JP2004533481A - 7−アミノsyn3,5−ジヒドロキシヘプタン酸誘導体の製造方法、それらの中間体及び中間体の製造方法 - Google Patents
7−アミノsyn3,5−ジヒドロキシヘプタン酸誘導体の製造方法、それらの中間体及び中間体の製造方法 Download PDFInfo
- Publication number
- JP2004533481A JP2004533481A JP2003510423A JP2003510423A JP2004533481A JP 2004533481 A JP2004533481 A JP 2004533481A JP 2003510423 A JP2003510423 A JP 2003510423A JP 2003510423 A JP2003510423 A JP 2003510423A JP 2004533481 A JP2004533481 A JP 2004533481A
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- Japan
- Prior art keywords
- protecting group
- hydrogen
- formula
- compound
- carboxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 0 C*N(*)C(C[C@](C[C@](CC(O*)=O)O*)O*)=O Chemical compound C*N(*)C(C[C@](C[C@](CC(O*)=O)O*)O*)=O 0.000 description 3
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/30—Preparation of optical isomers
- C07C227/32—Preparation of optical isomers by stereospecific synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
- C07C235/74—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of a saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/716—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Carbon And Carbon Compounds (AREA)
- Pyrrole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01810670 | 2001-07-06 | ||
PCT/EP2002/007308 WO2003004455A2 (en) | 2001-07-06 | 2002-07-02 | Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives, intermediates thereof and methods for their preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2004533481A true JP2004533481A (ja) | 2004-11-04 |
JP2004533481A5 JP2004533481A5 (US07420078-20080902-C00029.png) | 2005-12-22 |
Family
ID=41546668
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003510423A Pending JP2004533481A (ja) | 2001-07-06 | 2002-07-02 | 7−アミノsyn3,5−ジヒドロキシヘプタン酸誘導体の製造方法、それらの中間体及び中間体の製造方法 |
Country Status (15)
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002057229A1 (en) | 2001-01-19 | 2002-07-25 | Biocon India Limited | FORM V CRYSTALLINE [R-(R*,R*)]-2-(4-FLUOROPHENYL)-ß,$G(D)-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1- HEPTANOIC ACID HEMI CALCIUM SALT. (ATORVASTATIN) |
EP1404639A1 (en) | 2001-07-06 | 2004-04-07 | Ciba SC Holding AG | Process for the preparation of intermediates useful in the synthesis of statin derivatives especially 7-amino 3,5-dihydroxy heptanoic acid derivatives, and intermediates thereof |
US7361772B2 (en) | 2001-08-16 | 2008-04-22 | Biocon Limited | Process for the production of atorvastatin calcium |
WO2003078379A1 (en) | 2002-03-18 | 2003-09-25 | Biocon Limited | AMORPHOUS Hmg-CoA REDUCTASE INHIBITORS OF DESIRED PARTICLE SIZE |
US7179942B2 (en) | 2002-07-05 | 2007-02-20 | Bicon Limited | Halo-substituted active methylene compounds |
EP1631533B1 (en) | 2003-04-22 | 2009-03-11 | Biocon Limited | Novel process for stereoselective reduction of beta-ketoesters |
US7368468B2 (en) | 2003-06-18 | 2008-05-06 | Teva Pharmaceutical Industries Ltd. | Fluvastatin sodium crystal forms XIV, LXXIII, LXXIX, LXXX and LXXXVII, processes for preparing them, compositions containing them and methods of using them |
EP1726583A3 (en) | 2003-06-18 | 2007-05-09 | Teva Pharmaceutical Industries Ltd | Fluvastatin sodium crystal form LXXIX, processes for preparing it, compositions containing it and methods of using it. |
AU2003272080A1 (en) | 2003-09-18 | 2005-04-06 | Biocon Limited | Novel process for the preparation of tert-butyl 6-cyano-5-hydroxy-3-oxohexanoate |
US7851624B2 (en) | 2003-12-24 | 2010-12-14 | Teva Pharamaceutical Industries Ltd. | Triol form of rosuvastatin and synthesis of rosuvastatin |
WO2007022488A2 (en) | 2005-08-16 | 2007-02-22 | Teva Pharmaceutical Industries Ltd. | Crystalline rosuvastatin intermediate |
EP2778229A1 (de) | 2013-03-11 | 2014-09-17 | Sandoz Ag | Verfahren zur enantioselektiven Herstellung von 3-Hydroxyglutarsäuremonoestern und deren Verwendung |
CN103361386B (zh) * | 2013-06-28 | 2015-04-15 | 苏州汉酶生物技术有限公司 | 一种罗素伐他汀中间体的制备方法 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH02250870A (ja) * | 1988-07-28 | 1990-10-08 | Zambon Group Spa | コレステロール生合成抑制性化合物 |
JPH02289537A (ja) * | 1989-02-27 | 1990-11-29 | Takasago Internatl Corp | 光学活性6―t―ブトキシ―3,5―ジヒドロキシヘキサン酸エステルの製造法 |
JPH04208266A (ja) * | 1989-12-21 | 1992-07-29 | Zambon Group Spa | 酵素HMG−CoAレダクターゼの抑制剤として活性な化合物ならびに該化合物を含む医薬組成物 |
JPH08198832A (ja) * | 1995-01-27 | 1996-08-06 | Takasago Internatl Corp | N−置換−7−アミノ−5−ヒドロキシ−3−オキソヘプタン酸誘導体およびその製造法 |
JP2001526256A (ja) * | 1997-12-19 | 2001-12-18 | ワーナー−ランバート・エクスポート・リミテッド | 1,3−ジオールの合成方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5097045A (en) | 1989-02-01 | 1992-03-17 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
US5003080A (en) | 1988-02-22 | 1991-03-26 | Warner-Lambert Company | Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis |
JPH02115234A (ja) | 1988-10-26 | 1990-04-27 | Tdk Corp | 架橋ポリフッ化ビニリデンの製造方法 |
DE69009237T2 (de) * | 1989-02-27 | 1994-12-01 | Takasago Perfumery Co Ltd | Verfahren zur Herstellung von optisch aktiven Estern der 6-t-Butoxy-3,5-dihydroxyhexansäure. |
US5051502A (en) * | 1990-06-06 | 1991-09-24 | University Of Notre Dame Du Lac | Rhodium catalyzed cyclization process for bicyclic β-lactams |
US5248793A (en) | 1990-10-17 | 1993-09-28 | Warner-Lambert Company | Process for the synthesis of (4R-cis)-1,1-dimethylethyl 6-iodomethyl or 6-(phenyl-substituted)sulfonyloxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate |
US5155251A (en) | 1991-10-11 | 1992-10-13 | Warner-Lambert Company | Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate |
US5298627A (en) | 1993-03-03 | 1994-03-29 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
DE19920784A1 (de) | 1999-05-05 | 2000-11-09 | Bayer Ag | Stilbenaufheller |
-
2002
- 2002-07-02 SK SK79-2004A patent/SK792004A3/sk not_active Application Discontinuation
- 2002-07-02 CZ CZ2004158A patent/CZ2004158A3/cs unknown
- 2002-07-02 HU HU0401006A patent/HUP0401006A2/hu unknown
- 2002-07-02 DK DK02764615.7T patent/DK1404642T3/da active
- 2002-07-02 AT AT02764615T patent/ATE457972T1/de not_active IP Right Cessation
- 2002-07-02 JP JP2003510423A patent/JP2004533481A/ja active Pending
- 2002-07-02 WO PCT/EP2002/007308 patent/WO2003004455A2/en active Search and Examination
- 2002-07-02 US US10/482,946 patent/US7317123B2/en not_active Expired - Fee Related
- 2002-07-02 AU AU2002328835A patent/AU2002328835A1/en not_active Abandoned
- 2002-07-02 PL PL02367774A patent/PL367774A1/xx unknown
- 2002-07-02 CA CA002453211A patent/CA2453211A1/en not_active Abandoned
- 2002-07-02 IL IL15971802A patent/IL159718A0/xx unknown
- 2002-07-02 DE DE60235365T patent/DE60235365D1/de not_active Expired - Fee Related
- 2002-07-02 EP EP02764615A patent/EP1404642B1/en not_active Expired - Lifetime
-
2004
- 2004-02-03 HR HR20040117A patent/HRP20040117A2/hr not_active Application Discontinuation
-
2007
- 2007-11-16 US US11/941,347 patent/US7504532B2/en not_active Expired - Fee Related
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH02250870A (ja) * | 1988-07-28 | 1990-10-08 | Zambon Group Spa | コレステロール生合成抑制性化合物 |
JPH02289537A (ja) * | 1989-02-27 | 1990-11-29 | Takasago Internatl Corp | 光学活性6―t―ブトキシ―3,5―ジヒドロキシヘキサン酸エステルの製造法 |
JPH04208266A (ja) * | 1989-12-21 | 1992-07-29 | Zambon Group Spa | 酵素HMG−CoAレダクターゼの抑制剤として活性な化合物ならびに該化合物を含む医薬組成物 |
JPH08198832A (ja) * | 1995-01-27 | 1996-08-06 | Takasago Internatl Corp | N−置換−7−アミノ−5−ヒドロキシ−3−オキソヘプタン酸誘導体およびその製造法 |
JP2001526256A (ja) * | 1997-12-19 | 2001-12-18 | ワーナー−ランバート・エクスポート・リミテッド | 1,3−ジオールの合成方法 |
Also Published As
Publication number | Publication date |
---|---|
PL367774A1 (en) | 2005-03-07 |
HRP20040117A2 (en) | 2004-10-31 |
EP1404642B1 (en) | 2010-02-17 |
EP1404642A2 (en) | 2004-04-07 |
ATE457972T1 (de) | 2010-03-15 |
CA2453211A1 (en) | 2003-01-16 |
US7504532B2 (en) | 2009-03-17 |
CZ2004158A3 (cs) | 2005-01-12 |
SK792004A3 (sk) | 2005-03-04 |
US20080125601A1 (en) | 2008-05-29 |
DK1404642T3 (da) | 2010-05-17 |
WO2003004455A3 (en) | 2003-03-20 |
US7317123B2 (en) | 2008-01-08 |
DE60235365D1 (de) | 2010-04-01 |
US20040242916A1 (en) | 2004-12-02 |
AU2002328835A1 (en) | 2003-01-21 |
IL159718A0 (en) | 2004-06-20 |
HUP0401006A2 (hu) | 2004-08-30 |
WO2003004455A2 (en) | 2003-01-16 |
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