ATE501251T1 - Zellbibliothek - Google Patents
ZellbibliothekInfo
- Publication number
- ATE501251T1 ATE501251T1 AT02709979T AT02709979T ATE501251T1 AT E501251 T1 ATE501251 T1 AT E501251T1 AT 02709979 T AT02709979 T AT 02709979T AT 02709979 T AT02709979 T AT 02709979T AT E501251 T1 ATE501251 T1 AT E501251T1
- Authority
- AT
- Austria
- Prior art keywords
- novel
- libraries
- host cells
- cell library
- discovery
- Prior art date
Links
- 230000014509 gene expression Effects 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000007876 drug discovery Methods 0.000 abstract 1
- 230000037353 metabolic pathway Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1086—Preparation or screening of expression libraries, e.g. reporter assays
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/66—General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
Landscapes
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Eye Examination Apparatus (AREA)
- Holo Graphy (AREA)
- Aerials With Secondary Devices (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200100128 | 2001-01-25 | ||
| DKPA200100679 | 2001-05-01 | ||
| US30086301P | 2001-06-27 | 2001-06-27 | |
| PCT/DK2002/000056 WO2002059297A2 (en) | 2001-01-25 | 2002-01-25 | A library of a collection of cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE501251T1 true ATE501251T1 (de) | 2011-03-15 |
Family
ID=43646216
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02709979T ATE501251T1 (de) | 2001-01-25 | 2002-01-25 | Zellbibliothek |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7838287B2 (enExample) |
| EP (1) | EP1356037B1 (enExample) |
| JP (2) | JP2004525624A (enExample) |
| AT (1) | ATE501251T1 (enExample) |
| AU (1) | AU2002227883A1 (enExample) |
| CA (1) | CA2474172C (enExample) |
| DE (1) | DE60239386D1 (enExample) |
| DK (1) | DK1356037T3 (enExample) |
| WO (1) | WO2002059297A2 (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8008459B2 (en) | 2001-01-25 | 2011-08-30 | Evolva Sa | Concatemers of differentially expressed multiple genes |
| WO2002059297A2 (en) | 2001-01-25 | 2002-08-01 | Evolva Biotech A/S | A library of a collection of cells |
| US20050164162A1 (en) * | 2002-01-25 | 2005-07-28 | Evolva Ltd., C/O Dr. Iur. Martin Eisenring | Methods for multiple parameters screening and evolution of cells to produce small molecules with multiple functionalities |
| USRE47770E1 (en) | 2002-07-18 | 2019-12-17 | Merus N.V. | Recombinant production of mixtures of antibodies |
| NZ537277A (en) | 2002-07-18 | 2008-04-30 | Crucell Holland Bv | Recombinant production of mixtures of antibodies |
| DK1529110T3 (da) * | 2002-08-01 | 2012-01-30 | Evolva Ltd | Fremgangsmåde til blanding af store antal af heterologe gener |
| WO2004106375A1 (en) | 2003-05-30 | 2004-12-09 | Merus Biopharmaceuticals B.V. I.O. | Fab library for the preparation of anti vegf and anti rabies virus fabs |
| US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
| EP1737971B1 (en) * | 2004-01-20 | 2017-08-16 | Merus N.V. | Mixtures of binding proteins |
| AU2006227165B2 (en) | 2005-03-18 | 2011-11-10 | Microbia, Inc. | Production of carotenoids in oleaginous yeast and fungi |
| WO2008042338A2 (en) | 2006-09-28 | 2008-04-10 | Microbia, Inc. | Production of carotenoids in oleaginous yeast and fungi |
| BRPI0923225A2 (pt) | 2008-12-02 | 2016-10-04 | Chiralgen Ltd | metodo para sintese de acidos nucleicos modificados no atomo de fosforo |
| KR101153866B1 (ko) | 2009-05-21 | 2012-06-27 | 대한민국 | 형질전환용 운반체, 이의 제조방법, 이를 이용한 형질전환방법 및 형질전환체 |
| EP2451461A4 (en) | 2009-07-06 | 2013-05-29 | Ontorii Inc | NOVEL NUCLEIC ACID PRODRUGS AND METHOD OF USE THEREOF |
| WO2011146833A1 (en) | 2010-05-20 | 2011-11-24 | Evolva Inc. | Method of producing isoprenoid compounds in yeast |
| CN105671108A (zh) | 2010-06-02 | 2016-06-15 | 沃维公司 | 甜菊糖苷的重组生产 |
| DK2620428T3 (da) | 2010-09-24 | 2019-07-01 | Wave Life Sciences Ltd | Asymmetrisk hjælpegruppe |
| CN107365339A (zh) | 2011-07-19 | 2017-11-21 | 波涛生命科学有限公司 | 合成官能化核酸的方法 |
| EP2742142B2 (en) | 2011-08-08 | 2020-03-25 | Evolva SA | Recombinant production of steviol glycosides |
| WO2013157953A1 (en) | 2012-04-20 | 2013-10-24 | Merus B.V. | Methods and means for the production of ig-like molecules |
| US10829772B2 (en) | 2012-06-22 | 2020-11-10 | Monsanto Technology Llc | Unique modular vector design |
| SG11201500243WA (en) | 2012-07-13 | 2015-04-29 | Shin Nippon Biomedical Lab Ltd | Chiral nucleic acid adjuvant |
| WO2014010250A1 (en) | 2012-07-13 | 2014-01-16 | Chiralgen, Ltd. | Asymmetric auxiliary group |
| DK2872147T3 (da) | 2012-07-13 | 2023-02-20 | Wave Life Sciences Ltd | Fremgangsmåde til fremstilling af kirale oligonukleotider |
| US20150293076A1 (en) * | 2012-10-22 | 2015-10-15 | Bolt Threads, Inc. | Cellular Reprogramming for Product Optimization |
| CA2899276C (en) | 2013-02-06 | 2022-11-01 | Evolva Sa | Methods for improved production of rebaudioside d and rebaudioside m |
| US10017804B2 (en) | 2013-02-11 | 2018-07-10 | Evolva Sa | Efficient production of steviol glycosides in recombinant hosts |
| CA2924343C (en) | 2013-09-17 | 2025-09-16 | Bolt Threads, Inc. | PROCESSES AND COMPOSITIONS FOR SYNTHESIZING IMPROVED SILK FIBERS |
| US9580758B2 (en) | 2013-11-12 | 2017-02-28 | Luc Montagnier | System and method for the detection and treatment of infection by a microbial agent associated with HIV infection |
| EP3095459A4 (en) | 2014-01-15 | 2017-08-23 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having antitumor effect and antitumor agent |
| WO2015108046A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤 |
| EP3095461A4 (en) | 2014-01-15 | 2017-08-23 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator |
| EP3094728B1 (en) | 2014-01-16 | 2022-03-09 | Wave Life Sciences Ltd. | Chiral design |
| MX2017001859A (es) | 2014-08-11 | 2017-04-11 | Evolva Sa | Produccion de glicosidos de esteviol en hospederos recombinantes. |
| JP2017528134A (ja) | 2014-09-09 | 2017-09-28 | エヴォルヴァ エスアー.Evolva Sa. | 組み換え宿主におけるステビオールグリコシドの生産 |
| BR112017016338A2 (en) | 2015-01-30 | 2018-03-27 | Evolva Sa | production of steviol glycosides in recombinant hosts |
| CA3255837A1 (en) | 2015-03-16 | 2025-10-30 | Dsm Ip Assets B.V. | Udp-glycosyltransferases |
| JP2018522569A (ja) | 2015-08-07 | 2018-08-16 | エヴォルヴァ エスアー.Evolva Sa. | 組換え宿主内でのステビオールグリコシドの産生 |
| MY198001A (en) | 2016-04-13 | 2023-07-25 | Evolva SA | Production of steviol glycoside in recombinant hosts |
| WO2017198682A1 (en) | 2016-05-16 | 2017-11-23 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| US11447532B2 (en) | 2016-09-14 | 2022-09-20 | Bolt Threads, Inc. | Long uniform recombinant protein fibers |
| US11396669B2 (en) | 2016-11-07 | 2022-07-26 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| JP7212982B1 (ja) | 2022-10-05 | 2023-01-26 | 株式会社Logomix | 細胞ライブラリおよびその製造方法 |
| JP2025170455A (ja) * | 2022-10-05 | 2025-11-19 | 株式会社Logomix | 細胞ライブラリおよびその製造方法 |
| WO2024137877A1 (en) * | 2022-12-21 | 2024-06-27 | Clara Foods Co. | Systems and methods for high yielding recombinant microorganisms and uses thereof |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1341302C (en) | 1983-02-22 | 2001-10-09 | Rae Lyn Burke | Yeast expression systems with vectors having gapdh or pyk promoters and synthesis of foreign protein |
| AU3556789A (en) | 1988-04-22 | 1989-11-24 | Massachusetts Institute Of Technology | Process for forming and using microdroplets |
| ES2109238T3 (es) | 1989-07-07 | 1998-01-16 | Unilever Nv | Procedimiento para la preparacion de una proteina mediante un hongo transformado por integracion multicopia de un vector de expresion. |
| US5316922A (en) * | 1992-04-15 | 1994-05-31 | The United States Of America As Represented By Department Of Health And Human Services | Method for indentifying and expressing proteins that recognize and adhere to specific probes |
| US5482845A (en) | 1993-09-24 | 1996-01-09 | The Trustees Of Columbia University In The City Of New York | Method for construction of normalized cDNA libraries |
| WO1995011986A1 (en) | 1993-10-27 | 1995-05-04 | The Trustees Of Columbia University In The City Of New York | METHOD FOR GENERATING A SUBTRACTED cDNA LIBRARY AND USES OF THE GENERATED LIBRARY |
| US6268140B1 (en) * | 1994-02-03 | 2001-07-31 | Neugenesis | Combinatorial metabolic libraries |
| US5837458A (en) * | 1994-02-17 | 1998-11-17 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
| US6309883B1 (en) * | 1994-02-17 | 2001-10-30 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
| US6117679A (en) * | 1994-02-17 | 2000-09-12 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
| US6165793A (en) * | 1996-03-25 | 2000-12-26 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
| US5824485A (en) * | 1995-04-24 | 1998-10-20 | Chromaxome Corporation | Methods for generating and screening novel metabolic pathways |
| US6004788A (en) * | 1995-07-18 | 1999-12-21 | Diversa Corporation | Enzyme kits and libraries |
| US6030779A (en) * | 1995-07-18 | 2000-02-29 | Diversa Corporation | Screening for novel bioactivities |
| US6057103A (en) * | 1995-07-18 | 2000-05-02 | Diversa Corporation | Screening for novel bioactivities |
| US5958672A (en) * | 1995-07-18 | 1999-09-28 | Diversa Corporation | Protein activity screening of clones having DNA from uncultivated microorganisms |
| US20010041333A1 (en) * | 1997-06-16 | 2001-11-15 | Short Jay M. | High throughput screening for a bioactivity or biomolecule |
| US5939250A (en) * | 1995-12-07 | 1999-08-17 | Diversa Corporation | Production of enzymes having desired activities by mutagenesis |
| US6537776B1 (en) | 1999-06-14 | 2003-03-25 | Diversa Corporation | Synthetic ligation reassembly in directed evolution |
| US20030215798A1 (en) | 1997-06-16 | 2003-11-20 | Diversa Corporation | High throughput fluorescence-based screening for novel enzymes |
| WO2000053744A2 (en) | 1999-03-09 | 2000-09-14 | Diversa Corporation | End selection in directed evolution |
| GB9603803D0 (en) * | 1996-02-22 | 1996-04-24 | Zeneca Ltd | Production of proteins, plasmids coding therefor and organisms containing such plasmids |
| US6025155A (en) | 1996-04-10 | 2000-02-15 | Chromos Molecular Systems, Inc. | Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes |
| US5783431A (en) * | 1996-04-24 | 1998-07-21 | Chromaxome Corporation | Methods for generating and screening novel metabolic pathways |
| US6242211B1 (en) | 1996-04-24 | 2001-06-05 | Terragen Discovery, Inc. | Methods for generating and screening novel metabolic pathways |
| EP0922109A1 (en) | 1996-05-21 | 1999-06-16 | Novo Nordisk A/S | Novel yeast promoters suitable for expression cloning in yeast and heterologous expression of proteins in yeast |
| US5763239A (en) * | 1996-06-18 | 1998-06-09 | Diversa Corporation | Production and use of normalized DNA libraries |
| US6294325B1 (en) * | 1996-07-05 | 2001-09-25 | The Mount Sinai School Of Medicine Of The City University Of New York | Cloning and expression of thermostable multi genes and proteins and uses thereof |
| WO1998001573A1 (en) | 1996-07-09 | 1998-01-15 | The Government Of The United States Of America Represented By The Secretary, Department Of Health And Human Services | Transformation-associated recombination cloning |
| US6326204B1 (en) | 1997-01-17 | 2001-12-04 | Maxygen, Inc. | Evolution of whole cells and organisms by recursive sequence recombination |
| EP1717322B1 (en) | 1997-01-17 | 2012-07-18 | Codexis Mayflower Holdings, LLC | Evolution of whole cells and organisms by recursive sequence recombination |
| DE69839501D1 (de) | 1997-02-27 | 2008-06-26 | Cellomics Inc | System für Screening biologischer Zellen |
| CA2284066A1 (en) | 1997-03-18 | 1998-09-24 | Chromaxome Corporation | Methods for screening compounds using encapsulated cells |
| EP1015612B1 (en) | 1997-05-27 | 2005-01-26 | Hanil Synthetic Fiber Co., Ltd. | Process for preparing recombinant proteins using highly efficient expression vector from saccharomyces cerevisiae |
| GB9727512D0 (en) | 1997-12-31 | 1998-02-25 | Adprotech Plc | Fuzzy genes and their application in molecular adjuvants |
| AU744699B2 (en) | 1998-03-04 | 2002-02-28 | Verenium Corporation | Production and use of normalized DNA libraries |
| AU5217599A (en) | 1998-07-27 | 2000-02-21 | Genotypes, Inc. | Automatic eukaryotic artificial chromosome vector |
| WO2000008212A1 (en) | 1998-08-07 | 2000-02-17 | Cellay, Llc | Gel microdrops in genetic analysis |
| WO2000012680A1 (en) | 1998-08-31 | 2000-03-09 | Maxygen, Inc. | Transformation, selection, and screening of sequence-shuffled polynucleotides for development and optimization of plant phenotypes |
| AU6048599A (en) | 1998-09-18 | 2000-04-10 | Cellomics, Inc. | A system for cell-based screening |
| JP2004500019A (ja) | 1999-03-26 | 2004-01-08 | ディベルサ コーポレーション | 定方向進化におけるエキソヌクレアーゼ仲介核酸再集合 |
| GB9908814D0 (en) * | 1999-04-16 | 1999-06-09 | Celltech Therapeutics Ltd | Process |
| AU7646000A (en) | 1999-11-05 | 2001-05-14 | Novozymes A/S | Methods to screen microorganisms or gene libraries for products secreted from a cell |
| EP1276861A2 (en) * | 2000-03-24 | 2003-01-22 | Maxygen, Inc. | Methods for modulating cellular and organismal phenotypes |
| WO2002059297A2 (en) | 2001-01-25 | 2002-08-01 | Evolva Biotech A/S | A library of a collection of cells |
| CA2474161C (en) | 2001-01-25 | 2012-03-27 | Evolva Ltd. | Concatemers of differentially expressed multiple genes |
| US8008459B2 (en) * | 2001-01-25 | 2011-08-30 | Evolva Sa | Concatemers of differentially expressed multiple genes |
| DK1364005T3 (da) | 2001-01-25 | 2009-02-02 | Evolva Ltd | En metode til udvikling af en celle der har en önsket fænotype og udviklede celler |
| WO2002059330A2 (en) | 2001-01-25 | 2002-08-01 | Evolva Biotech A/S | Artificial chromosomes comprising concatemers of expressible nucleotide sequences |
| US20050164162A1 (en) * | 2002-01-25 | 2005-07-28 | Evolva Ltd., C/O Dr. Iur. Martin Eisenring | Methods for multiple parameters screening and evolution of cells to produce small molecules with multiple functionalities |
| WO2003106639A2 (en) | 2002-06-14 | 2003-12-24 | Dyax Corporation | Recombination of nucleic acid library members |
| US20030235823A1 (en) * | 2002-06-24 | 2003-12-25 | The University Of Alabama | Nucleotide sequences that code for torsin genes, torsin proteins, and methods of using the same to treat protein-aggregation |
| DK1529110T3 (da) | 2002-08-01 | 2012-01-30 | Evolva Ltd | Fremgangsmåde til blanding af store antal af heterologe gener |
-
2002
- 2002-01-25 WO PCT/DK2002/000056 patent/WO2002059297A2/en not_active Ceased
- 2002-01-25 JP JP2002559584A patent/JP2004525624A/ja not_active Withdrawn
- 2002-01-25 DK DK02709979.5T patent/DK1356037T3/da active
- 2002-01-25 EP EP02709979A patent/EP1356037B1/en not_active Expired - Lifetime
- 2002-01-25 US US10/466,960 patent/US7838287B2/en not_active Expired - Fee Related
- 2002-01-25 CA CA2474172A patent/CA2474172C/en not_active Expired - Fee Related
- 2002-01-25 AU AU2002227883A patent/AU2002227883A1/en not_active Abandoned
- 2002-01-25 AT AT02709979T patent/ATE501251T1/de not_active IP Right Cessation
- 2002-01-25 DE DE60239386T patent/DE60239386D1/de not_active Expired - Lifetime
-
2009
- 2009-10-07 JP JP2009233636A patent/JP4965625B2/ja not_active Expired - Fee Related
-
2010
- 2010-10-12 US US12/902,587 patent/US20120094870A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002059297A8 (en) | 2004-04-15 |
| WO2002059297A3 (en) | 2003-04-10 |
| JP2004525624A (ja) | 2004-08-26 |
| DE60239386D1 (de) | 2011-04-21 |
| CA2474172A1 (en) | 2002-08-01 |
| DK1356037T3 (da) | 2011-06-27 |
| US7838287B2 (en) | 2010-11-23 |
| US20120094870A1 (en) | 2012-04-19 |
| AU2002227883A1 (en) | 2002-08-06 |
| CA2474172C (en) | 2012-07-10 |
| US20040241672A1 (en) | 2004-12-02 |
| EP1356037B1 (en) | 2011-03-09 |
| EP1356037A2 (en) | 2003-10-29 |
| JP2010043108A (ja) | 2010-02-25 |
| JP4965625B2 (ja) | 2012-07-04 |
| WO2002059297A2 (en) | 2002-08-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |