JP2004530137A - 検出法における光学的回折要素の使用 - Google Patents

検出法における光学的回折要素の使用 Download PDF

Info

Publication number
JP2004530137A
JP2004530137A JP2003500537A JP2003500537A JP2004530137A JP 2004530137 A JP2004530137 A JP 2004530137A JP 2003500537 A JP2003500537 A JP 2003500537A JP 2003500537 A JP2003500537 A JP 2003500537A JP 2004530137 A JP2004530137 A JP 2004530137A
Authority
JP
Japan
Prior art keywords
probe
carrier
confocal
measuring
optical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2003500537A
Other languages
English (en)
Japanese (ja)
Other versions
JP2004530137A5 (enExample
Inventor
リグラー ルードルフ
ブローム ハンス
ヨハンソン マティアス
ハード スヴェルケル
Original Assignee
グノーティス ホールディング ソシエテ アノニム
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by グノーティス ホールディング ソシエテ アノニム filed Critical グノーティス ホールディング ソシエテ アノニム
Publication of JP2004530137A publication Critical patent/JP2004530137A/ja
Publication of JP2004530137A5 publication Critical patent/JP2004530137A5/ja
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G01N2021/6421—Measuring at two or more wavelengths
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy

Landscapes

  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
JP2003500537A 2001-05-29 2002-05-28 検出法における光学的回折要素の使用 Pending JP2004530137A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10126083A DE10126083A1 (de) 2001-05-29 2001-05-29 Verwendung von optischen Diffraktionselementen in Nachweisverfahren
PCT/EP2002/005866 WO2002097406A1 (de) 2001-05-29 2002-05-28 Verwendung von optischen diffraktionselementen in nachweisverfahren

Publications (2)

Publication Number Publication Date
JP2004530137A true JP2004530137A (ja) 2004-09-30
JP2004530137A5 JP2004530137A5 (enExample) 2006-01-05

Family

ID=7686488

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003500537A Pending JP2004530137A (ja) 2001-05-29 2002-05-28 検出法における光学的回折要素の使用

Country Status (6)

Country Link
US (1) US7259847B2 (enExample)
EP (1) EP1390725B1 (enExample)
JP (1) JP2004530137A (enExample)
CA (1) CA2449190A1 (enExample)
DE (1) DE10126083A1 (enExample)
WO (1) WO2002097406A1 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1637871B1 (en) * 2003-05-30 2011-03-23 Olympus Corporation Measuring apparatus including a light-receiving unit
DE10336080A1 (de) * 2003-08-06 2005-03-03 Gnothis Holding Sa Verfahren und Vorrichtung zur Bestimmung von lumineszierenden Molekülen, insbesondere nach der Methode der Fluoreszenzkorrelationsspektroskopie
DE202004012992U1 (de) * 2004-08-19 2005-12-29 Storz Endoskop Produktions Gmbh Endoskopisches Video-Meßsystem
JP2008523383A (ja) 2004-12-10 2008-07-03 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ マルチスポット調査装置
DE102005000840B4 (de) * 2005-01-05 2007-12-27 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren und Vorrichtung zur Elementanalyse mittels Laser-Emissionsspektrometrie
CN100372947C (zh) * 2005-03-03 2008-03-05 华南师范大学 转基因物种的荧光相关光谱检测方法
US20100049055A1 (en) * 2005-05-31 2010-02-25 W.O.M. World Of Medicine Ag Method and apparatus for visual characterization of tissue
US20100167413A1 (en) * 2007-05-10 2010-07-01 Paul Lundquist Methods and systems for analyzing fluorescent materials with reduced autofluorescence
US20080277595A1 (en) * 2007-05-10 2008-11-13 Pacific Biosciences Of California, Inc. Highly multiplexed confocal detection systems and methods of using same
AU2008251861B2 (en) * 2007-05-10 2014-03-20 Pacific Biosciences Of California, Inc. Methods and systems for analyzing fluorescent materials with reduced autofluorescence
DE102010016818A1 (de) * 2010-03-16 2011-09-22 Leica Microsystems Cms Gmbh Verfahren und Vorrichtung zur Durchführung von Multipoint-FCS
WO2013131888A1 (en) 2012-03-06 2013-09-12 Rudolf Rigler Cyclic single molecule sequencing process
CN106460034B (zh) 2014-01-10 2021-05-07 格诺特斯控股股份公司 具有高准确度的单分子分析
EP3112841A1 (en) 2015-06-30 2017-01-04 Gnothis Holding SA Single molecule analysis in an electrical field
EP3330763A1 (en) 2016-12-05 2018-06-06 Gnothis AB Apparatus for characterizing luminescent entities
DE102017105113B4 (de) 2017-03-10 2021-09-30 Leibniz-Institut für Photonische Technologien e.V. (Engl.Leibniz Institute of Photonic Technology) Anordnung und Verfahren für die Erfassung von Änderungen der optischen Weglänge in einem Nano-Kapillarkanal
CN112912715B (zh) * 2018-10-25 2024-08-09 浜松光子学株式会社 光学测定装置及光学测定方法
EP4379378A1 (en) 2022-11-29 2024-06-05 Gnothis Holding AG Selective-area coated protein resistant surface
EP4616193A1 (en) 2022-11-07 2025-09-17 Gnothis Holding AG Selective-area coated protein resistant surface
EP4623095A1 (en) 2022-11-21 2025-10-01 Gnothis Holding AG Multiple molecular binding sites
EP4403643A1 (en) 2023-01-19 2024-07-24 Gnothis Holding AG Multiple molecular binding sites
EP4375644A1 (en) 2022-11-22 2024-05-29 Gnothis Holding AG Fingerprint analysis of single molecule events
EP4379355A1 (en) 2022-11-29 2024-06-05 Gnothis Holding AG High throughput analysis of single molecule events
EP4382614A1 (en) 2022-12-06 2024-06-12 Gnothis Holding AG High yield support

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0679251T3 (da) 1993-01-18 1999-01-25 Evotec Biosystems Aktiengesell Fremgangsmåde og apparat til vurdering af biopolymerers fitness
JP3474652B2 (ja) * 1994-11-11 2003-12-08 株式会社モリテックス 多点レーザトラッピング装置及びその方法
DE19748211A1 (de) 1997-10-31 1999-05-06 Zeiss Carl Fa Optisches Array-System und Reader für Mikrotiterplatten
US6055106A (en) * 1998-02-03 2000-04-25 Arch Development Corporation Apparatus for applying optical gradient forces
US6208411B1 (en) * 1998-09-28 2001-03-27 Kla-Tencor Corporation Massively parallel inspection and imaging system
US6455861B1 (en) * 1998-11-24 2002-09-24 Cambridge Research & Instrumentation, Inc. Fluorescence polarization assay system and method
GB9906929D0 (en) * 1999-03-26 1999-05-19 Univ Glasgow Assay system
JP2001228756A (ja) * 2000-02-18 2001-08-24 Canon Inc 画像形成装置
WO2001063262A1 (en) * 2000-02-25 2001-08-30 Cambridge Research & Instrumentation Inc. Multiple label fluorescence polarization assay system and method
DE10065632A1 (de) 2000-05-12 2001-11-15 Smtech Biovision Holding Ag Ec Verfahren zum Nachweis von Polynukleotiden
DE10065626A1 (de) 2000-06-30 2002-01-10 Smtech Biovision Holding Ag Ec Einzelmolekül-Sequenzierungsverfahren

Also Published As

Publication number Publication date
DE10126083A1 (de) 2002-12-05
WO2002097406A1 (de) 2002-12-05
EP1390725A1 (de) 2004-02-25
US20040126780A1 (en) 2004-07-01
CA2449190A1 (en) 2002-12-05
US7259847B2 (en) 2007-08-21
EP1390725B1 (de) 2015-12-23

Similar Documents

Publication Publication Date Title
JP2004530137A (ja) 検出法における光学的回折要素の使用
Zanchetta et al. Emerging applications of label-free optical biosensors
JP3517241B2 (ja) 生体高分子の適応度を評価するための方法および装置
EP2765424B1 (en) Method for analyzing biomolecules
US6376177B1 (en) Apparatus and method for the analysis of nucleic acids hybridization on high density NA chips
JP2007524087A (ja) 生体試料をアッセイするためにラマン活性プローブ構築物を使用するための方法および装置
Korn et al. Gene expression analysis using single molecule detection
US7115365B2 (en) Method of analyzing a target nucleic acid
EP2913660A1 (en) Method for detecting target particles
US20050064452A1 (en) System and method for the detection of analytes
CA2545441A1 (en) Diffraction grating-based encoded articles for multiplexed experiments
EP2735618B1 (en) Nucleic acid analysis method
JP2004520052A (ja) 遺伝的特性を検出するための生化学的方法及び装置
JP2004520052A5 (enExample)
US20070122808A1 (en) Measurement of a polynuleotide amplification reaction
US7223985B2 (en) Single-channel multicolored correlation analysis
US20040151631A1 (en) Determination of analytes by means of fluorescence correlation spectroscopy
WO2001073120A1 (en) Method of measuring polymorphism
JP5133895B2 (ja) 生体分子の親和性を測定する方法
JP4262336B2 (ja) 標的核酸の定量分析方法
JP4217318B2 (ja) 標的核酸の定量分析方法および装置
JP3910000B2 (ja) １塩基置換検出方法
Herron et al. Planar waveguide biosensors for nucleic acid hybridization reactions
JP2004527742A (ja) 蛍光−相関分光法による分析物の測定
JP2001269198A (ja) 多型遺伝子の型を決定する方法

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20050527

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20050527

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20071116

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20080213

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20080220

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20080313

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20080321

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20080415

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20080422

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20080508

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20080905

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20081203

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20081210

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20081225

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20090108

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20090722