JP2004525908A5 - - Google Patents
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- Publication number
- JP2004525908A5 JP2004525908A5 JP2002569071A JP2002569071A JP2004525908A5 JP 2004525908 A5 JP2004525908 A5 JP 2004525908A5 JP 2002569071 A JP2002569071 A JP 2002569071A JP 2002569071 A JP2002569071 A JP 2002569071A JP 2004525908 A5 JP2004525908 A5 JP 2004525908A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- fluorostyryl
- alkoxy
- group
- radioprotective
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 12
- -1 penta-substituted phenyl Chemical group 0.000 claims 8
- 125000003545 alkoxy group Chemical group 0.000 claims 5
- 230000004223 radioprotective effect Effects 0.000 claims 5
- 230000005865 ionizing radiation Effects 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 3
- 230000001950 radioprotection Effects 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 3
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 2
- OVFAELKNQAHPES-UHFFFAOYSA-N cyano phosphono carbonate Chemical compound C(#N)OC(=O)OP(=O)(O)O OVFAELKNQAHPES-UHFFFAOYSA-N 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 230000002062 proliferating effect Effects 0.000 claims 2
- 230000005855 radiation Effects 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- LSQPHWBCMFQPAP-XPWSMXQVSA-N 1,3,5-trimethoxy-2-[(e)-3-(4-methoxyphenyl)-3-[(e)-1-(4-methoxyphenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-enyl]sulfonylprop-1-enyl]benzene Chemical compound C1=CC(OC)=CC=C1C(S(=O)(=O)C(\C=C\C=1C(=CC(OC)=CC=1OC)OC)C=1C=CC(OC)=CC=1)\C=C\C1=C(OC)C=C(OC)C=C1OC LSQPHWBCMFQPAP-XPWSMXQVSA-N 0.000 claims 1
- LRHCIAKITMHSNT-FDWQPRGYSA-N 1-[(z)-3-(4-chlorophenyl)-3-[(z)-1-(4-chlorophenyl)-3-(4-fluorophenyl)prop-2-enyl]sulfonylprop-1-enyl]-4-fluorobenzene Chemical compound C1=CC(F)=CC=C1\C=C/C(S(=O)(=O)C(\C=C/C=1C=CC(F)=CC=1)C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 LRHCIAKITMHSNT-FDWQPRGYSA-N 0.000 claims 1
- PTXRVHYRFPXJKU-OGBZJDJUSA-N 1-fluoro-4-[(e)-3-[(e)-3-(4-fluorophenyl)-1-[4-(trifluoromethyl)phenyl]prop-2-enyl]sulfonyl-3-[4-(trifluoromethyl)phenyl]prop-1-enyl]benzene Chemical compound C1=CC(F)=CC=C1\C=C\C(S(=O)(=O)C(\C=C\C=1C=CC(F)=CC=1)C=1C=CC(=CC=1)C(F)(F)F)C1=CC=C(C(F)(F)F)C=C1 PTXRVHYRFPXJKU-OGBZJDJUSA-N 0.000 claims 1
- XHHUIUHBUNSNOW-LQGKIZFRSA-N 4-[(e)-1-[(e)-1-(4-cyanophenyl)-3-(4-fluorophenyl)prop-2-enyl]sulfonyl-3-(4-fluorophenyl)prop-2-enyl]benzonitrile Chemical compound C1=CC(F)=CC=C1\C=C\C(S(=O)(=O)C(\C=C\C=1C=CC(F)=CC=1)C=1C=CC(=CC=1)C#N)C1=CC=C(C#N)C=C1 XHHUIUHBUNSNOW-LQGKIZFRSA-N 0.000 claims 1
- SNGZRCQJDGCGEF-OGBZJDJUSA-N 4-[(e)-3-[(e)-3-(4-carboxyphenyl)-1-(4-chlorophenyl)prop-2-enyl]sulfonyl-3-(4-chlorophenyl)prop-1-enyl]benzoic acid Chemical compound C1=CC(C(=O)O)=CC=C1\C=C\C(S(=O)(=O)C(\C=C\C=1C=CC(=CC=1)C(O)=O)C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 SNGZRCQJDGCGEF-OGBZJDJUSA-N 0.000 claims 1
- ARXGEFCQNAWAPD-FACPPWRESA-N 4-chloro-1-[4-chloro-2-[(e)-2-(4-fluorophenyl)ethenyl]phenyl]sulfonyl-2-[(e)-2-(4-fluorophenyl)ethenyl]benzene Chemical compound C1=CC(F)=CC=C1\C=C\C1=CC(Cl)=CC=C1S(=O)(=O)C1=CC=C(Cl)C=C1\C=C\C1=CC=C(F)C=C1 ARXGEFCQNAWAPD-FACPPWRESA-N 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000005362 aryl sulfone group Chemical group 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000004224 protection Effects 0.000 claims 1
- 230000001681 protective effect Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27199001P | 2001-02-28 | 2001-02-28 | |
| PCT/US2002/006107 WO2002069892A2 (en) | 2001-02-28 | 2002-02-28 | METHOD FOR PROTECTING CELLS AND TISSUES FROM IONIZING RADIATION TOXICITY WITH α, β UNSATURATED ARYL SULFONES |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004525908A JP2004525908A (ja) | 2004-08-26 |
| JP2004525908A5 true JP2004525908A5 (enExample) | 2005-12-22 |
| JP4302986B2 JP4302986B2 (ja) | 2009-07-29 |
Family
ID=23037934
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002569071A Expired - Lifetime JP4302986B2 (ja) | 2001-02-28 | 2002-02-28 | 細胞及び組織をα，β不飽和アリールスルホンにより電離放射線から防護する方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6667346B2 (enExample) |
| EP (1) | EP1370253B8 (enExample) |
| JP (1) | JP4302986B2 (enExample) |
| KR (1) | KR100850331B1 (enExample) |
| AT (1) | ATE406881T1 (enExample) |
| AU (1) | AU2002305942B2 (enExample) |
| CA (1) | CA2439288C (enExample) |
| DE (1) | DE60228692D1 (enExample) |
| IL (2) | IL157541A0 (enExample) |
| WO (1) | WO2002069892A2 (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2424884C (en) | 2000-10-05 | 2009-12-15 | E. Premkumar Reddy | Substituted (e)-styryl benzylsulfones for treating proliferative disorders |
| IL163608A0 (en) * | 2002-02-28 | 2005-12-18 | Univ Temple | Amino-substituted sulfonanilides and derivatives thereof for treating proliferative disorders |
| NZ535232A (en) * | 2002-02-28 | 2007-05-31 | Univ Temple | Amino-substituted (E)-2,6-dialkoxystyryl 4-substituted benzylsulfones for treating proliferative disorders |
| AU2004289281C1 (en) * | 2003-11-14 | 2011-12-08 | Onconova Therapeutics, Inc. | Alpha, beta-Unsaturated sulfoxides for treating proliferative disorders |
| WO2005053682A2 (en) * | 2003-11-26 | 2005-06-16 | Arqule, Inc. | Use of beta-lapachone for protecting against radiation injury |
| AU2005222947B2 (en) * | 2004-03-16 | 2010-12-23 | Onconova Therapeutics Inc. | Substituted phenoxy- and phenylthio- derivatives for treating proliferative disorders |
| US8058313B2 (en) | 2004-06-24 | 2011-11-15 | Temple University—Of the Commonwealth System of Higher Education | Alpha, beta-unsaturated sulfones, sulfoxides, sulfonimides, sulfinimides, acylsulfonamides and acylsulfinamides and therapeutic uses thereof |
| AU2005265412B2 (en) * | 2004-07-19 | 2010-09-02 | Onconova Therapeutics, Inc. | Formulations for parenteral administration of (e)-2,6-dialkoxystyryl 4-substituted benzylsulfones |
| US7537572B2 (en) | 2004-10-22 | 2009-05-26 | General Patent, Llc | Treatment or pre-treatment for radiation/chemical exposure |
| US20090306207A1 (en) * | 2005-01-05 | 2009-12-10 | Reddy M V Ramana | Treatment of Drug-Resistant Proliferative Disorders |
| US8143453B2 (en) * | 2005-02-25 | 2012-03-27 | Temple University—Of the Commonwealth System of Higher Education | Unsaturated sulfides, sulfones, sulfoxides and sulfonamides synthesis |
| WO2006104668A2 (en) * | 2005-03-11 | 2006-10-05 | Temple University - Of The Commonwealth System Of Higher Education | Composition and methods for the treatment of proliferative diseases |
| CA2617147C (en) * | 2005-07-29 | 2014-01-21 | Onconova Therapeutics, Inc. | Formulation of radioprotective .alpha.,.beta. unsaturated aryl sulfones |
| EP1864692A1 (en) * | 2006-06-07 | 2007-12-12 | Biotempt B.V. | Use of peptides for the control of radiation injury |
| JP2007302640A (ja) * | 2006-05-15 | 2007-11-22 | Natl Inst Of Radiological Sciences | 抗放射線被ばく障害剤 |
| JP5275985B2 (ja) * | 2006-07-28 | 2013-08-28 | オンコノバ・セラピューティックス・インコーポレーテッド | 放射線保護α，β不飽和アリールスルホン類の処方 |
| US8664272B2 (en) | 2006-08-30 | 2014-03-04 | Temple University—Of the Commonwealth System of Higher Education | Composition and methods for the treatment of myelodysplastic syndrome and acute myeloid leukemia |
| CA2663375A1 (en) * | 2006-09-15 | 2008-03-20 | Onconova Therapeutics, Inc. | Activated cytotoxic compounds for attachment to targeting molecules for the treatment of mammalian disease conditions |
| EP2091527B1 (en) * | 2006-12-13 | 2016-03-23 | Temple University - Of The Commonwealth System of Higher Education | Sulfide, sulfoxide and sulfone chalcone analogues, derivatives thereof and therapeutic uses thereof |
| US20100049284A1 (en) * | 2008-05-15 | 2010-02-25 | The Catholic University Of America | Use of heat to treat biological systems exposed to damaging radiation |
| AU2009310352A1 (en) * | 2008-10-01 | 2010-05-06 | The University Of North Carolina At Chapel Hill | Hematopoietic protection against ionizing radiation using selective cyclin-dependent kinase 4/6 inhibitors |
| WO2010039997A2 (en) * | 2008-10-01 | 2010-04-08 | The University Of North Carolina At Chapel Hill | Hematopoietic protection against chemotherapeutic compounds using selective cyclin-dependent kinase 4/6 inhibitors |
| JP5734869B2 (ja) * | 2008-12-16 | 2015-06-17 | オンコノバ・セラピューティックス・インコーポレーテッド | ヒトにおける細胞毒性物質の有害作用に対する治療レジメンの有効性を決定する方法 |
| EP3025724B1 (en) | 2009-05-13 | 2018-07-11 | The University of North Carolina At Chapel Hill | Cyclin dependent kinase inhibitors and methods of use |
| EA022360B1 (ru) * | 2010-03-24 | 2015-12-30 | Онконова Терапьютикс, Инк. | Композиции и способы для профилактики и лечения ран |
| CA2792913C (en) * | 2010-03-26 | 2020-01-21 | Onconova Therapeutics, Inc. | Improved stable aqueous formulation of (e)-4-carboxystyryl-4-chlorobenzyl sulfone |
| GB201010359D0 (en) | 2010-06-21 | 2010-08-04 | Univ Nottingham | Compounds for treating proliferative disorders |
| WO2012068381A2 (en) | 2010-11-17 | 2012-05-24 | The University Of North Carolina At Chapel Hill | Protection of renal tissues from schema through inhibition of the proliferative kisses cdk4 and cdk6 |
| CA2885217C (en) | 2012-09-20 | 2019-10-08 | Temple University - Of The Commonwealth System Of Higher Education | Substituted alkyl diaryl derivatives, methods of preparation and uses |
| CA2906157C (en) | 2013-03-15 | 2022-05-17 | G1 Therapeutics, Inc. | Highly active anti-neoplastic and anti-proliferative agents |
| JP6430483B2 (ja) | 2013-03-15 | 2018-11-28 | ジー１、セラピューティクス、インコーポレイテッドＧ１ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | 化学療法の間の正常細胞の一時的な保護 |
| CN104230770B (zh) * | 2013-06-17 | 2017-11-21 | 华夏生生药业(北京)有限公司 | 苯乙烯基砜类化合物、其制备方法以及其作为神经保护剂的应用 |
| US10195466B2 (en) * | 2014-01-06 | 2019-02-05 | Hackensack University Medical Center | Method for treating skin cancer using radiation therapy |
| WO2015161283A1 (en) | 2014-04-17 | 2015-10-22 | G1 Therapeutics, Inc. | Tricyclic lactams for use in hspc-sparing treatments for rb-positive abnormal cellular proliferation |
| EP3191098A4 (en) | 2014-09-12 | 2018-04-25 | G1 Therapeutics, Inc. | Combinations and dosing regimes to treat rb-positive tumors |
| WO2016040848A1 (en) | 2014-09-12 | 2016-03-17 | G1 Therapeutics, Inc. | Treatment of rb-negative tumors using topoisomerase inhibitors in combination with cyclin dependent kinase 4/6 inhibitors |
| US10383831B2 (en) | 2015-08-03 | 2019-08-20 | Temple University—Of the Commonwealth System of Higher Education | 2,4,6-trialkoxystryl aryl sulfones, sulfonamides and carboxamides, and methods of preparation and use |
| CN106432011B (zh) * | 2016-09-18 | 2018-11-02 | 中国医学科学院放射医学研究所 | 一类具有辐射防护作用的新化合物、其制备方法及其药物应用 |
| ES2927715T3 (es) | 2017-10-05 | 2022-11-10 | Fulcrum Therapeutics Inc | Inhibidores de la quinasa p38 reducen la expresión de dux4 y de los genes que le siguen para el tratamiento de la FSHD |
| JP7324930B2 (ja) * | 2019-07-18 | 2023-08-10 | フアシアシェンシェン ファーマシューティカル ベイジン カンパニー リミテッド | カルバメート置換スチリルスルホン類化合物及びその製造方法ならびにその使用 |
| US10988479B1 (en) | 2020-06-15 | 2021-04-27 | G1 Therapeutics, Inc. | Morphic forms of trilaciclib and methods of manufacture thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE284386T1 (de) | 1997-10-03 | 2004-12-15 | Univ Temple | Styrolsulfone als antikrebsmittel |
| US6201154B1 (en) * | 1999-03-31 | 2001-03-13 | Temple University-Of The Commonwealth Of Higher Education | Z-styryl sulfone anticancer agents |
| WO2000059494A1 (en) * | 1999-04-02 | 2000-10-12 | Temple University- Of The Commonwealth System Of Higher Education | Styryl sulfone anticancer agents |
| WO2000059495A1 (en) * | 1999-04-02 | 2000-10-12 | Temple University - Of The Commonwealth System Of Higher Education | (e)-styryl sulfone anticancer agents |
| IL149064A0 (en) * | 1999-10-12 | 2002-11-10 | Univ Temple | Method for protecting normal cells from cytotoxicity of chemotherapeutic agents |
| US6664287B2 (en) * | 2000-03-15 | 2003-12-16 | Bethesda Pharmaceuticals, Inc. | Antioxidants |
| AU2001251391A1 (en) * | 2000-04-06 | 2001-10-23 | Acorda Therapeutics, Inc. | Compositions and methods for promoting neural regeneration |
| US6486210B2 (en) | 2000-04-14 | 2002-11-26 | Temple University—Of the Commonwealth System of Higher Education | Substituted styryl benzylsulfones for treating proliferative disorders |
| DK1379508T3 (da) * | 2001-02-28 | 2011-01-03 | Univ Temple | N-(aryl)-2arylethensulfonamider og terapeutiske anvendelser deraf |
-
2002
- 2002-02-28 US US10/085,745 patent/US6667346B2/en not_active Expired - Lifetime
- 2002-02-28 JP JP2002569071A patent/JP4302986B2/ja not_active Expired - Lifetime
- 2002-02-28 EP EP02733811A patent/EP1370253B8/en not_active Expired - Lifetime
- 2002-02-28 DE DE60228692T patent/DE60228692D1/de not_active Expired - Lifetime
- 2002-02-28 IL IL15754102A patent/IL157541A0/xx unknown
- 2002-02-28 KR KR1020037011357A patent/KR100850331B1/ko not_active Expired - Lifetime
- 2002-02-28 AU AU2002305942A patent/AU2002305942B2/en not_active Expired
- 2002-02-28 AT AT02733811T patent/ATE406881T1/de not_active IP Right Cessation
- 2002-02-28 CA CA2439288A patent/CA2439288C/en not_active Expired - Lifetime
- 2002-02-28 WO PCT/US2002/006107 patent/WO2002069892A2/en not_active Ceased
-
2003
- 2003-08-21 IL IL157541A patent/IL157541A/en active IP Right Grant
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