JP2004522796A5 - - Google Patents
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- Publication number
- JP2004522796A5 JP2004522796A5 JP2002571030A JP2002571030A JP2004522796A5 JP 2004522796 A5 JP2004522796 A5 JP 2004522796A5 JP 2002571030 A JP2002571030 A JP 2002571030A JP 2002571030 A JP2002571030 A JP 2002571030A JP 2004522796 A5 JP2004522796 A5 JP 2004522796A5
- Authority
- JP
- Japan
- Prior art keywords
- weight
- alkaline salt
- fine particles
- microparticles
- acid labile
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 15
- 159000000011 group IA salts Chemical class 0.000 claims 14
- 239000011859 microparticle Substances 0.000 claims 14
- 239000002253 acid Substances 0.000 claims 9
- 239000000362 adenosine triphosphatase inhibitor Substances 0.000 claims 9
- 239000010419 fine particle Substances 0.000 claims 9
- 229940121819 ATPase inhibitor Drugs 0.000 claims 8
- 239000007788 liquid Substances 0.000 claims 7
- 229920000642 polymer Polymers 0.000 claims 7
- 239000007787 solid Substances 0.000 claims 7
- 238000009826 distribution Methods 0.000 claims 5
- 230000003287 optical effect Effects 0.000 claims 5
- 239000002245 particle Substances 0.000 claims 5
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000002702 enteric coating Substances 0.000 claims 2
- 238000009505 enteric coating Methods 0.000 claims 2
- SUBDBMMJDZJVOS-DEOSSOPVSA-N esomeprazole Chemical compound C([S@](=O)C1=NC2=CC=C(C=C2N1)OC)C1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-DEOSSOPVSA-N 0.000 claims 2
- 229960004770 esomeprazole Drugs 0.000 claims 2
- 210000004211 gastric acid Anatomy 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 229960000381 omeprazole Drugs 0.000 claims 2
- 229920003176 water-insoluble polymer Polymers 0.000 claims 2
- 229920003169 water-soluble polymer Polymers 0.000 claims 2
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims 1
- 208000007882 Gastritis Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 208000007107 Stomach Ulcer Diseases 0.000 claims 1
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000002183 duodenal effect Effects 0.000 claims 1
- 208000000718 duodenal ulcer Diseases 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 201000005917 gastric ulcer Diseases 0.000 claims 1
- 208000021302 gastroesophageal reflux disease Diseases 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 239000010410 layer Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229920005615 natural polymer Polymers 0.000 claims 1
- 208000000689 peptic esophagitis Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 238000005507 spraying Methods 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 229920001059 synthetic polymer Polymers 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0100822A SE0100822D0 (sv) | 2001-03-09 | 2001-03-09 | Method II to obtain microparticles |
| PCT/SE2002/000400 WO2002072071A1 (en) | 2001-03-09 | 2002-03-06 | Method to obtain microparticles containing a h+, k+ -atp-ase inhibitor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004522796A JP2004522796A (ja) | 2004-07-29 |
| JP2004522796A5 true JP2004522796A5 (OSRAM) | 2005-12-22 |
Family
ID=20283293
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002571030A Pending JP2004522796A (ja) | 2001-03-09 | 2002-03-06 | Ｈ＋，ｋ＋−ａｔｐアーゼ阻害剤を含む微粒子の製造方法 |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US20040101565A1 (OSRAM) |
| EP (1) | EP1370243B1 (OSRAM) |
| JP (1) | JP2004522796A (OSRAM) |
| KR (1) | KR20030081506A (OSRAM) |
| CN (1) | CN1507343A (OSRAM) |
| AT (1) | ATE400253T1 (OSRAM) |
| AU (1) | AU2002235101B8 (OSRAM) |
| BR (1) | BR0207827A (OSRAM) |
| CA (1) | CA2440163A1 (OSRAM) |
| DE (1) | DE60227488D1 (OSRAM) |
| DK (1) | DK1370243T3 (OSRAM) |
| ES (1) | ES2307722T3 (OSRAM) |
| IL (1) | IL157467A0 (OSRAM) |
| MX (1) | MXPA03007887A (OSRAM) |
| NO (1) | NO20033966L (OSRAM) |
| NZ (1) | NZ527997A (OSRAM) |
| PT (1) | PT1370243E (OSRAM) |
| SE (1) | SE0100822D0 (OSRAM) |
| SI (1) | SI1370243T1 (OSRAM) |
| WO (1) | WO2002072071A1 (OSRAM) |
| ZA (1) | ZA200306614B (OSRAM) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060159756A1 (en) * | 1999-09-10 | 2006-07-20 | Brita Sjoblom | Method to obtain microparticles containing an H+,K+-ATP-ASE inhibitor |
| SE0100823D0 (sv) * | 2001-03-09 | 2001-03-09 | Astrazeneca Ab | Method I to obtain microparticles |
| US6607784B2 (en) | 2000-12-22 | 2003-08-19 | Baxter International Inc. | Microprecipitation method for preparing submicron suspensions |
| US7193084B2 (en) | 2000-12-22 | 2007-03-20 | Baxter International Inc. | Polymorphic form of itraconazole |
| US6977085B2 (en) | 2000-12-22 | 2005-12-20 | Baxter International Inc. | Method for preparing submicron suspensions with polymorph control |
| US8067032B2 (en) | 2000-12-22 | 2011-11-29 | Baxter International Inc. | Method for preparing submicron particles of antineoplastic agents |
| US6951656B2 (en) | 2000-12-22 | 2005-10-04 | Baxter International Inc. | Microprecipitation method for preparing submicron suspensions |
| US6884436B2 (en) | 2000-12-22 | 2005-04-26 | Baxter International Inc. | Method for preparing submicron particle suspensions |
| US9700866B2 (en) | 2000-12-22 | 2017-07-11 | Baxter International Inc. | Surfactant systems for delivery of organic compounds |
| SE0100822D0 (sv) * | 2001-03-09 | 2001-03-09 | Astrazeneca Ab | Method II to obtain microparticles |
| SE0100824D0 (sv) * | 2001-03-09 | 2001-03-09 | Astrazeneca Ab | Method III to obtain microparticles |
| US20060003012A9 (en) | 2001-09-26 | 2006-01-05 | Sean Brynjelsen | Preparation of submicron solid particle suspensions by sonication of multiphase systems |
| AU2002337692B2 (en) | 2001-09-26 | 2007-09-13 | Baxter International Inc. | Preparation of submicron sized nanoparticles via dispersion and solvent or liquid phase removal |
| US7112340B2 (en) | 2001-10-19 | 2006-09-26 | Baxter International Inc. | Compositions of and method for preparing stable particles in a frozen aqueous matrix |
| WO2004080439A1 (ja) | 2003-03-12 | 2004-09-23 | Takeda Pharmaceutical Company Limited | 高濃度に活性成分を球形核に付着させた医薬組成物 |
| DE10325989A1 (de) * | 2003-06-07 | 2005-01-05 | Glatt Gmbh | Verfahren zur Herstellung von und daraus resultierende Mikropellets sowie deren Verwendung |
| US20050181052A1 (en) * | 2004-02-17 | 2005-08-18 | Patel Satishkumar A. | Lansoprazole microtablets |
| US20070207266A1 (en) * | 2006-02-15 | 2007-09-06 | Lemke Harald K | Method and apparatus for coating particulates utilizing physical vapor deposition |
| CH698658B1 (de) * | 2006-04-24 | 2009-09-30 | Mepha Ag | Orale pharmazeutische Formulierung mit schneller Freisetzung für Pyridylmethylsulfinyl-Benzimidazole. |
| US20090087569A1 (en) * | 2007-09-27 | 2009-04-02 | Fenchem Enterprises Ltd. | Methods for Preparing Highly Stable Hyaluronic Acid |
| IT1401284B1 (it) * | 2010-08-06 | 2013-07-18 | Valpharma S P A | Nuove formulazioni farmaceutiche idonee per la somministrazione orale di esomeprazolo magnesio diidrato, in forma di compresse mups (multi unit pellets system). |
| US10736855B2 (en) | 2016-02-25 | 2020-08-11 | Dexcel Pharma Technologies Ltd. | Compositions comprising proton pump inhibitors |
| US10076494B2 (en) | 2016-06-16 | 2018-09-18 | Dexcel Pharma Technologies Ltd. | Stable orally disintegrating pharmaceutical compositions |
| JPWO2021153525A1 (OSRAM) * | 2020-01-27 | 2021-08-05 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0163836B1 (de) * | 1984-04-07 | 1988-10-12 | Bayer Ag | Verfahren und Vorrichtung zur Herstellung von Granulaten |
| IL75400A (en) * | 1984-06-16 | 1988-10-31 | Byk Gulden Lomberg Chem Fab | Dialkoxypyridine methyl(sulfinyl or sulfonyl)benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing the same |
| GB2189698A (en) * | 1986-04-30 | 1987-11-04 | Haessle Ab | Coated omeprazole tablets |
| DE3909455A1 (de) * | 1989-03-22 | 1990-09-27 | Hoechst Ag | Verfahren zur herstellung von wasserdispergierbaren granulaten |
| CZ289804B6 (cs) * | 1994-07-08 | 2002-04-17 | Astrazeneca Ab | Multijednotková tabletovaná dávková forma I |
| FR2725623A1 (fr) * | 1994-10-18 | 1996-04-19 | Flamel Tech Sa | Microcapsules medicamenteuses et/ou nutritionnelles pour administration per os |
| DE19613395A1 (de) * | 1996-04-03 | 1997-10-09 | Basf Ag | Granulate hygroskopischer, wasserlöslicher Produkte |
| DE19733094A1 (de) * | 1997-07-31 | 1999-02-04 | Merck Patent Gmbh | Formulierung auf der Basis von Ascorbinsäure mit verbesserter Farbstabilität |
| DE59813833D1 (de) * | 1997-10-15 | 2007-01-11 | Merck Patent Gmbh | Herstellung eines direkt verpressbaren tablettierhilfsstoffes |
| US6174548B1 (en) * | 1998-08-28 | 2001-01-16 | Andrx Pharmaceuticals, Inc. | Omeprazole formulation |
| ATE303809T1 (de) * | 1997-12-08 | 2005-09-15 | Altana Pharma Ag | Orale verabreichungsform enthaltend einen protonenpumpeninhbitor (z.b. pantoprazole) |
| US20060159756A1 (en) * | 1999-09-10 | 2006-07-20 | Brita Sjoblom | Method to obtain microparticles containing an H+,K+-ATP-ASE inhibitor |
| SE0100823D0 (sv) * | 2001-03-09 | 2001-03-09 | Astrazeneca Ab | Method I to obtain microparticles |
| SE9903236D0 (sv) * | 1999-09-10 | 1999-09-10 | Astra Ab | Method to obtain microparticles |
| SE0100824D0 (sv) * | 2001-03-09 | 2001-03-09 | Astrazeneca Ab | Method III to obtain microparticles |
| SE0100822D0 (sv) * | 2001-03-09 | 2001-03-09 | Astrazeneca Ab | Method II to obtain microparticles |
-
2001
- 2001-03-09 SE SE0100822A patent/SE0100822D0/xx unknown
-
2002
- 2002-03-06 ES ES02701872T patent/ES2307722T3/es not_active Expired - Lifetime
- 2002-03-06 US US10/471,314 patent/US20040101565A1/en not_active Abandoned
- 2002-03-06 NZ NZ527997A patent/NZ527997A/en unknown
- 2002-03-06 IL IL15746702A patent/IL157467A0/xx unknown
- 2002-03-06 BR BR0207827-9A patent/BR0207827A/pt not_active IP Right Cessation
- 2002-03-06 JP JP2002571030A patent/JP2004522796A/ja active Pending
- 2002-03-06 MX MXPA03007887A patent/MXPA03007887A/es active IP Right Grant
- 2002-03-06 EP EP02701872A patent/EP1370243B1/en not_active Expired - Lifetime
- 2002-03-06 AT AT02701872T patent/ATE400253T1/de not_active IP Right Cessation
- 2002-03-06 SI SI200230729T patent/SI1370243T1/sl unknown
- 2002-03-06 DK DK02701872T patent/DK1370243T3/da active
- 2002-03-06 CA CA002440163A patent/CA2440163A1/en not_active Abandoned
- 2002-03-06 PT PT02701872T patent/PT1370243E/pt unknown
- 2002-03-06 WO PCT/SE2002/000400 patent/WO2002072071A1/en not_active Ceased
- 2002-03-06 AU AU2002235101A patent/AU2002235101B8/en not_active Ceased
- 2002-03-06 CN CNA028095987A patent/CN1507343A/zh active Pending
- 2002-03-06 DE DE60227488T patent/DE60227488D1/de not_active Expired - Fee Related
- 2002-03-06 KR KR10-2003-7011781A patent/KR20030081506A/ko not_active Ceased
-
2003
- 2003-08-25 ZA ZA200306614A patent/ZA200306614B/xx unknown
- 2003-09-08 NO NO20033966A patent/NO20033966L/no not_active Application Discontinuation
-
2007
- 2007-07-16 US US11/778,298 patent/US20080175917A1/en not_active Abandoned
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