JP2004534064A - アルツハイマー病の治療に有用な大環状分子 - Google Patents
アルツハイマー病の治療に有用な大環状分子 Download PDFInfo
- Publication number
- JP2004534064A JP2004534064A JP2003503623A JP2003503623A JP2004534064A JP 2004534064 A JP2004534064 A JP 2004534064A JP 2003503623 A JP2003503623 A JP 2003503623A JP 2003503623 A JP2003503623 A JP 2003503623A JP 2004534064 A JP2004534064 A JP 2004534064A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- ethyl
- optionally substituted
- diaza
- oxa
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 C*C*(NC(CBO**C)C(O)=O)=C Chemical compound C*C*(NC(CBO**C)C(O)=O)=C 0.000 description 11
- AKBQHEFAYJXUFF-RUZDIDTESA-N C#Cc1cc(C2(CC2)NCC[C@H](Cc2cc(F)cc(OCCCCCC(NC3)=O)c2)NC3=O)ccc1 Chemical compound C#Cc1cc(C2(CC2)NCC[C@H](Cc2cc(F)cc(OCCCCCC(NC3)=O)c2)NC3=O)ccc1 AKBQHEFAYJXUFF-RUZDIDTESA-N 0.000 description 1
- GINDPKSSQDSQIM-UHFFFAOYSA-N CCc1cc(C2(CC2)NCCC(Cc2cc(OCCCCCC(NC3)=O)cc(F)c2)NC3=O)ccc1 Chemical compound CCc1cc(C2(CC2)NCCC(Cc2cc(OCCCCCC(NC3)=O)cc(F)c2)NC3=O)ccc1 GINDPKSSQDSQIM-UHFFFAOYSA-N 0.000 description 1
- NWGGJGGVYSBLOP-WUBHUQEYSA-N CCc1cccc(CNC[C@H](C(Cc2cc(OCCCCCC(NC3)=O)cc(F)c2)NC3=O)O)c1 Chemical compound CCc1cccc(CNC[C@H](C(Cc2cc(OCCCCCC(NC3)=O)cc(F)c2)NC3=O)O)c1 NWGGJGGVYSBLOP-WUBHUQEYSA-N 0.000 description 1
- FHSDGTPZXWMCAE-BJKOFHAPSA-N CCc1cncc(CNC[C@H]([C@H](Cc2cc(OCCCCCC(NC3)=O)cc(F)c2)NC3=O)O)c1 Chemical compound CCc1cncc(CNC[C@H]([C@H](Cc2cc(OCCCCCC(NC3)=O)cc(F)c2)NC3=O)O)c1 FHSDGTPZXWMCAE-BJKOFHAPSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
- C07D273/02—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and only one oxygen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29754601P | 2001-06-12 | 2001-06-12 | |
| US33308301P | 2001-11-19 | 2001-11-19 | |
| PCT/US2002/019076 WO2002100856A1 (en) | 2001-06-12 | 2002-06-12 | Macrocycles useful in the treatment of alzheimer's disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004534064A true JP2004534064A (ja) | 2004-11-11 |
| JP2004534064A5 JP2004534064A5 (enExample) | 2006-01-05 |
Family
ID=26970209
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003503623A Pending JP2004534064A (ja) | 2001-06-12 | 2002-06-12 | アルツハイマー病の治療に有用な大環状分子 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US6969709B2 (enExample) |
| EP (1) | EP1404671B1 (enExample) |
| JP (1) | JP2004534064A (enExample) |
| AT (1) | ATE323084T1 (enExample) |
| BR (1) | BR0210392A (enExample) |
| CA (1) | CA2450202A1 (enExample) |
| DE (1) | DE60210614T2 (enExample) |
| ES (1) | ES2261699T3 (enExample) |
| MX (1) | MXPA03011466A (enExample) |
| WO (1) | WO2002100856A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008526913A (ja) * | 2005-01-13 | 2008-07-24 | ノバルティス アクチエンゲゼルシャフト | Ｂａｃｅ阻害剤として有用な大環状化合物 |
| JP2008526912A (ja) * | 2005-01-13 | 2008-07-24 | ノバルティス アクチエンゲゼルシャフト | Ｂａｃｅ阻害剤として有用な大環状化合物および組成物 |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003050073A1 (en) * | 2001-12-06 | 2003-06-19 | Elan Pharmaceuticals, Inc. | Substituted hydroxyethylamines |
| EP1583750B1 (en) | 2003-01-07 | 2013-02-27 | Merck Sharp & Dohme Corp. | Macrocyclic beta-secretase inhibitors for treatment of Alzheimer's disease |
| US7521481B2 (en) | 2003-02-27 | 2009-04-21 | Mclaurin Joanne | Methods of preventing, treating and diagnosing disorders of protein aggregation |
| DE602004025569D1 (de) | 2003-06-18 | 2010-04-01 | Tranzyme Pharma Inc | Makrozyklische motilin rezeptorantagonisten |
| GB0325830D0 (en) * | 2003-11-05 | 2003-12-10 | Novartis Ag | Organic compounds |
| CA2575340A1 (en) * | 2004-07-28 | 2006-02-09 | Schering Corporation | Macrocyclic beta-secretase inhibitors |
| MX2007012341A (es) | 2005-04-08 | 2008-02-12 | Comentis Inc | Compuestos que inhiben actividad beta-secretasa y metodos de uso de los mismos. |
| US7338974B2 (en) | 2005-08-12 | 2008-03-04 | Bristol-Myers Squibb Company | Macrocyclic diaminopropanes as beta-secretase inhibitors |
| GB0526614D0 (en) * | 2005-12-30 | 2006-02-08 | Novartis Ag | Organic compounds |
| KR20090041387A (ko) * | 2006-07-20 | 2009-04-28 | 노파르티스 아게 | 마크로시클릭 락탐 |
| CA2657280A1 (en) * | 2006-07-20 | 2008-01-24 | Novartis Ag | Macrocyclic compounds useful as bace inhibitors |
| US7678784B2 (en) | 2006-11-20 | 2010-03-16 | Bristol-Myers Squibb Company | Oxime-containing macrocyclic acyl guanidines as β-secretase inhibitors |
| US7772221B2 (en) | 2007-02-09 | 2010-08-10 | Bristol-Meyers Squibb Company | Diaminopropane derived macrocycles as inhibitors of β amyloid production |
| EP2139876A4 (en) * | 2007-03-26 | 2011-07-20 | Merck Canada Inc | Cathepsin cysteine protease inhibitor |
| US7732434B2 (en) | 2007-04-20 | 2010-06-08 | Bristol-Myers Squibb Company | Macrocyclic acyl guanidines as beta-secretase inhibitors |
| US10391059B2 (en) | 2009-11-11 | 2019-08-27 | Rapamycin Holdings, Inc. | Oral rapamycin nanoparticle preparations and use |
| EP2967058A4 (en) * | 2013-03-15 | 2017-03-01 | The Board of Regents of The University of Texas System | Use of inhibitors of mtor to improve vascular functions in apoe4 carriers |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPM982594A0 (en) * | 1994-12-02 | 1995-01-05 | University Of Queensland, The | HIV protease inhibitors |
| JP2003502342A (ja) * | 1999-06-15 | 2003-01-21 | エラン ファーマスーティカルズ インコーポレイテッド | ベータ−セクレターゼのスタチン誘導テトラペプチド阻害剤 |
-
2002
- 2002-06-12 JP JP2003503623A patent/JP2004534064A/ja active Pending
- 2002-06-12 MX MXPA03011466A patent/MXPA03011466A/es active IP Right Grant
- 2002-06-12 WO PCT/US2002/019076 patent/WO2002100856A1/en not_active Ceased
- 2002-06-12 US US10/171,182 patent/US6969709B2/en not_active Expired - Fee Related
- 2002-06-12 CA CA002450202A patent/CA2450202A1/en not_active Abandoned
- 2002-06-12 BR BR0210392-3A patent/BR0210392A/pt not_active IP Right Cessation
- 2002-06-12 DE DE60210614T patent/DE60210614T2/de not_active Expired - Fee Related
- 2002-06-12 EP EP02752056A patent/EP1404671B1/en not_active Expired - Lifetime
- 2002-06-12 AT AT02752056T patent/ATE323084T1/de not_active IP Right Cessation
- 2002-06-12 ES ES02752056T patent/ES2261699T3/es not_active Expired - Lifetime
-
2005
- 2005-09-02 US US11/218,879 patent/US7442691B2/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008526913A (ja) * | 2005-01-13 | 2008-07-24 | ノバルティス アクチエンゲゼルシャフト | Ｂａｃｅ阻害剤として有用な大環状化合物 |
| JP2008526912A (ja) * | 2005-01-13 | 2008-07-24 | ノバルティス アクチエンゲゼルシャフト | Ｂａｃｅ阻害剤として有用な大環状化合物および組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| DE60210614D1 (de) | 2006-05-24 |
| EP1404671A1 (en) | 2004-04-07 |
| US20060040910A1 (en) | 2006-02-23 |
| ATE323084T1 (de) | 2006-04-15 |
| MXPA03011466A (es) | 2004-07-01 |
| BR0210392A (pt) | 2004-10-13 |
| CA2450202A1 (en) | 2002-12-19 |
| US20030236199A1 (en) | 2003-12-25 |
| EP1404671B1 (en) | 2006-04-12 |
| US7442691B2 (en) | 2008-10-28 |
| US6969709B2 (en) | 2005-11-29 |
| WO2002100856A1 (en) | 2002-12-19 |
| DE60210614T2 (de) | 2007-03-01 |
| ES2261699T3 (es) | 2006-11-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20050608 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20050608 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20090210 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20090701 |