JP2004526492A5 - - Google Patents

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JP2004526492A5
JP2004526492A5 JP2002568977A JP2002568977A JP2004526492A5 JP 2004526492 A5 JP2004526492 A5 JP 2004526492A5 JP 2002568977 A JP2002568977 A JP 2002568977A JP 2002568977 A JP2002568977 A JP 2002568977A JP 2004526492 A5 JP2004526492 A5 JP 2004526492A5
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electrode
signal
frequency
circuit
measure
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Priority claimed from PCT/IB2001/000334 external-priority patent/WO2002069791A1/en
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Claims (21)

  1. 第１の電極(18)と、
    第１の電極(18)がその第１の表面(20)上に配置されている絶縁基板(17)と、
    第１の電極(18)に接続され、標本中に電界を生成するために変調された電圧を前記第１の電極(18)に供給する信号源(1)と、
    フィールドに対する標本の応答特性に依存する少なくとも１つのパラメータを測定する測定回路(7)と、
    パラメータ（Ａ，φ，ｆ０）を濃度に変換するための較正データを使用してそのパラメータから濃度を決定するデータプロセッサ(8)とを具備している、体液を含むインビトロまたはインビボ標本内のグルコースの濃度を決定するための装置において、
    第１の電極(18)は標本から第１の電極(18)を電気的に絶縁するための絶縁材料のカバー層(29)によってカバーされ、第１の電極は基板(17)とカバー層(29)との間に配置されていることを特徴とする装置。
  2. カバー層(29)が人体に面した状態で第１の電極(18)を人体の一部分に固定するためのホルダ(31)を備えている請求項１記載の装置。
  3. さらに基板上に配置されている第２の電極(19,22)を備えており、第１の電極(18)と第２の電極(19,22)との間に変調された電圧を供給するように信号源(2)が接続されている請求項１または２記載の装置。
  4. 第２の電極(19,22)は基板(17)の第２の面(21)上に配置された底部電極層(22)を含んでおり、前記底部電極層(22)は前記上部電極層(18)より広い範囲に延在している請求項３記載の装置。
  5. 第２の電極(19,22)は基板(17)の第１の面(20)上に配置された上部電極層(19)を含んでおり、前記上部電極層(19)は第１の電極(18)の少なくとも一部の周囲、とくに実質的に第１の電極全体の周囲に配置されている請求項３または４記載の装置。
  6. 第２の電極（19）は標本と電気的に接触するように構成されるようにカバー層（29）によりカバーされない請求項３乃至５のいずれか１項記載の装置。
  7. 第１の電極(18)は細長く、その幅はその長さよりはるかに狭く構成されている請求項１乃至６のいずれか１項記載の装置。
  8. 信号源(1)と測定回路(7)との間に第１の信号路(4)および第２の信号路(6)を備えており、第１の電極(18)は第１の信号路(4)中に配置され、基準負荷（Ｒ３）は第２の信号路(6)中に配置されており、測定回路(7)は第１および第２の信号路からの信号の相対振幅（Ａ）および、または位相（φ）を測定するように適応されている請求項１乃至７のいずれか１項記載の装置。
  9. 第１の電極(18)は、信号源(1)に接続されたキャパシタ（Ｃ）およびインダクタンス（Ｌ）を含む共振回路(5)のキャパシタ（Ｃ）の一部である請求項１乃至８のいずれか１項記載の装置。
  10. キャパシタ（Ｃ）およびインダクタンス（Ｌ）は直列に構成されている請求項９記載の装置。
  11. 測定回路(7)は、共振回路(5)全体の電圧を測定するように構成されている請求項９または１０記載の装置。
  12. 第１の電極(18)に近接して配置されたアンテナ電極(33)をさらに具備しており、測定回路(7)は第１の電極(18)からアンテナ電極(33)に伝送された信号を測定するように構成されている請求項９乃至１１のいずれか１項記載の装置。
  13. 標本の温度（Ｔ）を測定するための温度センサを具備し、前記データプロセッサは前記濃度を決定するときにその温度（Ｔ）を使用するように構成されている請求項１乃至１２のいずれか１項記載の装置。
  14. 変調された電圧は正弦波電圧である請求項１乃至１３のいずれか１項記載の装置。
  15. 変調された電圧は、１０ＭＨｚ乃至２ＧＨｚの、とくに２０ＭＨｚ乃至７０ＭＨｚの周波数を有している請求項１乃至１４のいずれか１項記載の装置。
  16. パラメータ（Ａ，φ，ｆ０）は、第１の電極における電気インピーダンスに依存している請求項１乃至１５のいずれか１項記載の装置。
  17. 測定回路（7）は、第１の電極から反射された信号を測定するように構成される請求項１乃至１６のいずれか１項記載の装置。
  18. 標本において第１の電極(18)の近くに配置されているアンテナ電極(33)をさらに具備し、測定回路（7）は第１の電極(18)からアンテナ電極(33)に伝送された信号を測定するように構成されている請求項１乃至１７のいずれか１項記載の装置。
  19. 第１の電極は共振周波数（ｆ０）を有する共振回路(5)の一部を形成し、装置は実質的に共振周波数で共振回路（5）を動作するように構成されている請求項１乃至１８のいずれか１項記載の装置。
  20. 共振回路(5)はアクティブ発振器(40)のタンク回路の少なくとも一部であり、パラメータは前記発振器(40)によって発生された信号の振幅（Ａ）および、または周波数（ｆ０）である請求項１９記載の装置。
  21. 装置は変調された電圧を共振周波数（ｆ０）より低い周波数（ｆｍｉｎ）から共振周波数より高い周波数（ｆｍａｘ）まで周波数掃引するように構成され、とくにパラメータは共振周波数（ｆ０）で第１の電極(18)に反射された信号、またはアンテナ電極(33)に伝送された信号である請求項１９記載の装置。
JP2002568977A 2001-03-06 2001-03-06 体液中の物質の濃度を決定する方法および装置 Expired - Lifetime JP4855639B2 (ja)

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PCT/IB2001/000334 WO2002069791A1 (en) 2001-03-06 2001-03-06 Method and device for determining the concentration of a substance in body liquid

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EP (2) EP1818010B1 (ja)
JP (1) JP4855639B2 (ja)
AT (2) ATE547045T1 (ja)
AU (1) AU2001239462B2 (ja)
CA (1) CA2439822C (ja)
CZ (1) CZ20032650A3 (ja)
DE (1) DE60124714T2 (ja)
IL (2) IL157755A0 (ja)
MX (1) MXPA03008047A (ja)
SK (1) SK12272003A3 (ja)
TW (1) TW524977B (ja)
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