JP2004525624A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2004525624A5 JP2004525624A5 JP2002559584A JP2002559584A JP2004525624A5 JP 2004525624 A5 JP2004525624 A5 JP 2004525624A5 JP 2002559584 A JP2002559584 A JP 2002559584A JP 2002559584 A JP2002559584 A JP 2002559584A JP 2004525624 A5 JP2004525624 A5 JP 2004525624A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- ability
- nucleotide sequence
- library
- expression
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 210000004027 cell Anatomy 0.000 claims 30
- 239000002773 nucleotide Substances 0.000 claims 16
- 125000003729 nucleotide group Chemical group 0.000 claims 16
- 238000000034 method Methods 0.000 claims 8
- 241000222120 Candida <Saccharomycetales> Species 0.000 claims 7
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 5
- 239000013598 vector Substances 0.000 claims 5
- 108091034117 Oligonucleotide Proteins 0.000 claims 4
- 125000006850 spacer group Chemical group 0.000 claims 4
- 241000235648 Pichia Species 0.000 claims 3
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 3
- 108091028732 Concatemer Proteins 0.000 claims 2
- 241000235058 Komagataella pastoris Species 0.000 claims 2
- 241000081271 Phaffia rhodozyma Species 0.000 claims 2
- 241000235015 Yarrowia lipolytica Species 0.000 claims 2
- 210000004507 artificial chromosome Anatomy 0.000 claims 2
- 238000010367 cloning Methods 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000003204 osmotic effect Effects 0.000 claims 2
- 108091008146 restriction endonucleases Proteins 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 210000005253 yeast cell Anatomy 0.000 claims 2
- 241000222178 Candida tropicalis Species 0.000 claims 1
- 201000007336 Cryptococcosis Diseases 0.000 claims 1
- 241000235646 Cyberlindnera jadinii Species 0.000 claims 1
- 241001465321 Eremothecium Species 0.000 claims 1
- 241001149669 Hanseniaspora Species 0.000 claims 1
- 108091092195 Intron Proteins 0.000 claims 1
- 241000235649 Kluyveromyces Species 0.000 claims 1
- 235000014663 Kluyveromyces fragilis Nutrition 0.000 claims 1
- 241001138401 Kluyveromyces lactis Species 0.000 claims 1
- 241000235650 Kluyveromyces marxianus Species 0.000 claims 1
- 241001489207 Lipomyces lipofer Species 0.000 claims 1
- 241000235048 Meyerozyma guilliermondii Species 0.000 claims 1
- 241000320412 Ogataea angusta Species 0.000 claims 1
- 101150053185 P450 gene Proteins 0.000 claims 1
- 241000235652 Pachysolen Species 0.000 claims 1
- 241000223252 Rhodotorula Species 0.000 claims 1
- 241000223253 Rhodotorula glutinis Species 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims 1
- 235000018368 Saccharomyces fragilis Nutrition 0.000 claims 1
- 241000235343 Saccharomycetales Species 0.000 claims 1
- 241000235003 Saccharomycopsis Species 0.000 claims 1
- 241000192263 Scheffersomyces shehatae Species 0.000 claims 1
- 241000235060 Scheffersomyces stipitis Species 0.000 claims 1
- 241000383403 Solen Species 0.000 claims 1
- 241000192348 [Candida] palmioleophila Species 0.000 claims 1
- 229940031154 kluyveromyces marxianus Drugs 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 239000002574 poison Substances 0.000 claims 1
- 231100000614 poison Toxicity 0.000 claims 1
- 230000000644 propagated effect Effects 0.000 claims 1
- 229960002181 saccharomyces boulardii Drugs 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 230000003595 spectral effect Effects 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200100128 | 2001-01-25 | ||
| DKPA200100679 | 2001-05-01 | ||
| US30086301P | 2001-06-27 | 2001-06-27 | |
| PCT/DK2002/000056 WO2002059297A2 (en) | 2001-01-25 | 2002-01-25 | A library of a collection of cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009233636A Division JP4965625B2 (ja) | 2001-01-25 | 2009-10-07 | 細胞コレクションのライブラリー |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004525624A JP2004525624A (ja) | 2004-08-26 |
| JP2004525624A5 true JP2004525624A5 (enExample) | 2005-12-22 |
Family
ID=43646216
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002559584A Withdrawn JP2004525624A (ja) | 2001-01-25 | 2002-01-25 | 細胞コレクションのライブラリー |
| JP2009233636A Expired - Fee Related JP4965625B2 (ja) | 2001-01-25 | 2009-10-07 | 細胞コレクションのライブラリー |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009233636A Expired - Fee Related JP4965625B2 (ja) | 2001-01-25 | 2009-10-07 | 細胞コレクションのライブラリー |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7838287B2 (enExample) |
| EP (1) | EP1356037B1 (enExample) |
| JP (2) | JP2004525624A (enExample) |
| AT (1) | ATE501251T1 (enExample) |
| AU (1) | AU2002227883A1 (enExample) |
| CA (1) | CA2474172C (enExample) |
| DE (1) | DE60239386D1 (enExample) |
| DK (1) | DK1356037T3 (enExample) |
| WO (1) | WO2002059297A2 (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8008459B2 (en) | 2001-01-25 | 2011-08-30 | Evolva Sa | Concatemers of differentially expressed multiple genes |
| WO2002059297A2 (en) | 2001-01-25 | 2002-08-01 | Evolva Biotech A/S | A library of a collection of cells |
| US20050164162A1 (en) * | 2002-01-25 | 2005-07-28 | Evolva Ltd., C/O Dr. Iur. Martin Eisenring | Methods for multiple parameters screening and evolution of cells to produce small molecules with multiple functionalities |
| USRE47770E1 (en) | 2002-07-18 | 2019-12-17 | Merus N.V. | Recombinant production of mixtures of antibodies |
| NZ537277A (en) | 2002-07-18 | 2008-04-30 | Crucell Holland Bv | Recombinant production of mixtures of antibodies |
| DK1529110T3 (da) * | 2002-08-01 | 2012-01-30 | Evolva Ltd | Fremgangsmåde til blanding af store antal af heterologe gener |
| WO2004106375A1 (en) | 2003-05-30 | 2004-12-09 | Merus Biopharmaceuticals B.V. I.O. | Fab library for the preparation of anti vegf and anti rabies virus fabs |
| US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
| EP1737971B1 (en) * | 2004-01-20 | 2017-08-16 | Merus N.V. | Mixtures of binding proteins |
| AU2006227165B2 (en) | 2005-03-18 | 2011-11-10 | Microbia, Inc. | Production of carotenoids in oleaginous yeast and fungi |
| WO2008042338A2 (en) | 2006-09-28 | 2008-04-10 | Microbia, Inc. | Production of carotenoids in oleaginous yeast and fungi |
| BRPI0923225A2 (pt) | 2008-12-02 | 2016-10-04 | Chiralgen Ltd | metodo para sintese de acidos nucleicos modificados no atomo de fosforo |
| KR101153866B1 (ko) | 2009-05-21 | 2012-06-27 | 대한민국 | 형질전환용 운반체, 이의 제조방법, 이를 이용한 형질전환방법 및 형질전환체 |
| EP2451461A4 (en) | 2009-07-06 | 2013-05-29 | Ontorii Inc | NOVEL NUCLEIC ACID PRODRUGS AND METHOD OF USE THEREOF |
| WO2011146833A1 (en) | 2010-05-20 | 2011-11-24 | Evolva Inc. | Method of producing isoprenoid compounds in yeast |
| CN105671108A (zh) | 2010-06-02 | 2016-06-15 | 沃维公司 | 甜菊糖苷的重组生产 |
| DK2620428T3 (da) | 2010-09-24 | 2019-07-01 | Wave Life Sciences Ltd | Asymmetrisk hjælpegruppe |
| CN107365339A (zh) | 2011-07-19 | 2017-11-21 | 波涛生命科学有限公司 | 合成官能化核酸的方法 |
| EP2742142B2 (en) | 2011-08-08 | 2020-03-25 | Evolva SA | Recombinant production of steviol glycosides |
| WO2013157953A1 (en) | 2012-04-20 | 2013-10-24 | Merus B.V. | Methods and means for the production of ig-like molecules |
| US10829772B2 (en) | 2012-06-22 | 2020-11-10 | Monsanto Technology Llc | Unique modular vector design |
| SG11201500243WA (en) | 2012-07-13 | 2015-04-29 | Shin Nippon Biomedical Lab Ltd | Chiral nucleic acid adjuvant |
| WO2014010250A1 (en) | 2012-07-13 | 2014-01-16 | Chiralgen, Ltd. | Asymmetric auxiliary group |
| DK2872147T3 (da) | 2012-07-13 | 2023-02-20 | Wave Life Sciences Ltd | Fremgangsmåde til fremstilling af kirale oligonukleotider |
| US20150293076A1 (en) * | 2012-10-22 | 2015-10-15 | Bolt Threads, Inc. | Cellular Reprogramming for Product Optimization |
| CA2899276C (en) | 2013-02-06 | 2022-11-01 | Evolva Sa | Methods for improved production of rebaudioside d and rebaudioside m |
| US10017804B2 (en) | 2013-02-11 | 2018-07-10 | Evolva Sa | Efficient production of steviol glycosides in recombinant hosts |
| CA2924343C (en) | 2013-09-17 | 2025-09-16 | Bolt Threads, Inc. | PROCESSES AND COMPOSITIONS FOR SYNTHESIZING IMPROVED SILK FIBERS |
| US9580758B2 (en) | 2013-11-12 | 2017-02-28 | Luc Montagnier | System and method for the detection and treatment of infection by a microbial agent associated with HIV infection |
| EP3095459A4 (en) | 2014-01-15 | 2017-08-23 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having antitumor effect and antitumor agent |
| WO2015108046A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤 |
| EP3095461A4 (en) | 2014-01-15 | 2017-08-23 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator |
| EP3094728B1 (en) | 2014-01-16 | 2022-03-09 | Wave Life Sciences Ltd. | Chiral design |
| MX2017001859A (es) | 2014-08-11 | 2017-04-11 | Evolva Sa | Produccion de glicosidos de esteviol en hospederos recombinantes. |
| JP2017528134A (ja) | 2014-09-09 | 2017-09-28 | エヴォルヴァ エスアー．Ｅｖｏｌｖａ Ｓａ． | 組み換え宿主におけるステビオールグリコシドの生産 |
| BR112017016338A2 (en) | 2015-01-30 | 2018-03-27 | Evolva Sa | production of steviol glycosides in recombinant hosts |
| CA3255837A1 (en) | 2015-03-16 | 2025-10-30 | Dsm Ip Assets B.V. | Udp-glycosyltransferases |
| JP2018522569A (ja) | 2015-08-07 | 2018-08-16 | エヴォルヴァ エスアー．Ｅｖｏｌｖａ Ｓａ． | 組換え宿主内でのステビオールグリコシドの産生 |
| MY198001A (en) | 2016-04-13 | 2023-07-25 | Evolva SA | Production of steviol glycoside in recombinant hosts |
| WO2017198682A1 (en) | 2016-05-16 | 2017-11-23 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| US11447532B2 (en) | 2016-09-14 | 2022-09-20 | Bolt Threads, Inc. | Long uniform recombinant protein fibers |
| US11396669B2 (en) | 2016-11-07 | 2022-07-26 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| JP7212982B1 (ja) | 2022-10-05 | 2023-01-26 | 株式会社Logomix | 細胞ライブラリおよびその製造方法 |
| JP2025170455A (ja) * | 2022-10-05 | 2025-11-19 | 株式会社Logomix | 細胞ライブラリおよびその製造方法 |
| WO2024137877A1 (en) * | 2022-12-21 | 2024-06-27 | Clara Foods Co. | Systems and methods for high yielding recombinant microorganisms and uses thereof |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1341302C (en) | 1983-02-22 | 2001-10-09 | Rae Lyn Burke | Yeast expression systems with vectors having gapdh or pyk promoters and synthesis of foreign protein |
| AU3556789A (en) | 1988-04-22 | 1989-11-24 | Massachusetts Institute Of Technology | Process for forming and using microdroplets |
| ES2109238T3 (es) | 1989-07-07 | 1998-01-16 | Unilever Nv | Procedimiento para la preparacion de una proteina mediante un hongo transformado por integracion multicopia de un vector de expresion. |
| US5316922A (en) * | 1992-04-15 | 1994-05-31 | The United States Of America As Represented By Department Of Health And Human Services | Method for indentifying and expressing proteins that recognize and adhere to specific probes |
| US5482845A (en) | 1993-09-24 | 1996-01-09 | The Trustees Of Columbia University In The City Of New York | Method for construction of normalized cDNA libraries |
| WO1995011986A1 (en) | 1993-10-27 | 1995-05-04 | The Trustees Of Columbia University In The City Of New York | METHOD FOR GENERATING A SUBTRACTED cDNA LIBRARY AND USES OF THE GENERATED LIBRARY |
| US6268140B1 (en) * | 1994-02-03 | 2001-07-31 | Neugenesis | Combinatorial metabolic libraries |
| US5837458A (en) * | 1994-02-17 | 1998-11-17 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
| US6309883B1 (en) * | 1994-02-17 | 2001-10-30 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
| US6117679A (en) * | 1994-02-17 | 2000-09-12 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
| US6165793A (en) * | 1996-03-25 | 2000-12-26 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
| US5824485A (en) * | 1995-04-24 | 1998-10-20 | Chromaxome Corporation | Methods for generating and screening novel metabolic pathways |
| US6004788A (en) * | 1995-07-18 | 1999-12-21 | Diversa Corporation | Enzyme kits and libraries |
| US6030779A (en) * | 1995-07-18 | 2000-02-29 | Diversa Corporation | Screening for novel bioactivities |
| US6057103A (en) * | 1995-07-18 | 2000-05-02 | Diversa Corporation | Screening for novel bioactivities |
| US5958672A (en) * | 1995-07-18 | 1999-09-28 | Diversa Corporation | Protein activity screening of clones having DNA from uncultivated microorganisms |
| US20010041333A1 (en) * | 1997-06-16 | 2001-11-15 | Short Jay M. | High throughput screening for a bioactivity or biomolecule |
| US5939250A (en) * | 1995-12-07 | 1999-08-17 | Diversa Corporation | Production of enzymes having desired activities by mutagenesis |
| US6537776B1 (en) | 1999-06-14 | 2003-03-25 | Diversa Corporation | Synthetic ligation reassembly in directed evolution |
| US20030215798A1 (en) | 1997-06-16 | 2003-11-20 | Diversa Corporation | High throughput fluorescence-based screening for novel enzymes |
| WO2000053744A2 (en) | 1999-03-09 | 2000-09-14 | Diversa Corporation | End selection in directed evolution |
| GB9603803D0 (en) * | 1996-02-22 | 1996-04-24 | Zeneca Ltd | Production of proteins, plasmids coding therefor and organisms containing such plasmids |
| US6025155A (en) | 1996-04-10 | 2000-02-15 | Chromos Molecular Systems, Inc. | Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes |
| US5783431A (en) * | 1996-04-24 | 1998-07-21 | Chromaxome Corporation | Methods for generating and screening novel metabolic pathways |
| US6242211B1 (en) | 1996-04-24 | 2001-06-05 | Terragen Discovery, Inc. | Methods for generating and screening novel metabolic pathways |
| EP0922109A1 (en) | 1996-05-21 | 1999-06-16 | Novo Nordisk A/S | Novel yeast promoters suitable for expression cloning in yeast and heterologous expression of proteins in yeast |
| US5763239A (en) * | 1996-06-18 | 1998-06-09 | Diversa Corporation | Production and use of normalized DNA libraries |
| US6294325B1 (en) * | 1996-07-05 | 2001-09-25 | The Mount Sinai School Of Medicine Of The City University Of New York | Cloning and expression of thermostable multi genes and proteins and uses thereof |
| WO1998001573A1 (en) | 1996-07-09 | 1998-01-15 | The Government Of The United States Of America Represented By The Secretary, Department Of Health And Human Services | Transformation-associated recombination cloning |
| US6326204B1 (en) | 1997-01-17 | 2001-12-04 | Maxygen, Inc. | Evolution of whole cells and organisms by recursive sequence recombination |
| EP1717322B1 (en) | 1997-01-17 | 2012-07-18 | Codexis Mayflower Holdings, LLC | Evolution of whole cells and organisms by recursive sequence recombination |
| DE69839501D1 (de) | 1997-02-27 | 2008-06-26 | Cellomics Inc | System für Screening biologischer Zellen |
| CA2284066A1 (en) | 1997-03-18 | 1998-09-24 | Chromaxome Corporation | Methods for screening compounds using encapsulated cells |
| EP1015612B1 (en) | 1997-05-27 | 2005-01-26 | Hanil Synthetic Fiber Co., Ltd. | Process for preparing recombinant proteins using highly efficient expression vector from saccharomyces cerevisiae |
| GB9727512D0 (en) | 1997-12-31 | 1998-02-25 | Adprotech Plc | Fuzzy genes and their application in molecular adjuvants |
| AU744699B2 (en) | 1998-03-04 | 2002-02-28 | Verenium Corporation | Production and use of normalized DNA libraries |
| AU5217599A (en) | 1998-07-27 | 2000-02-21 | Genotypes, Inc. | Automatic eukaryotic artificial chromosome vector |
| WO2000008212A1 (en) | 1998-08-07 | 2000-02-17 | Cellay, Llc | Gel microdrops in genetic analysis |
| WO2000012680A1 (en) | 1998-08-31 | 2000-03-09 | Maxygen, Inc. | Transformation, selection, and screening of sequence-shuffled polynucleotides for development and optimization of plant phenotypes |
| AU6048599A (en) | 1998-09-18 | 2000-04-10 | Cellomics, Inc. | A system for cell-based screening |
| JP2004500019A (ja) | 1999-03-26 | 2004-01-08 | ディベルサ コーポレーション | 定方向進化におけるエキソヌクレアーゼ仲介核酸再集合 |
| GB9908814D0 (en) * | 1999-04-16 | 1999-06-09 | Celltech Therapeutics Ltd | Process |
| AU7646000A (en) | 1999-11-05 | 2001-05-14 | Novozymes A/S | Methods to screen microorganisms or gene libraries for products secreted from a cell |
| EP1276861A2 (en) * | 2000-03-24 | 2003-01-22 | Maxygen, Inc. | Methods for modulating cellular and organismal phenotypes |
| WO2002059297A2 (en) | 2001-01-25 | 2002-08-01 | Evolva Biotech A/S | A library of a collection of cells |
| CA2474161C (en) | 2001-01-25 | 2012-03-27 | Evolva Ltd. | Concatemers of differentially expressed multiple genes |
| US8008459B2 (en) * | 2001-01-25 | 2011-08-30 | Evolva Sa | Concatemers of differentially expressed multiple genes |
| DK1364005T3 (da) | 2001-01-25 | 2009-02-02 | Evolva Ltd | En metode til udvikling af en celle der har en önsket fænotype og udviklede celler |
| WO2002059330A2 (en) | 2001-01-25 | 2002-08-01 | Evolva Biotech A/S | Artificial chromosomes comprising concatemers of expressible nucleotide sequences |
| US20050164162A1 (en) * | 2002-01-25 | 2005-07-28 | Evolva Ltd., C/O Dr. Iur. Martin Eisenring | Methods for multiple parameters screening and evolution of cells to produce small molecules with multiple functionalities |
| WO2003106639A2 (en) | 2002-06-14 | 2003-12-24 | Dyax Corporation | Recombination of nucleic acid library members |
| US20030235823A1 (en) * | 2002-06-24 | 2003-12-25 | The University Of Alabama | Nucleotide sequences that code for torsin genes, torsin proteins, and methods of using the same to treat protein-aggregation |
| DK1529110T3 (da) | 2002-08-01 | 2012-01-30 | Evolva Ltd | Fremgangsmåde til blanding af store antal af heterologe gener |
-
2002
- 2002-01-25 WO PCT/DK2002/000056 patent/WO2002059297A2/en not_active Ceased
- 2002-01-25 JP JP2002559584A patent/JP2004525624A/ja not_active Withdrawn
- 2002-01-25 DK DK02709979.5T patent/DK1356037T3/da active
- 2002-01-25 EP EP02709979A patent/EP1356037B1/en not_active Expired - Lifetime
- 2002-01-25 US US10/466,960 patent/US7838287B2/en not_active Expired - Fee Related
- 2002-01-25 CA CA2474172A patent/CA2474172C/en not_active Expired - Fee Related
- 2002-01-25 AU AU2002227883A patent/AU2002227883A1/en not_active Abandoned
- 2002-01-25 AT AT02709979T patent/ATE501251T1/de not_active IP Right Cessation
- 2002-01-25 DE DE60239386T patent/DE60239386D1/de not_active Expired - Lifetime
-
2009
- 2009-10-07 JP JP2009233636A patent/JP4965625B2/ja not_active Expired - Fee Related
-
2010
- 2010-10-12 US US12/902,587 patent/US20120094870A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2004525623A5 (enExample) | ||
| CA2474172A1 (en) | A library of a collection of cells | |
| Lazcano et al. | How long did it take for life to begin and evolve to cyanobacteria? | |
| Sharov | Coenzyme world model of the origin of life | |
| Perelson et al. | Protein evolution on partially correlated landscapes. | |
| JP4711955B2 (ja) | 遺伝子組換え酵母及び遺伝子組換え酵母を用いた発酵方法 | |
| Dubey et al. | Three ARS elements contribute to the ura4 replication origin region in the fission yeast, Schizosaccharomyces pombe. | |
| Orgel | The origin of life on the earth | |
| Penny | An interpretive review of the origin of life research | |
| CA2474161A1 (en) | Concatemers of differentially expressed multiple genes | |
| US9963696B2 (en) | Method for screening mutant microorganism overproducing target metabolite using synthetic suicide genetic circuit | |
| Steinmeyer et al. | Structured model for Saccharomyces cerevisiae | |
| Ma et al. | Computer simulation on the cooperation of functional molecules during the early stages of evolution | |
| US20240287581A1 (en) | Methods for Assembling Nucleic Acids | |
| CA2474146A1 (en) | A method for evolving a cell having desired phenotype and evolved cells | |
| BR112013026193A2 (pt) | composições e métodos para a produção aumentada de etanol a partir de biomassa | |
| Allen et al. | Energy transduction anchors genes in organelles | |
| US11214809B2 (en) | Vector containing centromere DNA sequence and use thereof | |
| JP2004527232A5 (enExample) | ||
| Wong | Emergence of life: from functional RNA selection to natural selection and beyond | |
| Hood et al. | Transformation of Schizosaccharomyces pombe by electroporation | |
| EP2855660B1 (fr) | Procede d'obtention de souches de levure ameliorees | |
| Sanders et al. | Maintaining an autocatalytic reaction system in a protocell: Nonenzymatic RNA templating and the link between replication and metabolism | |
| KR102301301B1 (ko) | 다중화 프로모터 엔지니어링 플랫폼 및 이의 제조 방법 | |
| Aleksenko | Cointegration of transforming DNAs in Aspergillus nidulans: a model using autonomously-replicating plasmids |