JP2004528307A5 - - Google Patents
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- Publication number
- JP2004528307A5 JP2004528307A5 JP2002573009A JP2002573009A JP2004528307A5 JP 2004528307 A5 JP2004528307 A5 JP 2004528307A5 JP 2002573009 A JP2002573009 A JP 2002573009A JP 2002573009 A JP2002573009 A JP 2002573009A JP 2004528307 A5 JP2004528307 A5 JP 2004528307A5
- Authority
- JP
- Japan
- Prior art keywords
- keto
- ketoalkanoic acid
- group
- mediated
- ketoalkanoic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 28
- 239000002253 acid Substances 0.000 claims 17
- 150000001875 compounds Chemical class 0.000 claims 10
- 230000004968 inflammatory condition Effects 0.000 claims 10
- 230000001404 mediated effect Effects 0.000 claims 8
- 102000004127 Cytokines Human genes 0.000 claims 7
- 108090000695 Cytokines Proteins 0.000 claims 7
- -1 acetoxymethyl Chemical group 0.000 claims 5
- 150000002148 esters Chemical class 0.000 claims 5
- 239000011575 calcium Substances 0.000 claims 4
- 239000012876 carrier material Substances 0.000 claims 4
- 150000001768 cations Chemical class 0.000 claims 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 3
- LCTONWCANYUPML-UHFFFAOYSA-N Pyruvic acid Chemical compound CC(=O)C(O)=O LCTONWCANYUPML-UHFFFAOYSA-N 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 150000001408 amides Chemical class 0.000 claims 3
- 229910052791 calcium Inorganic materials 0.000 claims 3
- 239000011777 magnesium Substances 0.000 claims 3
- XXRCUYVCPSWGCC-UHFFFAOYSA-N Ethyl pyruvate Chemical compound CCOC(=O)C(C)=O XXRCUYVCPSWGCC-UHFFFAOYSA-N 0.000 claims 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 125000004181 carboxyalkyl group Chemical group 0.000 claims 2
- RXKJFZQQPQGTFL-UHFFFAOYSA-N dihydroxyacetone Chemical compound OCC(=O)CO RXKJFZQQPQGTFL-UHFFFAOYSA-N 0.000 claims 2
- 238000005837 enolization reaction Methods 0.000 claims 2
- 229940117360 ethyl pyruvate Drugs 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 229910052749 magnesium Inorganic materials 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 230000000087 stabilizing effect Effects 0.000 claims 2
- LOGFVTREOLYCPF-KXNHARMFSA-N (2s,3r)-2-[[(2r)-1-[(2s)-2,6-diaminohexanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoic acid Chemical compound C[C@@H](O)[C@@H](C(O)=O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](N)CCCCN LOGFVTREOLYCPF-KXNHARMFSA-N 0.000 claims 1
- TYEYBOSBBBHJIV-UHFFFAOYSA-N 2-oxobutanoic acid Chemical compound CCC(=O)C(O)=O TYEYBOSBBBHJIV-UHFFFAOYSA-N 0.000 claims 1
- XNIHZNNZJHYHLC-UHFFFAOYSA-N 2-oxohexanoic acid Chemical compound CCCCC(=O)C(O)=O XNIHZNNZJHYHLC-UHFFFAOYSA-N 0.000 claims 1
- KDVFRMMRZOCFLS-UHFFFAOYSA-N 2-oxopentanoic acid Chemical compound CCCC(=O)C(O)=O KDVFRMMRZOCFLS-UHFFFAOYSA-N 0.000 claims 1
- QHKABHOOEWYVLI-UHFFFAOYSA-N 3-methyl-2-oxobutanoic acid Chemical compound CC(C)C(=O)C(O)=O QHKABHOOEWYVLI-UHFFFAOYSA-N 0.000 claims 1
- BKAJNAXTPSGJCU-UHFFFAOYSA-N 4-methyl-2-oxopentanoic acid Chemical compound CC(C)CC(=O)C(O)=O BKAJNAXTPSGJCU-UHFFFAOYSA-N 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 201000004624 Dermatitis Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 102000003777 Interleukin-1 beta Human genes 0.000 claims 1
- 108090000193 Interleukin-1 beta Proteins 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 239000012891 Ringer solution Substances 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- 206010040070 Septic Shock Diseases 0.000 claims 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 208000010668 atopic eczema Diseases 0.000 claims 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims 1
- 229940120503 dihydroxyacetone Drugs 0.000 claims 1
- 125000005745 ethoxymethyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])* 0.000 claims 1
- FJAKCEHATXBFJT-UHFFFAOYSA-N ethyl 2-oxobutanoate Chemical compound CCOC(=O)C(=O)CC FJAKCEHATXBFJT-UHFFFAOYSA-N 0.000 claims 1
- WRQGPGZATPOHHX-UHFFFAOYSA-N ethyl 2-oxohexanoate Chemical compound CCCCC(=O)C(=O)OCC WRQGPGZATPOHHX-UHFFFAOYSA-N 0.000 claims 1
- YERWBBMSDMSDKT-UHFFFAOYSA-N ethyl 2-oxopentanoate Chemical compound CCCC(=O)C(=O)OCC YERWBBMSDMSDKT-UHFFFAOYSA-N 0.000 claims 1
- CKTYYUQUWFEUCO-UHFFFAOYSA-N ethyl 3-methyl-2-oxobutanoate Chemical compound CCOC(=O)C(=O)C(C)C CKTYYUQUWFEUCO-UHFFFAOYSA-N 0.000 claims 1
- MGSWAHQQBHNCEI-UHFFFAOYSA-N ethyl 4-methyl-2-oxopentanoate Chemical compound CCOC(=O)C(=O)CC(C)C MGSWAHQQBHNCEI-UHFFFAOYSA-N 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 229910001414 potassium ion Inorganic materials 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- FPOLWERNILTNDK-UHFFFAOYSA-N pyruvamide Chemical compound CC(=O)C(N)=O FPOLWERNILTNDK-UHFFFAOYSA-N 0.000 claims 1
- 229940107700 pyruvic acid Drugs 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 239000012266 salt solution Substances 0.000 claims 1
- 230000036303 septic shock Effects 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- 102000003390 tumor necrosis factor Human genes 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27627901P | 2001-03-15 | 2001-03-15 | |
| PCT/US2002/008283 WO2002074301A1 (en) | 2001-03-15 | 2002-03-15 | Method of using pyruvate and/or its derivatives for the treatment of cytokine-mediated inflammatory conditions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004528307A JP2004528307A (ja) | 2004-09-16 |
| JP2004528307A5 true JP2004528307A5 (enExample) | 2005-12-22 |
Family
ID=23055992
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002573009A Pending JP2004528307A (ja) | 2001-03-15 | 2002-03-15 | サイトカインにより媒介される炎症性状態の治療のためのピルベートおよび／またはその誘導体の使用方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US6943190B2 (enExample) |
| EP (1) | EP1379230A4 (enExample) |
| JP (1) | JP2004528307A (enExample) |
| AU (1) | AU2002255805B2 (enExample) |
| CA (1) | CA2440480A1 (enExample) |
| WO (1) | WO2002074301A1 (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6303321B1 (en) | 1999-02-11 | 2001-10-16 | North Shore-Long Island Jewish Research Institute | Methods for diagnosing sepsis |
| CA2440480A1 (en) * | 2001-03-15 | 2002-09-26 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Method of using pyruvate and/or its derivatives for the treatment of cytokine-mediated inflammatory conditions |
| EP1377339A4 (en) * | 2001-04-04 | 2006-05-31 | Critical Therapeutics Inc | PROCEDURE FOR PREVENTING AKUTER NIERENINSUFFIZIENZ |
| US6916850B2 (en) | 2001-05-03 | 2005-07-12 | Galileo Pharmaceuticals, Inc. | Pyruvate derivatives |
| US7304034B2 (en) | 2001-05-15 | 2007-12-04 | The Feinstein Institute For Medical Research | Use of HMGB fragments as anti-inflammatory agents |
| US7122578B2 (en) * | 2001-09-11 | 2006-10-17 | Alain Martin | Method and composition for treating mammalian diseases and injuries which cause pain, erythema, swelling, crusting, ischemia scarring and excess white blood cell infiltration |
| US8076373B2 (en) * | 2001-09-11 | 2011-12-13 | North Cell Pharmacetical | Method for treating mammalian diseases and injuries caused by the over-expression of peroxynitrite |
| DE60326453D1 (de) * | 2002-07-03 | 2009-04-16 | Ct Cardiologico Monzino S P A | Die verwendung von hmgb1 zur behandlung von gewebeverletzungen und/oder zur unterstützung der gewebewiederherstellung |
| ATE378048T1 (de) * | 2002-12-06 | 2007-11-15 | The Feinstein Inst Medical Res | Hemmung von entzündungen unter verwendungvon alpha-7-rezeptor verbindenden cholinergen agonisten |
| US7696169B2 (en) | 2003-06-06 | 2010-04-13 | The Feinstein Institute For Medical Research | Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents |
| CA2528144A1 (en) * | 2003-06-09 | 2005-01-20 | Mitchell P. Fink | Method for treating acute pancreatitis |
| DE602004014140D1 (de) * | 2003-06-13 | 2008-07-10 | Univ Pittsburgh | Verfahren zur behandlung von alkoholischer hepatitis |
| ES2222093A1 (es) * | 2003-07-01 | 2005-01-16 | Advanced In Vitro Cell Technologies, S.L. | Metodo para el almacenamiento y/o transporte de cultivos celulares in vitro. |
| AU2004272607B2 (en) | 2003-09-11 | 2008-11-06 | Cornerstone Therapeutics Inc. | Monoclonal antibodies against HMGB1 |
| JP2007526022A (ja) * | 2003-10-24 | 2007-09-13 | メドトロニック・インコーポレーテッド | 炎症誘発性媒介物質の産生を減弱することによって神経性障害を処置する技法 |
| WO2006012373A2 (en) * | 2004-07-20 | 2006-02-02 | Critical Therapeutics, Inc. | Combination therapies of hmgb and complement inhibitors against inflammation |
| US20060253100A1 (en) | 2004-10-22 | 2006-11-09 | Medtronic, Inc. | Systems and Methods to Treat Pain Locally |
| WO2006108681A2 (en) | 2005-04-15 | 2006-10-19 | Biomac Privatinstitut Für Medizinische Und Zahnmedizinische Forschung, Entwicklung Und Diagnostik Gmbh | Substances and pharmaceutical compositions for the inhibition of glyoxalases and their use against bacteria |
| WO2007011606A2 (en) * | 2005-07-18 | 2007-01-25 | Critical Therapeutics, Inc. | USE OF HMGBl ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY SKIN CONDITIONS |
| JP2009533433A (ja) * | 2006-04-12 | 2009-09-17 | アレクサンダー，ランヤ，エル． | ピルビン酸アルキルエステルを含む組成物とその使用 |
| US7754247B2 (en) * | 2007-05-29 | 2010-07-13 | University Of South Carolina | Resuscitation fluid |
| US8114907B2 (en) * | 2007-08-08 | 2012-02-14 | Cellular Sciences Inc | Method for treating a pulmonary disease state in mammals by up regulating indigenous in vivo levels of inflammatory agents in mammalian cells |
| US8211943B2 (en) * | 2007-08-08 | 2012-07-03 | Alain Martin | Method for treating a pulmonary disease state in mammals by up regulating indigenous in vivo levels of inflammatory agents in mammalian cells |
| US8815946B2 (en) * | 2008-01-25 | 2014-08-26 | University of Pittsburgh—of the Commonwealth System of Higher Education | Inhibition of proliferation and fibrotic response of activated corneal stromal cells |
| WO2009116546A1 (ja) * | 2008-03-18 | 2009-09-24 | 国立大学法人 岡山大学 | 興奮性化学伝達調節剤およびそのスクリーニング法 |
| USRE48948E1 (en) | 2008-04-18 | 2022-03-01 | Warsaw Orthopedic, Inc. | Clonidine compounds in a biodegradable polymer |
| SI2358669T1 (sl) | 2008-11-20 | 2014-09-30 | CHD Bioscience, Inc. Research Innovation Ctr., At Colorado State University | Alfa-keto perkisline in postopki za proizvodnjo in uporabo le-teh |
| US8445717B2 (en) | 2008-11-20 | 2013-05-21 | Chd Bioscience, Inc. | α-Keto alkylperacids and methods for producing and using the same |
| DK2367549T3 (da) | 2008-12-30 | 2013-11-04 | Hills Pet Nutrition Inc | Anvendelse af alfalipoinsyre til behandling eller forebyggelse af nedbrydende ledsygdomme, osteoarthritis, bruskskade, og relaterede lidelser hos kæledyr |
| US20100239632A1 (en) | 2009-03-23 | 2010-09-23 | Warsaw Orthopedic, Inc. | Drug depots for treatment of pain and inflammation in sinus and nasal cavities or cardiac tissue |
| WO2011082080A1 (en) * | 2009-12-29 | 2011-07-07 | Hill's Pet Nutrition, Inc. | Compositions including pyruvate for companion animals and methods of use thereof |
| US11284621B2 (en) | 2010-04-15 | 2022-03-29 | Armis Biopharma, Inc. | Compositions comprising peroxyacid and methods for producing and using the same |
| RU2013142256A (ru) * | 2011-02-17 | 2015-03-27 | СиЭйчДи БАЙОСАЙЕНС, ИНК. | КОМПОЗИЦИИ, СОДЕРЖАЩИЕ ПЕРОКСИ-α-КЕТОКАРБОНОВУЮ КИСЛОТУ, И СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ИСПОЛЬЗОВАНИЯ |
| US9044527B2 (en) | 2011-02-17 | 2015-06-02 | Chd Bioscience, Inc. | Wound care products with peracid compositions |
| JP2014506889A (ja) * | 2011-02-18 | 2014-03-20 | ステムディーアール インク． | Ｓｉｒｔ１発現誘導物質を含む敗血症または敗血症性ショックの予防または治療用組成物 |
| US9561274B2 (en) | 2011-06-07 | 2017-02-07 | University Of Hawaii | Treatment and prevention of cancer with HMGB1 antagonists |
| US9244074B2 (en) * | 2011-06-07 | 2016-01-26 | University Of Hawaii | Biomarker of asbestos exposure and mesothelioma |
| KR20150087234A (ko) | 2012-10-18 | 2015-07-29 | 시에이치디 바이오사이언스 인코포레이티드 | 과산화 산을 포함하는 조성물 |
| US9578879B1 (en) | 2014-02-07 | 2017-02-28 | Gojo Industries, Inc. | Compositions and methods having improved efficacy against spores and other organisms |
| DE102017131059A1 (de) * | 2017-12-22 | 2019-06-27 | Christiane Kappert | Physiologisch verträgliche Lösung mit einem Gehalt an Pyruvat und Glycin, eine Pyruvat und Glycin enthaltende Zusammensetzung und Verfahren zu deren Herstellung |
| EP3797766A1 (en) * | 2019-09-24 | 2021-03-31 | Evonik Operations GmbH | Compositions for use in reducing inflammation |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2307075A (en) * | 1940-08-02 | 1943-01-05 | Carbide And Carbon Chemicais C | Vinyl resin composition |
| US4105782A (en) * | 1975-03-07 | 1978-08-08 | Yu Ruey J | Treatment of acne and dandruff |
| US4197316A (en) * | 1975-07-23 | 1980-04-08 | Scott Eugene J Van | Treatment of dry skin |
| JPS539847A (en) * | 1976-07-15 | 1978-01-28 | Akishima Kagaku Kogyo | Stabilized halogenncontained resin composition |
| US4234599A (en) * | 1978-10-04 | 1980-11-18 | Scott Eugene J Van | Treatment of skin keratoses with α-hydroxy acids and related compounds |
| US4246261A (en) * | 1979-08-09 | 1981-01-20 | Scott Eugene J Van | Additives enhancing topical corticosteroid action |
| DE3133132A1 (de) * | 1981-08-21 | 1983-03-03 | Schweiger Hubert | Terpene in synergistisch wirkenden kombinationen mit (alpha)-ketomono- und/oder (alpha)-ketodicarbonsaeuren und/oder deren mono- bzw. mono- und/oder diester und verwendung dieser pflanzlichen wirkstoffkombinationen als bioaktive mittel in arznei-, kosmetischen und dermatologischen mitteln |
| DE3581407D1 (de) * | 1985-09-06 | 1991-02-21 | Nestle Sa | Bewahrung lebender gewebe. |
| US6051609A (en) * | 1997-09-09 | 2000-04-18 | Tristrata Technology, Inc. | Additives enhancing the effect of therapeutic agents |
| US5210098A (en) * | 1990-09-21 | 1993-05-11 | Regents Of The University Of Minnesota | Use of pyruvate to treat acute renal failure |
| AU8539491A (en) * | 1990-09-21 | 1992-04-15 | Regents Of The University Of Minnesota | Pyruvate solutions to counteract acute renal failure |
| US5648380A (en) * | 1991-03-01 | 1997-07-15 | Warner-Lambert Company | Anti-inflammatory wound healing compositions and methods for preparing and using same |
| AU2694592A (en) * | 1991-09-30 | 1993-05-03 | Walser, Mackenzie | Methods for treatment of free-radical-mediated tissue injury |
| DE4415581C2 (de) * | 1994-05-04 | 1995-12-07 | Voith Gmbh J M | Papier-Streichvorrichtung |
| US5536751A (en) * | 1994-05-09 | 1996-07-16 | The United States Of America As Represented By The Secretary Of The Army | Pharmaceutical alpha-keto carboxylic acid compositions method of making and use thereof |
| US5480909A (en) * | 1994-08-08 | 1996-01-02 | University Of Pittsburgh Medical Center | Method for inhibiting generation of free-radicals |
| US5908611A (en) * | 1995-05-05 | 1999-06-01 | The Scripps Research Institute | Treatment of viscous mucous-associated diseases |
| EP0804181A4 (en) * | 1995-09-19 | 2005-02-02 | Cellular Sciences Inc | METHOD AND COMPOSITION FOR TREATING MAMMALIAN DISEASES CAUSED BY INFLAMMATORY REACTION |
| US5798388A (en) * | 1996-09-06 | 1998-08-25 | Cellular Sciences, Inc. | Method and composition for treating mammalian diseases caused by inflammatory response |
| US6086789A (en) * | 1996-03-18 | 2000-07-11 | Case Western Reserve University | Medical uses of pyruvates |
| US5756469A (en) * | 1996-07-26 | 1998-05-26 | Beale; Paxton K. | Composition of pyruvate and anti-cortisol compounds and method for increasing protein concentration in a mammal |
| US6417231B1 (en) * | 1996-12-23 | 2002-07-09 | Frank L. Greenway | Method and composition for delivering therapeutically effective amounts of pyruvate to a mammal |
| IL146391A0 (en) | 1999-05-14 | 2002-07-25 | Cellular Sciences Inc | Method and composition for treating mammalian nasal and sinus diseases caused by inflammatory response |
| ATE322897T1 (de) * | 1999-10-07 | 2006-04-15 | Xanthus Life Sciences Inc | Pyruvatesterzusammenstellung und verwendungsmethode zur wiederbelebung nach ischemie- und reperfusionsvorfällen |
| US6846842B2 (en) * | 1999-10-07 | 2005-01-25 | Beth Israel Deconess Medical Center, Inc. | Pyruvate ester composition and method of use for resuscitation after events of ischemia and reperfusion |
| CA2440480A1 (en) * | 2001-03-15 | 2002-09-26 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Method of using pyruvate and/or its derivatives for the treatment of cytokine-mediated inflammatory conditions |
-
2002
- 2002-03-15 CA CA002440480A patent/CA2440480A1/en not_active Abandoned
- 2002-03-15 EP EP02725226A patent/EP1379230A4/en not_active Withdrawn
- 2002-03-15 AU AU2002255805A patent/AU2002255805B2/en not_active Ceased
- 2002-03-15 WO PCT/US2002/008283 patent/WO2002074301A1/en not_active Ceased
- 2002-03-15 JP JP2002573009A patent/JP2004528307A/ja active Pending
-
2003
- 2003-09-15 US US10/662,975 patent/US6943190B2/en not_active Expired - Fee Related
-
2005
- 2005-03-31 US US11/095,031 patent/US20050245609A1/en not_active Abandoned
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