JP2004533841A5 - - Google Patents
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- Publication number
- JP2004533841A5 JP2004533841A5 JP2003510766A JP2003510766A JP2004533841A5 JP 2004533841 A5 JP2004533841 A5 JP 2004533841A5 JP 2003510766 A JP2003510766 A JP 2003510766A JP 2003510766 A JP2003510766 A JP 2003510766A JP 2004533841 A5 JP2004533841 A5 JP 2004533841A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- aggrecanase
- sequence
- amino acid
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108010003059 aggrecanase Proteins 0.000 claims 16
- 238000000034 method Methods 0.000 claims 9
- 125000003275 alpha amino acid group Chemical group 0.000 claims 7
- 150000001413 amino acids Chemical class 0.000 claims 5
- 239000012634 fragment Substances 0.000 claims 5
- 239000003112 inhibitor Substances 0.000 claims 5
- 239000002773 nucleotide Substances 0.000 claims 5
- 125000003729 nucleotide group Chemical group 0.000 claims 5
- 108020004414 DNA Proteins 0.000 claims 4
- 102000053602 DNA Human genes 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 108020004705 Codon Proteins 0.000 claims 1
- 241000238631 Hexapoda Species 0.000 claims 1
- 238000007792 addition Methods 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000009510 drug design Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 230000002797 proteolythic effect Effects 0.000 claims 1
- 238000012916 structural analysis Methods 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30305101P | 2001-07-05 | 2001-07-05 | |
| US34913302P | 2002-01-16 | 2002-01-16 | |
| PCT/US2002/021056 WO2003004607A2 (en) | 2001-07-05 | 2002-07-05 | Aggrecanase molecules |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004533841A JP2004533841A (ja) | 2004-11-11 |
| JP2004533841A5 true JP2004533841A5 (https=) | 2006-01-05 |
Family
ID=26973233
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003510766A Pending JP2004533841A (ja) | 2001-07-05 | 2002-07-05 | アグレカナーゼ分子 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20030148306A1 (https=) |
| EP (1) | EP1409658A4 (https=) |
| JP (1) | JP2004533841A (https=) |
| BR (1) | BR0210835A (https=) |
| CA (1) | CA2451374A1 (https=) |
| MX (1) | MXPA03011715A (https=) |
| NZ (1) | NZ530949A (https=) |
| PL (1) | PL367675A1 (https=) |
| WO (1) | WO2003004607A2 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003215070A1 (en) * | 2002-02-05 | 2003-09-02 | Wyeth | Truncated aggrecanase molecules |
| US7118902B2 (en) * | 2002-07-29 | 2006-10-10 | Wyeth | Modified ADAMTS4 molecules and method of use thereof |
| BRPI0414423A (pt) * | 2003-09-16 | 2006-11-14 | Pharmacia Corp | inibidores de pace4, suas composições farmacêuticas e respectivos usos |
| EP1737973A1 (en) * | 2004-04-16 | 2007-01-03 | Wyeth | Truncated adamts molecules |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4419446A (en) * | 1980-12-31 | 1983-12-06 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant DNA process utilizing a papilloma virus DNA as a vector |
| US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| WO2000058473A2 (en) * | 1999-03-31 | 2000-10-05 | Curagen Corporation | Nucleic acids including open reading frames encoding polypeptides; 'orfx' |
| JP2001008687A (ja) * | 1999-06-25 | 2001-01-16 | Yamanouchi Pharmaceut Co Ltd | 新規金属プロテアーゼ及び該金属プロテアーゼ遺伝子 |
| AU1230201A (en) * | 1999-10-25 | 2001-05-08 | Millennium Pharmaceuticals, Inc. | 27875 a human adam-ts homolog |
| EP1134286A3 (en) * | 2000-03-14 | 2003-05-02 | Pfizer Products Inc. | Adamts polypeptides, nucleic acids encoding them, and uses thereof |
-
2002
- 2002-07-05 EP EP02740013A patent/EP1409658A4/en not_active Withdrawn
- 2002-07-05 US US10/188,869 patent/US20030148306A1/en not_active Abandoned
- 2002-07-05 BR BR0210835-6A patent/BR0210835A/pt not_active IP Right Cessation
- 2002-07-05 CA CA002451374A patent/CA2451374A1/en not_active Abandoned
- 2002-07-05 WO PCT/US2002/021056 patent/WO2003004607A2/en not_active Ceased
- 2002-07-05 MX MXPA03011715A patent/MXPA03011715A/es unknown
- 2002-07-05 NZ NZ530949A patent/NZ530949A/en unknown
- 2002-07-05 PL PL02367675A patent/PL367675A1/xx unknown
- 2002-07-05 JP JP2003510766A patent/JP2004533841A/ja active Pending
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