JP2004525076A - Ｉｌ−２およびｉｌ−１５媒介ｔ細胞応答の調節 - Google Patents
Ｉｌ−２およびｉｌ−１５媒介ｔ細胞応答の調節 Download PDFInfo
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- C07K—PEPTIDES
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Landscapes
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| PCT/US2001/028612 WO2002022805A2 (en) | 2000-09-14 | 2001-09-14 | Modulation of il-2- and il-15-mediated t cell responses |
Publications (2)
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| JP2004525076A true JP2004525076A (ja) | 2004-08-19 |
| JP2004525076A5 JP2004525076A5 (enExample) | 2008-11-06 |
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| EP (2) | EP2123672A1 (enExample) |
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| BR (1) | BR0113906A (enExample) |
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| DE (1) | DE60138222D1 (enExample) |
| ES (1) | ES2322936T3 (enExample) |
| IL (1) | IL154925A0 (enExample) |
| MX (1) | MXPA03002278A (enExample) |
| RU (1) | RU2280255C2 (enExample) |
| WO (1) | WO2002022805A2 (enExample) |
| ZA (1) | ZA200302933B (enExample) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009065938A (ja) * | 2007-09-14 | 2009-04-02 | Matsumoto Shika Univ | タンパク質、破骨細胞分化阻害剤、炎症性骨破壊治療薬、遺伝子、組み替えベクター、及びタンパク質の製造方法 |
| JP2014508140A (ja) * | 2011-01-18 | 2014-04-03 | バイオニズ リミテッド ライアビリティー カンパニー | γｃサイトカイン活性を調節するための組成物および方法 |
| US9959384B2 (en) | 2013-12-10 | 2018-05-01 | Bioniz, Llc | Methods of developing selective peptide antagonists |
| US10030059B2 (en) | 2015-10-09 | 2018-07-24 | Bioniz, Llc | Modulators of gamma-C-cytokine activity |
| US12030936B2 (en) | 2019-05-03 | 2024-07-09 | Bioniz Therapeutics, Inc. | Modulating the effects of gamma-c-cytokine signaling for the treatment of alopecia and alopecia associated disorders |
| US12600757B2 (en) | 2017-04-07 | 2026-04-14 | Bioniz Therapeutics, Inc. | Peptides inhibiting gamma-c-cytokine activity and methods of use |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7541184B2 (en) | 2000-02-24 | 2009-06-02 | Invitrogen Corporation | Activation and expansion of cells |
| US7572631B2 (en) | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
| US7247304B2 (en) | 2001-08-23 | 2007-07-24 | Genmab A/S | Methods of treating using anti-IL-15 antibodies |
| US20050084967A1 (en) | 2002-06-28 | 2005-04-21 | Xcyte Therapies, Inc. | Compositions and methods for eliminating undesired subpopulations of T cells in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation |
| EP2347767A3 (en) * | 2003-01-31 | 2013-06-12 | Albor Biologics, Inc. | Immune regulation based on the targeting of early activation molecules |
| DE602004031341D1 (de) | 2003-07-21 | 2011-03-24 | Transgene Sa | Multifunktionelle cytokine |
| ES2356154T3 (es) | 2003-07-21 | 2011-04-05 | Transgene S.A. | Citoquinas multifuncionales. |
| US20050069521A1 (en) * | 2003-08-28 | 2005-03-31 | Emd Lexigen Research Center Corp. | Enhancing the circulating half-life of interleukin-2 proteins |
| CA2553883C (en) * | 2004-01-22 | 2013-04-02 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Anti-cancer antibodies with reduced complement fixation |
| WO2007001677A2 (en) | 2005-05-17 | 2007-01-04 | University Of Connecticut | Compositions and methods for immunomodulation in an organism |
| EP1777294A1 (en) | 2005-10-20 | 2007-04-25 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | IL-15Ralpha sushi domain as a selective and potent enhancer of IL-15 action through IL-15Rbeta/gamma, and hyperagonist (IL15Ralpha sushi -IL15) fusion proteins |
| EP2366787B1 (en) * | 2006-01-13 | 2019-12-11 | The Government Of The U.S.A, As Represented By The Secretary, Dept. Of Health And Human Services | Codon optimized IL-15 and IL-15R-Alpha genes for expression in mammalian cells |
| WO2007124331A2 (en) * | 2006-04-19 | 2007-11-01 | Virginia Commonwealth University | Cardioprotective and other uses of mammalian target of rapamycin (m-tor) inhibitors |
| WO2008138017A2 (en) * | 2007-05-08 | 2008-11-13 | Beth Israel Deaconess Medical Center, Inc. | Methods and compositions for modifying t cell immune responses and inflammation |
| EP2388266B1 (en) | 2007-05-11 | 2014-04-23 | Altor BioScience Corporation | Fusion molecules and IL-15 variants |
| EP2173378B1 (en) | 2007-06-27 | 2014-03-19 | Admune Therapeutics LLC | Complexes of il-15 and il-15ralpha and uses thereof |
| CN102333875B (zh) * | 2009-02-27 | 2014-04-16 | 诺华股份有限公司 | 选择表达异源蛋白质的真核细胞的方法 |
| WO2011020047A1 (en) | 2009-08-14 | 2011-02-17 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of il-15 to increase thymic output and to treat lymphopenia |
| JP6251570B2 (ja) | 2010-09-21 | 2017-12-20 | アルター・バイオサイエンス・コーポレーション | 多量体ｉｌ−１５可溶性融合分子並びにその製造及び使用方法 |
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| DK3578201T3 (da) | 2012-06-28 | 2023-05-08 | Univ Of Central Florida Research Foundation Incorporated | Fremgangsmåder og sammensætninger til naturlige dræberceller |
| JP2016518361A (ja) | 2013-04-19 | 2016-06-23 | シーチューヌ ファルマＣｙｔｕｎｅ Ｐｈａｒｍａ | 血管漏出症候群の発生を抑制するサイトカイン治療 |
| EP2915569A1 (en) | 2014-03-03 | 2015-09-09 | Cytune Pharma | IL-15/IL-15Ralpha based conjugates purification method |
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| JP6640834B2 (ja) | 2014-08-11 | 2020-02-05 | デリニア， インコーポレイテッド | 自己免疫疾患の処置のために調節性ｔ細胞を選択的に活性化させる改変ｉｌ−２変異体 |
| WO2017062832A1 (en) | 2015-10-08 | 2017-04-13 | Nektar Therapeutics | Combination of an il-2rbeta-selective agonist and a long-acting il-15 agonist |
| KR102908806B1 (ko) | 2015-10-22 | 2026-01-07 | 주노 테라퓨틱스 게엠베하 | 세포의 배양 방법 및 이를 위한 키트와 장치 |
| WO2017096262A1 (en) | 2015-12-04 | 2017-06-08 | Jomoco, Corp. | Compositions and methods to mitigate or prevent an immune response to an immunogenic therapeutic molecule in non-human primates |
| US20170204154A1 (en) | 2016-01-20 | 2017-07-20 | Delinia, Inc. | Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases |
| CN106591368A (zh) * | 2016-10-12 | 2017-04-26 | 郑州大学 | 携带il‑15r/il‑15融合基因的b亚群腺病毒11载体及其构建和用途 |
| MX2019004681A (es) | 2016-10-21 | 2019-10-07 | Altor Bioscience Corp | Moleculas basadas en il-15 multimericas. |
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| RU2698048C2 (ru) * | 2017-10-03 | 2019-08-21 | Закрытое Акционерное Общество "Биокад" | МОНОКЛОНАЛЬНОЕ АНТИТЕЛО К IL-5Rα |
| WO2019165121A1 (en) | 2018-02-21 | 2019-08-29 | Board Of Regents, The University Of Texas System | Methods for activation and expansion of natural killer cells and uses therof |
| CN114651003A (zh) | 2019-09-10 | 2022-06-21 | 黑曜石疗法公司 | 用于可调调节的ca2-il15融合蛋白 |
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| WO2024138175A1 (en) * | 2022-12-22 | 2024-06-27 | Forte Subsidiary, Inc. | Methods of treating acute and chronic graft versus host diseases |
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| WO1997041232A1 (en) * | 1996-04-26 | 1997-11-06 | Beth Israel Deaconess Medical Center | Antagonists of interleukin-15 |
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| US5011684A (en) | 1985-09-05 | 1991-04-30 | Beth Israel Hospital Association | Lysing or blocking unwanted cells with IL-2 receptor-specific binding substance |
| JP3101690B2 (ja) | 1987-03-18 | 2000-10-23 | エス・ビィ・２・インコーポレイテッド | 変性抗体の、または変性抗体に関する改良 |
| US5116964A (en) | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
| DK0567586T3 (da) | 1991-01-16 | 1995-12-04 | Schering Corp | Anvendelse af interleukin-10 ved adoptiv immunterapi af cancer |
| EP0667789A1 (en) | 1992-09-18 | 1995-08-23 | Schering Corporation | Restoration of immunocompetency to t helper cells in hiv infected patients |
| US5747024A (en) | 1993-03-08 | 1998-05-05 | Immunex Corporation | Vaccine adjuvant comprising interleukin-15 |
| US5574138A (en) | 1993-03-08 | 1996-11-12 | Immunex Corporation | Epithelium-derived T-cell factor |
| US5552303A (en) | 1993-03-08 | 1996-09-03 | Immunex Corporation | DNA encoding epithelium-derived T-cell factor |
| US5795966A (en) | 1995-02-22 | 1998-08-18 | Immunex Corp | Antagonists of interleukin-15 |
| EP0971728B1 (en) * | 1997-02-21 | 2002-12-11 | Vlaams Interuniversitair Instituut voor Biotechnologie vzw. | Use of interleukin-15 |
| DE19823351A1 (de) | 1997-05-16 | 1998-12-10 | Krause Hans | Mittel zur Verhinderung der Zellapoptose bei Krankheiten |
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2001
- 2001-09-14 MX MXPA03002278A patent/MXPA03002278A/es not_active Application Discontinuation
- 2001-09-14 AU AU2001292645A patent/AU2001292645A1/en not_active Abandoned
- 2001-09-14 EP EP09004784A patent/EP2123672A1/en not_active Withdrawn
- 2001-09-14 BR BR0113906-1A patent/BR0113906A/pt not_active IP Right Cessation
- 2001-09-14 ES ES01973022T patent/ES2322936T3/es not_active Expired - Lifetime
- 2001-09-14 IL IL15492501A patent/IL154925A0/xx unknown
- 2001-09-14 WO PCT/US2001/028612 patent/WO2002022805A2/en not_active Ceased
- 2001-09-14 US US09/953,323 patent/US20020114781A1/en not_active Abandoned
- 2001-09-14 CA CA2422294A patent/CA2422294C/en not_active Expired - Fee Related
- 2001-09-14 EP EP01973022A patent/EP1349873B1/en not_active Expired - Lifetime
- 2001-09-14 RU RU2003110571/15A patent/RU2280255C2/ru not_active IP Right Cessation
- 2001-09-14 AT AT01973022T patent/ATE427318T1/de not_active IP Right Cessation
- 2001-09-14 DE DE60138222T patent/DE60138222D1/de not_active Expired - Lifetime
- 2001-09-14 JP JP2002527247A patent/JP2004525076A/ja active Pending
- 2001-09-14 CN CNB018185339A patent/CN1317301C/zh not_active Expired - Fee Related
-
2003
- 2003-04-14 ZA ZA200302933A patent/ZA200302933B/en unknown
- 2003-12-30 US US10/749,699 patent/US7579439B2/en not_active Expired - Fee Related
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Cited By (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009065938A (ja) * | 2007-09-14 | 2009-04-02 | Matsumoto Shika Univ | タンパク質、破骨細胞分化阻害剤、炎症性骨破壊治療薬、遺伝子、組み替えベクター、及びタンパク質の製造方法 |
| US10227382B2 (en) | 2011-01-18 | 2019-03-12 | Bioniz, Llc | Method of designing a peptide and/or peptide derivative for modulating gamma-c-cytokine activity |
| US10808009B2 (en) | 2011-01-18 | 2020-10-20 | Bioniz, Llc | Peptide conjugates |
| JP2017222635A (ja) * | 2011-01-18 | 2017-12-21 | バイオニズ リミテッド ライアビリティー カンパニー | γｃサイトカイン活性を調節するための組成物および方法 |
| US9951105B2 (en) | 2011-01-18 | 2018-04-24 | Bioniz, Llc | Methods of developing selective peptide antagonists |
| JP2024029182A (ja) * | 2011-01-18 | 2024-03-05 | バイオニズ セラピューティクス インコーポレイテッド | γｃサイトカイン活性を調節するための組成物および方法 |
| US11834519B2 (en) | 2011-01-18 | 2023-12-05 | Bioniz Therapeutics, Inc. | Compositions and methods for modulating γ-c-cytokine activity |
| US11708392B2 (en) | 2011-01-18 | 2023-07-25 | Bioniz, Llc | Peptide conjugates |
| JP2014508140A (ja) * | 2011-01-18 | 2014-04-03 | バイオニズ リミテッド ライアビリティー カンパニー | γｃサイトカイン活性を調節するための組成物および方法 |
| US9675672B2 (en) | 2011-01-18 | 2017-06-13 | Bioniz, Llc | Compositions and methods for modulating gamma-C-cytokine activity |
| JP2020002154A (ja) * | 2011-01-18 | 2020-01-09 | バイオニズ リミテッド ライアビリティー カンパニー | γｃサイトカイン活性を調節するための組成物および方法 |
| US10854312B2 (en) | 2013-12-10 | 2020-12-01 | Bioniz, Llc | Selective peptide antagonists |
| US11462297B2 (en) | 2013-12-10 | 2022-10-04 | Bioniz, Llc | Selective peptide antagonists |
| US9959384B2 (en) | 2013-12-10 | 2018-05-01 | Bioniz, Llc | Methods of developing selective peptide antagonists |
| US11400134B2 (en) | 2015-10-09 | 2022-08-02 | Bioniz, Llc | Modulating gamma-c-cytokine activity |
| US10030058B2 (en) | 2015-10-09 | 2018-07-24 | Bioniz, Llc | Modulating gamma-C-cytokine activity |
| US10030059B2 (en) | 2015-10-09 | 2018-07-24 | Bioniz, Llc | Modulators of gamma-C-cytokine activity |
| US12600757B2 (en) | 2017-04-07 | 2026-04-14 | Bioniz Therapeutics, Inc. | Peptides inhibiting gamma-c-cytokine activity and methods of use |
| US12030936B2 (en) | 2019-05-03 | 2024-07-09 | Bioniz Therapeutics, Inc. | Modulating the effects of gamma-c-cytokine signaling for the treatment of alopecia and alopecia associated disorders |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2322936T3 (es) | 2009-07-02 |
| BR0113906A (pt) | 2004-12-07 |
| AU2001292645A1 (en) | 2002-03-26 |
| DE60138222D1 (de) | 2009-05-14 |
| US7579439B2 (en) | 2009-08-25 |
| US20020114781A1 (en) | 2002-08-22 |
| HK1061408A1 (en) | 2004-09-17 |
| ZA200302933B (en) | 2004-07-14 |
| EP1349873A2 (en) | 2003-10-08 |
| CA2422294A1 (en) | 2002-03-21 |
| EP2123672A1 (en) | 2009-11-25 |
| MXPA03002278A (es) | 2004-12-03 |
| CN1478098A (zh) | 2004-02-25 |
| RU2280255C2 (ru) | 2006-07-20 |
| CN1317301C (zh) | 2007-05-23 |
| ATE427318T1 (de) | 2009-04-15 |
| EP1349873B1 (en) | 2009-04-01 |
| US20040185048A1 (en) | 2004-09-23 |
| WO2002022805A2 (en) | 2002-03-21 |
| WO2002022805A3 (en) | 2003-07-17 |
| CA2422294C (en) | 2012-12-04 |
| IL154925A0 (en) | 2003-10-31 |
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