JP2004533246A5 - - Google Patents
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- Publication number
- JP2004533246A5 JP2004533246A5 JP2002587611A JP2002587611A JP2004533246A5 JP 2004533246 A5 JP2004533246 A5 JP 2004533246A5 JP 2002587611 A JP2002587611 A JP 2002587611A JP 2002587611 A JP2002587611 A JP 2002587611A JP 2004533246 A5 JP2004533246 A5 JP 2004533246A5
- Authority
- JP
- Japan
- Prior art keywords
- lactococcus
- strain
- gene
- transformed strain
- transformed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000178948 Lactococcus sp. Species 0.000 claims 11
- 108010022394 Threonine synthase Proteins 0.000 claims 3
- 230000003449 preventive effect Effects 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 230000001225 therapeutic effect Effects 0.000 claims 3
- 230000009466 transformation Effects 0.000 claims 3
- 239000013612 plasmid Substances 0.000 claims 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 102000003814 Interleukin-10 Human genes 0.000 claims 1
- 108090000174 Interleukin-10 Proteins 0.000 claims 1
- 241000194035 Lactococcus lactis Species 0.000 claims 1
- 235000014897 Streptococcus lactis Nutrition 0.000 claims 1
- 230000002950 deficient Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940076144 interleukin-10 Drugs 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01201631 | 2001-05-03 | ||
| EP01204785 | 2001-12-07 | ||
| PCT/EP2002/004942 WO2002090551A2 (en) | 2001-05-03 | 2002-05-03 | Self-containing lactococcus strain |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008260591A Division JP2009060913A (ja) | 2001-05-03 | 2008-10-07 | 自己自制ラクトコッカス（Ｌｏｃｔｏｃｏｃｃｕｓ）株 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004533246A JP2004533246A (ja) | 2004-11-04 |
| JP2004533246A5 true JP2004533246A5 (enExample) | 2005-12-22 |
| JP4347575B2 JP4347575B2 (ja) | 2009-10-21 |
Family
ID=26076897
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002587611A Expired - Fee Related JP4347575B2 (ja) | 2001-05-03 | 2002-05-03 | 自己自制ラクトコッカス（Ｌｏｃｔｏｃｏｃｃｕｓ）株 |
| JP2008260591A Withdrawn JP2009060913A (ja) | 2001-05-03 | 2008-10-07 | 自己自制ラクトコッカス（Ｌｏｃｔｏｃｏｃｃｕｓ）株 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008260591A Withdrawn JP2009060913A (ja) | 2001-05-03 | 2008-10-07 | 自己自制ラクトコッカス（Ｌｏｃｔｏｃｏｃｃｕｓ）株 |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1383897B1 (enExample) |
| JP (2) | JP4347575B2 (enExample) |
| AT (1) | ATE331789T1 (enExample) |
| AU (1) | AU2002314040B2 (enExample) |
| CA (1) | CA2446776C (enExample) |
| DE (1) | DE60212825T2 (enExample) |
| DK (1) | DK1383897T3 (enExample) |
| ES (1) | ES2266515T3 (enExample) |
| WO (1) | WO2002090551A2 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7780961B2 (en) | 2001-05-03 | 2010-08-24 | Actogenix N.V. | Self-containing Lactococcus strain |
| DE60319822T2 (de) | 2002-06-19 | 2009-06-04 | Actogenix Nv | Verfahren und mittel zur erhöhung der darmabsorption |
| WO2004056850A2 (en) * | 2002-12-19 | 2004-07-08 | Vib Vzw | Mutant proteins showing increased secretion |
| JP4589618B2 (ja) * | 2003-11-28 | 2010-12-01 | 独立行政法人農業生物資源研究所 | 免疫調節性機能を誘導する乳酸菌類とその成分 |
| WO2006018446A2 (en) * | 2004-08-20 | 2006-02-23 | Actogenix Nv | Method to improve lactococcus preservation |
| DK2119450T3 (da) * | 2005-11-29 | 2013-05-06 | Actogenix Nv | Induktion af mucosal tolerance over for pankreatisk ø-beta-celle-autoantigener |
| CA2672229A1 (en) * | 2006-12-14 | 2008-06-19 | Actogenix N.V. | Delivery of binding molecules to induce immunomodulation |
| CN101605900B (zh) * | 2007-01-12 | 2014-04-23 | 阿克图杰尼斯公司 | 乳球菌启动子和其用途 |
| BRPI0807857A2 (pt) | 2007-01-25 | 2014-05-27 | Actogenix Nv | Tratamento de doença imune por meio de distribuição através da mucosa de antígenos. |
| JP2012504116A (ja) * | 2008-09-29 | 2012-02-16 | アクトジェニックス・エヌブイ | 粘膜での微生物のコロニー形成の低減 |
| EP2714912B1 (en) | 2011-06-01 | 2018-05-02 | Intrexon Actobiotics NV | Polycistronic expression system for bacteria |
| HUE038830T2 (hu) | 2011-09-23 | 2018-11-28 | Intrexon Actobiotics Nv | Módosított gram-pozitív baktériumok és alkalmazásaik |
| CN103917639B (zh) | 2011-09-23 | 2017-09-26 | 英特瑞克斯顿阿克图比奥帝克斯有限公司 | 经修饰的革兰氏阳性细菌及其用途 |
| US9688967B2 (en) | 2014-12-05 | 2017-06-27 | Synlogic, Inc. | Bacteria engineered to treat diseases associated with hyperammonemia |
| US20160206666A1 (en) | 2014-12-22 | 2016-07-21 | Synlogic, Inc. | Bacteria engineered to treat diseases that benefit from reduced gut inflammation and/or tighten gut mucosal barrier |
| KR20170121291A (ko) * | 2015-03-02 | 2017-11-01 | 신로직 인코포레이티드 | 감소된 창자 염증 및/또는 강화된 창자 점막 장벽으로부터 이익을 얻는 질병을 치료하기 위해 공학처리된 박테리아 |
| CN106148254B (zh) * | 2015-03-26 | 2019-11-12 | 南京华贞生物医药科技有限公司 | 一种用于减肥降脂的转化体及其构建方法与应用 |
| EP3882259B1 (en) | 2015-05-13 | 2026-01-28 | Synlogic Operating Company, Inc. | Bacteria engineered to reduce hyperphenylalaninemia |
| US11685925B2 (en) | 2015-10-30 | 2023-06-27 | Synlogic Operating Company, Inc. | Bacteria engineered to treat diseases that benefit from reduced gut inflammation and/or tightened gut mucosal barrier |
| JP6993970B2 (ja) | 2015-11-16 | 2022-02-15 | シンロジック オペレーティング カンパニー インコーポレイテッド | 高フェニルアラニン血症を低減させるように操作された細菌 |
| JP7292877B2 (ja) | 2016-01-14 | 2023-06-19 | イントレクソン・アクトバイオテイクス・エヌブイ | １型糖尿病を処置するための組成物および方法 |
| US10858663B2 (en) | 2016-09-02 | 2020-12-08 | Intrexon Actobiotics N.V. | Genetically modified bacteria stably expressing IL-10 and insulin |
| KR102469701B1 (ko) | 2016-09-13 | 2022-11-22 | 인트랙슨 액토바이오틱스 엔.브이. | 점막부착성 미생물 |
| EP3642221A1 (en) | 2017-06-21 | 2020-04-29 | Synlogic Operating Company, Inc. | Bacteria for the treatment of disorders |
| EP3864048A1 (en) | 2018-10-11 | 2021-08-18 | Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. | Bacteria expressing single chain antibodies against toll-like receptors |
| CA3156035A1 (en) | 2019-09-27 | 2021-04-01 | Intrexon Actobiotics Nv D/B/A Precigen Actobio | Treatment of celiac disease |
| WO2021188819A1 (en) | 2020-03-20 | 2021-09-23 | Synlogic Operating Company, Inc. | Microorganisms engineered to reduce hyperphenylalaninemia |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4231764A1 (de) * | 1992-09-23 | 1994-03-24 | Inst Pflanzengenetik & Kultur | Verfahren zur chromosomalen Integration eines Produkt-Gens |
-
2002
- 2002-05-03 CA CA2446776A patent/CA2446776C/en not_active Expired - Fee Related
- 2002-05-03 JP JP2002587611A patent/JP4347575B2/ja not_active Expired - Fee Related
- 2002-05-03 EP EP02740565A patent/EP1383897B1/en not_active Expired - Lifetime
- 2002-05-03 AU AU2002314040A patent/AU2002314040B2/en not_active Ceased
- 2002-05-03 WO PCT/EP2002/004942 patent/WO2002090551A2/en not_active Ceased
- 2002-05-03 AT AT02740565T patent/ATE331789T1/de active
- 2002-05-03 ES ES02740565T patent/ES2266515T3/es not_active Expired - Lifetime
- 2002-05-03 DK DK02740565T patent/DK1383897T3/da active
- 2002-05-03 DE DE60212825T patent/DE60212825T2/de not_active Expired - Lifetime
-
2008
- 2008-10-07 JP JP2008260591A patent/JP2009060913A/ja not_active Withdrawn