JP2004533500A5 - - Google Patents
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- Publication number
- JP2004533500A5 JP2004533500A5 JP2002580026A JP2002580026A JP2004533500A5 JP 2004533500 A5 JP2004533500 A5 JP 2004533500A5 JP 2002580026 A JP2002580026 A JP 2002580026A JP 2002580026 A JP2002580026 A JP 2002580026A JP 2004533500 A5 JP2004533500 A5 JP 2004533500A5
- Authority
- JP
- Japan
- Prior art keywords
- hydrogel
- biological material
- isocyanate
- prepolymer
- spots
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000017 hydrogel Substances 0.000 claims 17
- 239000012620 biological material Substances 0.000 claims 14
- 239000000203 mixture Substances 0.000 claims 9
- 239000004971 Cross linker Substances 0.000 claims 5
- 239000003431 cross linking reagent Substances 0.000 claims 5
- 238000000018 DNA microarray Methods 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 239000002202 Polyethylene glycol Substances 0.000 claims 3
- 239000007864 aqueous solution Substances 0.000 claims 3
- 229920001577 copolymer Polymers 0.000 claims 3
- 239000012948 isocyanate Substances 0.000 claims 3
- 150000002513 isocyanates Chemical class 0.000 claims 3
- 229920001223 polyethylene glycol Polymers 0.000 claims 3
- 229920001451 polypropylene glycol Polymers 0.000 claims 3
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 3
- 239000012491 analyte Substances 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 235000018102 proteins Nutrition 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 239000000243 solution Substances 0.000 claims 2
- 239000000758 substrate Substances 0.000 claims 2
- 150000003573 thiols Chemical class 0.000 claims 2
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 1
- FFFHZYDWPBMWHY-VKHMYHEASA-N L-homocysteine Chemical compound OC(=O)[C@@H](N)CCS FFFHZYDWPBMWHY-VKHMYHEASA-N 0.000 claims 1
- 238000004166 bioassay Methods 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 238000004132 cross linking Methods 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- IQPQWNKOIGAROB-UHFFFAOYSA-N isocyanate group Chemical group [N-]=C=O IQPQWNKOIGAROB-UHFFFAOYSA-N 0.000 claims 1
- 230000000269 nucleophilic effect Effects 0.000 claims 1
- 230000004962 physiological condition Effects 0.000 claims 1
- 238000006116 polymerization reaction Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28126801P | 2001-04-03 | 2001-04-03 | |
| PCT/US2002/010411 WO2002081662A1 (en) | 2001-04-03 | 2002-04-02 | Methods and gel compositions for encapsulating living cells and organic molecules |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004533500A JP2004533500A (ja) | 2004-11-04 |
| JP2004533500A5 true JP2004533500A5 (enExample) | 2005-12-22 |
| JP4198468B2 JP4198468B2 (ja) | 2008-12-17 |
Family
ID=23076600
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002580026A Expired - Fee Related JP4198468B2 (ja) | 2001-04-03 | 2002-04-02 | 生細胞および有機分子をカプセル封入するための方法およびゲル組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7172866B2 (enExample) |
| EP (1) | EP1373472B1 (enExample) |
| JP (1) | JP4198468B2 (enExample) |
| AT (1) | ATE365792T1 (enExample) |
| CA (1) | CA2443060A1 (enExample) |
| DE (1) | DE60220893T2 (enExample) |
| IL (2) | IL158128A0 (enExample) |
| WO (1) | WO2002081662A1 (enExample) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002094900A1 (en) * | 2001-05-21 | 2002-11-28 | Dow Global Technologies Inc. | Transparent polyurethane-hydrogel composition, method of making transparent polyurethane-hydrogel composition, and air-freshener application |
| WO2003050276A1 (en) * | 2001-12-05 | 2003-06-19 | Dow Global Technologies Inc. | Method for immobilizing a biologic in a polyurethane-hydrogel composition, a composition prepared from the method, and biomedical applications |
| WO2003104444A1 (en) | 2002-06-05 | 2003-12-18 | Es Cell International Pte Ltd | Generation of neural stem cells from undifferentiated human embryonic stem cells |
| CA2521862C (en) | 2003-04-10 | 2012-10-16 | President And Fellows Of Harvard College | Formation and control of fluidic species |
| US9200245B2 (en) | 2003-06-26 | 2015-12-01 | Seng Enterprises Ltd. | Multiwell plate |
| EP1654347B1 (en) * | 2003-06-26 | 2014-06-04 | Seng Enterprises Limited | Improved materials for constructing cell-chips, cell-chip covers, cell-chip coats, processed cell-chips and uses thereof |
| EP2662135A3 (en) | 2003-08-27 | 2013-12-25 | President and Fellows of Harvard College | Method for mixing droplets in a microchannel |
| US20050112650A1 (en) * | 2003-10-20 | 2005-05-26 | Ciphergen Biosystems, Inc. | Reactive polyurethane-based polymers |
| US20060040377A1 (en) * | 2004-08-17 | 2006-02-23 | Biocept, Inc. | Protein microarrays |
| WO2006042132A2 (en) * | 2004-10-08 | 2006-04-20 | Georgia Tech Research Corporation | Microencapsulation of cells in hydrogels using electrostatic potentials |
| US7439062B2 (en) | 2004-12-23 | 2008-10-21 | Biocept, Inc. | Beads for capturing target cells from bodily fluid |
| US8158410B2 (en) | 2005-01-18 | 2012-04-17 | Biocept, Inc. | Recovery of rare cells using a microchannel apparatus with patterned posts |
| US20090136982A1 (en) | 2005-01-18 | 2009-05-28 | Biocept, Inc. | Cell separation using microchannel having patterned posts |
| JP2008526251A (ja) | 2005-01-18 | 2008-07-24 | バイオセプト インコーポレイティッド | パターン化されたポストを有するマイクロチャネルを用いた細胞分離 |
| US20080287604A1 (en) * | 2005-09-09 | 2008-11-20 | Avery Dennison Corporation | Hydrogel Including Modified Cyclodextrin Crosslinked With Polyurethane Prepolymer |
| ES2377479T3 (es) * | 2005-09-27 | 2012-03-28 | Universite Joseph Fourier - Grenoble 1 | Hidrogel funcionalizado con una porción polimerizable y sus utilizaciones como biosensores o biorreactores. |
| EP1970400B1 (en) | 2005-11-24 | 2014-03-12 | Mitsuru Akashi | Stimuli-responsive degradable gel |
| US7695956B2 (en) | 2006-01-12 | 2010-04-13 | Biocept, Inc. | Device for cell separation and analysis and method of using |
| KR100849185B1 (ko) * | 2006-01-19 | 2008-07-30 | 서울산업대학교 산학협력단 | 키토산 또는 히알루론산-폴리에틸렌옥사이드 및키토산-히알루론산-폴리에틸렌옥사이드를 기저로 하는하이드로젤과 이의 제조방법 |
| US20070243549A1 (en) * | 2006-04-12 | 2007-10-18 | Biocept, Inc. | Enrichment of circulating fetal dna |
| KR100721431B1 (ko) | 2006-04-19 | 2007-05-25 | 학교법인 포항공과대학교 | 고분자 캡슐 및 그 제조방법 |
| CA2704768A1 (en) | 2006-11-03 | 2008-10-23 | Trustees Of Tufts College | Biopolymer sensor and method of manufacturing the same |
| EP2650112B1 (en) | 2006-11-03 | 2016-08-24 | Trustees Of Tufts College | Nanopatterned biopolymer optical device and method of manufacturing the same |
| US8574461B2 (en) | 2006-11-03 | 2013-11-05 | Tufts University | Electroactive biopolymer optical and electro-optical devices and method of manufacturing the same |
| WO2008118211A2 (en) * | 2006-11-03 | 2008-10-02 | Trustees Of Tufts College | Biopolymer photonic crystals and method of manufacturing the same |
| US20080176768A1 (en) * | 2007-01-23 | 2008-07-24 | Honeywell Honeywell International | Hydrogel microarray with embedded metal nanoparticles |
| US9599891B2 (en) | 2007-11-05 | 2017-03-21 | Trustees Of Tufts College | Fabrication of silk fibroin photonic structures by nanocontact imprinting |
| US9145540B1 (en) | 2007-11-15 | 2015-09-29 | Seng Enterprises Ltd. | Device for the study of living cells |
| US9975118B2 (en) | 2007-11-15 | 2018-05-22 | Seng Enterprises Ltd. | Device for the study of living cells |
| SG162265A1 (en) * | 2007-12-13 | 2010-07-29 | Danisco Us Inc | Compositions and methods for producing isoprene |
| WO2009155397A2 (en) * | 2008-06-18 | 2009-12-23 | Trustees Of Tufts College | Edible holographic silk products |
| JP5188314B2 (ja) * | 2008-08-04 | 2013-04-24 | キヤノン株式会社 | 生体高分子検査装置及びその方法 |
| US20100240054A1 (en) * | 2008-09-22 | 2010-09-23 | Biocept, Inc. | Identification and isolation of fetal cells and nucleic acid |
| US8747886B2 (en) | 2009-02-12 | 2014-06-10 | Tufts University | Nanoimprinting of silk fibroin structures for biomedical and biophotonic applications |
| WO2011046652A2 (en) | 2009-07-20 | 2011-04-21 | Trustees Of Tufts College | All-protein implantable, resorbable reflectors |
| WO2011026101A2 (en) | 2009-08-31 | 2011-03-03 | Trustees Of Tufts College | Silk transistor devices |
| NZ599524A (en) | 2009-11-09 | 2014-04-30 | Spotlight Technology Partners Llc | Polysaccharide based hydrogels |
| WO2011057133A1 (en) | 2009-11-09 | 2011-05-12 | Spotlight Technology Partners Llc | Fragmented hydrogels |
| US9174216B2 (en) | 2013-03-13 | 2015-11-03 | DeNovo Science, Inc. | System for capturing and analyzing cells |
| US9404864B2 (en) | 2013-03-13 | 2016-08-02 | Denovo Sciences, Inc. | System for imaging captured cells |
| US10466160B2 (en) | 2011-08-01 | 2019-11-05 | Celsee Diagnostics, Inc. | System and method for retrieving and analyzing particles |
| ES2797448T3 (es) | 2011-08-01 | 2020-12-02 | Bio Rad Laboratories | Sistema de captura de células |
| US9752181B2 (en) | 2013-01-26 | 2017-09-05 | Denovo Sciences, Inc. | System and method for capturing and analyzing cells |
| US9707562B2 (en) | 2013-03-13 | 2017-07-18 | Denovo Sciences, Inc. | System for capturing and analyzing cells |
| EP2796873A1 (en) * | 2013-04-25 | 2014-10-29 | QGel SA | Method for a cell-based drug screening assay and the use thereof |
| US9856535B2 (en) | 2013-05-31 | 2018-01-02 | Denovo Sciences, Inc. | System for isolating cells |
| US10391490B2 (en) | 2013-05-31 | 2019-08-27 | Celsee Diagnostics, Inc. | System and method for isolating and analyzing cells |
| JPWO2015147147A1 (ja) * | 2014-03-26 | 2017-04-13 | 国立大学法人北海道大学 | 生物学的試料をハイドロゲルで高速固定する方法及びそのための装置 |
| US9694338B2 (en) * | 2014-12-18 | 2017-07-04 | Wisconsin Alumni Research Foundation | Covalently-immobilized hydrogel arrays in multi-well plates |
| WO2017123537A1 (en) | 2016-01-12 | 2017-07-20 | Bioatla, Llc | Diagnostics using conditionally active antibodies |
| US10391492B2 (en) | 2017-08-29 | 2019-08-27 | Celsee Diagnostics, Inc. | System and method for isolating and analyzing cells |
| US10633693B1 (en) | 2019-04-16 | 2020-04-28 | Celsee Diagnostics, Inc. | System and method for leakage control in a particle capture system |
| US11578322B2 (en) | 2019-05-07 | 2023-02-14 | Bio-Rad Laboratories, Inc. | System and method for automated single cell processing |
| US11273439B2 (en) | 2019-05-07 | 2022-03-15 | Bio-Rad Laboratories, Inc. | System and method for target material retrieval from microwells |
| KR102814885B1 (ko) | 2019-06-14 | 2025-06-02 | 바이오 래드 래버러토리스 인코오포레이티드 | 자동화된 단일 세포 처리 및 분석을 위한 시스템 및 방법 |
| US11504719B2 (en) | 2020-03-12 | 2022-11-22 | Bio-Rad Laboratories, Inc. | System and method for receiving and delivering a fluid for sample processing |
| US20220340949A1 (en) | 2021-04-16 | 2022-10-27 | Capra Biosciences, Inc. | Methods of Isoprenoid Synthesis Using a Genetically Engineered Hydrocarbonoclastic Organism in a Biofilm Bioreactor |
| AU2022376537A1 (en) * | 2021-10-29 | 2024-05-16 | Sigilon Therapeutics, Inc. | Compositions for cell-based therapies and related methods |
| WO2023107539A1 (en) | 2021-12-10 | 2023-06-15 | Bio-Rad Laboratories, Inc. | Compositions, methods, and systems for sample processing with morphology-adjustable functionalized particles |
| KR20250047360A (ko) | 2022-08-10 | 2025-04-03 | 카프라 바이오사이언시즈 인코포레이티드 | 순환식 바이오 필름 생물 반응기 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4098645A (en) * | 1976-02-24 | 1978-07-04 | W. R. Grace & Co. | Immobilization of proteins with polyurethane polymers |
| US4436813A (en) * | 1982-03-16 | 1984-03-13 | Purification Engineering, Inc. | Immobilized microbial cell composition for making L-aspartic acid |
| US4794090A (en) | 1986-09-26 | 1988-12-27 | W. R. Grace & Co.-Conn. | Immobilization support for biologicals |
| US5175229A (en) | 1986-11-18 | 1992-12-29 | W. R. Grace & Co.-Conn. | Biocompatible polyurea-urethane hydrated polymers |
| US5403750A (en) | 1991-03-06 | 1995-04-04 | W. R. Grace & Co.-Conn. | Biocompatible, low protein adsorption affinity matrix |
| US5573934A (en) | 1992-04-20 | 1996-11-12 | Board Of Regents, The University Of Texas System | Gels for encapsulation of biological materials |
| DE69625799T2 (de) * | 1995-02-01 | 2003-10-23 | Schneider (Usa) Inc., Plymouth | Verfahren zur hydrophilisierung von hydrophoben polymeren |
| EP0859051B1 (en) * | 1997-02-14 | 2002-01-16 | Nippon Shokubai Co., Ltd. | Immobilized biocatalyst |
| AU4965499A (en) | 1998-07-09 | 2000-02-01 | Biocept, Inc. | Method of using an improved peptide nucleic acid universal library to optimize dna sequence hybridation |
| US6818018B1 (en) * | 1998-08-14 | 2004-11-16 | Incept Llc | In situ polymerizable hydrogels |
| ATE286746T1 (de) | 1999-01-29 | 2005-01-15 | Beiersdorf Ag | Proteinhaltige hydrogele |
| US6174683B1 (en) * | 1999-04-26 | 2001-01-16 | Biocept, Inc. | Method of making biochips and the biochips resulting therefrom |
| US6642046B1 (en) * | 1999-12-09 | 2003-11-04 | Motorola, Inc. | Method and apparatus for performing biological reactions on a substrate surface |
| DE60137523D1 (de) * | 2000-10-26 | 2009-03-12 | Biocept Inc | Dreidimensionales format aufweisender biochip |
| WO2003050276A1 (en) * | 2001-12-05 | 2003-06-19 | Dow Global Technologies Inc. | Method for immobilizing a biologic in a polyurethane-hydrogel composition, a composition prepared from the method, and biomedical applications |
-
2002
- 2002-04-02 AT AT02763911T patent/ATE365792T1/de not_active IP Right Cessation
- 2002-04-02 EP EP02763911A patent/EP1373472B1/en not_active Expired - Lifetime
- 2002-04-02 WO PCT/US2002/010411 patent/WO2002081662A1/en not_active Ceased
- 2002-04-02 JP JP2002580026A patent/JP4198468B2/ja not_active Expired - Fee Related
- 2002-04-02 US US10/398,725 patent/US7172866B2/en not_active Expired - Lifetime
- 2002-04-02 CA CA002443060A patent/CA2443060A1/en not_active Abandoned
- 2002-04-02 DE DE60220893T patent/DE60220893T2/de not_active Expired - Fee Related
- 2002-04-02 IL IL15812802A patent/IL158128A0/xx active IP Right Grant
-
2003
- 2003-09-25 IL IL158128A patent/IL158128A/en not_active IP Right Cessation
-
2007
- 2007-02-01 US US11/670,061 patent/US20070141164A1/en not_active Abandoned
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