JP2004533415A5 - - Google Patents
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- Publication number
- JP2004533415A5 JP2004533415A5 JP2002567288A JP2002567288A JP2004533415A5 JP 2004533415 A5 JP2004533415 A5 JP 2004533415A5 JP 2002567288 A JP2002567288 A JP 2002567288A JP 2002567288 A JP2002567288 A JP 2002567288A JP 2004533415 A5 JP2004533415 A5 JP 2004533415A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- formula
- enantiomer
- phenyl
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 25
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 12
- 208000020925 Bipolar disease Diseases 0.000 claims 6
- 229910052801 chlorine Inorganic materials 0.000 claims 6
- 239000000460 chlorine Substances 0.000 claims 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 206010026749 Mania Diseases 0.000 claims 4
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 3
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 3
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 3
- 229910052794 bromium Inorganic materials 0.000 claims 3
- 125000001309 chloro group Chemical group Cl* 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 229910052731 fluorine Inorganic materials 0.000 claims 3
- 239000011737 fluorine Substances 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 125000005843 halogen group Chemical group 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 229910052740 iodine Inorganic materials 0.000 claims 3
- 239000011630 iodine Substances 0.000 claims 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 206010021030 Hypomania Diseases 0.000 claims 1
- 208000028683 bipolar I disease Diseases 0.000 claims 1
- 208000025307 bipolar depression Diseases 0.000 claims 1
- 230000002060 circadian Effects 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27168101P | 2001-02-27 | 2001-02-27 | |
| US10/081,766 US6562867B2 (en) | 2001-02-27 | 2002-02-21 | Carbamate compounds for use in preventing or treating bipolar disorder |
| PCT/US2002/005297 WO2002067921A1 (en) | 2001-02-27 | 2002-02-21 | Carbamate compounds for use in preventing or treating bipolar disorder |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004533415A JP2004533415A (ja) | 2004-11-04 |
| JP2004533415A5 true JP2004533415A5 (enExample) | 2005-12-22 |
| JP4276837B2 JP4276837B2 (ja) | 2009-06-10 |
Family
ID=26765948
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002567288A Expired - Lifetime JP4276837B2 (ja) | 2001-02-27 | 2002-02-21 | 双極性障害の予防もしくは治療における使用のためのカルバメート化合物 |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6562867B2 (enExample) |
| EP (1) | EP1408953B1 (enExample) |
| JP (1) | JP4276837B2 (enExample) |
| KR (1) | KR100946944B1 (enExample) |
| CN (1) | CN1250215C (enExample) |
| AT (1) | ATE324108T1 (enExample) |
| BR (1) | BR0207644A (enExample) |
| CA (1) | CA2439475C (enExample) |
| CY (1) | CY1105330T1 (enExample) |
| CZ (1) | CZ20032300A3 (enExample) |
| DE (1) | DE60210976T2 (enExample) |
| DK (1) | DK1408953T3 (enExample) |
| ES (1) | ES2262801T3 (enExample) |
| HU (1) | HUP0303243A3 (enExample) |
| IL (1) | IL157590A0 (enExample) |
| MX (1) | MXPA03007717A (enExample) |
| MY (1) | MY129304A (enExample) |
| NO (1) | NO20033802L (enExample) |
| NZ (1) | NZ527988A (enExample) |
| PL (1) | PL364638A1 (enExample) |
| PT (1) | PT1408953E (enExample) |
| RS (1) | RS50677B (enExample) |
| RU (1) | RU2300372C2 (enExample) |
| TW (1) | TWI250872B (enExample) |
| WO (1) | WO2002067921A1 (enExample) |
| ZA (1) | ZA200307465B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1305082E (pt) * | 2000-07-21 | 2004-09-30 | Ortho Mcneil Pharm Inc | Compostos de carbamato para utilizacao na prevencao ou tratamento da dor neuropatica e dor associada a cefaleia de salvas e enxaqueca |
| IL157594A0 (en) | 2001-02-27 | 2004-03-28 | Ortho Mcneil Pharm Inc | Carbamate compounds for use in preventing or treating anxiety disorders |
| PT1383489E (pt) * | 2001-02-27 | 2007-06-21 | Ortho Mcneil Pharm Inc | Compostos carbamato para utilização na prevenção ou tratamento de distúrbios neurodegenerativos |
| HUP0401367A2 (hu) | 2001-07-16 | 2004-12-28 | Ortho-Mcneil Pharmaceutical, Inc. | Karbamátvegyületek alkalmazása neuropátiás fájdalom, valamint cluster és migrénes fejfájással társuló fájdalom megelőzésére vagy kezelésére |
| CN101056629B (zh) * | 2004-09-16 | 2012-01-11 | 詹森药业有限公司 | 2-苯基-1,2-乙二醇-(二)氨基甲酸酯在制备治疗癫痫发生的药物中的用途 |
| PL1890684T3 (pl) | 2005-06-08 | 2014-05-30 | Sk Biopharmaceuticals Co Ltd | Leczenie zaburzeń snu i czuwania |
| US20070021501A1 (en) * | 2005-07-12 | 2007-01-25 | Twyman Roy E | Methods of treating epileptogenesis |
| US20080317883A1 (en) * | 2006-10-30 | 2008-12-25 | Yong Moon Choi | Methods for treating depression |
| MX2009004798A (es) * | 2006-10-31 | 2009-08-12 | Janssen Pharmaceutica Nv | Tratamiento de los trastornos generalizados del desarrollo. |
| US8609849B1 (en) | 2010-11-30 | 2013-12-17 | Fox Chase Chemical Diversity Center, Inc. | Hydroxylated sulfamides exhibiting neuroprotective action and their method of use |
| CN105164103B (zh) * | 2013-03-12 | 2019-12-06 | 比皮艾思药物研发有限公司 | 苯基氨基甲酸酯化合物和含有其的预防或治疗记忆缺失相关疾病的组合物 |
| US10195151B2 (en) | 2016-09-06 | 2019-02-05 | Jazz Pharmaceuticals International Iii Limited | Formulations of (R)-2-amino-3-phenylpropyl carbamate |
| KR102635938B1 (ko) | 2016-12-14 | 2024-02-13 | 에스케이바이오팜 주식회사 | 양극성 장애의 예방, 경감 또는 치료를 위한 카바메이트 화합물의 용도 |
| KR20240162165A (ko) | 2017-06-02 | 2024-11-14 | 재즈 파마슈티칼즈 아일랜드 리미티드 | 과다 졸림증을 치료하기 위한 방법 및 조성물 |
| US10940133B1 (en) | 2020-03-19 | 2021-03-09 | Jazz Pharmaceuticals Ireland Limited | Methods of providing solriamfetol therapy to subjects with impaired renal function |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3313692A (en) * | 1958-04-21 | 1967-04-11 | Armour Pharma | Method of inducing calming and muscle relaxation with carbamates |
| US3278380A (en) * | 1962-02-06 | 1966-10-11 | Armour Pharma | Methods of calming employing diphenyl hydroxy carbamate compounds |
| US3265728A (en) * | 1962-07-18 | 1966-08-09 | Armour Pharma | Substituted phenethyl carbamates |
| EP0765327B1 (en) * | 1994-06-16 | 1999-07-21 | Pfizer Inc. | Pyrazolo and pyrrolopyridines |
| US5698588A (en) * | 1996-01-16 | 1997-12-16 | Yukong Limited | Halogen substituted carbamate compounds from 2-phenyl-1,2-ethanediol |
-
2002
- 2002-02-21 CN CNB028089170A patent/CN1250215C/zh not_active Expired - Fee Related
- 2002-02-21 PT PT02724984T patent/PT1408953E/pt unknown
- 2002-02-21 PL PL02364638A patent/PL364638A1/xx not_active Application Discontinuation
- 2002-02-21 ES ES02724984T patent/ES2262801T3/es not_active Expired - Lifetime
- 2002-02-21 MX MXPA03007717A patent/MXPA03007717A/es active IP Right Grant
- 2002-02-21 RU RU2003128997/14A patent/RU2300372C2/ru active
- 2002-02-21 KR KR1020037011296A patent/KR100946944B1/ko not_active Expired - Lifetime
- 2002-02-21 DK DK02724984T patent/DK1408953T3/da active
- 2002-02-21 IL IL15759002A patent/IL157590A0/xx not_active IP Right Cessation
- 2002-02-21 RS YUP-678/03A patent/RS50677B/sr unknown
- 2002-02-21 AT AT02724984T patent/ATE324108T1/de active
- 2002-02-21 US US10/081,766 patent/US6562867B2/en not_active Expired - Lifetime
- 2002-02-21 HU HU0303243A patent/HUP0303243A3/hu unknown
- 2002-02-21 WO PCT/US2002/005297 patent/WO2002067921A1/en not_active Ceased
- 2002-02-21 BR BR0207644-6A patent/BR0207644A/pt not_active Application Discontinuation
- 2002-02-21 DE DE60210976T patent/DE60210976T2/de not_active Expired - Lifetime
- 2002-02-21 CZ CZ20032300A patent/CZ20032300A3/cs unknown
- 2002-02-21 NZ NZ527988A patent/NZ527988A/en unknown
- 2002-02-21 JP JP2002567288A patent/JP4276837B2/ja not_active Expired - Lifetime
- 2002-02-21 EP EP02724984A patent/EP1408953B1/en not_active Expired - Lifetime
- 2002-02-21 CA CA2439475A patent/CA2439475C/en not_active Expired - Fee Related
- 2002-02-27 MY MYPI20020691A patent/MY129304A/en unknown
- 2002-02-27 TW TW091103500A patent/TWI250872B/zh active
-
2003
- 2003-08-26 NO NO20033802A patent/NO20033802L/no not_active Application Discontinuation
- 2003-09-25 ZA ZA200307465A patent/ZA200307465B/en unknown
-
2006
- 2006-06-21 CY CY20061100844T patent/CY1105330T1/el unknown
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