JP4347575B2 - 自己自制ラクトコッカス(Loctococcus)株 - Google Patents

自己自制ラクトコッカス(Loctococcus)株 Download PDF

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Publication number
JP4347575B2
JP4347575B2 JP2002587611A JP2002587611A JP4347575B2 JP 4347575 B2 JP4347575 B2 JP 4347575B2 JP 2002587611 A JP2002587611 A JP 2002587611A JP 2002587611 A JP2002587611 A JP 2002587611A JP 4347575 B2 JP4347575 B2 JP 4347575B2
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JP
Japan
Prior art keywords
lactococcus
gene
thya
strain
lactis
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Expired - Fee Related
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JP2002587611A
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English (en)
Japanese (ja)
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JP2004533246A (ja
JP2004533246A5 (enExample
Inventor
ステイドラー,ロウザー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Intrexon Actobiotics NV
Original Assignee
Actogenix NV
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Application filed by Actogenix NV filed Critical Actogenix NV
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Publication of JP2004533246A5 publication Critical patent/JP2004533246A5/ja
Application granted granted Critical
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1003Transferases (2.) transferring one-carbon groups (2.1)
    • C12N9/1007Methyltransferases (general) (2.1.1.)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y201/00Transferases transferring one-carbon groups (2.1)
    • C12Y201/01Methyltransferases (2.1.1)
    • C12Y201/01045Thymidylate synthase (2.1.1.45)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K2035/11Medicinal preparations comprising living procariotic cells

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
JP2002587611A 2001-05-03 2002-05-03 自己自制ラクトコッカス(Loctococcus)株 Expired - Fee Related JP4347575B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01201631 2001-05-03
EP01204785 2001-12-07
PCT/EP2002/004942 WO2002090551A2 (en) 2001-05-03 2002-05-03 Self-containing lactococcus strain

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2008260591A Division JP2009060913A (ja) 2001-05-03 2008-10-07 自己自制ラクトコッカス(Loctococcus)株

Publications (3)

Publication Number Publication Date
JP2004533246A JP2004533246A (ja) 2004-11-04
JP2004533246A5 JP2004533246A5 (enExample) 2005-12-22
JP4347575B2 true JP4347575B2 (ja) 2009-10-21

Family

ID=26076897

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2002587611A Expired - Fee Related JP4347575B2 (ja) 2001-05-03 2002-05-03 自己自制ラクトコッカス(Loctococcus)株
JP2008260591A Withdrawn JP2009060913A (ja) 2001-05-03 2008-10-07 自己自制ラクトコッカス(Loctococcus)株

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2008260591A Withdrawn JP2009060913A (ja) 2001-05-03 2008-10-07 自己自制ラクトコッカス(Loctococcus)株

Country Status (9)

Country Link
EP (1) EP1383897B1 (enExample)
JP (2) JP4347575B2 (enExample)
AT (1) ATE331789T1 (enExample)
AU (1) AU2002314040B2 (enExample)
CA (1) CA2446776C (enExample)
DE (1) DE60212825T2 (enExample)
DK (1) DK1383897T3 (enExample)
ES (1) ES2266515T3 (enExample)
WO (1) WO2002090551A2 (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7780961B2 (en) 2001-05-03 2010-08-24 Actogenix N.V. Self-containing Lactococcus strain
WO2004001020A2 (en) 2002-06-19 2003-12-31 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Methods and means to promote gut absorption
AU2003303222A1 (en) * 2002-12-19 2004-07-14 Universiteit Gent Mutant proteins showing increased secretion
JP4589618B2 (ja) * 2003-11-28 2010-12-01 独立行政法人農業生物資源研究所 免疫調節性機能を誘導する乳酸菌類とその成分
US9200249B2 (en) 2004-08-20 2015-12-01 Actogenix N.V. Method to improve Lactococcus preservation
AU2006319216B2 (en) * 2005-11-29 2012-09-13 Intrexon Actobiotics Nv Induction of mucosal tolerance to antigens
WO2008071751A1 (en) * 2006-12-14 2008-06-19 Actogenix N.V. Delivery of binding molecules to induce immunomodulation
ES2595729T3 (es) * 2007-01-12 2017-01-03 Intrexon Actobiotics Nv Promotores de Lactococcus y usos de los mismos
EP3351268B1 (en) 2007-01-25 2020-08-05 Intrexon Actobiotics NV Treatment of immune disease by mucosal delivery of antigens
WO2010034844A1 (en) * 2008-09-29 2010-04-01 Actogenix N.V. Reduced colonization of microbes at the mucosa
RU2766157C2 (ru) 2011-06-01 2022-02-08 Интрексон Актобиотикс Н.В. Система полицистронной экспрессии для бактерий
CA2848471C (en) 2011-09-23 2021-11-16 Actogenix Nv Modified gram positive bacteria and uses thereof
DK2758512T3 (en) 2011-09-23 2018-07-23 Intrexon Actobiotics Nv MODIFIED GRAM POSITIVE BACTERIES AND APPLICATIONS THEREOF
US9688967B2 (en) 2014-12-05 2017-06-27 Synlogic, Inc. Bacteria engineered to treat diseases associated with hyperammonemia
US20160206666A1 (en) 2014-12-22 2016-07-21 Synlogic, Inc. Bacteria engineered to treat diseases that benefit from reduced gut inflammation and/or tighten gut mucosal barrier
MX385397B (es) * 2015-03-02 2025-03-18 Synlogic Operating Co Inc Bacteria manejada genéticamente para producir butirato, interleucina-10 y/o interleucina-22 para tratar enfermedades que se benefician de inflamación intestinal reducida y/o barrera mucosa intestinal fortalecida.
CN106148254B (zh) * 2015-03-26 2019-11-12 南京华贞生物医药科技有限公司 一种用于减肥降脂的转化体及其构建方法与应用
EP3294760B1 (en) 2015-05-13 2021-03-24 Synlogic Operating Company, Inc. Bacteria engineered to reduce hyperphenylalaninemia
US11685925B2 (en) 2015-10-30 2023-06-27 Synlogic Operating Company, Inc. Bacteria engineered to treat diseases that benefit from reduced gut inflammation and/or tightened gut mucosal barrier
WO2017087580A1 (en) 2015-11-16 2017-05-26 Synlogic, Inc. Bacteria engineered to reduce hyperphenylalaninemia
US10905727B2 (en) 2016-01-14 2021-02-02 Intrexon Actobiotics N.V. Compositions and methods for the treatment of type 1 diabetes
AU2017319707B2 (en) 2016-09-02 2023-11-09 Intrexon Actobiotics N.V. Genetically modified bacteria stably expressing IL-10 and insulin
EP3512872A1 (en) 2016-09-13 2019-07-24 Intrexon Actobiotics NV Mucoadhesive microorganism
AU2018290278B2 (en) 2017-06-21 2022-12-15 Synlogic Operating Company, Inc. Bacteria for the treatment of disorders
US20210393711A1 (en) 2018-10-11 2021-12-23 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Bacteria expressing single chain antibodies against toll-like receptors
AU2020356592A1 (en) 2019-09-27 2022-04-07 Intrexon Actobiotics Nv D/B/A Precigen Actobio Treatment of celiac disease
JP2023518184A (ja) 2020-03-20 2023-04-28 シンロジック オペレーティング カンパニー インコーポレイテッド 高フェニルアラニン血症を軽減するように遺伝子改変された微生物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4231764A1 (de) * 1992-09-23 1994-03-24 Inst Pflanzengenetik & Kultur Verfahren zur chromosomalen Integration eines Produkt-Gens

Also Published As

Publication number Publication date
JP2004533246A (ja) 2004-11-04
CA2446776A1 (en) 2002-11-14
JP2009060913A (ja) 2009-03-26
DE60212825T2 (de) 2007-01-11
ATE331789T1 (de) 2006-07-15
DK1383897T3 (da) 2006-10-30
WO2002090551A2 (en) 2002-11-14
CA2446776C (en) 2011-07-12
EP1383897A2 (en) 2004-01-28
AU2002314040B2 (en) 2007-06-28
WO2002090551A3 (en) 2003-03-27
EP1383897B1 (en) 2006-06-28
DE60212825D1 (de) 2006-08-10
ES2266515T3 (es) 2007-03-01

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