ZA200302933B - Modulation of IL-2- and IL-5-mediated T cell responses. - Google Patents
Modulation of IL-2- and IL-5-mediated T cell responses. Download PDFInfo
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- ZA200302933B ZA200302933B ZA200302933A ZA200302933A ZA200302933B ZA 200302933 B ZA200302933 B ZA 200302933B ZA 200302933 A ZA200302933 A ZA 200302933A ZA 200302933 A ZA200302933 A ZA 200302933A ZA 200302933 B ZA200302933 B ZA 200302933B
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| US7572631B2 (en) | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
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| ES2356154T3 (es) | 2003-07-21 | 2011-04-05 | Transgene S.A. | Citoquinas multifuncionales. |
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| CA2553883C (en) * | 2004-01-22 | 2013-04-02 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Anti-cancer antibodies with reduced complement fixation |
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| EP1777294A1 (en) | 2005-10-20 | 2007-04-25 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | IL-15Ralpha sushi domain as a selective and potent enhancer of IL-15 action through IL-15Rbeta/gamma, and hyperagonist (IL15Ralpha sushi -IL15) fusion proteins |
| EP2366787B1 (en) * | 2006-01-13 | 2019-12-11 | The Government Of The U.S.A, As Represented By The Secretary, Dept. Of Health And Human Services | Codon optimized IL-15 and IL-15R-Alpha genes for expression in mammalian cells |
| WO2007124331A2 (en) * | 2006-04-19 | 2007-11-01 | Virginia Commonwealth University | Cardioprotective and other uses of mammalian target of rapamycin (m-tor) inhibitors |
| WO2008138017A2 (en) * | 2007-05-08 | 2008-11-13 | Beth Israel Deaconess Medical Center, Inc. | Methods and compositions for modifying t cell immune responses and inflammation |
| EP2388266B1 (en) | 2007-05-11 | 2014-04-23 | Altor BioScience Corporation | Fusion molecules and IL-15 variants |
| EP2173378B1 (en) | 2007-06-27 | 2014-03-19 | Admune Therapeutics LLC | Complexes of il-15 and il-15ralpha and uses thereof |
| JP2009065938A (ja) * | 2007-09-14 | 2009-04-02 | Matsumoto Shika Univ | タンパク質、破骨細胞分化阻害剤、炎症性骨破壊治療薬、遺伝子、組み替えベクター、及びタンパク質の製造方法 |
| CN102333875B (zh) * | 2009-02-27 | 2014-04-16 | 诺华股份有限公司 | 选择表达异源蛋白质的真核细胞的方法 |
| WO2011020047A1 (en) | 2009-08-14 | 2011-02-17 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of il-15 to increase thymic output and to treat lymphopenia |
| JP6251570B2 (ja) | 2010-09-21 | 2017-12-20 | アルター・バイオサイエンス・コーポレーション | 多量体ｉｌ−１５可溶性融合分子並びにその製造及び使用方法 |
| US11053299B2 (en) | 2010-09-21 | 2021-07-06 | Immunity Bio, Inc. | Superkine |
| CA2824515C (en) * | 2011-01-18 | 2022-09-13 | Bioniz, Llc | Compositions and methods for modulating gamma-c-cytokine activity |
| DK3578201T3 (da) | 2012-06-28 | 2023-05-08 | Univ Of Central Florida Research Foundation Incorporated | Fremgangsmåder og sammensætninger til naturlige dræberceller |
| JP2016518361A (ja) | 2013-04-19 | 2016-06-23 | シーチューヌ ファルマＣｙｔｕｎｅ Ｐｈａｒｍａ | 血管漏出症候群の発生を抑制するサイトカイン治療 |
| US9959384B2 (en) | 2013-12-10 | 2018-05-01 | Bioniz, Llc | Methods of developing selective peptide antagonists |
| EP2915569A1 (en) | 2014-03-03 | 2015-09-09 | Cytune Pharma | IL-15/IL-15Ralpha based conjugates purification method |
| CA2953816C (en) | 2014-06-30 | 2022-03-15 | Altor Bioscience Corporation | Il-15-based molecules and methods of use thereof |
| JP6640834B2 (ja) | 2014-08-11 | 2020-02-05 | デリニア， インコーポレイテッド | 自己免疫疾患の処置のために調節性ｔ細胞を選択的に活性化させる改変ｉｌ−２変異体 |
| WO2017062832A1 (en) | 2015-10-08 | 2017-04-13 | Nektar Therapeutics | Combination of an il-2rbeta-selective agonist and a long-acting il-15 agonist |
| EP3978512A1 (en) | 2015-10-09 | 2022-04-06 | Bioniz, LLC | Modulating gamma-c-cytokine activity |
| KR102908806B1 (ko) | 2015-10-22 | 2026-01-07 | 주노 테라퓨틱스 게엠베하 | 세포의 배양 방법 및 이를 위한 키트와 장치 |
| WO2017096262A1 (en) | 2015-12-04 | 2017-06-08 | Jomoco, Corp. | Compositions and methods to mitigate or prevent an immune response to an immunogenic therapeutic molecule in non-human primates |
| US20170204154A1 (en) | 2016-01-20 | 2017-07-20 | Delinia, Inc. | Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases |
| CN106591368A (zh) * | 2016-10-12 | 2017-04-26 | 郑州大学 | 携带il‑15r/il‑15融合基因的b亚群腺病毒11载体及其构建和用途 |
| MX2019004681A (es) | 2016-10-21 | 2019-10-07 | Altor Bioscience Corp | Moleculas basadas en il-15 multimericas. |
| EP3538548A4 (en) | 2016-11-08 | 2020-08-19 | Delinia, Inc. | IL-2 VARIANTS FOR THE TREATMENT OF AUTOIMMUNE DISEASES |
| US11629340B2 (en) | 2017-03-03 | 2023-04-18 | Obsidian Therapeutics, Inc. | DHFR tunable protein regulation |
| KR102707650B1 (ko) | 2017-04-07 | 2024-09-19 | 바이오니즈 테라퓨틱스, 아이엔씨. | 감마-c-사이토카인 활성의 안정한 조절자 |
| JP2020517259A (ja) | 2017-04-19 | 2020-06-18 | ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム | 操作された抗原受容体を発現する免疫細胞 |
| RU2698048C2 (ru) * | 2017-10-03 | 2019-08-21 | Закрытое Акционерное Общество "Биокад" | МОНОКЛОНАЛЬНОЕ АНТИТЕЛО К IL-5Rα |
| WO2019165121A1 (en) | 2018-02-21 | 2019-08-29 | Board Of Regents, The University Of Texas System | Methods for activation and expansion of natural killer cells and uses therof |
| BR112021021878A2 (pt) | 2019-05-03 | 2022-01-18 | Bioniz Llc | Modulação dos efeitos de sinalização da gama-c-citocina para tratamento da alopecia e distúrbios associados |
| CN114651003A (zh) | 2019-09-10 | 2022-06-21 | 黑曜石疗法公司 | 用于可调调节的ca2-il15融合蛋白 |
| WO2021222178A1 (en) * | 2020-04-27 | 2021-11-04 | The Trustees Of Indiana University | Adjunct therapy for suppressing immune response against gene therapy |
| US11661459B2 (en) | 2020-12-03 | 2023-05-30 | Century Therapeutics, Inc. | Artificial cell death polypeptide for chimeric antigen receptor and uses thereof |
| IL303269A (en) | 2020-12-03 | 2023-07-01 | Century Therapeutics Inc | Genetically engineered cells and uses thereof |
| CN113209277A (zh) * | 2021-05-17 | 2021-08-06 | 武汉大学 | Neogenin在制备预防、缓解和/或治疗心肌梗死及其相关疾病药物中的应用 |
| CN114773433B (zh) * | 2022-06-23 | 2022-09-06 | 北京肿瘤医院(北京大学肿瘤医院) | 一种cd25靶向多肽、分子探针及应用 |
| WO2024138175A1 (en) * | 2022-12-22 | 2024-06-27 | Forte Subsidiary, Inc. | Methods of treating acute and chronic graft versus host diseases |
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| US5011684A (en) | 1985-09-05 | 1991-04-30 | Beth Israel Hospital Association | Lysing or blocking unwanted cells with IL-2 receptor-specific binding substance |
| JP3101690B2 (ja) | 1987-03-18 | 2000-10-23 | エス・ビィ・２・インコーポレイテッド | 変性抗体の、または変性抗体に関する改良 |
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| DK0567586T3 (da) | 1991-01-16 | 1995-12-04 | Schering Corp | Anvendelse af interleukin-10 ved adoptiv immunterapi af cancer |
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2001
- 2001-09-14 MX MXPA03002278A patent/MXPA03002278A/es not_active Application Discontinuation
- 2001-09-14 AU AU2001292645A patent/AU2001292645A1/en not_active Abandoned
- 2001-09-14 EP EP09004784A patent/EP2123672A1/en not_active Withdrawn
- 2001-09-14 BR BR0113906-1A patent/BR0113906A/pt not_active IP Right Cessation
- 2001-09-14 ES ES01973022T patent/ES2322936T3/es not_active Expired - Lifetime
- 2001-09-14 IL IL15492501A patent/IL154925A0/xx unknown
- 2001-09-14 WO PCT/US2001/028612 patent/WO2002022805A2/en not_active Ceased
- 2001-09-14 US US09/953,323 patent/US20020114781A1/en not_active Abandoned
- 2001-09-14 CA CA2422294A patent/CA2422294C/en not_active Expired - Fee Related
- 2001-09-14 EP EP01973022A patent/EP1349873B1/en not_active Expired - Lifetime
- 2001-09-14 RU RU2003110571/15A patent/RU2280255C2/ru not_active IP Right Cessation
- 2001-09-14 AT AT01973022T patent/ATE427318T1/de not_active IP Right Cessation
- 2001-09-14 DE DE60138222T patent/DE60138222D1/de not_active Expired - Lifetime
- 2001-09-14 JP JP2002527247A patent/JP2004525076A/ja active Pending
- 2001-09-14 CN CNB018185339A patent/CN1317301C/zh not_active Expired - Fee Related
-
2003
- 2003-04-14 ZA ZA200302933A patent/ZA200302933B/en unknown
- 2003-12-30 US US10/749,699 patent/US7579439B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2322936T3 (es) | 2009-07-02 |
| BR0113906A (pt) | 2004-12-07 |
| AU2001292645A1 (en) | 2002-03-26 |
| DE60138222D1 (de) | 2009-05-14 |
| US7579439B2 (en) | 2009-08-25 |
| US20020114781A1 (en) | 2002-08-22 |
| HK1061408A1 (en) | 2004-09-17 |
| EP1349873A2 (en) | 2003-10-08 |
| CA2422294A1 (en) | 2002-03-21 |
| EP2123672A1 (en) | 2009-11-25 |
| MXPA03002278A (es) | 2004-12-03 |
| CN1478098A (zh) | 2004-02-25 |
| RU2280255C2 (ru) | 2006-07-20 |
| CN1317301C (zh) | 2007-05-23 |
| ATE427318T1 (de) | 2009-04-15 |
| JP2004525076A (ja) | 2004-08-19 |
| EP1349873B1 (en) | 2009-04-01 |
| US20040185048A1 (en) | 2004-09-23 |
| WO2002022805A2 (en) | 2002-03-21 |
| WO2002022805A3 (en) | 2003-07-17 |
| CA2422294C (en) | 2012-12-04 |
| IL154925A0 (en) | 2003-10-31 |
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