JP2004528342A5 - - Google Patents
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- Publication number
- JP2004528342A5 JP2004528342A5 JP2002584918A JP2002584918A JP2004528342A5 JP 2004528342 A5 JP2004528342 A5 JP 2004528342A5 JP 2002584918 A JP2002584918 A JP 2002584918A JP 2002584918 A JP2002584918 A JP 2002584918A JP 2004528342 A5 JP2004528342 A5 JP 2004528342A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- compound
- dichlorophenyl
- hexahydro
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 31
- -1 halo C1-C6 alkoxy Chemical group 0.000 claims 28
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 7
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- 239000001257 hydrogen Substances 0.000 claims 7
- 125000004201 2,4-dichlorophenyl group Chemical group [H]C1=C([H])C(*)=C(Cl)C([H])=C1Cl 0.000 claims 6
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 6
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 5
- 150000002367 halogens Chemical class 0.000 claims 5
- 150000002431 hydrogen Chemical class 0.000 claims 5
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 4
- 125000004093 cyano group Chemical group *C#N 0.000 claims 4
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 3
- 208000019901 Anxiety disease Diseases 0.000 claims 3
- 208000020401 Depressive disease Diseases 0.000 claims 3
- 230000036506 anxiety Effects 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 239000000969 carrier Substances 0.000 claims 3
- 125000004663 dialkyl amino group Chemical group 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 230000001404 mediated effect Effects 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims 3
- 238000002360 preparation method Methods 0.000 claims 3
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 2
- KTENNVUEGBJCHO-UHFFFAOYSA-N 12-(2,4-dichlorophenyl)-3-methyl-6-pentan-3-yl-2,4,6-triazatricyclo[7.3.1.05,13]trideca-1(13),2,4-triene Chemical compound C=12C3=NC(C)=NC=1N(C(CC)CC)CCC2CCC3C1=CC=C(Cl)C=C1Cl KTENNVUEGBJCHO-UHFFFAOYSA-N 0.000 claims 2
- 239000000275 Adrenocorticotropic Hormone Substances 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 101800000414 Corticotropin Proteins 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 102100027467 Pro-opiomelanocortin Human genes 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 claims 2
- 229960000258 corticotropin Drugs 0.000 claims 2
- 239000003488 releasing hormone Substances 0.000 claims 2
- QAAQDIUDQAOWTK-UHFFFAOYSA-N 2-(2,4-dichlorophenyl)-7-(2-ethylbutyl)-10-methyl-2,7,9,11-tetrazatricyclo[6.3.1.04,12]dodeca-1(11),8(12),9-triene Chemical group C=12C3=NC(C)=NC=1N(CC(CC)CC)CCC2CN3C1=CC=C(Cl)C=C1Cl QAAQDIUDQAOWTK-UHFFFAOYSA-N 0.000 claims 1
- PHNRYLGTWPVWGK-UHFFFAOYSA-N 2-(2,4-dichlorophenyl)-7-(2-methoxyethyl)-10-methyl-2,7,9,11-tetrazatricyclo[6.3.1.04,12]dodeca-1(11),8(12),9-triene Chemical group C=12C3=NC(C)=NC=1N(CCOC)CCC2CN3C1=CC=C(Cl)C=C1Cl PHNRYLGTWPVWGK-UHFFFAOYSA-N 0.000 claims 1
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000004199 4-trifluoromethylphenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C(F)(F)F 0.000 claims 1
- CNBNLEBKVWQZNX-UHFFFAOYSA-N 6-butyl-7-(cyclopropylmethyl)-2-(2,4-dichlorophenyl)-10-methyl-2,7,9,11-tetrazatricyclo[6.3.1.04,12]dodeca-1(12),8,10-triene Chemical group CCCCC1CC(C=23)CN(C=4C(=CC(Cl)=CC=4)Cl)C3=NC(C)=NC=2N1CC1CC1 CNBNLEBKVWQZNX-UHFFFAOYSA-N 0.000 claims 1
- VYUMTEKEJKJMQG-UHFFFAOYSA-N 7-(2,4-dichlorophenyl)-10-methyl-2-pentan-3-yl-2,9,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),8(12),9-triene Chemical group C=12C3=NC(C)=NC=1N(C(CC)CC)CC2CCC3C1=CC=C(Cl)C=C1Cl VYUMTEKEJKJMQG-UHFFFAOYSA-N 0.000 claims 1
- BOTTWHRLZDCVOZ-UHFFFAOYSA-N 7-(2,4-dichlorophenyl)-2-(2-ethylbutyl)-10-methyl-2,7,9,11-tetrazatricyclo[6.3.1.04,12]dodeca-1(11),9-diene Chemical group C12C3N=C(C)N=C1N(CC(CC)CC)CC2CCN3C1=CC=C(Cl)C=C1Cl BOTTWHRLZDCVOZ-UHFFFAOYSA-N 0.000 claims 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims 1
- WMBGNRWVJYODMA-UHFFFAOYSA-N C=12C3=NC(C)=NC=1N(C(CCC)CCC)CC2CCN3C1=CC=C(C(F)(F)CF)C=C1C(F)(F)F Chemical group C=12C3=NC(C)=NC=1N(C(CCC)CCC)CC2CCN3C1=CC=C(C(F)(F)CF)C=C1C(F)(F)F WMBGNRWVJYODMA-UHFFFAOYSA-N 0.000 claims 1
- GFRXIUZQVJCISJ-UHFFFAOYSA-N C=12C3=NC(C)=NC=1N(C(CCC)CCC)CCC2CN3C1=CC=C(C(F)(F)CF)C=C1C(F)(F)F Chemical group C=12C3=NC(C)=NC=1N(C(CCC)CCC)CCC2CN3C1=CC=C(C(F)(F)CF)C=C1C(F)(F)F GFRXIUZQVJCISJ-UHFFFAOYSA-N 0.000 claims 1
- DCLWIFOQEHQVQZ-UHFFFAOYSA-N C=12C3=NC(C)=NC=1N(CCCC)C(CCCC)CC2CN3C1=CC=C(Cl)C=C1Cl Chemical group C=12C3=NC(C)=NC=1N(CCCC)C(CCCC)CC2CN3C1=CC=C(Cl)C=C1Cl DCLWIFOQEHQVQZ-UHFFFAOYSA-N 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- IOMQSAPFIUXPEO-UHFFFAOYSA-N chembl176145 Chemical group C=12C3=NC(C)=NC=1N(C(CC)CC)CC2CCN3C1=CC=C(Cl)C=C1Cl IOMQSAPFIUXPEO-UHFFFAOYSA-N 0.000 claims 1
- YALBAQFFCQQJKN-UHFFFAOYSA-N chembl178176 Chemical group C1=2C3=NC(C)=NC=2N(C=2C(=CC(Cl)=CC=2)Cl)CC1CCN3CC1CC1 YALBAQFFCQQJKN-UHFFFAOYSA-N 0.000 claims 1
- ATYWTDSKRJOYQU-UHFFFAOYSA-N chembl179608 Chemical group C=12C3=NC(C)=NC=1N(C(CCC)CCC)CCC2CN3C1=CC=C(Cl)C=C1Cl ATYWTDSKRJOYQU-UHFFFAOYSA-N 0.000 claims 1
- DAHAIPSBEBRKTA-UHFFFAOYSA-N chembl180116 Chemical group C=12C3=NC(C)=NC=1N(C(CC)CC)CCC2CN3C1=CC=C(Cl)C=C1Cl DAHAIPSBEBRKTA-UHFFFAOYSA-N 0.000 claims 1
- VJJBGPHBOZISOV-UHFFFAOYSA-N chembl369510 Chemical group C=12C3=NC(C)=NC=1N(C(CCC)CCC)CC2CCN3C1=CC=C(Cl)C=C1Cl VJJBGPHBOZISOV-UHFFFAOYSA-N 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 150000002902 organometallic compounds Chemical class 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0110566A GB0110566D0 (en) | 2001-04-30 | 2001-04-30 | Chemical compounds |
| GB0110579A GB0110579D0 (en) | 2001-04-30 | 2001-04-30 | Chemical compounds |
| GB0117423A GB0117423D0 (en) | 2001-07-17 | 2001-07-17 | Chemical compounds |
| GB0203203A GB0203203D0 (en) | 2002-02-11 | 2002-02-11 | Chemical compounds |
| PCT/GB2002/001981 WO2002087573A1 (en) | 2001-04-30 | 2002-04-30 | Crf receptor antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004528342A JP2004528342A (ja) | 2004-09-16 |
| JP2004528342A5 true JP2004528342A5 (https=) | 2005-12-22 |
Family
ID=27447943
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002584918A Pending JP2004528342A (ja) | 2001-04-30 | 2002-04-30 | Ｃｒｆ受容体アンタゴニスト |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US7329667B2 (https=) |
| EP (1) | EP1383498B1 (https=) |
| JP (1) | JP2004528342A (https=) |
| KR (1) | KR20040015205A (https=) |
| CN (1) | CN1512883A (https=) |
| AR (1) | AR033296A1 (https=) |
| AT (1) | ATE320254T1 (https=) |
| AU (1) | AU2002249474B2 (https=) |
| BR (1) | BR0209035A (https=) |
| CA (1) | CA2446497A1 (https=) |
| CZ (1) | CZ20032945A3 (https=) |
| DE (1) | DE60209885T2 (https=) |
| ES (1) | ES2255610T3 (https=) |
| HU (1) | HUP0304035A2 (https=) |
| IL (1) | IL158063A0 (https=) |
| MX (1) | MXPA03009930A (https=) |
| NO (1) | NO20034837L (https=) |
| NZ (1) | NZ528364A (https=) |
| PL (1) | PL366854A1 (https=) |
| TW (1) | TWI236908B (https=) |
| WO (1) | WO2002087573A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0308208D0 (en) | 2003-04-09 | 2003-05-14 | Glaxo Group Ltd | Chemical compounds |
| ES2540964T3 (es) | 2009-06-08 | 2015-07-15 | Takeda Pharmaceutical Company Limited | Compuestos de dihidropirrolonaftiridinona como inhibidores de JAK |
| RU2498986C2 (ru) * | 2011-07-20 | 2013-11-20 | Учреждение Российской Академии Наук Институт Проблем Химической Физики Ран (Ипхф Ран) | ТЕТРАЦИАНОЗАМЕЩЕННЫЕ 1,4,9b-ТРИАЗАФЕНАЛЕНЫ И СПОСОБ ИХ ПОЛУЧЕНИЯ |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6403599B1 (en) | 1995-11-08 | 2002-06-11 | Pfizer Inc | Corticotropin releasing factor antagonists |
| ZA973884B (en) * | 1996-05-23 | 1998-11-06 | Du Pont Merck Pharma | Tetrahydropteridines and pyridylpiperazines for treatment of neurological disorders |
| EP1129096B1 (en) * | 1998-11-12 | 2003-05-21 | Neurocrine Biosciences, Inc. | Crf receptor antagonists and methods relating thereto |
| IL142893A0 (en) | 1998-11-12 | 2002-04-21 | Neurocrine Biosciences Inc | Fused polyclic heterocyclic compounds and pharmaceutical compositions containing the same |
| GB0117395D0 (en) | 2001-07-17 | 2001-09-05 | Glaxo Group Ltd | Chemical compounds |
-
2002
- 2002-04-30 ES ES02718405T patent/ES2255610T3/es not_active Expired - Lifetime
- 2002-04-30 DE DE60209885T patent/DE60209885T2/de not_active Expired - Fee Related
- 2002-04-30 PL PL02366854A patent/PL366854A1/xx not_active Application Discontinuation
- 2002-04-30 HU HU0304035A patent/HUP0304035A2/hu unknown
- 2002-04-30 CZ CZ20032945A patent/CZ20032945A3/cs unknown
- 2002-04-30 CA CA002446497A patent/CA2446497A1/en not_active Abandoned
- 2002-04-30 AU AU2002249474A patent/AU2002249474B2/en not_active Ceased
- 2002-04-30 KR KR10-2003-7014159A patent/KR20040015205A/ko not_active Withdrawn
- 2002-04-30 US US10/476,441 patent/US7329667B2/en not_active Expired - Fee Related
- 2002-04-30 AR ARP020101598A patent/AR033296A1/es unknown
- 2002-04-30 CN CNA028107454A patent/CN1512883A/zh active Pending
- 2002-04-30 TW TW091108900A patent/TWI236908B/zh not_active IP Right Cessation
- 2002-04-30 BR BR0209035-0A patent/BR0209035A/pt not_active IP Right Cessation
- 2002-04-30 MX MXPA03009930A patent/MXPA03009930A/es active IP Right Grant
- 2002-04-30 WO PCT/GB2002/001981 patent/WO2002087573A1/en not_active Ceased
- 2002-04-30 NZ NZ528364A patent/NZ528364A/en unknown
- 2002-04-30 JP JP2002584918A patent/JP2004528342A/ja active Pending
- 2002-04-30 EP EP02718405A patent/EP1383498B1/en not_active Expired - Lifetime
- 2002-04-30 AT AT02718405T patent/ATE320254T1/de not_active IP Right Cessation
- 2002-04-30 IL IL15806302A patent/IL158063A0/xx unknown
-
2003
- 2003-10-29 NO NO20034837A patent/NO20034837L/no not_active Application Discontinuation