DE60209885T2 - Crf-rezeptorantagonisten - Google Patents
Crf-rezeptorantagonisten Download PDFInfo
- Publication number
- DE60209885T2 DE60209885T2 DE60209885T DE60209885T DE60209885T2 DE 60209885 T2 DE60209885 T2 DE 60209885T2 DE 60209885 T DE60209885 T DE 60209885T DE 60209885 T DE60209885 T DE 60209885T DE 60209885 T2 DE60209885 T2 DE 60209885T2
- Authority
- DE
- Germany
- Prior art keywords
- methyl
- dichlorophenyl
- hexahydro
- formula
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 229940044551 receptor antagonist Drugs 0.000 title description 13
- 239000002464 receptor antagonist Substances 0.000 title description 13
- 150000001875 compounds Chemical class 0.000 claims description 257
- -1 C 2 -C 6 -alkyl Chemical group 0.000 claims description 161
- 238000006243 chemical reaction Methods 0.000 claims description 50
- 238000011282 treatment Methods 0.000 claims description 43
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 29
- 229910052739 hydrogen Inorganic materials 0.000 claims description 29
- 239000000055 Corticotropin-Releasing Hormone Substances 0.000 claims description 28
- 239000001257 hydrogen Substances 0.000 claims description 28
- 108010022152 Corticotropin-Releasing Hormone Proteins 0.000 claims description 25
- 102000012289 Corticotropin-Releasing Hormone Human genes 0.000 claims description 25
- 125000004201 2,4-dichlorophenyl group Chemical group [H]C1=C([H])C(*)=C(Cl)C([H])=C1Cl 0.000 claims description 24
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 20
- 229910052799 carbon Inorganic materials 0.000 claims description 19
- 238000000034 method Methods 0.000 claims description 19
- 150000003254 radicals Chemical class 0.000 claims description 18
- 150000003839 salts Chemical class 0.000 claims description 17
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 16
- 150000001412 amines Chemical class 0.000 claims description 16
- 239000003814 drug Substances 0.000 claims description 16
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 14
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 13
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 12
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- KTENNVUEGBJCHO-UHFFFAOYSA-N 12-(2,4-dichlorophenyl)-3-methyl-6-pentan-3-yl-2,4,6-triazatricyclo[7.3.1.05,13]trideca-1(13),2,4-triene Chemical compound C=12C3=NC(C)=NC=1N(C(CC)CC)CCC2CCC3C1=CC=C(Cl)C=C1Cl KTENNVUEGBJCHO-UHFFFAOYSA-N 0.000 claims description 6
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- 125000001072 heteroaryl group Chemical group 0.000 claims description 4
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims description 3
- PHNRYLGTWPVWGK-UHFFFAOYSA-N 2-(2,4-dichlorophenyl)-7-(2-methoxyethyl)-10-methyl-2,7,9,11-tetrazatricyclo[6.3.1.04,12]dodeca-1(11),8(12),9-triene Chemical group C=12C3=NC(C)=NC=1N(CCOC)CCC2CN3C1=CC=C(Cl)C=C1Cl PHNRYLGTWPVWGK-UHFFFAOYSA-N 0.000 claims description 3
- BOTTWHRLZDCVOZ-UHFFFAOYSA-N 7-(2,4-dichlorophenyl)-2-(2-ethylbutyl)-10-methyl-2,7,9,11-tetrazatricyclo[6.3.1.04,12]dodeca-1(11),9-diene Chemical group C12C3N=C(C)N=C1N(CC(CC)CC)CC2CCN3C1=CC=C(Cl)C=C1Cl BOTTWHRLZDCVOZ-UHFFFAOYSA-N 0.000 claims description 3
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- ATYWTDSKRJOYQU-UHFFFAOYSA-N chembl179608 Chemical group C=12C3=NC(C)=NC=1N(C(CCC)CCC)CCC2CN3C1=CC=C(Cl)C=C1Cl ATYWTDSKRJOYQU-UHFFFAOYSA-N 0.000 claims description 3
- DAHAIPSBEBRKTA-UHFFFAOYSA-N chembl180116 Chemical group C=12C3=NC(C)=NC=1N(C(CC)CC)CCC2CN3C1=CC=C(Cl)C=C1Cl DAHAIPSBEBRKTA-UHFFFAOYSA-N 0.000 claims description 3
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- QAAQDIUDQAOWTK-UHFFFAOYSA-N 2-(2,4-dichlorophenyl)-7-(2-ethylbutyl)-10-methyl-2,7,9,11-tetrazatricyclo[6.3.1.04,12]dodeca-1(11),8(12),9-triene Chemical group C=12C3=NC(C)=NC=1N(CC(CC)CC)CCC2CN3C1=CC=C(Cl)C=C1Cl QAAQDIUDQAOWTK-UHFFFAOYSA-N 0.000 claims description 2
- 125000004199 4-trifluoromethylphenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C(F)(F)F 0.000 claims description 2
- CNBNLEBKVWQZNX-UHFFFAOYSA-N 6-butyl-7-(cyclopropylmethyl)-2-(2,4-dichlorophenyl)-10-methyl-2,7,9,11-tetrazatricyclo[6.3.1.04,12]dodeca-1(12),8,10-triene Chemical group CCCCC1CC(C=23)CN(C=4C(=CC(Cl)=CC=4)Cl)C3=NC(C)=NC=2N1CC1CC1 CNBNLEBKVWQZNX-UHFFFAOYSA-N 0.000 claims description 2
- VYUMTEKEJKJMQG-UHFFFAOYSA-N 7-(2,4-dichlorophenyl)-10-methyl-2-pentan-3-yl-2,9,11-triazatricyclo[6.3.1.04,12]dodeca-1(11),8(12),9-triene Chemical group C=12C3=NC(C)=NC=1N(C(CC)CC)CC2CCC3C1=CC=C(Cl)C=C1Cl VYUMTEKEJKJMQG-UHFFFAOYSA-N 0.000 claims description 2
- MVSXPVRYNDCRJQ-UHFFFAOYSA-N 7-(cyclopropylmethyl)-2-(2,4-dichlorophenyl)-10-methyl-6-propoxy-2,7,9,11-tetrazatricyclo[6.3.1.04,12]dodeca-1(12),8,10-triene Chemical group CCCOC1CC(C=23)CN(C=4C(=CC(Cl)=CC=4)Cl)C3=NC(C)=NC=2N1CC1CC1 MVSXPVRYNDCRJQ-UHFFFAOYSA-N 0.000 claims description 2
- WJQCZTYTCMWBGD-UHFFFAOYSA-N 7-(cyclopropylmethyl)-2-(2,4-dichlorophenyl)-10-methyl-6-propyl-2,7,9,11-tetrazatricyclo[6.3.1.04,12]dodeca-1(12),8,10-triene Chemical group CCCC1CC(C=23)CN(C=4C(=CC(Cl)=CC=4)Cl)C3=NC(C)=NC=2N1CC1CC1 WJQCZTYTCMWBGD-UHFFFAOYSA-N 0.000 claims description 2
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- DCLWIFOQEHQVQZ-UHFFFAOYSA-N C=12C3=NC(C)=NC=1N(CCCC)C(CCCC)CC2CN3C1=CC=C(Cl)C=C1Cl Chemical group C=12C3=NC(C)=NC=1N(CCCC)C(CCCC)CC2CN3C1=CC=C(Cl)C=C1Cl DCLWIFOQEHQVQZ-UHFFFAOYSA-N 0.000 claims description 2
- 125000000304 alkynyl group Chemical group 0.000 claims description 2
- 230000036506 anxiety Effects 0.000 claims description 2
- 150000005840 aryl radicals Chemical group 0.000 claims description 2
- 239000000969 carrier Substances 0.000 claims description 2
- VJJBGPHBOZISOV-UHFFFAOYSA-N chembl369510 Chemical group C=12C3=NC(C)=NC=1N(C(CCC)CCC)CC2CCN3C1=CC=C(Cl)C=C1Cl VJJBGPHBOZISOV-UHFFFAOYSA-N 0.000 claims description 2
- 238000010438 heat treatment Methods 0.000 claims description 2
- 125000003538 pentan-3-yl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 125000001424 substituent group Chemical group 0.000 claims description 2
- 125000001475 halogen functional group Chemical group 0.000 claims 3
- BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical compound OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 claims 1
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- HEDRZPFGACZZDS-MICDWDOJSA-N Trichloro(2H)methane Chemical compound [2H]C(Cl)(Cl)Cl HEDRZPFGACZZDS-MICDWDOJSA-N 0.000 description 46
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- KJDLNJOJDXLVDR-UHFFFAOYSA-N tert-butyl n-[5-[1-[tert-butyl(diphenyl)silyl]oxy-4-hydroxybutan-2-yl]-6-chloro-2-methylpyrimidin-4-yl]-n-(2,4-dichlorophenyl)carbamate Chemical compound C=1C=C(Cl)C=C(Cl)C=1N(C(=O)OC(C)(C)C)C1=NC(C)=NC(Cl)=C1C(CCO)CO[Si](C(C)(C)C)(C=1C=CC=CC=1)C1=CC=CC=C1 KJDLNJOJDXLVDR-UHFFFAOYSA-N 0.000 description 1
- CRMKWXHKLLUEOO-UHFFFAOYSA-N tert-butyl n-[5-[1-[tert-butyl(diphenyl)silyl]oxypent-4-en-2-yl]-6-chloro-2-methylpyrimidin-4-yl]-n-(2,4-dichlorophenyl)carbamate Chemical compound C=1C=C(Cl)C=C(Cl)C=1N(C(=O)OC(C)(C)C)C1=NC(C)=NC(Cl)=C1C(CC=C)CO[Si](C(C)(C)C)(C=1C=CC=CC=1)C1=CC=CC=C1 CRMKWXHKLLUEOO-UHFFFAOYSA-N 0.000 description 1
- QWFTZHFIUOBRKD-UHFFFAOYSA-N tert-butyl-[2-(4,6-dichloro-2-methylpyrimidin-5-yl)pent-4-enoxy]-dimethylsilane Chemical compound CC1=NC(Cl)=C(C(CO[Si](C)(C)C(C)(C)C)CC=C)C(Cl)=N1 QWFTZHFIUOBRKD-UHFFFAOYSA-N 0.000 description 1
- ZXKGPENEMLGUOU-UHFFFAOYSA-N tert-butyl-[[4-chloro-8-(2,4-dichlorophenyl)-2-methyl-6,7-dihydro-5h-pyrido[2,3-d]pyrimidin-5-yl]methoxy]-diphenylsilane Chemical compound C1CN(C=2C(=CC(Cl)=CC=2)Cl)C2=NC(C)=NC(Cl)=C2C1CO[Si](C(C)(C)C)(C=1C=CC=CC=1)C1=CC=CC=C1 ZXKGPENEMLGUOU-UHFFFAOYSA-N 0.000 description 1
- FGTJJHCZWOVVNH-UHFFFAOYSA-N tert-butyl-[tert-butyl(dimethyl)silyl]oxy-dimethylsilane Chemical compound CC(C)(C)[Si](C)(C)O[Si](C)(C)C(C)(C)C FGTJJHCZWOVVNH-UHFFFAOYSA-N 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000003325 tomography Methods 0.000 description 1
- 208000004371 toothache Diseases 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 125000004306 triazinyl group Chemical group 0.000 description 1
- TVWZLLYAJDSSCJ-UHFFFAOYSA-N triethyl ethane-1,1,2-tricarboxylate Chemical compound CCOC(=O)CC(C(=O)OCC)C(=O)OCC TVWZLLYAJDSSCJ-UHFFFAOYSA-N 0.000 description 1
- 206010044652 trigeminal neuralgia Diseases 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 206010046494 urge incontinence Diseases 0.000 description 1
- 239000006216 vaginal suppository Substances 0.000 description 1
- 230000002455 vasospastic effect Effects 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 208000027491 vestibular disease Diseases 0.000 description 1
- 229960003048 vinblastine Drugs 0.000 description 1
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
- 229960004528 vincristine Drugs 0.000 description 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 230000009278 visceral effect Effects 0.000 description 1
- 208000009935 visceral pain Diseases 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/16—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0110566A GB0110566D0 (en) | 2001-04-30 | 2001-04-30 | Chemical compounds |
| GB0110566 | 2001-04-30 | ||
| GB0110579 | 2001-04-30 | ||
| GB0110579A GB0110579D0 (en) | 2001-04-30 | 2001-04-30 | Chemical compounds |
| GB0117423A GB0117423D0 (en) | 2001-07-17 | 2001-07-17 | Chemical compounds |
| GB0117423 | 2001-07-17 | ||
| GB0203203 | 2002-02-11 | ||
| GB0203203A GB0203203D0 (en) | 2002-02-11 | 2002-02-11 | Chemical compounds |
| PCT/GB2002/001981 WO2002087573A1 (en) | 2001-04-30 | 2002-04-30 | Crf receptor antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60209885D1 DE60209885D1 (de) | 2006-05-11 |
| DE60209885T2 true DE60209885T2 (de) | 2006-08-10 |
Family
ID=27447943
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60209885T Expired - Fee Related DE60209885T2 (de) | 2001-04-30 | 2002-04-30 | Crf-rezeptorantagonisten |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US7329667B2 (https=) |
| EP (1) | EP1383498B1 (https=) |
| JP (1) | JP2004528342A (https=) |
| KR (1) | KR20040015205A (https=) |
| CN (1) | CN1512883A (https=) |
| AR (1) | AR033296A1 (https=) |
| AT (1) | ATE320254T1 (https=) |
| AU (1) | AU2002249474B2 (https=) |
| BR (1) | BR0209035A (https=) |
| CA (1) | CA2446497A1 (https=) |
| CZ (1) | CZ20032945A3 (https=) |
| DE (1) | DE60209885T2 (https=) |
| ES (1) | ES2255610T3 (https=) |
| HU (1) | HUP0304035A2 (https=) |
| IL (1) | IL158063A0 (https=) |
| MX (1) | MXPA03009930A (https=) |
| NO (1) | NO20034837L (https=) |
| NZ (1) | NZ528364A (https=) |
| PL (1) | PL366854A1 (https=) |
| TW (1) | TWI236908B (https=) |
| WO (1) | WO2002087573A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0308208D0 (en) | 2003-04-09 | 2003-05-14 | Glaxo Group Ltd | Chemical compounds |
| ES2540964T3 (es) | 2009-06-08 | 2015-07-15 | Takeda Pharmaceutical Company Limited | Compuestos de dihidropirrolonaftiridinona como inhibidores de JAK |
| RU2498986C2 (ru) * | 2011-07-20 | 2013-11-20 | Учреждение Российской Академии Наук Институт Проблем Химической Физики Ран (Ипхф Ран) | ТЕТРАЦИАНОЗАМЕЩЕННЫЕ 1,4,9b-ТРИАЗАФЕНАЛЕНЫ И СПОСОБ ИХ ПОЛУЧЕНИЯ |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6403599B1 (en) | 1995-11-08 | 2002-06-11 | Pfizer Inc | Corticotropin releasing factor antagonists |
| ZA973884B (en) * | 1996-05-23 | 1998-11-06 | Du Pont Merck Pharma | Tetrahydropteridines and pyridylpiperazines for treatment of neurological disorders |
| EP1129096B1 (en) * | 1998-11-12 | 2003-05-21 | Neurocrine Biosciences, Inc. | Crf receptor antagonists and methods relating thereto |
| IL142893A0 (en) | 1998-11-12 | 2002-04-21 | Neurocrine Biosciences Inc | Fused polyclic heterocyclic compounds and pharmaceutical compositions containing the same |
| GB0117395D0 (en) | 2001-07-17 | 2001-09-05 | Glaxo Group Ltd | Chemical compounds |
-
2002
- 2002-04-30 ES ES02718405T patent/ES2255610T3/es not_active Expired - Lifetime
- 2002-04-30 DE DE60209885T patent/DE60209885T2/de not_active Expired - Fee Related
- 2002-04-30 PL PL02366854A patent/PL366854A1/xx not_active Application Discontinuation
- 2002-04-30 HU HU0304035A patent/HUP0304035A2/hu unknown
- 2002-04-30 CZ CZ20032945A patent/CZ20032945A3/cs unknown
- 2002-04-30 CA CA002446497A patent/CA2446497A1/en not_active Abandoned
- 2002-04-30 AU AU2002249474A patent/AU2002249474B2/en not_active Ceased
- 2002-04-30 KR KR10-2003-7014159A patent/KR20040015205A/ko not_active Withdrawn
- 2002-04-30 US US10/476,441 patent/US7329667B2/en not_active Expired - Fee Related
- 2002-04-30 AR ARP020101598A patent/AR033296A1/es unknown
- 2002-04-30 CN CNA028107454A patent/CN1512883A/zh active Pending
- 2002-04-30 TW TW091108900A patent/TWI236908B/zh not_active IP Right Cessation
- 2002-04-30 BR BR0209035-0A patent/BR0209035A/pt not_active IP Right Cessation
- 2002-04-30 MX MXPA03009930A patent/MXPA03009930A/es active IP Right Grant
- 2002-04-30 WO PCT/GB2002/001981 patent/WO2002087573A1/en not_active Ceased
- 2002-04-30 NZ NZ528364A patent/NZ528364A/en unknown
- 2002-04-30 JP JP2002584918A patent/JP2004528342A/ja active Pending
- 2002-04-30 EP EP02718405A patent/EP1383498B1/en not_active Expired - Lifetime
- 2002-04-30 AT AT02718405T patent/ATE320254T1/de not_active IP Right Cessation
- 2002-04-30 IL IL15806302A patent/IL158063A0/xx unknown
-
2003
- 2003-10-29 NO NO20034837A patent/NO20034837L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA03009930A (es) | 2004-01-29 |
| TWI236908B (en) | 2005-08-01 |
| EP1383498B1 (en) | 2006-03-15 |
| CN1512883A (zh) | 2004-07-14 |
| CZ20032945A3 (cs) | 2004-02-18 |
| AU2002249474B2 (en) | 2006-01-12 |
| JP2004528342A (ja) | 2004-09-16 |
| WO2002087573A1 (en) | 2002-11-07 |
| NO20034837L (no) | 2003-12-09 |
| ES2255610T3 (es) | 2006-07-01 |
| NO20034837D0 (no) | 2003-10-29 |
| US20040235871A1 (en) | 2004-11-25 |
| HUP0304035A2 (hu) | 2004-04-28 |
| ATE320254T1 (de) | 2006-04-15 |
| PL366854A1 (en) | 2005-02-07 |
| KR20040015205A (ko) | 2004-02-18 |
| IL158063A0 (en) | 2004-03-28 |
| CA2446497A1 (en) | 2002-11-07 |
| AR033296A1 (es) | 2003-12-10 |
| DE60209885D1 (de) | 2006-05-11 |
| BR0209035A (pt) | 2004-08-10 |
| EP1383498A1 (en) | 2004-01-28 |
| NZ528364A (en) | 2005-12-23 |
| US7329667B2 (en) | 2008-02-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |