイマー病の治療に有用な大環状分子 Download PDFInfo
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- JP2004534064A JP2004534064A JP2003503623A JP2003503623A JP2004534064A JP 2004534064 A JP2004534064 A JP 2004534064A JP 2003503623 A JP2003503623 A JP 2003503623A JP 2003503623 A JP2003503623 A JP 2003503623A JP 2004534064 A JP2004534064 A JP 2004534064A
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
- C07D273/02—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and only one oxygen atom
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Psychiatry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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| US33308301P | 2001-11-19 | 2001-11-19 | |
| PCT/US2002/019076 WO2002100856A1 (en) | 2001-06-12 | 2002-06-12 | Macrocycles useful in the treatment of alzheimer's disease |
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|---|---|
| JP2004534064A true JP2004534064A (ja) | 2004-11-11 |
| JP2004534064A5 JP2004534064A5 (enExample) | 2006-01-05 |
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| MX (1) | MXPA03011466A (enExample) |
| WO (1) | WO2002100856A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008526913A (ja) * | 2005-01-13 | 2008-07-24 | ノバルティス アクチエンゲゼルシャフト | Ｂａｃｅ阻害剤として有用な大環状化合物 |
| JP2008526912A (ja) * | 2005-01-13 | 2008-07-24 | ノバルティス アクチエンゲゼルシャフト | Ｂａｃｅ阻害剤として有用な大環状化合物および組成物 |
Families Citing this family (17)
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| US7312360B2 (en) | 2001-12-06 | 2007-12-25 | Elan Pharmaceuticals, Inc. | Substituted hydroxyethylamines |
| WO2004062625A2 (en) | 2003-01-07 | 2004-07-29 | Merck & Co., Inc. | Macrocyclic beta-secretase inhibitors for treatment of alzheimer's disease |
| US7521481B2 (en) | 2003-02-27 | 2009-04-21 | Mclaurin Joanne | Methods of preventing, treating and diagnosing disorders of protein aggregation |
| CA2528375C (en) | 2003-06-18 | 2013-11-19 | Tranzyme Pharma, Inc. | Macrocyclic antagonists of the motilin receptor |
| GB0325830D0 (en) * | 2003-11-05 | 2003-12-10 | Novartis Ag | Organic compounds |
| JP2008508289A (ja) | 2004-07-28 | 2008-03-21 | シェーリング コーポレイション | 大環状βセクレターゼ阻害剤 |
| KR20080015079A (ko) | 2005-04-08 | 2008-02-18 | 코멘티스, 인코포레이티드 | 베타 세크레타제 활성을 억제하는 화합물 및 이것의 사용방법 |
| US7338974B2 (en) | 2005-08-12 | 2008-03-04 | Bristol-Myers Squibb Company | Macrocyclic diaminopropanes as beta-secretase inhibitors |
| GB0526614D0 (en) * | 2005-12-30 | 2006-02-08 | Novartis Ag | Organic compounds |
| JP2009544599A (ja) * | 2006-07-20 | 2009-12-17 | ノバルティス アクチエンゲゼルシャフト | Ｂａｃｅ阻害剤として有用な大環状化合物 |
| KR20090041387A (ko) * | 2006-07-20 | 2009-04-28 | 노파르티스 아게 | 마크로시클릭 락탐 |
| US7678784B2 (en) | 2006-11-20 | 2010-03-16 | Bristol-Myers Squibb Company | Oxime-containing macrocyclic acyl guanidines as β-secretase inhibitors |
| US7772221B2 (en) | 2007-02-09 | 2010-08-10 | Bristol-Meyers Squibb Company | Diaminopropane derived macrocycles as inhibitors of β amyloid production |
| EP2139876A4 (en) * | 2007-03-26 | 2011-07-20 | Merck Canada Inc | Cathepsin cysteine protease inhibitor |
| US7732434B2 (en) | 2007-04-20 | 2010-06-08 | Bristol-Myers Squibb Company | Macrocyclic acyl guanidines as beta-secretase inhibitors |
| EP2967058A4 (en) * | 2013-03-15 | 2017-03-01 | The Board of Regents of The University of Texas System | Use of inhibitors of mtor to improve vascular functions in apoe4 carriers |
| AU2014373683B2 (en) | 2013-12-31 | 2020-05-07 | Rapamycin Holdings, Llc | Oral rapamycin nanoparticle preparations and use |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPM982594A0 (en) * | 1994-12-02 | 1995-01-05 | University Of Queensland, The | HIV protease inhibitors |
| WO2000077030A1 (en) * | 1999-06-15 | 2000-12-21 | Elan Pharmaceuticals, Inc. | Statine-derived tetrapeptide inhibitors of beta-secretase |
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2002
- 2002-06-12 US US10/171,182 patent/US6969709B2/en not_active Expired - Fee Related
- 2002-06-12 BR BR0210392-3A patent/BR0210392A/pt not_active IP Right Cessation
- 2002-06-12 WO PCT/US2002/019076 patent/WO2002100856A1/en not_active Ceased
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- 2002-06-12 DE DE60210614T patent/DE60210614T2/de not_active Expired - Fee Related
- 2002-06-12 MX MXPA03011466A patent/MXPA03011466A/es active IP Right Grant
- 2002-06-12 EP EP02752056A patent/EP1404671B1/en not_active Expired - Lifetime
- 2002-06-12 ES ES02752056T patent/ES2261699T3/es not_active Expired - Lifetime
- 2002-06-12 CA CA002450202A patent/CA2450202A1/en not_active Abandoned
- 2002-06-12 JP JP2003503623A patent/JP2004534064A/ja active Pending
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2005
- 2005-09-02 US US11/218,879 patent/US7442691B2/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008526913A (ja) * | 2005-01-13 | 2008-07-24 | ノバルティス アクチエンゲゼルシャフト | Ｂａｃｅ阻害剤として有用な大環状化合物 |
| JP2008526912A (ja) * | 2005-01-13 | 2008-07-24 | ノバルティス アクチエンゲゼルシャフト | Ｂａｃｅ阻害剤として有用な大環状化合物および組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| DE60210614D1 (de) | 2006-05-24 |
| MXPA03011466A (es) | 2004-07-01 |
| EP1404671A1 (en) | 2004-04-07 |
| US20060040910A1 (en) | 2006-02-23 |
| CA2450202A1 (en) | 2002-12-19 |
| US20030236199A1 (en) | 2003-12-25 |
| ES2261699T3 (es) | 2006-11-16 |
| EP1404671B1 (en) | 2006-04-12 |
| WO2002100856A1 (en) | 2002-12-19 |
| ATE323084T1 (de) | 2006-04-15 |
| US7442691B2 (en) | 2008-10-28 |
| BR0210392A (pt) | 2004-10-13 |
| DE60210614T2 (de) | 2007-03-01 |
| US6969709B2 (en) | 2005-11-29 |
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