JP2004533246A5 - - Google Patents
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- Publication number
- JP2004533246A5 JP2004533246A5 JP2002587611A JP2002587611A JP2004533246A5 JP 2004533246 A5 JP2004533246 A5 JP 2004533246A5 JP 2002587611 A JP2002587611 A JP 2002587611A JP 2002587611 A JP2002587611 A JP 2002587611A JP 2004533246 A5 JP2004533246 A5 JP 2004533246A5
- Authority
- JP
- Japan
- Prior art keywords
- lactococcus
- strain
- gene
- transformed strain
- transformed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000178948 Lactococcus sp. Species 0.000 claims 11
- 108010022394 Threonine synthase Proteins 0.000 claims 3
- 230000003449 preventive effect Effects 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 230000001225 therapeutic effect Effects 0.000 claims 3
- 230000009466 transformation Effects 0.000 claims 3
- 239000013612 plasmid Substances 0.000 claims 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 102000003814 Interleukin-10 Human genes 0.000 claims 1
- 108090000174 Interleukin-10 Proteins 0.000 claims 1
- 241000194035 Lactococcus lactis Species 0.000 claims 1
- 235000014897 Streptococcus lactis Nutrition 0.000 claims 1
- 230000002950 deficient Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940076144 interleukin-10 Drugs 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01201631 | 2001-05-03 | ||
| EP01204785 | 2001-12-07 | ||
| PCT/EP2002/004942 WO2002090551A2 (en) | 2001-05-03 | 2002-05-03 | Self-containing lactococcus strain |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008260591A Division JP2009060913A (ja) | 2001-05-03 | 2008-10-07 | 自己自制ラクトコッカス（Ｌｏｃｔｏｃｏｃｃｕｓ）株 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004533246A JP2004533246A (ja) | 2004-11-04 |
| JP2004533246A5 true JP2004533246A5 (enExample) | 2005-12-22 |
| JP4347575B2 JP4347575B2 (ja) | 2009-10-21 |
Family
ID=26076897
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002587611A Expired - Fee Related JP4347575B2 (ja) | 2001-05-03 | 2002-05-03 | 自己自制ラクトコッカス（Ｌｏｃｔｏｃｏｃｃｕｓ）株 |
| JP2008260591A Withdrawn JP2009060913A (ja) | 2001-05-03 | 2008-10-07 | 自己自制ラクトコッカス（Ｌｏｃｔｏｃｏｃｃｕｓ）株 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008260591A Withdrawn JP2009060913A (ja) | 2001-05-03 | 2008-10-07 | 自己自制ラクトコッカス（Ｌｏｃｔｏｃｏｃｃｕｓ）株 |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1383897B1 (enExample) |
| JP (2) | JP4347575B2 (enExample) |
| AT (1) | ATE331789T1 (enExample) |
| AU (1) | AU2002314040B2 (enExample) |
| CA (1) | CA2446776C (enExample) |
| DE (1) | DE60212825T2 (enExample) |
| DK (1) | DK1383897T3 (enExample) |
| ES (1) | ES2266515T3 (enExample) |
| WO (1) | WO2002090551A2 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7780961B2 (en) | 2001-05-03 | 2010-08-24 | Actogenix N.V. | Self-containing Lactococcus strain |
| EP1513545B1 (en) | 2002-06-19 | 2008-03-19 | Actogenix N.V. | Methods and means to promote gut absorption |
| WO2004056850A2 (en) * | 2002-12-19 | 2004-07-08 | Vib Vzw | Mutant proteins showing increased secretion |
| JP4589618B2 (ja) | 2003-11-28 | 2010-12-01 | 独立行政法人農業生物資源研究所 | 免疫調節性機能を誘導する乳酸菌類とその成分 |
| WO2006018446A2 (en) | 2004-08-20 | 2006-02-23 | Actogenix Nv | Method to improve lactococcus preservation |
| ES2405552T3 (es) | 2005-11-29 | 2013-05-31 | Actogenix N.V. | Inducción de tolerancia mucosa a antiantígenos de células beta de islotes pancreáticos |
| CA2672229A1 (en) * | 2006-12-14 | 2008-06-19 | Actogenix N.V. | Delivery of binding molecules to induce immunomodulation |
| EP3124614B1 (en) | 2007-01-12 | 2022-06-08 | Intrexon Actobiotics NV | Lactococcus promoters and uses thereof |
| EP2774621B1 (en) | 2007-01-25 | 2018-01-24 | Intrexon Actobiotics NV | Treatment of immune disease by mucosal delivery of antigens |
| EP2344626B1 (en) * | 2008-09-29 | 2017-03-29 | Intrexon Actobiotics NV | Reduced colonization of microbes at the mucosa |
| US9920324B2 (en) | 2011-06-01 | 2018-03-20 | Intrexon Actobiotics Nv | Polycistronic expression system for bacteria |
| EP2758512B1 (en) | 2011-09-23 | 2018-05-09 | Intrexon Actobiotics NV | Modified gram positive bacteria and uses thereof |
| BR112014006883A8 (pt) | 2011-09-23 | 2018-06-26 | Actogenix Nv | bactéria gram-positiva não patogênica carecendo de atividade do componente llc do sistema pts celobiose específico (ptcc), medicamento, aditivo alimentar, composição probiótica, ou cultura iniciadora, produto alimentar e métodos |
| US9688967B2 (en) | 2014-12-05 | 2017-06-27 | Synlogic, Inc. | Bacteria engineered to treat diseases associated with hyperammonemia |
| US10610546B2 (en) | 2015-05-13 | 2020-04-07 | Synlogic Operating Company Inc. | Bacteria engineered to reduce hyperphenylalaninemia |
| US20160206666A1 (en) | 2014-12-22 | 2016-07-21 | Synlogic, Inc. | Bacteria engineered to treat diseases that benefit from reduced gut inflammation and/or tighten gut mucosal barrier |
| JP7095993B2 (ja) * | 2015-03-02 | 2022-07-05 | シンロジック オペレーティング カンパニー インコーポレイテッド | 消化管炎症低下および／または消化管粘膜バリア強化の利益を享受する疾患処置のために操作された細菌 |
| CN106148254B (zh) * | 2015-03-26 | 2019-11-12 | 南京华贞生物医药科技有限公司 | 一种用于减肥降脂的转化体及其构建方法与应用 |
| US11685925B2 (en) | 2015-10-30 | 2023-06-27 | Synlogic Operating Company, Inc. | Bacteria engineered to treat diseases that benefit from reduced gut inflammation and/or tightened gut mucosal barrier |
| EP3377518B1 (en) | 2015-11-16 | 2022-04-13 | Synlogic Operating Company, Inc. | Bacteria engineered to reduce hyperphenylalaninemia |
| EP3402499B1 (en) | 2016-01-14 | 2021-07-21 | Intrexon Actobiotics NV | Compositions and methods for the treatment of type 1 diabetes |
| CN109843320A (zh) | 2016-09-02 | 2019-06-04 | 英特瑞克斯顿阿克图比奥帝克斯有限公司 | 稳定表达il-10和胰岛素的遗传修饰的细菌 |
| RU2762940C2 (ru) | 2016-09-13 | 2021-12-24 | Интрексон Актобиотикс Н.В. | Мукоадгезивный микроорганизм |
| WO2020075171A1 (en) | 2018-10-11 | 2020-04-16 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Bacteria expressing single chain antibodies against toll-like receptors |
| CN114761028A (zh) | 2019-09-27 | 2022-07-15 | 英特瑞克斯顿阿克图比奥帝克斯有限公司 | 乳糜泻的治疗 |
| BR112022018571A2 (pt) | 2020-03-20 | 2022-11-01 | Synlogic Operating Co Inc | Microrganismos manipulados para reduzir a hiperfenilalaninemia |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4231764A1 (de) * | 1992-09-23 | 1994-03-24 | Inst Pflanzengenetik & Kultur | Verfahren zur chromosomalen Integration eines Produkt-Gens |
-
2002
- 2002-05-03 JP JP2002587611A patent/JP4347575B2/ja not_active Expired - Fee Related
- 2002-05-03 CA CA2446776A patent/CA2446776C/en not_active Expired - Fee Related
- 2002-05-03 EP EP02740565A patent/EP1383897B1/en not_active Expired - Lifetime
- 2002-05-03 DE DE60212825T patent/DE60212825T2/de not_active Expired - Lifetime
- 2002-05-03 DK DK02740565T patent/DK1383897T3/da active
- 2002-05-03 ES ES02740565T patent/ES2266515T3/es not_active Expired - Lifetime
- 2002-05-03 WO PCT/EP2002/004942 patent/WO2002090551A2/en not_active Ceased
- 2002-05-03 AT AT02740565T patent/ATE331789T1/de active
- 2002-05-03 AU AU2002314040A patent/AU2002314040B2/en not_active Ceased
-
2008
- 2008-10-07 JP JP2008260591A patent/JP2009060913A/ja not_active Withdrawn