JP4347575B2 - 自己自制ラクトコッカス(Loctococcus)株 - Google Patents

自己自制ラクトコッカス(Loctococcus)株 Download PDF

Info

Publication number
JP4347575B2
JP4347575B2 JP2002587611A JP2002587611A JP4347575B2 JP 4347575 B2 JP4347575 B2 JP 4347575B2 JP 2002587611 A JP2002587611 A JP 2002587611A JP 2002587611 A JP2002587611 A JP 2002587611A JP 4347575 B2 JP4347575 B2 JP 4347575B2
Authority
JP
Japan
Prior art keywords
lactococcus
gene
thya
strain
lactis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2002587611A
Other languages
English (en)
Japanese (ja)
Other versions
JP2004533246A (ja
JP2004533246A5 (enExample
Inventor
ステイドラー,ロウザー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Intrexon Actobiotics NV
Original Assignee
Actogenix NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actogenix NV filed Critical Actogenix NV
Publication of JP2004533246A publication Critical patent/JP2004533246A/ja
Publication of JP2004533246A5 publication Critical patent/JP2004533246A5/ja
Application granted granted Critical
Publication of JP4347575B2 publication Critical patent/JP4347575B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
    • C12N9/1007—Methyltransferases (general) (2.1.1.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y201/00—Transferases transferring one-carbon groups (2.1)
    • C12Y201/01—Methyltransferases (2.1.1)
    • C12Y201/01045—Thymidylate synthase (2.1.1.45)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K2035/11—Medicinal preparations comprising living procariotic cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
JP2002587611A 2001-05-03 2002-05-03 自己自制ラクトコッカス(Loctococcus)株 Expired - Fee Related JP4347575B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01201631 2001-05-03
EP01204785 2001-12-07
PCT/EP2002/004942 WO2002090551A2 (en) 2001-05-03 2002-05-03 Self-containing lactococcus strain

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2008260591A Division JP2009060913A (ja) 2001-05-03 2008-10-07 自己自制ラクトコッカス(Loctococcus)株

Publications (3)

Publication Number Publication Date
JP2004533246A JP2004533246A (ja) 2004-11-04
JP2004533246A5 JP2004533246A5 (enExample) 2005-12-22
JP4347575B2 true JP4347575B2 (ja) 2009-10-21

Family

ID=26076897

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2002587611A Expired - Fee Related JP4347575B2 (ja) 2001-05-03 2002-05-03 自己自制ラクトコッカス(Loctococcus)株
JP2008260591A Withdrawn JP2009060913A (ja) 2001-05-03 2008-10-07 自己自制ラクトコッカス(Loctococcus)株

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2008260591A Withdrawn JP2009060913A (ja) 2001-05-03 2008-10-07 自己自制ラクトコッカス(Loctococcus)株

Country Status (9)

Country Link
EP (1) EP1383897B1 (enExample)
JP (2) JP4347575B2 (enExample)
AT (1) ATE331789T1 (enExample)
AU (1) AU2002314040B2 (enExample)
CA (1) CA2446776C (enExample)
DE (1) DE60212825T2 (enExample)
DK (1) DK1383897T3 (enExample)
ES (1) ES2266515T3 (enExample)
WO (1) WO2002090551A2 (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7780961B2 (en) 2001-05-03 2010-08-24 Actogenix N.V. Self-containing Lactococcus strain
DE60319822T2 (de) 2002-06-19 2009-06-04 Actogenix Nv Verfahren und mittel zur erhöhung der darmabsorption
WO2004056850A2 (en) * 2002-12-19 2004-07-08 Vib Vzw Mutant proteins showing increased secretion
JP4589618B2 (ja) * 2003-11-28 2010-12-01 独立行政法人農業生物資源研究所 免疫調節性機能を誘導する乳酸菌類とその成分
WO2006018446A2 (en) * 2004-08-20 2006-02-23 Actogenix Nv Method to improve lactococcus preservation
DK2119450T3 (da) * 2005-11-29 2013-05-06 Actogenix Nv Induktion af mucosal tolerance over for pankreatisk ø-beta-celle-autoantigener
CA2672229A1 (en) * 2006-12-14 2008-06-19 Actogenix N.V. Delivery of binding molecules to induce immunomodulation
CN101605900B (zh) * 2007-01-12 2014-04-23 阿克图杰尼斯公司 乳球菌启动子和其用途
BRPI0807857A2 (pt) 2007-01-25 2014-05-27 Actogenix Nv Tratamento de doença imune por meio de distribuição através da mucosa de antígenos.
JP2012504116A (ja) * 2008-09-29 2012-02-16 アクトジェニックス・エヌブイ 粘膜での微生物のコロニー形成の低減
EP2714912B1 (en) 2011-06-01 2018-05-02 Intrexon Actobiotics NV Polycistronic expression system for bacteria
HUE038830T2 (hu) 2011-09-23 2018-11-28 Intrexon Actobiotics Nv Módosított gram-pozitív baktériumok és alkalmazásaik
CN103917639B (zh) 2011-09-23 2017-09-26 英特瑞克斯顿阿克图比奥帝克斯有限公司 经修饰的革兰氏阳性细菌及其用途
US9688967B2 (en) 2014-12-05 2017-06-27 Synlogic, Inc. Bacteria engineered to treat diseases associated with hyperammonemia
US20160206666A1 (en) 2014-12-22 2016-07-21 Synlogic, Inc. Bacteria engineered to treat diseases that benefit from reduced gut inflammation and/or tighten gut mucosal barrier
KR20170121291A (ko) * 2015-03-02 2017-11-01 신로직 인코포레이티드 감소된 창자 염증 및/또는 강화된 창자 점막 장벽으로부터 이익을 얻는 질병을 치료하기 위해 공학처리된 박테리아
CN106148254B (zh) * 2015-03-26 2019-11-12 南京华贞生物医药科技有限公司 一种用于减肥降脂的转化体及其构建方法与应用
EP3882259B1 (en) 2015-05-13 2026-01-28 Synlogic Operating Company, Inc. Bacteria engineered to reduce hyperphenylalaninemia
US11685925B2 (en) 2015-10-30 2023-06-27 Synlogic Operating Company, Inc. Bacteria engineered to treat diseases that benefit from reduced gut inflammation and/or tightened gut mucosal barrier
JP6993970B2 (ja) 2015-11-16 2022-02-15 シンロジック オペレーティング カンパニー インコーポレイテッド 高フェニルアラニン血症を低減させるように操作された細菌
JP7292877B2 (ja) 2016-01-14 2023-06-19 イントレクソン・アクトバイオテイクス・エヌブイ 1型糖尿病を処置するための組成物および方法
US10858663B2 (en) 2016-09-02 2020-12-08 Intrexon Actobiotics N.V. Genetically modified bacteria stably expressing IL-10 and insulin
KR102469701B1 (ko) 2016-09-13 2022-11-22 인트랙슨 액토바이오틱스 엔.브이. 점막부착성 미생물
EP3642221A1 (en) 2017-06-21 2020-04-29 Synlogic Operating Company, Inc. Bacteria for the treatment of disorders
EP3864048A1 (en) 2018-10-11 2021-08-18 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Bacteria expressing single chain antibodies against toll-like receptors
CA3156035A1 (en) 2019-09-27 2021-04-01 Intrexon Actobiotics Nv D/B/A Precigen Actobio Treatment of celiac disease
WO2021188819A1 (en) 2020-03-20 2021-09-23 Synlogic Operating Company, Inc. Microorganisms engineered to reduce hyperphenylalaninemia

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4231764A1 (de) * 1992-09-23 1994-03-24 Inst Pflanzengenetik & Kultur Verfahren zur chromosomalen Integration eines Produkt-Gens

Also Published As

Publication number Publication date
DK1383897T3 (da) 2006-10-30
JP2004533246A (ja) 2004-11-04
ATE331789T1 (de) 2006-07-15
CA2446776A1 (en) 2002-11-14
DE60212825T2 (de) 2007-01-11
ES2266515T3 (es) 2007-03-01
DE60212825D1 (de) 2006-08-10
EP1383897A2 (en) 2004-01-28
CA2446776C (en) 2011-07-12
JP2009060913A (ja) 2009-03-26
WO2002090551A2 (en) 2002-11-14
EP1383897B1 (en) 2006-06-28
WO2002090551A3 (en) 2003-03-27
AU2002314040B2 (en) 2007-06-28

Similar Documents

Publication Publication Date Title
JP2009060913A (ja) 自己自制ラクトコッカス(Loctococcus)株
US20100316611A1 (en) Self-containing lactococcus strain
US20050276788A1 (en) Self-containing lactobacillus strain
AU2002314040A1 (en) Self-containing lactococcus strain
US8759088B2 (en) Lactococcus promoters and uses thereof
EP2344626B1 (en) Reduced colonization of microbes at the mucosa
Garrido et al. Engineering a genome‐reduced bacterium to eliminate Staphylococcus aureus biofilms in vivo
JP6918854B2 (ja) 免疫調節ミニ細胞および使用方法
PT97081B (pt) Processo para a preparacao de vectores bacterianos
TW200408410A (en) Clinical grade vectors based on natural microflora for use in delivering therapeutic compositions
JP2007537741A (ja) 自己収容性乳酸桿株
WO2020245093A1 (en) Bacterial delivery of gene editing tools into eukaryotic cells
US20210093679A1 (en) Engineered gut microbes and uses thereof
CN119955699B (zh) 产微菌素MccY和MccJ25重组工程益生菌的构建及抗菌应用
EP3708180A1 (en) Transgenic probiotic e. coli cell
CN116479031A (zh) 一种利用布拉迪酵母表达四环素降解酶Tet(X)的方法与应用
CN121293372A (zh) 融合蛋白及编码其的mRNA和在抑制结核分枝杆菌中的应用
CN121609804A (zh) 一种鱼源抗菌肽及其制备方法和应用
HK1227928A1 (en) Lactococcus promoters and uses thereof
DE10326189A1 (de) Bakterielle Träger für Nukleotidsequenzen kodierend für Wirkstoffe

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20050428

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20050428

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20070220

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A711

Effective date: 20070220

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20071030

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20080118

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20080125

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20080610

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20080908

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20081007

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20081226

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20090324

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20090601

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20090707

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20090716

R150 Certificate of patent or registration of utility model

Ref document number: 4347575

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20120724

Year of fee payment: 3

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20120724

Year of fee payment: 3

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20130724

Year of fee payment: 4

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

S533 Written request for registration of change of name

Free format text: JAPANESE INTERMEDIATE CODE: R313533

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees